Immunological tolerance induced by Kampo medicine kakkonto through the regulation of helper T cell differentiation in the mucosal immune system of the intestine.
| Project/Area Number |
21590760
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | University of Toyama |
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Principal Investigator |
KADOWAKI Makoto 富山大学, 和漢医薬学総合研究所, 教授 (20305709)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Takeshi 富山大学, 和漢医薬学総合研究所, 助教 (70316181)
影山 夏子 富山大学, 和漢医薬学総合研究所, 助教 (90342865)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 東洋医学 / 腸管粘膜免疫系 / 葛根湯 / 食物アレルギー / 制御性T細胞 / 活性化T細胞 / 末梢性免疫寛容 / 樹状細胞 / Foxp3 / CD25 |
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| Research Abstract |
The mechanisms underlying the pharmacological effects of kakkonto in murine food allergy model were examined. As a result, kakkonto facilitated the differentiation from naive helper T cells to CD25 negative CD3+CD4+FR4+Foxp3+T cells in the immunological responses within the mucosal immune system of the intestine and thereby alleviated the allergic responses. However, the further detailed investigation of the underlying mechanisms is needed.
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Report
(4 results)
Research Products
(20 results)
