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Immunological tolerance induced by Kampo medicine kakkonto through the regulation of helper T cell differentiation in the mucosal immune system of the intestine.

Research Project

Project/Area Number 21590760
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionUniversity of Toyama

Principal Investigator

KADOWAKI Makoto  富山大学, 和漢医薬学総合研究所, 教授 (20305709)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Takeshi  富山大学, 和漢医薬学総合研究所, 助教 (70316181)
影山 夏子  富山大学, 和漢医薬学総合研究所, 助教 (90342865)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords東洋医学 / 腸管粘膜免疫系 / 葛根湯 / 食物アレルギー / 制御性T細胞 / 活性化T細胞 / 末梢性免疫寛容 / 樹状細胞 / Foxp3 / CD25
Research Abstract

The mechanisms underlying the pharmacological effects of kakkonto in murine food allergy model were examined. As a result, kakkonto facilitated the differentiation from naive helper T cells to CD25 negative CD3+CD4+FR4+Foxp3+T cells in the immunological responses within the mucosal immune system of the intestine and thereby alleviated the allergic responses. However, the further detailed investigation of the underlying mechanisms is needed.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (20 results)

All 2012 2011 2010 2009

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (10 results)

  • [Journal Article] Oral Tolerance Induced by Transfer of Food Antigens via Breast Milk of Allergic Mothers Prevents Offspring from Developing Allergic Symptoms in a Mouse Food Allergy Model2012

    • Author(s)
      Yamamoto T, Tsubota Y, Kodama T, Kageyama-Yahara N, Kadowaki M
    • Journal Title

      Clinical and Developmental Immunology Volume 2012(2012)

      Volume: 2012 Pages: 721085-721085

    • DOI

      10.1155/2012/721085

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rab5a regulates surface expression of FcεRI and functional activation in mast cells2011

    • Author(s)
      Kageyama-Yahara N., Suehiro Y., Yamamoto T., Kadowaki M
    • Journal Title

      Biological & Pharmaceutical Bulletin

      Volume: 34 Pages: 760-763

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of phospholipase Cγ1 phosphorylation by cinnamaldehyde inhibits antigen-induced extracellular calcium influx and degranulation in mucosal mast cells2011

    • Author(s)
      Kageyama-Yahara N., Wang X., Katagiri T., Wang P., Yamamoto T., Tominaga M., Kadowaki M
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 416 Pages: 283-288

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of phospholipase Cγ1 phosphorylation by cinnamaldehyde in hibits antigen-induced extracellular calcium influx and degranulation in mucosal mast cells2011

    • Author(s)
      Kageyama-Yahara N, Wang X, Katagiri T, Wang P, Yamamoto T, Tominaga M, Kadowaki M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 416 Issue: 3-4 Pages: 283-8

    • DOI

      10.1016/j.bbrc.2011.11.014

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rab5a Regulates Surface Expression of Fc.EPSILON.RI and Functional Activation in Mast Cells2011

    • Author(s)
      Kageyama-Yahara N, Suehiro Y, Yamamoto T, Kadowaki M
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 34 Issue: 5 Pages: 760-763

    • DOI

      10.1248/bpb.34.760

    • NAID

      130000657792

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The inhibitory effect of ergosterol, a bioactive constituent of a traditional Japanese herbal medicine saireito on the activity of mucosal-type mast cells2010

    • Author(s)
      Kageyama-Yahara N., Wang P., Wang X., Yamamoto T., Kadowaki M
    • Journal Title

      Biological & Pharmaceutical Bulletin

      Volume: 33 Pages: 142-145

    • NAID

      130000140209

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pentagalloy lglucose down-regulates mast cell surface FcepsilonRI expression in vitro and in vivo2010

    • Author(s)
      Kageyama-Yahara N., Suehiro Y., Maeda F., Kageyama S., Fukuoka J., Katagiri T., Yamamoto T., Kadowaki M
    • Journal Title

      FEBS Letter

      Volume: 584 Pages: 111-118

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pentagalloylglucose down-regulates mast cell surface FcepsilonRI expression in vitro and in vivo.2010

    • Author(s)
      Kageyama-Yahara N, Suehiro Y, Maeda F, Kageyama S, Fukuoka J, Katagiri T, Yamamoto T, Kadowaki M.
    • Journal Title

      FEBS Lett.

      Volume: 584 Pages: 111-118

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The inhibitory effect of ergosterol, a bioactive constituent of a traditional Japanese herbal medicine saireito on the activity of mucosal-type mast cells.2010

    • Author(s)
      Kageyama-Yahara N., Wang P., Wang X., Yamamoto T., Kadowaki M.
    • Journal Title

      Biological & Pharmaceutical Bulletin

      Volume: 33 Pages: 142-145

    • NAID

      130000140209

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pentagalloylglucose down-regulates mast cell surface FcepsilonRI expression in vitro and in vivo.2010

    • Author(s)
      Kageyama-Yahara N, Suehiro Y, Maeda F, Kageyama S, Fukuoka J, Katagiri T, Yamamoto T, Kadowaki M.
    • Journal Title

      FEBS Lett. 584

      Pages: 111-118

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 樹状細胞を介した葛根湯によるエフェクターT細胞の分化・増殖の抑制2011

    • Author(s)
      山本武,原優加,門脇真
    • Organizer
      第28回和漢医薬学会学術大会
    • Place of Presentation
      富山
    • Related Report
      2011 Final Research Report
  • [Presentation] 樹状細胞を介した葛根湯によるエフェクターT細胞の分化・増殖の抑制2011

    • Author(s)
      山本武
    • Organizer
      第28回和漢医薬学会学術大会
    • Place of Presentation
      富山県民会館
    • Related Report
      2011 Annual Research Report
  • [Presentation] 食物アレルギー病態モデルにおける葛根湯の新規制御性T細胞を介した腸管粘膜免疫抑制作用2010

    • Author(s)
      山本武
    • Organizer
      第27回和漢医薬学会
    • Place of Presentation
      京都薬科大学
    • Year and Date
      2010-08-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Traditional Chinese-Japanese medicine research in mucosal immunity.2010

    • Author(s)
      Kadowaki M.
    • Organizer
      East-West Scientific Symposia on Allergy & Traditional Oriental Medicine
    • Place of Presentation
      Luoyang, China
    • Year and Date
      2010-04-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Traditional Chinese-Japanese medicine research in mucosal immunity2010

    • Author(s)
      Kadowaki M
    • Organizer
      East-West Scientific Symposia on Allergy & Traditional Oriental Medicine
    • Place of Presentation
      Luoyang, China
    • Related Report
      2011 Final Research Report
  • [Presentation] 食物アレルギー病態モデルにおける葛根湯の新規制御性T細胞を介した腸管粘膜免疫抑制作用2010

    • Author(s)
      山本武,藤原加苗,坪田悠真,門脇真
    • Organizer
      第27回和漢医薬学会学術大会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] 食物アレルギー性消化器症状誘発病態モデルにおける葛根湯による制御性T細胞への分化亢進を介する腸管粘膜免疫系の制御機構2009

    • Author(s)
      山本武
    • Organizer
      第26回和漢医薬学会
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2009-08-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effect of kakkonto, a traditional Japanese herbal medicine, on the differentiation of CD4+T cells in the colon of food allergy model mouse2009

    • Author(s)
      門脇真
    • Organizer
      国際粘膜免疫学会
    • Place of Presentation
      ボストン アメリカ合衆国
    • Year and Date
      2009-07-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effect of kakkonto, a traditional Japanese herbal medicine, on the differentiation of CD4+T cells in the colon of food allergy model mouse2009

    • Author(s)
      Yamamoto T., Fujiwara K., Yoshida M., Kadowaki M
    • Organizer
      International Congress of Mucosal Immunology
    • Place of Presentation
      Boston, U. S. A.
    • Related Report
      2011 Final Research Report
  • [Presentation] 食物アレルギー性消化器症状誘発病態モデルにおける葛根湯による制御性T細胞への分化亢進を介する腸管粘膜免疫系の制御機構(プレナリーセッション講演)2009

    • Author(s)
      山本武,藤原加苗,氣賀澤愛,吉田益奈子,門脇真
    • Organizer
      第26回和漢医薬学会学術大会
    • Place of Presentation
      千葉
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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