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Molecular-biological analysis of the effect of methamphetamine on the heart in stressed mice

Research Project

Project/Area Number 21590735
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Legal medicine
Research InstitutionMie University

Principal Investigator

NATA Masayuki  三重大学, 大学院・医学系研究科, 教授 (70241627)

Co-Investigator(Kenkyū-buntansha) TOMITA Masahumi  川崎医科大学, 医学部, 准教授 (50113197)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords覚醒剤 / ストレス / 遺伝子発現 / サイトカイン / メタンフェタミン / 水浸拘束 / Heat shock protein / コルチコステロン / gap junction / connexin / 炎症性サイトカイン / 心筋障害 / 致死性不整脈 / 身体拘束 / 心臓 / NFκB / MAPK / 炎症反応 / Renin-angiotensin-aldosterone(RAA)系
Research Abstract

Interaction in the heart between the administration of methamphetamine(MAP) and stress was investigated. The result suggests induction of an inflammatory condition such as damage to the myocardium, and indicated that these insults affected the circulatory system additively or synergistically. Long term interaction of Map and stress was also investigated, some interesting findings were obtained.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (14 results)

All 2011 2010 2009

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (6 results)

  • [Journal Article] Water-restraint stress enhances methamphetamine induced cardiotoxicity2011

    • Author(s)
      Tomita M, Katsuyama H, Watanabe Y, Hidaka K, Yoshitome K, Miyaishi S, Ishikawa T, Shinone K, Nata M
    • Journal Title

      Chem Biol Interact

      Volume: 190 Pages: 54-61

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Water-restraint stress enhances methamphetamine-induced cardiotoxicity2011

    • Author(s)
      Tomita M, Katsuyama H, Watanabe Y, Hidaka K, Yoshitome K, Miyaishi S, Ishikawa T, Shinone K, Nata M
    • Journal Title

      Chem Biol Interact

      Volume: 190 Pages: 54-61

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Water-restraint stress enhances methamphetamine-induced cardiotoxicity2011

    • Author(s)
      Masafumi Tomita, Hironobu Katsuyama, Yoko Watanabe, Kazuo Hidaka, Kei Yoshitome, Satoru Miyaishi, Takaki Ihikawa, Kotaro, Shinone, Masayuki Nata
    • Journal Title

      Chemico-biological interactions

      Volume: 190 Pages: 54-61

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular biological analysis of cardiac effect of high temperature in rats2010

    • Author(s)
      Nakagawa Y, Inoue H, Shinone K, Ikemura M, Nata M
    • Journal Title

      leg Med

      Volume: 14 Pages: 63-68

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular-biological analysis of the effect of methamphetamine on the heart in restrained mice2010

    • Author(s)
      Shinone K, Tomita M, Inoue H, Nakagawa Y, Ikemura M, Nata M
    • Journal Title

      Legal Med

      Volume: 12 Pages: 79-83

    • NAID

      10029882868

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular-biological analysis of the effect of methamphetamine on the heart in restrained mice2010

    • Author(s)
      Shinone K, Tomita M, Inoue H, Nakagawa Y, Ikemura M, Nata M.
    • Journal Title

      Leg Med

      Volume: 12 Pages: 79-83

    • NAID

      10029882868

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methanphetamine protects against stress-induced gastric mucosal lesions in miice2009

    • Author(s)
      Tomita M, Okuyama T, Nata M, et al.
    • Journal Title

      Legal Medicine 11 Suppl

      Pages: 437-439

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pulmonary fat embolization as a diagnostic finding for heat exposure2009

    • Author(s)
      Inoue H, Ikeda N, Tsuji A, Kudo K, Hanagama M, Nata M
    • Journal Title

      Legal Medicine 11

      Pages: 1-3

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] ストレスと覚醒剤の長期相互作用.とくに心筋への影響2011

    • Author(s)
      富田正文,石川隆紀,篠根光太郎,那谷雅之
    • Organizer
      第95次日本法医学会学術全国集会
    • Place of Presentation
      福島
    • Year and Date
      2011-06-17
    • Related Report
      2011 Final Research Report
  • [Presentation] ストレスと覚醒剤の長期相互作用-とくに心筋への影響-2011

    • Author(s)
      富田正文、石川隆紀、篠根光太郎、那谷雅之
    • Organizer
      第95次日本法医学会学術全国集会
    • Place of Presentation
      福島県福島市
    • Year and Date
      2011-06-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] ストレス環境下で覚醒剤の心筋に及ぼす影響. Heat shock proteinの関与2010

    • Author(s)
      富田正文,吉留敬,宮石智,篠根光太郎,那谷雅之
    • Organizer
      第94次日本法医学会学術全国集会
    • Place of Presentation
      東京
    • Year and Date
      2010-06-24
    • Related Report
      2011 Final Research Report
  • [Presentation] ストレス環境下で覚醒剤の心筋に及ぼす影響-Heat shock proteinの関与2010

    • Author(s)
      富田正文、吉留敬、宮石智、篠根光太郎、那谷雅之、守屋文夫、石津日出雄
    • Organizer
      第94次日本法医学会学術全国集会
    • Place of Presentation
      東京(タワーホール船堀)
    • Year and Date
      2010-06-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 覚醒剤及び身体拘束の心臓における遺伝子発現への影響(第2報)2009

    • Author(s)
      篠根光太郎,富田正文,那谷雅之,井上裕匡,伊藤真弓
    • Organizer
      第93次日本法医学会学術全国集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-05-15
    • Related Report
      2011 Final Research Report
  • [Presentation] 覚醒剤及び身体拘束の心臓における遺伝子発現への影響2009

    • Author(s)
      篠根光太郎, 富田正文, 那谷雅之, 井上裕匡, 伊藤真弓
    • Organizer
      第93次日本法医学会学術全国集会
    • Place of Presentation
      大阪、千里ライフサイエンスセンター
    • Year and Date
      2009-05-14
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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