Analysis of distribution and cellular dynamics of memory B cells

• Project/Area Number: 21590545
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Immunology
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: AIBA Yuichi 独立行政法人理化学研究所, 分化制御研究グループ, 研究員 (00273516)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 免疫記憶 / B細胞 / 胚中心

Research Abstract

For clarifying the location of memory B cells at peripheral lymphoid organs, I performed immunohitological analysis. This analysis reveals that IgG positive memory B cells locate adjacent to contracted germinal centers. I also clarified that IgG positive memory B cells enter S/G2/M phase of cell cycling after antigen re-stimulation in vivo adjacent to germinal center, where they reside. In contrast to IgG positive memory B cells, IgM positive memory B cells reside at follicle outside germinal center.

Research Products

• [Journal Article] ERKs induce expression of the transcriptional repressor Blimp-1 and subsequent plasma cell differentiation (2011)
  • Author(s): Yasuda T., Kometani K., Takahashi N., Imai Y., Aiba Y. and Kurosaki T.
  • Journal Title: Sci. Signal Volume: vol.4
  • Peer Reviewed
• [Journal Article] ERKs induce expression of the transcriptional repressor Blimp-1 and subsequent plasma cell differentiation (2011)
  • Author(s): Yasuda T., Kometani, K., Takahashi, N., Imai, Y., Aiba, Y. and Kurosaki, T
  • Journal Title: Sci. Signal Volume: 4, (169) Issue: 169 Pages: 104-16
  • DOI: 10.1126/scisignal.2001592
  • Peer Reviewed
• [Journal Article] Preferential localization of IgG memory B cells adjacent to contracted germinal centers (2010)
  • Author(s): Aiba Y., Kometani K., Hamadate M., Moriyama S., Sakaue-Sawano A., Tomura M., Luche H., Fehling HJ., Casellas R., Kanagawa O., Miyawaki A. and Kurosaki T.
  • Journal Title: Proc. Natl. Acad. Sci Volume: Vol.107 Pages: 12192-12197
  • Peer Reviewed
• [Journal Article] Preferential localization of IgG memory B cells adjacent to contracted germinal centers. (2010)
  • Author(s): Aiba Y, et al.
  • Journal Title: Proc.Natl.Acad.Sci.USA Volume: 107 Pages: 12192-12197
  • Peer Reviewed