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認知症の易転倒性に関与する、骨・筋・運動機能及び脳画像の縦断解析研究

Research Project

Project/Area Number 21590774
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionNational Center for Geriatrics and Gerontology (2010-2011)
Kyorin University (2009)

Principal Investigator

TOBA Kenji  独立行政法人国立長寿医療研究センター, 病院, 病院長 (60155546)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords転倒 / 認知症 / 転倒危険因子 / 大脳白質病変 / 姿勢 / 脈波伝搬速度 / 虚血 / SPECT / 脳表血流量 / ビタミンD / 脈波伝播速度 / 白質病変 / 骨粗鬆症
Research Abstract

We performed comprehensive study on falls in the cognitively declined elderly(approximately 400 people). The findings were(1) DLB and VaD patients fell more frequently than other type of patients.(2) SPECT study showed that declined volition was associated with decreased perfusion in the limbic cortex and white matter area as well as front-temporal lobe and hypothalamus.(3) Patients showing greater kyphosis and decreased dorsiflexion fell more frequently.(4) Approximately 34% of outpatients attending memory clinic experienced falling. Previous fall history, fall risk index, number of geriatric syndromes, one-leg standing time, TUG, Functional reach(FR), greater body sway, serum concentration of iP and alb were significantly different between fallers and non-fallers.(5) The magnitude of brain white matter lesion was positively associated with that of aortic stiffness.(6) Handkerchief test, to detect anxiety to falling, was possibly predicable to detect high-risk fallers.(7) Serum 25(OH) VitD showed positive association with grasping power, TUG, and FR.(8) We succeeded in introducing ischemia in corpus callosum in a mouse. This is a useful model, which will open a study of brain white matter lesions.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (18 results)

All 2012 2011 2010 2009 2008

All Journal Article (11 results) (of which Peer Reviewed: 2 results) Presentation (5 results) Book (2 results)

  • [Journal Article] 特集「高齢者リハビリテーション」神経変性疾患認知症2012

    • Author(s)
      鳥羽研二
    • Journal Title

      THE BONE

      Volume: 1月号 Pages: 49-56

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 老年内科標榜をめざして老年症候群の考え方と高齢者の寝たきりの原因と対策2011

    • Author(s)
      鳥羽研二
    • Journal Title

      日本医事新報

      Volume: No.4552 Pages: 43-46

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 手段的ADLと基本的ADL2011

    • Author(s)
      鳥羽研二、木村紗矢香, 山田如子、町田綾子, 神崎恒一
    • Journal Title

      認知症学

      Volume: 上 Pages: 313-318

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 服薬コンプライアンスとアドヘレンス2011

    • Author(s)
      鳥羽研二
    • Journal Title

      認知症学

      Volume: 下 Pages: 22-25

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Relationship between interleukin-6 and cerebral deep white matter and periventricular hyperintensity in elderly women.2011

    • Author(s)
      Nagai K, Kozaki K, Sonohara K, Akishita M, Toba K.
    • Journal Title

      Geriatr Gerontol Int.

      Volume: 10 Pages: 323-332

    • NAID

      10031147972

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Plasma sex hormone levels and mortality in disabled older men and women.2011

    • Author(s)
      Fukai S, Akishita M, Yamada S, Ogawa S, Yamaguchi K, Kozaki K, Toba K, Ouchi Y
    • Journal Title

      Geriatr Gerontol Int

      Volume: 11(2) Pages: 196-203

    • NAID

      10029333495

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Effects of dehydroepiandrosterone supplementation on cognitive function and activities of daily living in older women with mild to moderate cognitive impairment.2010

    • Author(s)
      Yamada S, Akishita M, Fukai S, Ogawa S, Yamaguchi K, Matsuyama J, Kozaki K, Toba K, Ouchi Y.
    • Journal Title

      Geriatr Gerontol Int

      Volume: 10(4) Pages: 280-287

    • NAID

      10027755257

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 姿勢と転倒2009

    • Author(s)
      清水昌彦、長谷川浩、鳥羽研二
    • Journal Title

      Geriatric Medicine 47

      Pages: 759-760

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Evaluation of risk of falls in patientas at a memry impairment outpatient clinic2009

    • Author(s)
      Kikuchi R, Kozaki K, Toba K, et al
    • Journal Title

      Geriatrics and Gerontology International 9

      Pages: 298-303

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A randomized cross-over study of a traditional Japanese medicine(kanpo), yokukannsann, in the treatment of the behavioral and psychological symptoms of dementia2009

    • Author(s)
      Mizukami M, Asada T, Toba K, et al
    • Journal Title

      International Jounal of Neuropsychopaharmacology 12

      Pages: 191-199

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 認知症高齢者の意欲低下に関連する脳血流分布2008

    • Author(s)
      園原和樹,鳥羽研
    • Journal Title

      日本老年医学会雑誌

      Volume: 6 Pages: 615-21

    • NAID

      10024963441

    • Related Report
      2011 Final Research Report
  • [Presentation] 虚弱と類似概念2011

    • Author(s)
      鳥羽研二
    • Organizer
      第48回日本リハビリテーション医学会学術集会
    • Place of Presentation
      幕張メッセ(千葉市)
    • Year and Date
      2011-11-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 認知症と虚弱を支えるホームヘルスケア2011

    • Author(s)
      鳥羽研二
    • Organizer
      第53回日本老年医学会学術集会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2011-06-15
    • Related Report
      2011 Annual Research Report
  • [Presentation]2011

    • Author(s)
      鳥羽研二
    • Organizer
      第28回日本医学会総会
    • Place of Presentation
      (震災のため総会は中止学術講演収録DVD)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 高齢者医療の行方と老年医学会の役割2010

    • Author(s)
      鳥羽研二
    • Organizer
      日本老年医学会学術集会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2010-06-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 認知症に対する包括的アプローチ2009

    • Author(s)
      鳥羽研二
    • Organizer
      日本認知症学会
    • Place of Presentation
      仙台
    • Year and Date
      2009-11-28
    • Related Report
      2009 Annual Research Report
  • [Book] 高齢者の生活機能の操業的評価2010

    • Author(s)
      鳥羽研二
    • Total Pages
      172
    • Publisher
      新興医学出版社
    • Related Report
      2010 Annual Research Report
  • [Book] 認知症安心生活読本2009

    • Author(s)
      鳥羽研二
    • Total Pages
      159
    • Publisher
      主婦と生活社
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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