Mechanisms involved in spontaneous development of hepatocellular carcinoma in mouse model of non-alcoholic steatohepatitis
Project/Area Number |
21590849
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Gastroenterology
|
Research Institution | Kochi University |
Principal Investigator |
SAIBARA Toshiji 高知大学, 教育研究部・医療学系, 教授 (60145125)
|
Co-Investigator(Renkei-kenkyūsha) |
TODA Katsumi 高知大学, 教育研究部・医療学系, 准教授 (40197893)
OCHI Tsunehiro 高知大学, 医学部附属病院, 医員 (30617840)
MUNEKAGE Kensuke 高知大学, 医学部附属病院, 医員 (60617843)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 肝臓学 / NASH / NAFLD / 肝細胞癌 / マイクロアレイ |
Research Abstract |
This model mouse developed enhanced fatty acid synthesis and its beta-oxidation at the age of 8 weeks. These changes resulted in inflammatory cell infiltration induced by enhanced mRNA expression of scavenger receptor, catalase, IL-1, and IL-8. Supplementation of estradiol attenuated these changes significantly. Accelerated PPAR-alpha is a well-known risk factor for the development of hepatocellular carcinoma and its effective attenuation in such situation could be a novel strategy for the management of NASH patients.
|
Report
(4 results)
Research Products
(81 results)
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[Journal Article]2009
Author(s)
西原利治
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Journal Title
Annual Review 消化器 2009(中外医学社)
Pages: 157-166
Related Report
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[Journal Article]2009
Author(s)
西原利治, 小野正文
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Journal Title
病気と薬パーフェクトBOOK 2009(南山堂)
Pages: 384-386
Related Report
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[Journal Article]2009
Author(s)
西原利治, 大西三朗
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Journal Title
現場の疑問に答える肝臓病診療Q&A(中外医学社)
Pages: 17-19
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