Development of hyperthermicimmunetherapy for cancer
Project/Area Number |
21590770
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General internal medicine (including Psychosomatic medicine)
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Research Institution | Kyoto Prefectural University of Medicine |
Principal Investigator |
KOKURA Satoshi 京都府立医科大学, 医学研究科, 准教授 (80347442)
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Co-Investigator(Kenkyū-buntansha) |
ISHIKAWA Takeshi 京都府立医科大学, 医学研究科, 講師 (90372846)
NAITO Yuji 京都府立医科大学, 医学研究科, 准教授 (00305575)
TAKAGI Tomohisa 京都府立医科大学, 医学研究科, 講師 (70405257)
HANDA Osamu 京都府立医科大学, 医学研究科, 助教 (90381970)
|
Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 癌 / 温熱療法 / 免疫療法 / ナイーブT細胞 / 癌ワクチン / 大腸癌細胞 / 免疫細胞療法 / colon26大腸癌細胞 / CD62L+細胞 / CD3-LAK細胞 / メラノーマ |
Research Abstract |
It has been reported that less-differentiated T cells rather than late effector T cells are more efficacious for adoptive T-cell therapy in animal models. We have shown that hyperthermia attenuates the production of immunosuppressive cytokines from cancer tissue in the mouse model. Thus, hyperthermia has a potential to enhance the tumor immunotherapy through the several mechanisms. In this study, we assessed the effects of hyperthermia on adoptive T-cell therapy using naive T-cells in a subcutaneous tumor model.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Adoptive cellular therapy enhances the helper T cell response and reduces the number of regulatory T cells2011
Author(s)
Ishikawa T, Kokura S, Sakamoto N, Matsumoto T, Funaki J, Adachi S, Okayama T, Uchiyama K, Handa O, Takagi T, Yagi N, Ando T, Uno K, Naito U and Yoshikawa T
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Journal Title
EXPERIMENTAL AND THERAPEUTICMEDICINE
Volume: 2
Pages: 737-743
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[Journal Article] Decrease of the regulatory T cells population by adoptive T cell transfer in a mouse colorectal cancer transplant model
Author(s)
Tsuguhiro Matsumoto, Satoshi Kokura**, Takeshi Ishikawa, Jun Funaki, Satoko Adachi, Koji Mori, Naoyuki Sakamoto, Kazuhiro Katada, Kazuhiro Kamada, Nobuaki Yagi, Osamu Handa, Tomohisa Takagi, Kazuhiko Uchiyama, Yuji Naito, and Toshikazu Yosikawa
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Journal Title
Oncology Research
Volume: (in press)
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[Presentation] Impact of adoptive T cell therapy on the cytokines production and the number of Treg in peripheral blood of patients with cancer2010
Author(s)
Ishikawa T, Kokura S, Sakamoto N, Funaki J, Adachi S, Matsumoto T, Matsuura Y, Okayama T, Yoshida N, Uchiyama K, Takagi T, Handa O, Konishi H, Wakabayashi N, Yagi N, Naito Y, Uno K, Yoshikawa T
Organizer
9th International Conference of The Asian Clinical Oncology Society
Place of Presentation
Gifu
Year and Date
2010-08-26
Related Report
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[Presentation] Hyperthermia enhances the anti-tumor activity of adoptive transfer of naive T cells2010
Author(s)
Matsumoto T, Kokura S, Ishikawa T, Funaki J, Adachi S, Okayama T, Yoshida N, Sakamoto N, Uchiyama K, Takagi T, Handa O, Konishi H, Wakabayashi N, Yagi N, Naito Y, Kato A, Tomita K, Enoki T, Yoshikawa T
Organizer
101st American Association for Cancer Research(AACR)
Place of Presentation
Washington, DC, USA
Year and Date
2010-04-19
Related Report
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[Presentation] Adoptive T cell therapy shifts the secretion ability of cytokines to Th1 and decreases the number of Tregs in patients with cancer2010
Author(s)
Ishikawa T, Kokura S, Sakamoto N, Matsumoto T, Funaki J, Adachi S, Okayama T, Yoshida N, Uchiyama K, Takagi T, Handa O, Konishi H, Wakabayashi N, Yagi N, Tanigawa M, Uno K, Naito Y, Yoshikawa T
Organizer
101st American Association for Cancer Research(AACR)
Place of Presentation
Washington, DC, USA
Year and Date
2010-04-19
Related Report
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[Presentation] Hyperthermia enhances the anti-tumor activity of adoptive transfer of naive T cells2010
Author(s)
Tsuguhiro Matsumoto, Satoshi Kokura, Takeshi Ishikawa, Jun Funaki, Satoko Adachi, Tetsuya Okayama, Naohisa Yoshida, Naoyuki Sakamoto, Kazuhiko Uchiyama, Tomohisa Takagi, Osamu Handa, Hideyuki Konishi, Naoki Wakabayashi, Nobuaki Yagi, Yuji Naito, Akiko Kato, Keisuke Tomita, Tatsuji Enoki, Toshikazu Yoshikawa
Organizer
101th AACR
Place of Presentation
ワシントンDC
Year and Date
2010-04-19
Related Report
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