| Project/Area Number |
21590770
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
KOKURA Satoshi 京都府立医科大学, 医学研究科, 准教授 (80347442)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIKAWA Takeshi 京都府立医科大学, 医学研究科, 講師 (90372846)
NAITO Yuji 京都府立医科大学, 医学研究科, 准教授 (00305575)
TAKAGI Tomohisa 京都府立医科大学, 医学研究科, 講師 (70405257)
HANDA Osamu 京都府立医科大学, 医学研究科, 助教 (90381970)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 癌 / 温熱療法 / 免疫療法 / ナイーブT細胞 / 癌ワクチン / 大腸癌細胞 / 免疫細胞療法 / colon26大腸癌細胞 / CD62L+細胞 / CD3-LAK細胞 / メラノーマ |
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| Research Abstract |
It has been reported that less-differentiated T cells rather than late effector T cells are more efficacious for adoptive T-cell therapy in animal models. We have shown that hyperthermia attenuates the production of immunosuppressive cytokines from cancer tissue in the mouse model. Thus, hyperthermia has a potential to enhance the tumor immunotherapy through the several mechanisms. In this study, we assessed the effects of hyperthermia on adoptive T-cell therapy using naive T-cells in a subcutaneous tumor model.
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