| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
Exosome is a nanovesicle, which is secreted by human gastrointestinal cancer cells, possesses tumor-specific micro RNA. Function and clinical application of the micro RNA in the exosome remained unclear. The present study identified colorectal cancer specific micro RNA in the exosome of sera by microarray analysis. These micro RNAs were detected most of colorectal cancer patients' sera and cancer tissues. In addition, tumor-derived exosome-containing micro RNAs were absorbed by surrounding cells and regulate gene expression in the recipient cells. These findings indicated the function of tumor-derived exosomes and their diagnostic value.
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