Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Research Abstract |
The mechanisms underlying the pharmacological effects of kakkonto in murine food allergy model were examined. As a result, kakkonto facilitated the differentiation from naive helper T cells to CD25 negative CD3+CD4+FR4+Foxp3+T cells in the immunological responses within the mucosal immune system of the intestine and thereby alleviated the allergic responses. However, the further detailed investigation of the underlying mechanisms is needed.
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