| Project/Area Number |
21590914
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Fujita Health University |
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Principal Investigator |
IZAWA Hideo 藤田保健衛生大学, 医学部, 教授 (80402569)
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| Co-Investigator(Kenkyū-buntansha) |
OZAKI Yukio 藤田保健衛生大学, 医学部, 教授 (50298569)
CHENG Xian wu 名古屋大学, 医学部, 講師 (30378228)
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| Co-Investigator(Renkei-kenkyūsha) |
CHENG Xian wu 名古屋大学, 医学部, 講師 (30378228)
NOMURA Masanori 藤田保健衛生大学, 医学部, 教授
MORIMOTO Shinichiro 藤田保健衛生大学, 医学部, 教授
MUROHARA Toyoaki 名古屋大学, 大学院・医学系研究科, 教授 (90299503)
HIRASHIKI Akihiro 名古屋大学, 医学部, 助教 (10418741)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 心臓病態学 / 心不全 / マイクロRNA / 心筋線維化 / 分子生物学 / 線維化 |
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| Research Abstract |
Both myocardial fibrosis and reduce catecholamine sensitivity had been fully demonstrated to be involved in pathogenesis of heart failure. However, the molecular mechanisms that underlie myocardial fibrosis remain incompletely understood. First, we performed microarray analysis for a total of 485 miRNAs using endomyocardial biopsy specimen from 14 patients with idiopathic dilated cardiomyopathy(DCM). Out of 485 miRNAs, 7 were differentially expressed in the myocardium with reduced catecholamine sensitivity. Second, 7 miRNAs were differentially expressed significantly in 4 patients with severe myocardial fibrosis compared with 4 patients with less severe myocardial fibrosis. We demonstrated that 4 specific miRNAs could play key roles in myocardial fibrosis in patients with DCM.
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