| Project/Area Number |
21590857
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAWARA Kei 岩手医科大学, 医学部, 助教 (40405816)
TAKIKAWA Yasuhiro 岩手医科大学, 医学部, 教授 (50254751)
MIYASAKA Akio 岩手医科大学, 医学部, 助教 (80382597)
WANG Tei 岩手医科大学, 医学部, 助教 (70416171)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ウイルス / インターフェロン / 薬剤反応 / 細胞・組織 / シグナル伝達 / 肝炎ウイルス / 薬物反応 / 細胞・祖時期 |
|---|
| Research Abstract |
Clinical study : Among the patients with chronic hepatitis C treated with PEG-IFN/Ribavirin, the neuropsychiatric symptoms(insomnia, poor mood and depressive state) appeared more commonly in males than females. The age and sex were not associated with the sustained viral response. The self-rating depression scale(SDS) points worsened during the treatment and PDG-PET scan revealed a tendency of decreased cerebral glucose metabolism(CMRglu) in the entire brain regions, However, SDS points and CMRglu returned to pre-treatment values after the therapy. However, no relationship was seen between two parameters. Experimental study : The expressions of both IFN receptors(IFN-R1 and R2) were detectable in the cultured human astrocytes. A physiologically-relevant concentrations of IFNα2a and α2b(i. e., 2 IU/ml) both inhibited the expression of the INF receptors and significantly decreased the proliferation of human astrocytes. In contrast, IFN-β did not affect astrocyte proliferation. IFN-α treatment inhibited the Glut-1 expression, resulting in deceased glucose consumption. These effects were associated, in part, with the alterations in cytokines such as interleukin-8.
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