Androgen receptor signaling in liver and pancreatic cancer
| Project/Area Number |
21590829
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Chiba University |
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Principal Investigator |
KANDA Tatsuo 千葉大学, 大学院・医学研究院, 特任講師 (20345002)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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|---|
| Keywords | 肝臓学 / 膵臓癌 / 肝臓癌 / アンドロジェンレセプター / サイトカイン / 肝炎ウイルス / 性差 |
|---|
| Research Abstract |
1)Interleukin-6 acts a positive regulator in androgen receptor signaling in pancreatic cancer cell lines, suggesting that interleukin-6 and androgen receptor signaling might play important roles in the progression of pancreatic carcinogenesis. 2) Hepatitis B virus affects nuclear receptors and their related signal transduction. They also might be involved in replication of hepatitis B virus and hepatitis B virus-related hepatocarcinogenesis.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] HCV NS5A Protein Inhibits Lipopolysaccharide-Mediated Apoptosis of Hepatocytes by Decreasing Toll-Like Receptor 4 Expression2011
Author(s)
R. Tamura, T. Kanda, F. Imazeki, S. Wu, S. Nakamoto, T. Tanaka, M. Arai, K. Fujiwara, K. Saito, T. Roger, T. Wakita, H. Shirasawa, O. Yokosuka
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Journal Title
J Infect Dis
Volume: 204(5)
Issue: 5
Pages: 793-801
DOI
NAID
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Peer Reviewed
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[Presentation] Hepatitis C virus NS5A attenuates LPS-induced apoptosis by downregulation of toll-like receptor 4 signaling pathway2010
Author(s)
T. Kanda, R. Tamura, F. Imazeki, S. Nakamoto, S. Wu, R. Thierry, T. Wakita, H. Shirasawa, O. Yokosuka
Organizer
HCV2010 17th International Meeting on Hepatitis C Virus and Related Viruses, Pacific Yokohama
Place of Presentation
kohama, Japan
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[Presentation] HCV core蛋白によるandrogen receptorを介したシグナル伝達の増強について2009
Author(s)
神田達郎, 今関文夫, 米満裕, 沖津恒一郎, 中本晋吾, 田村玲, 藤原慶一, 呉霜, 新井誠人, 藤原慶一, 深井健一, 金井文彦, 横須賀收, Robert Steele, Ranjit Ray, Ratna Ray
Organizer
第45回日本肝臓学会総会
Place of Presentation
神戸
Year and Date
2009-06-05
Related Report
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