| Project/Area Number |
21590749
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
AMENO Kiyoshi 香川大学, 医学部, 准教授 (50019626)
TAKAHASHI Motonori 神戸大学, 医学部, 講師 (90509100)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 薬毒物 / 体内動態 / ストレス / 病態 / エタノール / 中毒 / 医薬品 / 化学物質 / 分布 / 農薬 / グルココルチコイド / 行動異常 / 個体差 / メタンフェタミン / 食餌摂取量 / アルコール / 嗜好性 |
|---|
| Research Abstract |
There was no difference of plasma corticosterone concentration between HAP(high alcohol preferring) and LAP(low alcohol preferring) rats following ethanol administration. We observed significant lowering of body weight gain, due to the decreased food intake and elevation of plasma corticosterone concentration following repeated methamphetamine administration, even in the short term.
We observed the different distribution patterns compare to the regular condition, from the analysis of drug concentrations in poisoning cases. We concluded that it is important to consider the residual amount of the drugs in the gastrointestinal tract for the toxicological evaluation in massive ingestion case.
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