• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Investigation on characteristics of chronic pain and psychosomatic aspect of fibromyalgia

Research Project

Project/Area Number 21590777
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionNihon University

Principal Investigator

MURAKAMI Masato  日本大学, 医学部, 准教授 (60142501)

Co-Investigator(Kenkyū-buntansha) 金 外淑  兵庫県立大学 (90331371)
松野 俊夫  日本大学, 医学部, 講師 (20173859)
Co-Investigator(Renkei-kenkyūsha) 松野 俊夫  日本大学, 医学部 (20173859)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords線維筋痛症 / 慢性疼痛 / 心身医学 / ストレス / 行動科学 / 線維筋痛症症候群 / 心療内科 / カテコラミン / セロトニン / 認知行動療法
Research Abstract

Fibromyalgia(FM) is one of the common diseases characterized by the chronic pain and various unidentified complaints. Onset and clinical course of FM involve many psychosocial stress factors and distorted endocrine system of womanhood in addition to genetic and physiological factors. Most of the FM patients were found to have experienced physical strains such as surgery, accident, trauma, delivery, physical overload and excessive exercise. Remarkable personality traits such as anxiety, fear, anger, obsession, depression and sorrow were observed from clinical interview and psychological test. Participation of specialist of psychosomatic medicine is required.
For the physiological background, the amount of urinary metabolites such as VMS, MHPG or 5HIAA showed significantly lower than control healthy subjects, but very similar to the patients with depression. It is suggested that the dysfunction of serotonin and noradrenalin-mediated descending pain control system followed by circulatory disorders may be involved in chronic pain and various symptoms of FM. As for medication, addition to the ordinary treatment, antidepressants such as SSRI or SNRI, anticonvulsants and Kampo herbal medicine often show remarkable effect. To the problems of psychological stress and personality, counseling and advanced psychotherapy such as cognitive behavioral therapy(CBT) based on "the personal growth model" may be more important rather than "medical model".

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (28 results)

All 2011 2010 2009

All Journal Article (12 results) (of which Peer Reviewed: 2 results) Presentation (12 results) Book (4 results)

  • [Journal Article] 特集「痛みと精神医学」線維筋痛症の精神疾患とのcomorbidityと治療上の問題点2011

    • Author(s)
      村上正人, 三浦勝浩, 丸岡秀一郎
    • Journal Title

      精神科

      Volume: 19(1) Pages: 21-27

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] 線維筋痛症の診断と治療に活かすNarrative Based Medicine2010

    • Author(s)
      村上正人
    • Journal Title

      ペインクリニック

      Volume: 31(3) Pages: 299-306

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] 心療内科領域の線維筋痛症-心身医学的視点からみた線維筋痛症の疾患概念と病態-2010

    • Author(s)
      村上正人, 松野俊夫, 金外淑, 三浦勝浩, 井上幹紀親
    • Journal Title

      神経内科

      Volume: 72(5) Pages: 480-485

    • Related Report
      2011 Final Research Report
  • [Journal Article] 耳鼻咽喉科領域の線維筋痛症2010

    • Author(s)
      五島史行, 中井貴美子, 村上正人, 小川郁
    • Journal Title

      神経内科

      Volume: 72(5) Pages: 494-197

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] 筋骨格系の慢性疼痛2010

    • Author(s)
      村上正人, 松野俊夫, 三浦勝浩
    • Journal Title

      総合臨床

      Volume: 59(11) Pages: 2238-2248

    • Related Report
      2011 Final Research Report
  • [Journal Article] 線維筋痛症と否定的感情2010

    • Author(s)
      村上正人, 松野俊夫, 金外淑, 三浦勝浩
    • Journal Title

      心身医学

      Volume: 50(12) Pages: 1157-1163

    • Related Report
      2011 Final Research Report
  • [Journal Article] 筋骨格系の慢性疼痛と心理社会的ストレス-心療内科における診断と治療-2010

    • Author(s)
      村上正人、松野俊夫
    • Journal Title

      日大医学雑誌

      Volume: 69(1) Pages: 183-188

    • NAID

      10026989073

    • Related Report
      2011 Final Research Report
  • [Journal Article] 心療内科領域の線維筋痛症-心躯学的視点からみた線維筋痛症の疾患概念と病態-2010

    • Author(s)
      村上正人, 松野俊夫, 金外淑, 三浦勝浩, 井上幹紀近
    • Journal Title

      神経内科

      Volume: 72(5) Pages: 480-485

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 線維筋痛症の診断と治療に生かす Narrative Based Medicine2010

    • Author(s)
      村上正人
    • Journal Title

      ペインクリニック 31(3)

      Pages: 299-306

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 耳鼻咽喉科領域における線維筋痛症2009

    • Author(s)
      五島史行, 中井貴美子, 村上正人, 小川郁
    • Journal Title

      筋痛症の診断治療:日本心療内科学会誌

      Volume: 13(1) Pages: 323-333

    • Related Report
      2011 Final Research Report
  • [Journal Article] 線維筋痛症の痛みをどうとらえるか-慢性疼痛のモデル的疾患として-2009

    • Author(s)
      村上正人, 松野俊夫, 金外淑, 他
    • Journal Title

      心身医学 49(8)

      Pages: 893-902

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 耳鼻咽喉科領域における線維筋痛症, 筋痛症の診断と治療2009

    • Author(s)
      五島史行, 中井貴美子, 村上正人, 他
    • Journal Title

      日本心療内科学会誌 3(1)

      Pages: 323-333

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Invited Symposium 1 : Epigenesis, Pain and Complementary Medicine : Comorbidity and Psychosomatic Aspect of Chronic Fatigue Syndrome and Fibromyalgia2011

    • Author(s)
      M Murakami, T Matsuno, W Kim, K Koike, M Murakami, K Miura, S Maruoka, S Ebana, S Hashimoto
    • Organizer
      The 21^<st> World Congress on Psycho somatic Medicine
    • Place of Presentation
      Seoul
    • Year and Date
      2011-08-26
    • Related Report
      2011 Final Research Report
  • [Presentation] Invited Symposium 1: Epigenesis, Pain and Complementary Medicine : Comorbidity and Psychosomatic Aspect of Chronic Fatigue Syndrome and Fibromyalgia2011

    • Author(s)
      Murakami M, Matsuno T, Kim W, Koike K, Murakami M, Miura K, Maruoka S, Ebana S, Hashimoto S
    • Organizer
      The 21st World Congress On Psychosomatic Medicine
    • Place of Presentation
      Seoul
    • Year and Date
      2011-08-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 市民公開講座「線維筋痛症の全人的治療をめぐって」線維筋痛症の全人的治療をめぐって2010

    • Author(s)
      村上正人
    • Organizer
      日本線維筋痛症学会第2回学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-14
    • Related Report
      2011 Final Research Report
  • [Presentation] シンポジウム(1)臨床各科で診る線維筋痛症-臓器別症状をどうとらえるか-」耳鼻咽喉科における筋痛症、線維筋痛症2010

    • Author(s)
      五島史行、中井貴美子、小川郁、村上正人
    • Organizer
      日本線維筋痛症学会第2回学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-13
    • Related Report
      2011 Final Research Report
  • [Presentation] 線維筋痛症患者の心理行動特性を踏まえた治療的アプローチ2010

    • Author(s)
      村上正人, 松野俊夫, 金外叔, 小池一善, 三浦勝浩, 江花昭一
    • Organizer
      第23回日本疼痛心身医学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-10-11
    • Related Report
      2011 Final Research Report
  • [Presentation] Symposium, WHO Forum on Pain Management, Psychiatric Comorbidity and Psycho-somatic Aspect of Fibromyalgia2010

    • Author(s)
      M Murakami, T Matsuno, W Kim, K Koike, K, Miura, S Hashimoto
    • Organizer
      The 14th Congress of the Asian College of Psycho-somatic Medicine
    • Place of Presentation
      Beijing, China
    • Year and Date
      2010-09-12
    • Related Report
      2011 Final Research Report
  • [Presentation] Symposium : WHO Forum on Pain Management, Psychiatric Comorbidity and Psychosomatic Aspect of Fibromyalgia2010

    • Author(s)
      Murakami M, Matsuno T, Kim W, Koike K, Miura K, Hashimoto S
    • Organizer
      The 14th Congress of the Asian College of Psychosomatic Medicine
    • Place of Presentation
      Beijing, China
    • Year and Date
      2010-09-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] onset of fibromyalgia furing the clinical course of mental disorder2009

    • Author(s)
      M Murakami, T Matsuno, K Koike, W Kim, K Hanaoka, A Aoki, S Hashimoto S
    • Organizer
      20th World Congress on Psychosomatic Medicine
    • Place of Presentation
      Torino
    • Related Report
      2011 Final Research Report
  • [Presentation] The correlation between Symptoms of depression and anxiety with pain in Fibromyalgia Syndrome patients2009

    • Author(s)
      W Kim, M Murakami, T Matsuno, R Kawahara, A Aoki
    • Organizer
      20th World Congress on Psychosomatic Medicine
    • Place of Presentation
      Torino
    • Related Report
      2011 Final Research Report
  • [Presentation] The drivers of patients with Fibromyalgia Syndrome from the viewpoint of Transactional Analysis(Report1)2009

    • Author(s)
      A Aoki, M Murakami, K Hanaoka, R Miyamura, M Miwa, W Kim, T Matsuno
    • Organizer
      20th World Congress on Psychosomatic Medicine
    • Place of Presentation
      Torino
    • Related Report
      2011 Final Research Report
  • [Presentation] 日本におけるNarrative based medicineの実践と将来展望線維筋痛症の診断と治療に生かすNarrative based medicine2009

    • Author(s)
      村上正人、松野俊夫、金外淑、小池一喜、井上幹紀親、三浦勝浩、橋本修
    • Organizer
      第31回日本疼痛学会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Final Research Report
  • [Presentation] Onset of fibromyalgia during the clinical course of mental disorder2009

    • Author(s)
      Murakami M, Matsuno T, Koike, et al
    • Organizer
      20th World Congress on Psychosomatic Medicine
    • Place of Presentation
      Torino, Italy
    • Related Report
      2009 Annual Research Report
  • [Book] 線維筋痛症と心療内科的疾患(心身症・ストレス関連疾患)の合併,線維筋痛症診療ガイドライン20112011

    • Author(s)
      村上正人
    • Publisher
      日本医事新報社
    • Related Report
      2011 Final Research Report
  • [Book] 線維筋痛症診療ガイドライン2011:線維筋痛症と心療内科的疾患(心身症・ストレス関連疾患)の合併2011

    • Author(s)
      村上正人
    • Total Pages
      207
    • Publisher
      日本医事新報社
    • Related Report
      2011 Annual Research Report
  • [Book] 心療内科的治療-特に線維筋痛症に対して-,標準的神経治療:慢性疼痛2010

    • Author(s)
      村上正人
    • Publisher
      日本神経治療学会治療指針作成委員会
    • Related Report
      2011 Final Research Report
  • [Book] 標準的神経治療:慢性落痛(辻貞俊編):心療内科的治療-特に線維筋痛症に対して-2010

    • Author(s)
      村上正人
    • Publisher
      日本神経治療学会治療指針作成委員会
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi