Analysis of distribution and cellular dynamics of memory B cells

Research Project

Project/Area Number	21590545
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Immunology
Research Institution	The Institute of Physical and Chemical Research
Principal Investigator	AIBA Yuichi 独立行政法人理化学研究所, 分化制御研究グループ, 研究員 (00273516)
Project Period (FY)	2009 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	免疫記憶 / B細胞 / 胚中心
Research Abstract	For clarifying the location of memory B cells at peripheral lymphoid organs, I performed immunohitological analysis. This analysis reveals that IgG positive memory B cells locate adjacent to contracted germinal centers. I also clarified that IgG positive memory B cells enter S/G2/M phase of cell cycling after antigen re-stimulation in vivo adjacent to germinal center, where they reside. In contrast to IgG positive memory B cells, IgM positive memory B cells reside at follicle outside germinal center.

Report

(4 results)