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Development of Diagnostic System of Vascular Function for Assessment of Atherosclerosis

Research Project

Project/Area Number 21590898
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionHiroshima University

Principal Investigator

HIGASHI Yukihito  広島大学, 原爆放射線医科学研究所, 教授 (40346490)

Co-Investigator(Kenkyū-buntansha) KIHARSA Yasuki  広島大学, 医歯薬学総合研究科, 教授 (40214853)
TSUJI Toshio  広島大学, 工学研究院, 教授 (90179995)
寺川 宏樹  広島大学, 医歯薬学総合研究科, 助教 (70346500)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords血管内皮機能 / 血管弾性 / バイオマーカー / 動脈硬化 / 血管状態測定装置
Research Abstract

We built a database for assessment of grade of atherosclerosis using measurement of endothelial function, including vascular unltrasound and plethysmography, measurement of arterial stiffness, including pulse-wave velocity and ankle-brachial pressure index, measurement of chemical biomarkers, and analysis of gene. In addition, we developed a new device for assessment of endothelial function. We are developing the analytic system software for diagnosis of grade of at herosclerosis.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (93 results)

All 2012 2011 2010 2009 Other

All Journal Article (55 results) (of which Peer Reviewed: 55 results) Presentation (31 results) Remarks (3 results) Patent(Industrial Property Rights) (4 results) (of which Overseas: 1 results)

  • [Journal Article] Geranylgeranylacetone, Hsp90/ AMPK/ eNOS/ NO pathway, and endothelial function in humans2012

    • Author(s)
      Fujimura N, Jitsuiki D, Goto C, Soga J, Hidaka T, Umemura T, Nishioka K, OshimaT, Chayama K, Higashi Y.
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 32 Pages: 153-160

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Xanthine oxidoreductase is involved inmacrophage foam cell formation and atherosclerosis development2012

    • Author(s)
      Kushiyama A, Zhang J, Sakoda H, KikuchiT, Fujishiro M, Sato H, Kushiyama S, Iwashita M, Nishimura F, Fukushima T, Nakatsu Y, Kamata, H, Kikuchi M, KawazuS, Higashi Y, Kurihara, H, Asano T.
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 32 Pages: 291-298

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vascular dysfunction even after 20 years inchildren exposed to passive smoking : alarming results and need for awareness2012

    • Author(s)
      Suzuki T, Tomiyama H, Higashi Y.
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 32 Pages: 841-842

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Selective mineralocorticoid receptor blockere plerenone improves endothelialfunction and inhibits Rho-associatedkinase activity in patients with essential hypertension2012

    • Author(s)
      Fujimura N, Hata T, Soga J, Hidaka T, IdeiN, Fujii Y, Mikami S, Maruhashi T, Iwamoto Y, Kihara Y, Chayama K, Kato H, Noma K, Liao JK, Higashi Y.
    • Journal Title

      Clin Pharmacol & Therapeut

      Volume: 91 Pages: 289-297

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A study design of multi-center study to evaluatethe clinical usefulness of semi-automatic measurement offlow-mediated vasodilatation of thebrachial artery in Japan(FMD-J study)2012

    • Author(s)
      Tomiyama H, Kohro T, Higashi Y, Takase B, Suzuki T, Ishizu T, Ueda S, Yamazaki T, Furumoto T, Kario K, Inoue T, Koba S, Watanabe K, Takemoto Y, Hano T, Sata M, Ishibashi Y, Node K, Maemura K, Ohya Y, Furukawa T, Ito H, Yamashina A.
    • Journal Title

      Int Heart J.

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The therapeutic potential of ex vivo expanded CD133+ cells derived from human peripheral blood for peripheral nerve injuries2012

    • Author(s)
      Ohtsubo S, Ishikawa M, Kamei N, Kijima Y, Suzuki O, Sunagawa T, Higashi Y, MasudaH, Asahara T, Ochi M.
    • Journal Title

      J Neurosurg

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endothelial function and hypertension in aging(review)2012

    • Author(s)
      Higashi Y, Noma K.
    • Journal Title

      Hypertens Res

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Strings of ROCK activity and endothelial function(review)2012

    • Author(s)
      Noma K, Kihara Y, Higashi Y.
    • Journal Title

      J Cardiol

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Geranylgeranylacetone, Hsp90/AMPK/eNOS/NO pathway, and endothelial function in humans2012

    • Author(s)
      Fujimura N, Titsulki D, Goto C, Soga J, Hidaka T, Umemura T, Nishioka K, Oshima T, Chayama K, Higashi Y
    • Journal Title

      Arterioscler Thromb Vase Biol

      Volume: 32 Pages: 153-160

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Xanthine oxidoreductase is involved in macrophage foam cell formation and atherosclerosis development2012

    • Author(s)
      Kushiyama A, Zhang J, Sakoda H, Kikuchi T, Fujishiro M, Sato H, Kushlyama S, Iwashita M, Nishimura F, Fukushima T, Nakatsu Y, Kamata, H, Kikuchi M, Kawazu S, Higashi Y, Kurihara, H, Asano T
    • Journal Title

      Arterioscler Thromb Vase Biol

      Volume: 32 Pages: 291-298

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vascular dysfunction even after 20 years in children exposed to passive smoking : alarming results and need for awareness2012

    • Author(s)
      Suzuki T, Tomiyama H, Higashi Y
    • Journal Title

      Arterioscler Thromb Vase Biol

      Volume: 32 Pages: 841-842

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective mineralocorticoid receptor blocker eplerenone improves endothellal function and Inhibits Rho-associated kinase activity in patients with essential hypertension2012

    • Author(s)
      Fujimura N, Hata T, Soga J, Hidaka T, Idei N, Fujii Y, Mikami S, Maruhashi T, Iwamoto Y, Kihara Y, Chayama K, Kato H, Noma K, Liao JK, Higashi Y
    • Journal Title

      Clin Pharmacol & Therapeut

      Volume: 91 Pages: 289-297

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rho-associated kinase (ROCK) activity, endothelial function and cardiovascular risk factors2012

    • Author(s)
      Soga J, Hata T, Hidaka T, Fujii Y, Idei N, Fujimura N, Mikami S, Maruhashi T, Kihara Y, Chayama K, Kato H, Noma K, Liao JK, Higashi Y
    • Journal Title

      Arterioscler Thromb Vase Biol

      Volume: 31 Pages: 2353-2359

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vascular functionand circulating progenitor cell inthromboangiitis obliterans(Buergerdisease) and atherosclerosis obliterans2011

    • Author(s)
      Idei N, Nishioka K, Soga J, Hidaka T, HataT, Fujii Y, Fujimura N, Maruhashi T, Mikami S, Teragawa H, Kihara Y, Noma K, Chayama K, Higashi Y.
    • Journal Title

      Hypertension

      Volume: 57 Pages: 70-78

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Autologous bone-marrow mononuclear cellimplantation reduces long-term majoramputation risk in patients withcritical limb ischemia : a comparison ofatherosclerotic peripheral arterialdisease and Buerger disease2011

    • Author(s)
      Idei N, Chowdhury M, Soga J, Hata T, FujiiY, Fujimura N, Mikami S, Maruhashi T, Nishioka K, Hidaka T, Kihara Y, Noma K, Taguchi A, Chayama K, Sueda T, Higashi Y.
    • Journal Title

      Circulation : Cardiovascular Intervention

      Volume: 4 Pages: 15-25

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Response to Letter Regarding Article, Autologous bone-marrow mononuclear cellimplantation reduces long-term major amputation risk in patients withcritical limb ischemia : a comparison ofatherosclerotic peripheral arterialdisease and Buerger disease2011

    • Author(s)
      Idei N, Chowdhury M, Soga J, Hata T, FujiiY, Fujimura N, Mikami S, Maruhashi T, Nishioka K, Hidaka T, Kihara Y, Noma K, Taguchi A, Chayama K, Sueda T, Higashi Y.
    • Journal Title

      Circulation : Cardiovascular Intervention

      Volume: 4

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Calcium channel blockerand rho-associated kinae activity inpatients with hypertension2011

    • Author(s)
      Hata T, Soga J, Hidaka T, Idei N, FujiiY, Fujimura N, Mikami S, Maruhashi T, Kihara Y, Chayama K, Kato H, Noma K, LiaoJK, Higashi Y.
    • Journal Title

      J Hypertens

      Volume: 29 Pages: 373-379

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Measurement of Rho-associatedkinase(ROCK) activity in humans : acomparison of leukocyte p-MBS/ t-MBS and forearm blood flow response to fasudil2011

    • Author(s)
      Hata T, Soga J, Hidaka T, Idei N, FujiiY, Fujimura N, Mikami S, Maruhashi T, Kihara Y, Chayama K, Noma K, Liao JK, Higashi Y.
    • Journal Title

      Atherosclerosis

      Volume: 241 Pages: 117-121

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rho-associated kinase(ROCK) activity, endothelial functionand cardiovascular risk factors2011

    • Author(s)
      Soga J, Hata T, Hidaka T, Fujii Y, IdeiN, Fujimura N, Mikami S, Maruhashi T, Kihara Y, Chayama K, Kato H, Noma K, LiaoJK, Higashi Y.
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 31 Pages: 2353-2359

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Color Doppler flows of corkscrew collaterals in thromboangiitis obliterans(Buergerdisease) using color duplex ultrasonography2011

    • Author(s)
      Fujii Y, Soga J, Hidaka T, Hata T, IdeiN, Fujimura N, Mikami S, Maruhashi T, Noma K, Kihara Y, Higashi Y.
    • Journal Title

      J Am Coll Cardiol

      Volume: 57 Pages: 2539-2539

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Flow-mediated vasodilation is augmented in corkscrew collateral arterycompared with that in a native artery inpatients with thromboangiitis obliterans(Bureger disease)2011

    • Author(s)
      Fujii Y, Fujimura N, Mikami S, MaruhashiT, Kihara Y, Chayama K, Noma K, Higashi Y.
    • Journal Title

      J Vas Surg

      Volume: 54 Pages: 546-547

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Is cell therapy promising orlost in translation in patients withacute myocardial infarction2011

    • Author(s)
      Higashi Y.
    • Journal Title

      Circ J.

      Volume: 75 Pages: 546-547

    • NAID

      10028101734

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship among hyperuricemia, metabolic syndrome, and endothelial dysfunction2011

    • Author(s)
      Tomiyama H, Higashi Y, Takase B, Node K, Sata M, Inoue T, Ishibashi Y, Ueda S, Yamashina A.
    • Journal Title

      Am J Hypertens

      Volume: 24 Pages: 770-774

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Flow-mediated vasodilation is augmented in corkscrew collateral artery compared with that in a native artery in patients with thromboangiitis obliterans (Bureger disease)2011

    • Author(s)
      Fujii Y, Fujimura N, Mikami S, Maruhashi T, Kihara Y, Chayama K, Noma K, Higashi Y
    • Journal Title

      J Vas Surg

      Volume: 54 Pages: 1689-1697

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Color Doppler flows of corkscrew collaterals in thromboangiitis obliterans (Buerger disease) using color duplex ultrasonography2011

    • Author(s)
      Fujii Y, Soga J, Hidaka T, Hata T, Idei N, Fujimura N, Mikami S, Maruhashi T, Noma K, Kihara Y, Higashi Y
    • Journal Title

      J Am Coll Cardiol

      Volume: 57 Pages: 2539-2539

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Response to Letter Regarding Article, Autologous bone-marrow mononuclear cell implantation reduces long-term major amputation risk in patients with critical limb ischemia : a comparison of atherosclerotic peripheral arterial disease and Buerger disease.2011

    • Author(s)
      Idei N, Chowdhury M, Soga J, Hata T, Fujii Y, Fujimura N, Mikami S, Maruhashi T, Nishioka K, Hidaka T, Kihara Y, Noma K, Taguchi A, Chayama K, Sueda, T, Higashi Y.
    • Journal Title

      Circulation : Cardiovascular Intervention

      Volume: 4

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Is cell therapy promising or lost in translation in acute myocardial infarction?2011

    • Author(s)
      Higashi Y
    • Journal Title

      Circulation Journal

      Volume: 75 Pages: 546-547

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autologous bone-marrow mononuclear cell implantation reduces long-term major amputation risk in patients with critical limb ischemia : a comparison of atherosclerotic peripheral arterial disease and Buerger disease.2011

    • Author(s)
      Idei N, Chowdhury M, Soga J, Hata T, Fujii Y, Fujimura N, Mikami S, Maruhashi T, Nishioka K, Hidaka T, Kihara Y, Noma K, Taguchi A, Chayama K, Sueda T, Higashi Y.
    • Journal Title

      Circulation : Cardiovascular Intervention

      Volume: 4 Pages: 15-25

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Measurement of Rho-associated kinase (ROCK) activity in humans : a comparison of leukocyte p-MBS/t-MBS and forearm blood flow response to fasudil. Atherosclerosis.2011

    • Author(s)
      Hata T, Soga J, Hidaka T, Idei N, Fujii Y, Fujimura N, Mikami S, Maruhashi T, Kihara Y, Chayama K, Noma K, Liao JK, Higashi Y.
    • Journal Title

      Atherosclerosis.

      Volume: 214 Pages: 117-121

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Calcium channel blocker and rho-associated kinase activity in patients with hypertension.2011

    • Author(s)
      Hata T, Soga J, Hidaka T, Idei N, Fujii Y, Fujimura N, Mikami S, Maruhashi T, Kihara Y, Chayama K, Kato H, Noma K, Liao JK, Higashi Y
    • Journal Title

      Journal of Hypertension

      Volume: 29 Pages: 373-379

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vascular function and circulating progenitor cell in thromboangitis obliterans (Buerger's disease) and atherosclerosis obliterans.2011

    • Author(s)
      Idei N, Nishioka K, Soga J, Hidaka T, Hata T, Fujii Y, Fujimura N, Maruhashi T, Mikami S, Teragawa H, Kihara Y, Noma K, Chayama K, Higashi Y
    • Journal Title

      Hypertension

      Volume: 57 Pages: 70-78

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sarpogrelate, aselective 5-HT_<2A> antagonist, augments autologous bone-marrow mononuclear cellimplantation-induced improvement in endothelium-dependent vasodilation in patients with critical limb ischemia2010

    • Author(s)
      Higashi Y, Miyazaki M, Goto C, Sanada H, Chayama K, Sueda T.
    • Journal Title

      J Cardiovasc Pharmacol

      Volume: 55 Pages: 56-61

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased leukocyte Rhokinase(ROCK) and endothelial dysfunction in cigarette smokers2010

    • Author(s)
      Hidaka T, Hata T, Soga J, Nakamura S, Fujii Y, Idei N, Fujimura N, Nishioka K, Kihara Y, Chayama K, Noma K, Liao JK, Higashi Y.
    • Journal Title

      Hypertens Res

      Volume: 33 Pages: 354-359

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pioglitazone improves endothelium-dependent vasodilation in hypertensive patients with impairedglucose tolerance through a decrease inoxidative stress2010

    • Author(s)
      Hidaka T, Nakagawa K, Goto C, Soga J, Fujii Y, Hata T, Idei N, Fujimura N, Chayama K, Kihara Y, Higashi Y.
    • Journal Title

      Atherosclerosis

      Volume: 210 Pages: 521-524

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endothelial function in subjects with isolated low HDL cholesterol : role of nitric oxide andcirculating progenitor cells2010

    • Author(s)
      Higashi Y, Matsuoka H, Umei H, Sugano R, Soga J, Fujii Y, Chayama K, Kihara Y, Imaizumi T.
    • Journal Title

      Am J Physiol Endorinol Metab

      Volume: 298

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Classification of corkscrew collateralsin thromboangiitis obliterans(Buerger' s disease): relationship between corkscrew type and prevalence of ischemic ulcers2010

    • Author(s)
      Fujii Y, Nishioka K, Nakamura S, HidakaT, Soga J, Hata T, Idei N, Fujimura N, Chayama K, Kihara Y, Higashi Y.
    • Journal Title

      Circ J.

      Volume: 74 Pages: 1684-1688

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anti-Aging Medicine in Cardiovascular Disease(review)2010

    • Author(s)
      Morishita R, Komuro I, Horiuchi M, Nakagami H, Minamino T, Higashi Y.
    • Journal Title

      Anti-Aging Medicine

      Volume: 7 Pages: 45-49

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impaired coronary microvascular endothelial function in men with metabolic syndrome2010

    • Author(s)
      Teragawa H, Mitsuba N, Nishioka K, UedaK, Kono S, Higashi Y, Chayama K, Kihara Y.
    • Journal Title

      World J Cardiol

      Volume: 2 Pages: 205-210

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mesenchymal stem cellsenhance growth and metastasis of coloncancer2010

    • Author(s)
      Shinagawa K, Kitadai Y, Tanaka M, SumidaT, Kodama M, Higashi Y, Tanaka S, YasuiW, Chayama K.
    • Journal Title

      Int J Cancer

      Volume: 127 Pages: 2323-2333

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] on the behalf of the SEASON investigators. Study design of SEASON registry : prospective Surveillance of vascular Events in antiplatelet-treated Artero Sclerosis Obliterans patients inJapaN(SEASON)2010

    • Author(s)
      Higashi Y, Fujita M, Origasa H, NaritomiH, Matsuo H, Miyata T, Shigematsu H.
    • Journal Title

      Int Heart J

      Volume: 51 Pages: 337-342

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Study design of SEASON registry : prospective Surveillance of vascular Events in antiplatelet-treated ArteroSclerosis Obliterans patients in JapaN (SEASON).2010

    • Author(s)
      Higashi Y, Fujita M, Origasa H, Naritomi H, Matsuo H, Miyata T, Shigematsu H, on the behalf of the SEASON investigators.
    • Journal Title

      International Heart Journal

      Volume: 51 Pages: 337-342

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sarpogrelate, a selective 5-HT_<2A> antagonist, augments autologous bone-marrow mononuclear cell implantation-induced improvement in endothelium-dependent vasodilation in patients with critical limb ischemia.2010

    • Author(s)
      Higashi Y, Miyazaki M, Goto C, Sanada H, Chayama K, Sueda T.
    • Journal Title

      J Cardiovasc Pharmacol

      Volume: 55 Pages: 56-61

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endothelial function in subjects with isolated low HDL cholesterol : role of nitric oxide and circulating progenitor cells.2010

    • Author(s)
      Higashi Y, Matsuoka H, Umei H, Sugano R, Soga J, Fujii Y, Chayama K, Kihara Y, Imaizumi T.
    • Journal Title

      Am J Physiol Endorinol Metab.

      Volume: 298

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sarpogrelate, a selective 5-HT_<2A> antagonist, augments autologous bone-marrow mononuclear cell implantation-induced improvement in endothelium-dependent vasodilation in patients with critical limb ischemia2010

    • Author(s)
      Higashi Y, Miyazaki M, Goto C, Sanada H, Chayama K, Sueda T.
    • Journal Title

      J Cardiovasc Pharmacol 55

      Pages: 56-61

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endothelial function in subjects with isolated low HDL cholesterol : role of nitric oxide and circulating progenitor cells2010

    • Author(s)
      Higashi Y, Matsuoka H, Umei H, Sugano R, Soga J, Fujii Y, Chayama K, Kihara Y, Imaizumi T.
    • Journal Title

      Am J Physiol Endormol Metab 298

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cigarette smoking abolished ischemic preconditioning-induced augmentation of endothelium-dependent vasodilation2009

    • Author(s)
      Nakamura S, Kimura M, Goto C, Kensuke N, Yoshizumi M, Chayama K, Kihara Y, Higashi Y.
    • Journal Title

      Hypertension

      Volume: 53 Pages: 674-681

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Edaravone for Extending the therapeutic time window and rescue of ischemic penumbra in acute cerebralinfarction : role of endothelium-derivednitric oxide and oxidative stress(review)2009

    • Author(s)
      Higashi Y.
    • Journal Title

      Expert Opin Pharmaco

      Volume: 10 Pages: 323-331

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oxidative stress and endothelial function in cardiovascular diseases(review)2009

    • Author(s)
      Higashi Y, Noma K, Yoshizumi M, Kihara Y
    • Journal Title

      Circ J.

      Volume: 73 Pages: 411-418

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dietary Phosphorus Acutely Impairs Endothelial Function2009

    • Author(s)
      Shuto E, Taketani Y, Tanaka R, Harada N, Isshiki M, Sato M, Nashiki K, Amo K, Yamamoto H, Higashi Y, Nakaya N, Takeda E.
    • Journal Title

      J Am Soc Nephrol

      Volume: 20 Pages: 1504-1512

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oral infection-inflammatory pathway, periodontitis, is a risk factor for endothelial dysfunction in patients with coronary artery disease2009

    • Author(s)
      Higashi Y, Goto C, Hidaka T, Soga J, Nakamura S, Fujii Y, Hata T, Idei N, Fujimura N, Chayama K, Kihara Y, Taguchi A.
    • Journal Title

      Atherosclerosis

      Volume: 206 Pages: 604-610

    • NAID

      120001898374

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cigarette smoking abolished ischemic preconditioning-induced augmentation of endothelium-dependent vasodilation2009

    • Author(s)
      Nakamura S, Kimura M, Goto C, Kensuke N, Yoshizumi M, Chayama K, Kihara Y, Higashi Y
    • Journal Title

      Hypertension 53

      Pages: 674-681

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Edaravone for Extending the therapeutic time window and rescue of ischemic penumbra in acute cerebral infarction : role of endothelium-derived nitric oxide and oxidative stress (review)2009

    • Author(s)
      Higashi Y
    • Journal Title

      Expert Opin Pharmaco 10

      Pages: 323-331

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxidative stress and endothelial function in cardiovascular diseases (review)2009

    • Author(s)
      Higashi Y, Noma K, Yoshizumi M, Kihara Y
    • Journal Title

      Circ J 73

      Pages: 411-418

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dietary Phosphorus Acutely Impairs Endothelial Function2009

    • Author(s)
      Shuto E, Taketani Y, Tanaka R, Harada N, Isshiki M, Sato M, Nashiki K, Amo K, Yamamoto H, Higashi Y, Nakaya N, Takeda E
    • Journal Title

      J Am Soc Nephrol 20

      Pages: 1504-1512

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oral infection-inflammatory pathway, periodontitis, is a risk factor for endothelial dysfunction in patients with coronary artery disease2009

    • Author(s)
      Higashi Y, Goto C, Hidaka T, Soga J, Nakamura S, Fujii Y, Hata T, Idei N, Fujimura N, Chayama K, Kihara Y, Taguchi A
    • Journal Title

      Atherosclerosis 206

      Pages: 604-610

    • NAID

      120001898374

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Assessment for Endothelial Function : Flow-mediated vasodilation(FMD)2012

    • Author(s)
      Yukihito Higashi
    • Organizer
      第76回日本循環器学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2012-03-17
    • Related Report
      2011 Final Research Report
  • [Presentation] Assessment for Endothelial Function : Flow-mediated vasodilation (FMD)2012

    • Author(s)
      東幸仁
    • Organizer
      第76回日本循環器学会総会
    • Place of Presentation
      福岡(招待講演)
    • Year and Date
      2012-03-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Rho-Associated Kinase(ROCK) Activity and Left Ventricular Hypertrophy in Patients with Essential Hypertension2011

    • Author(s)
      Shinsuke Mikami, Yukihito Higashi, Yuichi Fujii, Naomi Idei, Noritaka Fujimura, Takayuki Hidaka, Tatsuya Maruhashi, Yumiko Iwamoto, Yasuki Kihara
    • Organizer
      80^<th> Scientific Sessions, American Heart Association
    • Place of Presentation
      Orlando, FA. USA
    • Year and Date
      2011-11-14
    • Related Report
      2011 Final Research Report
  • [Presentation] Effects of Selective Mineralocorticoid Receptor Blocker Eplerenone on Endothelial Functionand the Activity of Rho-Associated Kinase in Patients with Essential Hypertension2011

    • Author(s)
      Noritaka Fujimura, Yukihito Higashi, Yumiko Iwamoto, Tatsuya Maruhashi, Shinsuke Mikami, Naomi Idei, Takayuki Hidaka, Kensuke Noma, James K Liao, Yasuki Kihara
    • Organizer
      80^<th> Scientific Sessions, American Heart Association
    • Place of Presentation
      Orlando, FA. USA
    • Year and Date
      2011-11-13
    • Related Report
      2011 Final Research Report
  • [Presentation] 歯周病と血管内皮機能2011

    • Author(s)
      東幸仁
    • Organizer
      第54回日本歯周病学会
    • Place of Presentation
      下関
    • Year and Date
      2011-09-24
    • Related Report
      2011 Final Research Report
  • [Presentation] 歯周病と血管内皮機能2011

    • Author(s)
      東幸仁
    • Organizer
      第54回日本歯周病学会
    • Place of Presentation
      下関(招待講演)
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 内皮機能評価:その実際と意義2011

    • Author(s)
      東幸仁
    • Organizer
      第59回日本心臓病学会
    • Place of Presentation
      神戸
    • Year and Date
      2011-09-23
    • Related Report
      2011 Final Research Report
  • [Presentation] 内皮機能評価:その実際と意義2011

    • Author(s)
      東幸仁
    • Organizer
      第59回日本心臓病学会
    • Place of Presentation
      神戸(招待講演)
    • Year and Date
      2011-09-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] 心臓が動脈・血管に与える影響(FMD):心不全とFMD2011

    • Author(s)
      東幸仁
    • Organizer
      第84回日本超音波学会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-28
    • Related Report
      2011 Final Research Report
  • [Presentation] 心臓が動脈・血管に与える影響(FMD):心不全とFMD2011

    • Author(s)
      東幸仁
    • Organizer
      第84回日本超音波学会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2011-05-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] FMD測定とNADPH oxidase欠損症患者からの教訓2011

    • Author(s)
      東幸仁
    • Organizer
      第11回日本NO学会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-14
    • Related Report
      2011 Final Research Report
  • [Presentation] FMD測定とNADPH oxidase欠損症患者からの教訓2011

    • Author(s)
      東幸仁
    • Organizer
      第11回日本NO学会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2011-05-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] How to MeasureEndothelial Function in Patients with Hypertension : from Plethysmograhy, FMD, and Biomarkers to a New Device2011

    • Author(s)
      Yukihito Higashi
    • Organizer
      第75回日本循環器学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-19
    • Related Report
      2011 Final Research Report
  • [Presentation] 血管内皮機能を捉える2011

    • Author(s)
      東幸仁
    • Organizer
      第11回動脈硬化学会教育フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2011-02-06
    • Related Report
      2011 Final Research Report
  • [Presentation] Role of Endothelial Function in Atherosclerosis. The 18th Annual Meeting of the JapaneseVascular Biology and Medicine Organization2010

    • Author(s)
      Yukihito Higashi
    • Organizer
      The 8^<th> Korea-JapanJoint Symposium on Vascular Biology
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2010-12-03
    • Related Report
      2011 Final Research Report
  • [Presentation] Role of Endothelial Function in Atherosclerosis2010

    • Author(s)
      Yukihito Higashi
    • Organizer
      日本血管生物医学会
    • Place of Presentation
      大阪(招待講演)
    • Year and Date
      2010-12-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Endothelial Function and Oxidative Stress in X-Linked, gp91phox Deficiency2010

    • Author(s)
      Yukihito Higashi, Junko Soga, Noritaka Fujimura, Masao Kobayash
    • Organizer
      Chronic GranulomatousDisease. 79th Scientific Sessions
    • Place of Presentation
      Chicago, IL. USA
    • Year and Date
      2010-11-14
    • Related Report
      2011 Final Research Report
  • [Presentation] 血管内皮機能の役割2010

    • Author(s)
      東幸仁
    • Organizer
      日本臨床スポーツ医学会
    • Place of Presentation
      筑波(招待講演)
    • Year and Date
      2010-11-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] 血管内皮機能はどう臨床に応用するか?2010

    • Author(s)
      東幸仁
    • Organizer
      日本動脈硬化学会・診断技術向上セミナー
    • Place of Presentation
      福岡(招待講演)
    • Year and Date
      2010-10-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] 血管内皮機能Up to Date2010

    • Author(s)
      東幸仁
    • Organizer
      日本心エコー図学会
    • Place of Presentation
      神戸(招待講演)
    • Year and Date
      2010-07-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Oxidative Stressand NO in Cardiovascular Disease2010

    • Author(s)
      Yukihito Higashi
    • Organizer
      The 10^<th> International Conference on theBiology, Chemistry, and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-06-17
    • Related Report
      2011 Final Research Report
  • [Presentation] Oxidative Stress and NO in Cardiovascular Disease.2010

    • Author(s)
      Yukihito Higashi
    • Organizer
      International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      京都(招待講演)
    • Year and Date
      2010-06-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] 重症末梢血管疾患における細胞治療による血管再生の長期予後と今後の課題2010

    • Author(s)
      東幸仁
    • Organizer
      日本再生医療学会
    • Place of Presentation
      広島
    • Year and Date
      2010-03-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Latest Methods to Evaluate Endothelial Function2010

    • Author(s)
      Kensuke Noma, Yasuki Kihara, Masao Yoshizumi, Yukihito Higashi
    • Organizer
      日本循環器学会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 閉塞性動脈硬化症と血管内皮機能2009

    • Author(s)
      東幸仁
    • Organizer
      日本脈管学会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] Pharmacological Therapy for Peripheral Arterial Disease : from Platelet Function to Endothelial Function2009

    • Author(s)
      東幸仁
    • Organizer
      日本心臓リハビリテーション学会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Vascular ROCK activity evaluated by a strain-gauge plethysmography2009

    • Author(s)
      野間玄督, 東幸仁, 吉栖正生
    • Organizer
      日本動脈硬化学会
    • Place of Presentation
      山口
    • Year and Date
      2009-07-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Therapeutic Strategy for Peripheral Arterial Disease : Pharmacological Therapy and Angiogenesis. Roles of serotonin andnitric oxide2009

    • Author(s)
      Yukihito Higashi
    • Organizer
      10^<th> International Symposium on Mechanisms on Vasodilation
    • Place of Presentation
      Matsushima, Japan
    • Year and Date
      2009-06-01
    • Related Report
      2011 Final Research Report
  • [Presentation] Therapeutic Strategy for Peripheral Arterial Disease : Pharmacological Therapy and Angiogenesis -Roles of serotonin and nitric oxide-2009

    • Author(s)
      東幸仁
    • Organizer
      International Symposium on Mechanisms on Vasodilation
    • Place of Presentation
      Matsushima, Japan
    • Year and Date
      2009-06-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] 加齢と血管内皮機能:NO、血管内皮前駆細胞、酸化ストレスの役割2009

    • Author(s)
      東幸仁
    • Organizer
      日本坑加齢学会
    • Place of Presentation
      東京
    • Year and Date
      2009-05-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 血管機能2009

    • Author(s)
      東幸仁
    • Organizer
      日本超音波学会
    • Place of Presentation
      東京
    • Year and Date
      2009-05-22
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://home.hiroshima-u.ac.jp/angio/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://home.hiroshima-u.ac.jp/angio/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://home.hiroshima-u.ac.jp/angio/index.html

    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 血管内皮機能評価装置2011

    • Inventor(s)
      辻敏夫、吉栖正雄、東幸仁、河本昌志、小沢秀夫、鵜川貞二、高柳恒夫、森本陽香、久保諒祐
    • Industrial Property Rights Holder
      日本光電株式会社、国立大学法人広島大学
    • Filing Date
      2011-12-19
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] PGC-1の発現制御装置、並びに虚血性疾患の治療装置及び治療方法2009

    • Inventor(s)
      東幸仁、久保裕嗣、隅田潔、西村嘉博、新実信夫
    • Industrial Property Rights Holder
      国立大学法人広島大学、日本シグマックス株式会社
    • Filing Date
      2009-11-11
    • Related Report
      2011 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 血管壁モニタリング装置、血管壁モニタリング用プログラム及びコンピュター読み込み可能な記録媒体2009

    • Inventor(s)
      辻敏夫、吉栖正雄、河本昌志、東幸仁、佐伯昇、中村隆治、アブドゲニクトュルク、河野曜暢、堀内徹也、鵜川貞二
    • Industrial Property Rights Holder
      日本光電株式会社、国立大学法人広島大学
    • Filing Date
      2009-11-26
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 血管内皮機能評価装置2009

    • Inventor(s)
      東幸仁
    • Industrial Property Rights Holder
      広島大学
    • Industrial Property Number
      2009-212533
    • Filing Date
      2009-09-14
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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