Androgen receptor signaling in liver and pancreatic cancer

• Project/Area Number: 21590829
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Chiba University
• Principal Investigator: KANDA Tatsuo 千葉大学, 大学院・医学研究院, 特任講師 (20345002)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 肝臓学 / 膵臓癌 / 肝臓癌 / アンドロジェンレセプター / サイトカイン / 肝炎ウイルス / 性差

Research Abstract

1)Interleukin-6 acts a positive regulator in androgen receptor signaling in pancreatic cancer cell lines, suggesting that interleukin-6 and androgen receptor signaling might play important roles in the progression of pancreatic carcinogenesis. 2) Hepatitis B virus affects nuclear receptors and their related signal transduction. They also might be involved in replication of hepatitis B virus and hepatitis B virus-related hepatocarcinogenesis.

Research Products

• [Journal Article] Nuclear receptor mRNA expression by HBV in human hepatoblastoma cell lines (2011)
  • Author(s): S. Wu, T. Kanda, F. Imazeki, S. Nakamoto, H. Shirasawa, O. Yokosuka
  • Journal Title: Cancer Lett Volume: 312 Pages: 33-42
  • URL: http://dx.doi.org/10.1016/j.canlet.2011.07.025
  • Peer Reviewed
• [Journal Article] Hepatic STAT1-Nuclear Translocation and Interleukin 28B Polymorphisms Predict Treatment Outcomes in Hepatitis C Virus Genotype 1-Infected Patients (2011)
  • Author(s): T. Miyamura, T. Kanda, S. Nakamoto, S. Wu, K. Fujiwara, F. Imazeki, O. Yokosuka
  • Journal Title: PLoS ONE Volume: 6(12) Issue: 12 Pages: e28617-e28617
  • DOI: 10.1371/journal.pone.0028617
  • Peer Reviewed
• [Journal Article] HCV NS5A Protein Inhibits Lipopolysaccharide-Mediated Apoptosis of Hepatocytes by Decreasing Toll-Like Receptor 4 Expression (2011)
  • Author(s): R. Tamura, T. Kanda, F. Imazeki, S. Wu, S. Nakamoto, T. Tanaka, M. Arai, K. Fujiwara, K. Saito, T. Roger, T. Wakita, H. Shirasawa, O. Yokosuka
  • Journal Title: J Infect Dis Volume: 204(5) Issue: 5 Pages: 793-801
  • DOI: 10.1093/infdis/jir381
  • NAID: 40019158548
  • Peer Reviewed
• [Journal Article] Nuclear receptor mRNA expression by HBV in human hepatoblastoma cell lines (2011)
  • Author(s): S.Wu, T.Kanda, F.Imazeki, S.Nakamoto, H.Shirasawa, O.Yokosuka
  • Journal Title: Cancer Letters Volume: 312 Issue: 1 Pages: 33-42
  • DOI: 10.1016/j.canlet.2011.07.025
  • Peer Reviewed
• [Journal Article] Involvement of interleukin-6 and androgen receptor signaling in pancreatic cancer (2010)
  • Author(s): K. Okitsu, T. Kanda, F. Imazeki, Y. Yonemitsu, R. B. Ray, C. Chang, O. Yokosuka
  • Journal Title: Genes & Cancer Volume: 1 Issue: 8 Pages: 859-867
  • DOI: 10.1177/1947601910383417
  • Peer Reviewed
• [Journal Article] Hepatitis A (HAV) proteinase 3C inhibits HAV IRES-dependent translation and cleaves the polypyrimidine tract-binding protein (2010)
  • Author(s): T. Kanda, V. Gauss-Muller, S. Cordes, R. Tamura, K. Okitsu, W. Shuang, S. Nakamoto, K. Fujiwara, F. Imazeki, O. Yokosuka
  • Journal Title: J. Viral. Hepat Volume: 17 Pages: 618-23
  • DOI: 10.1111/j.1365-2893.2009.01221.x
  • Peer Reviewed
• [Journal Article] Hepatitis B virus e antigen down-regulates cytokine production in human hepatoma cell lines (2010)
  • Author(s): S. Wu, T. Kanda, F. Imazeki, M. Arai, Y. Yonemitsu, S. Nakamoto, K. Fujiwara, K. Fukai, F. Nomura, O. Yokosuka
  • Journal Title: Viral Immunol Volume: 23 Issue: 5 Pages: 467-476
  • DOI: 10.1089/vim.2010.0042
  • Peer Reviewed
• [Journal Article] New antiviral therapies for chronic hepatitis C (2010)
  • Author(s): T. Kanda, F. Imazeki, O. Yokosuka
  • Journal Title: Hepatol Int Volume: 4 Issue: 3 Pages: 548-561
  • DOI: 10.1007/s12072-010-9193-3
  • Peer Reviewed
• [Journal Article] Inhibitory effects on HAV IRES-mediated translation and replication by a combination of amantadine and interferon-alpha (2010)
  • Author(s): L. Yang, T. Kiyohara, T. Kanda, F. Imazeki, K. Fujiwara, V. Gauss-Muller, K. Ishii, T. Wakita, O. Yokosuka
  • Journal Title: Virol J Volume: 7 Issue: 1 Pages: 212-212
  • DOI: 10.1186/1743-422x-7-212
  • Peer Reviewed
• [Journal Article] Involvement of interleukin-6 and androgen receptor signaling inpancreatic cancer. (2010)
  • Author(s): K.Okitsu, T.Kanda, F.Imazeki, Y.Yonemitsu, R.B.Ray, C.Chang, O.Yokosuka.
  • Journal Title: Genes & Cancer Volume: 1 Pages: 859867-859867
  • Peer Reviewed
• [Journal Article] Hepatitis B virus e antigen down-regulates cytokine production in human hepatoma cell lines. (2010)
  • Author(s): S.Wu, T.Kanda, F.Imazeki, M.Arai, Y.Yonemitsu, S.Nakamoto, K.Fujiwara, K.Fukai, F.Nomura, O.Yokosuka.
  • Journal Title: Viral Immunology Volume: 23 Pages: 467-476
  • Peer Reviewed
• [Journal Article] New antiviral therapies for chronic hepatitis C (2010)
  • Author(s): T.Kanda, F.Imazeki, O. Yokosuka.
  • Journal Title: Hepatology International Volume: 4 Pages: 548-561
  • Peer Reviewed
• [Journal Article] Hepatitis A (HAV) proteinase 3C inhibits HAV IRES-dependent translation and cleaves the polypyrimidine tract-binding protein. (2010)
  • Author(s): T.Kanda, V.Gauss-Muller, S.Cordes, R.Tamura, K.Okitsu, W.Shuang, S.Nakamoto, K.Fujiwara, F.Imazeki, O.Yokosuka
  • Journal Title: Journal of viral hepatitis (In press)
  • Peer Reviewed
• [Journal Article] Association between mutations in the core region of hepatitis C virus genotype 1 and hepatocellular carcinoma development. (2010)
  • Author(s): S.Nakamoto, F.Imazeki, K.Fukai, M.Arai, K.Fujiwara, M.Arai, T.Kanda, Y.Yonemitsu, O.Yokosuka
  • Journal Title: Journal of Hepatology (In press)
  • Peer Reviewed
• [Journal Article] Quantification of hepatitis C amino acid substitutions 70 and 91 in core coding region by real-time amplification refractory mutation system reverse transcription-polymerase chain reaction (2009)
  • Author(s): S. Nakamoto, T. Kanda, Y. Yonemitsu, M. Arai, K. Fujiwara, K. Fukai, F. Kanai, F. Imazeki, O. Yokosuka
  • Journal Title: Scand. J. Gastroenterol Volume: 44 Issue: 7 Pages: 872-877
  • DOI: 10.1080/00365520902937362
  • Peer Reviewed
• [Journal Article] Association between mutations in the core region of hepatitis C virus genotype 1 and hepatocellular carcinoma development (2009)
  • Author(s): S. Nakamoto, F. Imazeki, K. Fukai, M. Arai, K. Fujiwara, M. Arai, T. Kanda, Y. Yonemitsu, O. Yokosuka
  • Journal Title: J. Hepatol Volume: 52 Pages: 72-78
  • URL: http://dx.doi.org/10.1016/j.jhep.2009.10.001
  • Peer Reviewed
• [Journal Article] Quantification of hepatitis C amino acid substitutions 70 and 91 in core coding region by real-time amplification refractory mutation system reverse transcription-polymerase chain reaction. (2009)
  • Author(s): S.Nakamoto, T.Kanda, Y.Yonemitsu, M.Arai, K.Fujiwara, K.Fukai, F.Kanai, F.Imazeki, O.Yokosuka
  • Journal Title: Scandinavian Journal of Gastroenterology 44 Pages: 872-877
  • Peer Reviewed
• [Presentation] Alterations of nuclear receptors and related genes expression by HBV in human hepatoma cell lines (2011)
  • Author(s): S. Wu, T. Kanda, F. Imazeki, S. Nakamoto, A. Tawada, M. Arai, K. Fujiwara, O. Yokosuka
  • Organizer: 21^<th> Conference of the Asian Pacific Association for the Study of the Liver, Queen Sirkit National Convention Center
  • Place of Presentation: Bangkok, Thailand
• [Presentation] 膵癌におけるIL-6, STAT3, androgen receptorシグナル伝達経路に関する検討 (2010)
  • Author(s): 神田達郎, 沖津恒一郎, 呉霜, 中本晋吾, 太和田暁之, 今関文夫, 横須賀收
  • Organizer: 第18回浜名湖シンポジウム
  • Place of Presentation: アクトシテイ浜松コングレスセンター(浜松)
  • Year and Date: 2010-12-25
• [Presentation] 膵癌におけるIL-6, STAT3, androgen receptorシグナル伝達経路に関する検討 (2010)
  • Author(s): 神田達郎、沖津恒一郎、呉霜、中本晋吾、太和田暁之、今関文夫、横須賀牧
  • Organizer: 第18回浜名湖シンポジウム
  • Place of Presentation: アクトシティ浜松コングレスセンター(浜松)
  • Year and Date: 2010-12-25
• [Presentation] 肝細胞癌におけるAndrogen receptorの発現～ポリコーム遺伝子との関連について～ (2010)
  • Author(s): 米満裕, 今関文夫, 神田達郎, 沖津恒一郎, 千葉哲博, 新井誠人, 藤原慶一, 横須賀收
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形
  • Year and Date: 2010-05-27
• [Presentation] HCV NS5AはLPS-TLR4経路を介するApoptosisを阻害する (2010)
  • Author(s): 田村玲, 神田達郎, 今関文夫, 米満裕, 沖津恒一郎, 中本晋吾, 新井誠人, 藤原慶一, 横須賀收
  • Organizer: 第96回日本消化器病学会総会
  • Place of Presentation: 新潟
  • Year and Date: 2010-04-23
• [Presentation] 膵臓癌におけるIL-6/STAT3/MAPK/ARシグナル活性と腫瘍進展効果の検討 (2010)
  • Author(s): 沖津恒一郎, 神田達郎, 今関文夫, 米満裕, Chang C, 横須賀收
  • Organizer: 第96回日本消化器病学会総会
  • Place of Presentation: 新潟
  • Year and Date: 2010-04-22
• [Presentation] Hepatitis C virus NS5A attenuates LPS-induced apoptosis by downregulation of toll-like receptor 4 signaling pathway (2010)
  • Author(s): T. Kanda, R. Tamura, F. Imazeki, S. Nakamoto, S. Wu, R. Thierry, T. Wakita, H. Shirasawa, O. Yokosuka
  • Organizer: HCV2010 17th International Meeting on Hepatitis C Virus and Related Viruses, Pacific Yokohama
  • Place of Presentation: kohama, Japan
• [Presentation] Hepatitis C virus nonstructural protein 5A downregulates toll-like receptor-4 signaling and blocks LPS-induced apoptosis in hepatoma cell lines (2010)
  • Author(s): R. Tamura, T. Kanda, Y. Yonemitsu, K. Okitsu, S. Nakamoto, M. Arai, K. Fujiwara, F. Imazeki, O. Yokosuka
  • Organizer: 20th Conference of the Asian Pacific Association for the Study of the Liver. China National Convention Center
  • Place of Presentation: Beijing, China
• [Presentation] Interaction of hepatitis C virus core and androgen signaling in hepatocarcinogenesis (2009)
  • Author(s): T. Kanda
  • Organizer: Asian Hepatitis Forum 2009
  • Place of Presentation: The Grand Hotel, Taipei, Taiwan
  • Year and Date: 2009-12-13
• [Presentation] Interaction of hepatitis C virus core and androgen signaling in hepatocarcinogenesis. (2009)
  • Author(s): T.Kanda
  • Organizer: Asian Hepatitis Forumn 2009
  • Place of Presentation: The Grand Hotel, Taipei, Taiwan
  • Year and Date: 2009-12-13
• [Presentation] 膵臓癌におけるIL-6によるAndrogenレセプターシグナル活性化の検討 (2009)
  • Author(s): 沖津恒一郎, 神田達郎, 米満裕, 今関文夫, Chawnshang Chang, 横須賀收
  • Organizer: 第51回日本消化器病学会大会
  • Place of Presentation: 京都
  • Year and Date: 2009-10-16
• [Presentation] 膵臟癌におけるIL-6によるAndrogenレセプターシグナル活性化の検討 (2009)
  • Author(s): 沖津恒一郎、神田達郎、米満裕、今関文夫、Chawnshang Chang、横須賀収
  • Organizer: 第51回日本消化器病学会大会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2009-10-16
• [Presentation] Interleukin-6 acticates androgen receptor signaling in pancreatic cancer. (2009)
  • Author(s): K.Okitsu, T.Kanda, F.Imazeki, C.Chang, O.Yokosuka.
  • Organizer: Asian Pacific Digestive Week 2009
  • Place of Presentation: Taipei International Convention Center (TICC), Taipei, Taiwan
  • Year and Date: 2009-09-28
• [Presentation] C型肝炎ウイルスによる肝発癌におけるAndrogen receptor (AR) シグナリングの関与 (2009)
  • Author(s): 横須賀收, 神田達郎
  • Organizer: 犬山シンポジウム
  • Place of Presentation: 犬山
  • Year and Date: 2009-08-06
• [Presentation] 膵癌における男性ホルモンandrogen receptor (AR)関連シグナルの関与について (2009)
  • Author(s): 沖津恒一郎, 神田達郎, 米満裕, 新井誠人, 深井健一, 金井文彦, 今関文夫, 横須賀收
  • Organizer: 第5回消化器病における性差医学・医療研究会(日本消化器病学会関連研究会)
  • Place of Presentation: 大阪
  • Year and Date: 2009-07-25
• [Presentation] 膵癌における男性ホルモンandrogen receptor(AR)関連シグナルの関与について (2009)
  • Author(s): 沖津恒一郎、神田達郎、米満裕、新井誠人、深井健一、金井文彦、今関文夫、横須賀収
  • Organizer: 第5回消化器病における性差医学・医療研究会(日本消化器病学会関連研究会)
  • Place of Presentation: 大阪国際会議場12階1202室
  • Year and Date: 2009-07-25
• [Presentation] HCV core蛋白によるandrogen receptorを介したシグナル伝達の増強について (2009)
  • Author(s): 神田達郎, 今関文夫, 米満裕, 沖津恒一郎, 中本晋吾, 田村玲, 藤原慶一, 呉霜, 新井誠人, 藤原慶一, 深井健一, 金井文彦, 横須賀收, Robert Steele, Ranjit Ray, Ratna Ray
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2009-06-05
• [Presentation] HCV core蛋白によるandrogen receptorな介したシグナル伝達の増強について (2009)
  • Author(s): 神田達郎、今関文夫、米満裕、沖津恒一郎、中本晋吾、田村玲、藤原慶一、呉霜、新井誠人、藤原慶一、深井健一、金井文彦、横須賀収、Robert Steele、Ranjit Ray、Ratna Ray
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸国際展示場
  • Year and Date: 2009-06-05
• [Presentation] Interleukin-6 activates androgen receptor signaling in pancreatic cancer (2009)
  • Author(s): K. Okitsu, T. Kanda, F. Imazeki, C. Chang, O. Yokosuka
  • Organizer: Asian Pacific Digestive Week 2009
  • Place of Presentation: Taipei International Convention Center (TICC), Taipei, Taiwan