Effects of patho-physiological changes on the toxicokinetics of drug and chemicals.

• Project/Area Number: 21590749
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Legal medicine
• Research Institution: Kagawa University
• Principal Investigator: KINOSHITA Hiroshi 香川大学, 医学部, 教授 (00284357)
• Co-Investigator(Kenkyū-buntansha): AMENO Kiyoshi 香川大学, 医学部, 准教授 (50019626) ; TAKAHASHI Motonori 神戸大学, 医学部, 講師 (90509100)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 薬毒物 / 体内動態 / ストレス / 病態 / エタノール / 中毒 / 医薬品 / 化学物質 / 分布 / 農薬 / グルココルチコイド / 行動異常 / 個体差 / メタンフェタミン / 食餌摂取量 / アルコール / 嗜好性

Research Abstract

There was no difference of plasma corticosterone concentration between HAP(high alcohol preferring) and LAP(low alcohol preferring) rats following ethanol administration. We observed significant lowering of body weight gain, due to the decreased food intake and elevation of plasma corticosterone concentration following repeated methamphetamine administration, even in the short term.
We observed the different distribution patterns compare to the regular condition, from the analysis of drug concentrations in poisoning cases. We concluded that it is important to consider the residual amount of the drugs in the gastrointestinal tract for the toxicological evaluation in massive ingestion case.

Research Products

• [Journal Article] Determination of acephate and methamidphos in tissues : apperance of matrix effect in gas chromatography-mass spectrometry (2011)
  • Author(s): Adachi N, Kinoshita H, Nishiguchi M, Takahashi M, Ouchi H, Minami T, Matsui K, Yamamura T, Yoshida S, Nishio H
  • Journal Title: Forensic Toxicol Volume: 29 Pages: 159-62
  • Peer Reviewed
• [Journal Article] 体外検査用オキシメータ(エーボックス4000)の法医実務への応用(第2報)-凍死の補助診断への応用- (2011)
  • Author(s): 田中直子, 飴野清, ジャーマルモストファ, 組橋充, 木下博之
  • Journal Title: 法医学の実際と研究 Volume: 54 Pages: 205-209
  • Peer Reviewed
• [Journal Article] A case of drowning whilst under the influence of brotizolam, flunitrazepam and ethanol (2011)
  • Author(s): Tanaka N, Kinoshita H, Jamal M, Ohkubo E, Kumihashi M, Ameno K
  • Journal Title: Soud Lek Volume: 56 Pages: 5-6
  • Peer Reviewed
• [Journal Article] An autopsy case of multiple psychotropic drug poisoning (2011)
  • Author(s): Tanaka N, Kinoshita H, Nishiguchi M, Jamal M, Kumihashi M, Takahashi M, Nishio H, Ameno K
  • Journal Title: Soud Lek Volume: 56 Pages: 38-9
  • Peer Reviewed
• [Journal Article] A fatal case of severe methemoglobinemia presumably due to chlorate ingestion (2011)
  • Author(s): Kinoshita H, Yoshioka N, Kuse A, Nishiguchi M, Tanaka N, Jamal M, Kumihashi M, Nagasaki Y, Ueno Y, Ameno K
  • Journal Title: Soud Lek Volume: 56 Pages: 43-4
  • Peer Reviewed
• [Journal Article] A fatal case of severe methemoglobinemia presumably due to chlorate ingestion (2011)
  • Author(s): Kinoshita H, Yoshioka N, et al
  • Journal Title: Soud Lek Volume: 56 Pages: 43-44
  • Peer Reviewed
• [Journal Article] Determination of acephate and methamidphos in tissues : apperance of matrix effect in gas chromatography-mass spectrometry (2011)
  • Author(s): Adachi N, Kinoshita H, et al
  • Journal Title: Forensic Toxicol Volume: 29 Issue: 2 Pages: 159-162
  • DOI: 10.1007/s11419-011-0110-9
  • Peer Reviewed
• [Journal Article] Detection of metallic elements from paraffin-embedded tissue blocks by energy dispersive X-ray fluorescent spectrometry (2010)
  • Author(s): Takahashi M, Kinoshita H, Nishiguchi M, Nishio H
  • Journal Title: Legal Med Volume: 12 Pages: 102-103
  • NAID: 10029883000
  • Peer Reviewed
• [Journal Article] Effects of repeated administration of methamphetamine on corticosterone secretion in rats (2010)
  • Author(s): Kinoshita H, Takahashi M, Matsui K, Nishiguchi M, Ouchi H, Minami T, Hishida H, Jamal M, Ohkubo E, Tanaka N, Ameno K
  • Journal Title: Current study of environmental and medical science Volume: 3 Pages: 3-4
  • Peer Reviewed
• [Journal Article] An autopsy case of poisoning with selective serotonin reuptake inhibitor, paroxetine (2010)
  • Author(s): Takahashi M, Kinoshita H, Kuse A, Morichika M, Nishiguchi M, Ouchi H, Minami T, Matsui K, Yamamura T, Motomura H, Otsu N, Yoshida S., Adachi N, Ueno Y, Hishida S, Nishio H
  • Journal Title: Soud Lek Volume: 55 Pages: 2-4
  • Peer Reviewed
• [Journal Article] An autopsy case of carbamazepine poisoning (2010)
  • Author(s): Kinoshita H, Morikawa K, Kuse A, Nagasaki Y, Takahashi M, Nishiguchi M, Nishio H, Ueno Y, Jamal M, Kubo Y, Tanaka N, Ameno K
  • Journal Title: Soud Lek Volume: 55 Pages: 22-24
  • Peer Reviewed
• [Journal Article] An autopsy case of butane gas abuse (2010)
  • Author(s): Tanaka N, Kinoshita H, Haba R, Jamal M, Ohkubo E, Ameno K
  • Journal Title: Soud Lek Volume: 55 Pages: 44-45
  • Peer Reviewed
• [Journal Article] 体外検査用オキシメータ(エーボックス4000)の法医実務への応用(第1報)-一酸化炭素ヘモグロビン飽和度測定- (2010)
  • Author(s): 田中直子, 飴野清, ジャーマルモストファ, 久保裕介, 組橋充, 大久保恵理子, 木下博之
  • Journal Title: 法医学の実際と研究 Volume: 53 Pages: 39-43
  • Peer Reviewed
• [Journal Article] Effects of repeated administration of methamphetamine on corticosterone secretion in rats. (2010)
  • Author(s): Kinoshita H, et al.
  • Journal Title: Current study of environmental and medical science Volume: 3 Pages: 3-4
  • Peer Reviewed
• [Journal Article] An autopsy case of carbamazepine poisoning. (2010)
  • Author(s): Kinoshita H, et al.
  • Journal Title: Soud Lek Volume: 55 Pages: 22-24
  • Peer Reviewed
• [Journal Article] An autopsy case of butane gas abuse. (2010)
  • Author(s): Tanaka N, et al.
  • Journal Title: Soud Lek Volume: 55 Pages: 44-45
  • Peer Reviewed
• [Journal Article] Corticosterone concentration following ethanol administration in high alcohol preferring(HAP) and low alcohol preferring(LAP) rats (2009)
  • Author(s): Kinoshita H, Takahashi M, Matsui K, Nishiguchi M, Ouchi H, Minami T, Hishida H, Jamal M, Ameno K
  • Journal Title: Current study of environmental and medical science Volume: 2 Pages: 13-15
  • Peer Reviewed
• [Journal Article] Corticosterone concentration following ethanol administration in high alcohol preferring (HAP) and low alcohol preferring (LAP) rats (2009)
  • Author(s): Kinoshita H
  • Journal Title: Current Study of Environmental and Medical Sciences 2 Pages: 13-15
  • Peer Reviewed
• [Presentation] カーバメート系農薬中毒の1例 (2011)
  • Author(s): 木下博之, 田中直子, ジャーマルモストファ, 組橋充, 飴野清
  • Organizer: 第23回日本中毒学会中四国地方会学術集会
  • Place of Presentation: 倉敷
  • Year and Date: 2011-12-10
• [Presentation] 大腿骨骨折後に凍死に至ったと考えられた一剖検例 (2011)
  • Author(s): 田中直子, 飴野清, ジャーマルモストファ, 組橋充, 木下博之
  • Organizer: 第28回日本法医学会学術中四国地方集会
  • Place of Presentation: 倉敷
  • Year and Date: 2011-10-15
• [Presentation] けい肺の1例 (2011)
  • Author(s): 木下博之, 田中直子, ジャーマルモストファ, 組橋充, 高橋玄倫, 西尾元, 飴野清
  • Organizer: 第28回日本法医学会学術中四国地方集会
  • Place of Presentation: 倉敷
  • Year and Date: 2011-10-15
• [Presentation] Poisoning cases due to the multiple drug ingestion (2011)
  • Author(s): Kinoshita H, et al
  • Organizer: 8th International Symposium Advances in Legal Medicine
  • Place of Presentation: Johgnn Wolfgang Goethe -University, Frankfurt(招待講演)
  • Year and Date: 2011-09-30
• [Presentation] アルコールの影響評価 (2011)
  • Author(s): 飴野清, 木下博之, ジャーマルモストファ, 田中直子, 組橋充
  • Organizer: 第19回法医病理勉強会・第17回法中毒懇話会(シンポジウム)「薬物関連死をめぐる法病理・法中毒のクロストーク」
  • Place of Presentation: 福島
  • Year and Date: 2011-06-15
• [Presentation] 体外検査用オキシメータ(エーボックス4000)の法医実務への応用(3) (2011)
  • Author(s): 田中直子, 飴野清, ジャーマルモストファ, 大久保恵理子, 組橋充, 木下博之
  • Organizer: 第95次日本法医学会総会
  • Place of Presentation: 福島
• [Presentation] Poisoning cases due to the multiple drug ingestion (2011)
  • Author(s): Kinoshita H, Ameno K, Jamal M, Tanaka N
  • Organizer: 8th International Symposium Advances in Legal Medicine
  • Place of Presentation: Frankfurt, Germany
• [Presentation] Autopsy case of butane gas abuse (2011)
  • Author(s): Kinoshita H, Tanaka N, Haba R, Jamal M, Kumihashi M, Ameno K
  • Organizer: 8th International Symposium Advances in Legal Medicine
  • Place of Presentation: Frankfurt, Germany
• [Presentation] Application of oximeter AVOX 4000 in the forensic practice (2011)
  • Author(s): Tanaka N, Ameno K, Jamal M, Kumihashi M, Kinoshita H
  • Organizer: 8th International Symposium Advances in Legal Medicine
  • Place of Presentation: Frankfurt, Germany
• [Presentation] ブタンガス中毒の2例 (2010)
  • Author(s): 木下博之, 田中直子, ジャーマルモストファ, 大久保恵理子, 組橋充, 飴野清
  • Organizer: 第22回日本中毒学会中四国地方会学術集会
  • Place of Presentation: 高松
  • Year and Date: 2010-12-11
• [Presentation] ブタンガス中毒の2例 (2010)
  • Author(s): 木下博之, 他
  • Organizer: 第22回日本中毒学会中四国地方会学術集会
  • Place of Presentation: サンポートホール(香川県)
  • Year and Date: 2010-12-11
• [Presentation] 向精神薬とエタノールの影響下での溺水の1例 (2010)
  • Author(s): 木下博之, 田中直子, ジャーマルモストファ, 大久保恵理子, 組橋充, 飴野清
  • Organizer: 第27回日本法医学会学術中四国地方集会
  • Place of Presentation: 徳島
  • Year and Date: 2010-10-16
• [Presentation] 体外検査用オキシメータ(エーボックス4000)の法医実務への応用(2) (2010)
  • Author(s): 田中直子, 飴野清, ジャーマルモストファ, 大久保恵理子, 組橋充, 木下博之
  • Organizer: 第27回日本法医学会学術中四国地方集会
  • Place of Presentation: 徳島
  • Year and Date: 2010-10-16
• [Presentation] 蛍光X線分析を用いたパラフィン包埋組織中の金属元素の検出 (2010)
  • Author(s): 高橋玄倫, 木下博之, 南貴子, 西口美紀, 大内晴美, 松井清司, 本村浩之, 吉田史絵, 足立伸行, 西尾元
  • Organizer: 第94次日本法医学会総会
  • Place of Presentation: 東京
• [Presentation] 体外検査用オキシメータ(エーボックス4000)の法医中毒学への応用(1) (2010)
  • Author(s): 田中直子, 飴野清, ジャーマルモストファ, 久保裕介, 組橋充, 大久保恵理子, 木下博之
  • Organizer: 第94次日本法医学会総会
  • Place of Presentation: 東京
• [Presentation] カルバマゼピン中毒の1例 (2009)
  • Author(s): 木下博之, 森川公子, 久世亜澄, 長崎靖, 高橋玄倫, 西口美紀, 西尾元, 上野易弘, Mostofa Jamal, 久保裕介, 飴野清
  • Organizer: 第26回日本法医学会学術中四国地方集会
  • Place of Presentation: 小郡
  • Year and Date: 2009-10-17
• [Presentation] Application of energy dispersive X-ray fluorescent spectroscopy(EDXRF) in screening test for drug related case (2009)
  • Author(s): Takahashi M, Kinoshita H, Nishio, H
  • Organizer: XXI Congress of the International Academy of Legal Medicine
  • Place of Presentation: Lisbon. Portugal
• [Presentation] Analysis of acephate and its metabolite in serum by GC-MS (2009)
  • Author(s): Adachi N, Kinoshita H, Nishiguchi M, Takahashi M, Ouchi H, Minami T, Matsui K, Yamamura T, Motomura H, Otsu N, Yoshida S, Hishida, S
  • Organizer: XXI Congress of the International Academy of Legal Medicine
  • Place of Presentation: Lisbon. Portugal
• [Presentation] Studies for the asbestos exposure in Japanese urban populations (2009)
  • Author(s): Kinoshita H, Matsui K, Takahashi M, Nishiguchi M, Minami T, Otsu N, Yoshida S, Adachi N, Hishida, S, Jamal M, Ameno K
  • Organizer: XXI Congress of the International Academy of Legal Medicine
  • Place of Presentation: Lisbon. Portugal
• [Book] Application of energy dispersive X-ray fluorescent spectroscopy(EDX) in medico-Legal autopsy case. In" Acta Medicinae Legalis et Socialis" (2010)
  • Author(s): Takahashi M, Kinoshita H, Kuse A, Morichika M, Nishiguchi M, Ouchi H, Minami T, Matsui K, Yamamura T, Motomura H, Ohtsu N, Yoshida S, Adachi N, Hishida S, Ueno Y, Nishio, H
  • Publisher: Vieira DN, Busuttil A, Cusack D, Beth P. eds
• [Book] Studies for the asbestos exposure in Japanese urban populations. In" Acta Medicinae Legalis et Socialis" (2010)
  • Author(s): Kinoshita H, Matsui K, Takahashi M, Nishiguchi M, Ouchi H, Minami T, Otsu N, Yoshida S, Adachi N, Hishida, S, Jamal M, Tanaka N, Ohkubo E, Ameno K
  • Publisher: Vieira DN, Busuttil A, Cusack D, Beth P. eds