Molecular-biological analysis of the effect of methamphetamine on the heart in stressed mice
Project/Area Number |
21590735
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Legal medicine
|
Research Institution | Mie University |
Principal Investigator |
NATA Masayuki 三重大学, 大学院・医学系研究科, 教授 (70241627)
|
Co-Investigator(Kenkyū-buntansha) |
TOMITA Masahumi 川崎医科大学, 医学部, 准教授 (50113197)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 覚醒剤 / ストレス / 遺伝子発現 / サイトカイン / メタンフェタミン / 水浸拘束 / Heat shock protein / コルチコステロン / gap junction / connexin / 炎症性サイトカイン / 心筋障害 / 致死性不整脈 / 身体拘束 / 心臓 / NFκB / MAPK / 炎症反応 / Renin-angiotensin-aldosterone(RAA)系 |
Research Abstract |
Interaction in the heart between the administration of methamphetamine(MAP) and stress was investigated. The result suggests induction of an inflammatory condition such as damage to the myocardium, and indicated that these insults affected the circulatory system additively or synergistically. Long term interaction of Map and stress was also investigated, some interesting findings were obtained.
|
Report
(4 results)
Research Products
(14 results)