| Project/Area Number |
21590665
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Seisen University. |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 産業衛生 / 希土類 / 吸入 / ユーロピウム(Eu) / セリウム(Ce) / マウス / 吸入曝露 / 体内動態 / セリウムCe / ユーロピウムEu / 吸入暴露 / 体内分布 / 経時変化 / サマリウムSm |
|---|
| Research Abstract |
Biological behavior of inhaled particles containing twokinds of rare earth elements, cerium(Ce) and europium(Eu), with different sizes(average diameter of 1 and 5μm) had been investigated. Oxide particles wereinhaled to male mice. Administered elements distributed mainly in lung, wheretheir concentrations were higher in smaller particle group and in longer exposuregroup, and decreased time-dependently after exposure. Ce was hardly detected inother organs, however, Eu was distributed also in liver, kidney, spleen and bonealthough the concentrations were much lower than those in lung. Eu concentrationsin bone showed some increase after exposure suggesting that a part of Eu in otherorgans moved to bone. Lung toxicity of these particles was thought to be lowbecause inflammation of lung was not observed. These results indicated that organdistribution of rare earth particles depended on the elements and exposureconditions, and suggested the necessity to consider these factors in theindustrial health and prevention.
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