| Project/Area Number |
21590704
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKEUCHI Toru 鹿児島大学, 医歯学総合研究科, 教授 (00188161)
ASAKAWA Akihiro 鹿児島大学, 医歯学総合研究科, 准教授 (10452947)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | カルニチン / ヘテロ接合体 / 脂肪酸代謝異常 / 肥満 / レプチン抵抗性 / 高脂肪食 / AGRP / POMC / 食事 / 食事脂質 |
|---|
| Research Abstract |
JVS mice, an animal model for systemic carnitine deficiency, were examined in effects of high-fat diets on weight. Male heterozygous JVS mice showed higher body weight due to higher food intake, in association with higher leptin in blood, compared with wild type of mice. Additionally, male heterozygous JVS mice showed higher AGRP and lower POMC mRNAs in the hypothalamus, indicating that heterozygotes may have leptin resistant state in central nervous system. The low carnitine levels in brain may be involved in the central leptin resistance, because carnitine ingestion from periphery was not effective.
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