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2011 Fiscal Year Final Research Report

Effects of fat in diets on heterozygous mutants of carnitine-deficient mice

Research Project

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Project/Area Number 21590704
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionKagoshima University

Principal Investigator

HORIUCHI Masahisa  鹿児島大学, 医歯学総合研究科, 准教授 (50264403)

Co-Investigator(Kenkyū-buntansha) TAKEUCHI Toru  鹿児島大学, 医歯学総合研究科, 教授 (00188161)
ASAKAWA Akihiro  鹿児島大学, 医歯学総合研究科, 准教授 (10452947)
Project Period (FY) 2009 – 2011
Keywordsカルニチン / ヘテロ接合体 / 脂肪酸代謝異常 / 肥満 / レプチン抵抗性 / 高脂肪食
Research Abstract

JVS mice, an animal model for systemic carnitine deficiency, were examined in effects of high-fat diets on weight. Male heterozygous JVS mice showed higher body weight due to higher food intake, in association with higher leptin in blood, compared with wild type of mice. Additionally, male heterozygous JVS mice showed higher AGRP and lower POMC mRNAs in the hypothalamus, indicating that heterozygotes may have leptin resistant state in central nervous system. The low carnitine levels in brain may be involved in the central leptin resistance, because carnitine ingestion from periphery was not effective.

  • Research Products

    (17 results)

All 2012 2011 2010 2009

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (4 results)

  • [Journal Article] Low-protein diet improves blood and urinary glucose levels and renal manifestations of diabetes in C57BLKS-db/db mice2012

    • Author(s)
      Arimura E, Horiuchi M, Kawaguchi H, Miyoshi N, Aoyama K, Takeuchi T
    • Journal Title

      Eur J Nutr

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Acupuncture improves sleep conditions of minipigs representing diurnal animals through an anatomically similar point to the acupoint(GV20) effective for humans2012

    • Author(s)
      Takeishi K-I, Horiuchi M, Kawaguchi H, Deguchi Y, Izumi H, Arimura E, Kuchiiwa S, Tanimoto A, Takeuchi T
    • Journal Title

      Evid Based Complement Alternat Med

      Volume: 2012 Pages: 472982

    • Peer Reviewed
  • [Journal Article] Benzene metabolite, 1, 2, 4-benzenetriol, induced halogenated DNA and tyrosine representing halogenative stress in human myeloid cell line HL-602012

    • Author(s)
      Nishikawa T, Miyahara E, Horiuchi M, Izumo K, Okamoto Y, Kawai Y, Kawano Y, Takeuchi T.
    • Journal Title

      Environ Health Perspect

      Volume: 120 Pages: 62-67

    • Peer Reviewed
  • [Journal Article] Long-term voluntary exercise, representing habitual exercise, lowers visceral fat and alters plasma amino acid levels in mice2011

    • Author(s)
      Takeshita H, Horiuchi M, Izumo K, Kawaguchi H, Arimura E, Aoyama K, Takeuchi T
    • Journal Title

      Environ Health Prev Med

      Volume: 4

    • Peer Reviewed
  • [Journal Article] Effect of exercise and high-fat diet on plasma adiponectin and nesfatin levels in mice2011

    • Author(s)
      Chaolu H, Asakawa H, Ushikai M, Li YX, Cheng KC, Li JB, Zoshiki T, Terashi M, Tanaka C, Atsuchi K, Sakoguchi T, Tsai M, Amitani H, Horiuchi M, Takeuchi T, Inui A
    • Journal Title

      Exp Ther Med

      Volume: 2 Pages: 369-373

    • Peer Reviewed
  • [Journal Article] Effect of habitual exercise on renal carcinogenesis by ferric nitrilotriacetate2011

    • Author(s)
      Kato T, Kawaguchi H, Miyoshi N, Aoyama K, Komatsu M, Horiuchi M, Yoshida H, Takeuchi T.
    • Journal Title

      Environ Health Prev Med

      Volume: 16 Pages: 232-238

    • Peer Reviewed
  • [Journal Article] Benzene induces cytotoxicity without metabolic activation2011

    • Author(s)
      Nishikawa T, Izumo K, Miyahara E, Horiuchi M, Okamoto Y, Kawano Y, Takeuchi T.
    • Journal Title

      J Occup Health

      Volume: 53 Pages: 84-92

    • Peer Reviewed
  • [Journal Article] Environmental mutagens may be implicated in the emergence of drug-resistant microorganisms2011

    • Author(s)
      Miyahara E, Nishie M, Takumi S, Miyanohara H, Nishi J, Yoshiie K, Oda H, Takeuchi M, Komatsu M, Aoyama K, Horiuchi M, Takeuchi T
    • Journal Title

      FEMS Microbiol Lett

      Volume: 317 Pages: 109-116

    • Peer Reviewed
  • [Journal Article] Induction of PDK4 in the heart muscle of JVS mice, an animal model of systemic carnitine deficiency, does not appear to reduce glucose utilization by the heart2011

    • Author(s)
      Ushikai M, Horiuchi M, Kobayashi K, Matuda S, Inui A, Takeuchi T, Saheki T
    • Journal Title

      Mol Genet Metab

      Volume: 102 Pages: 349-355

    • Peer Reviewed
  • [Journal Article] Novel microminipig model of atherosclerosis by high fat and high cholesterol diet,established in Japan2010

    • Author(s)
      Miyoshi N, Horiuchi M, Inokuchi Y, Miyamoto Y, Miura N, Tokunaga S, Fujiki M, Izumi Y, Miyajima H, Nagata R, Misumi K, Takeuchi T, Tanimoto A, Yasuda N, Yoshida H, Kawaguchi H.
    • Journal Title

      in vivo

      Volume: 24 Pages: 671-680

    • Peer Reviewed
  • [Journal Article] Early neonatal onset carbamoyl-phosphate synthase 1 deficiency treated with continuous hemodiafiltration and early living-related liver transplantation2009

    • Author(s)
      Ishida T, Hiroma T, Hashikura Y, Horiuchi M, Kobayashi K, Nakamura T.
    • Journal Title

      Pediatr Int

      Volume: 51 Pages: 409-410

    • Peer Reviewed
  • [Journal Article] Failure of the feeding response to fasting in carnitine-deficient juvenile visceral steatosis(JVS) mice : involvement of defective acyl-ghrelin secretion and enhanced corticotropin-releasing factor signaling in the hypothalamus2009

    • Author(s)
      Sakoguchi T, Horiuchi M, Asakawa A, Ushikai M, Yoshida G, Fujimiya M, Kato I, Nakazato M, Takeuchi T, Saheki T, Inui A.
    • Journal Title

      Biochim Biophys Acta(Molecular Basis of Disease)

      Volume: 1792 Pages: 1087-1093

    • Peer Reviewed
  • [Journal Article] Dehyderoepiandrosterone increased oxidative stress in a human cell line during differentiation2009

    • Author(s)
      Izumo K, Horiuchi M, Komatsu M, Aoyama K, Bandow K, Matsuguchi T, Takeuchi M, Takeuchi T.
    • Journal Title

      Free Radic Res

      Volume: 43 Pages: 922-931

    • Peer Reviewed
  • [Presentation] 世界最小ミニブタの産業医学研究への展開2011

    • Author(s)
      堀内正久
    • Organizer
      日本産業衛生学会九州地方会
    • Place of Presentation
      佐賀市
    • Year and Date
      2011-07-01
  • [Presentation] 世界最小ミニブタの栄養学実験への応用2011

    • Author(s)
      堀内正久、川口博明
    • Organizer
      日本病態栄養学会
    • Place of Presentation
      横浜市
    • Year and Date
      2011-01-16
  • [Presentation] 習慣的な自発運動の肺炎予防効果に関する実験的研究:日の遺伝子発現変化からの考察2009

    • Author(s)
      堀内正久、出雲公子、竹下温子、川口博明、青山公治、竹内亨
    • Organizer
      第7回日本予防医学会学術総会
    • Place of Presentation
      千葉市
    • Year and Date
      2009-12-12
  • [Presentation] 大学における労働衛生管理の現状2009

    • Author(s)
      堀内正久
    • Organizer
      日本産業衛生学会九州地方会
    • Place of Presentation
      那覇市
    • Year and Date
      2009-06-27

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Published: 2013-07-31  

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