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Cardiac Autophagy and Mitochondria in the Progress of Heart Failure

Research Project

Project/Area Number 21590939
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionMeiji University of Integrative Medicine (2010-2011)
Kyoto Prefectural University of Medicine (2009)

Principal Investigator

IWAI-KANAI Eri  明治国際医療大学, 医学教育研究センター, 教授 (20372584)

Co-Investigator(Kenkyū-buntansha) MATOBA Satoaki  京都府立医科大学, 医学研究科, 助教 (10305576)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords心不全 / ミトコンドリア / 細胞死 / オートファジー
Research Abstract

Using a new method for cardiac autophagy which was established by us, we examined the mechanism of cardiac repair in the progress of heart failure. Cardiac autophagy was accelerated in the early phase of heart failure, which was key for cardiac protection. In the heart of metabolic disorder, ischemia, or anti-cancer drug, the control of cardiac autophagy was impaired and p53-TIGAR pathway acted as a critical role for cardiac cellular fate.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (74 results)

All 2012 2011 2010 2009 Other

All Journal Article (20 results) (of which Peer Reviewed: 5 results) Presentation (48 results) Book (4 results) Remarks (2 results)

  • [Journal Article] Prognostic impact of systolic blood pressure at admission on in-hospital outcome after primary percutaneous coronary intervention for acute myocardial infarction2012

    • Author(s)
      Shiraishi J, Kohno Y, Sawada T, Hashimoto S, Ito D, Kimura M, Matsui A, Yokoi H, Arihara M, Irie H, Hyogo M, Shima T, Nakamura T, Matoba S, Yamada H, Matsumuro A, Shirayama T, Kitamura M, Furukawa K, Matsubara H.
    • Journal Title

      J Cardiol

    • Related Report
      2011 Final Research Report
  • [Journal Article] p53 promotes cardiac dysfunction in diabetic mellitus caused by excessive mitochondrial respiration-mediated reactive oxygen species generation and lipid accumulation2012

    • Author(s)
      Nakamura H, Matoba S, Iwai-Kanai E, Kimata M, Hoshino A, Nakaoka M, Katamura M, Okawa Y, Ariyoshi M, Mita Y, Ikeda K, Okigaki M, Adachi S, Tanaka H, Takamatsu T, Matsubara H.
    • Journal Title

      Circ Heart Fail

      Volume: 5(1) Pages: 106-15

    • Related Report
      2011 Final Research Report
  • [Journal Article] p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia2012

    • Author(s)
      Hoshino A, Matoba S, Iwai-Kanai E, Nakamura H, Kimata M, Nakaoka M, Katamura M, Okawa Y, Ariyoshi M, Mita Y, Ikeda K, Ueyama T, Okigaki M, Matsubara H.
    • Journal Title

      J Mol Cell Cardiol

      Volume: 52(1) Pages: 175-84

    • Related Report
      2011 Final Research Report
  • [Journal Article] Mitochondrial Respiration-Mediated ROS Generation and Lipid Accumulation2012

    • Author(s)
      Nakamura H, Matoba S, Iwai-Kanai E, Kimata M, Hoshino A, Katamura M, Adachi S, Matsubara H
    • Journal Title

      Circ Heart Fail

      Volume: (Epub ahead of print)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia2012

    • Author(s)
      Hoshino A, Matoba S, Iwai-Kanai E, Kimata M, Nakamura H, Katamura M, Adachi S, Matsubara H
    • Journal Title

      J Mol Cell Cardiol

      Volume: 52 Pages: 175-184

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loss of bcl-2 during the senescence exacerbates the impaired angiogenic functions in endothelial cells by deteriorating the mitochondrial redox state2011

    • Author(s)
      Uraoka M, Ikeda K, Kurimoto-Nakano R, Nakagawa Y, Koide M, Akakabe Y, Kitamura Y, Ueyama T, Matoba S, Yamada H, Okigaki M, Matsubara H.
    • Journal Title

      Hypertension

      Volume: 58(2) Pages: 254-63

    • Related Report
      2011 Final Research Report
  • [Journal Article] Early inflammatory reactions in atherosclerosis are induced by proline-rich tyrosine kinase/reactive oxygen species-mediated release of tumor necrosis factor-alpha and subsequent activation of the p21Cip1/Ets-1/p300 system2011

    • Author(s)
      Katsume A, Okigaki M, Matsui A, Che J, Adachi Y, Kishita E, Yamaguchi S, Ikeda K, Ueyama T, Matoba S, Yamada H, Matsubara H.
    • Journal Title

      Arterioscler Thromb Vasc Biol

    • Related Report
      2011 Final Research Report
  • [Journal Article] 心筋梗塞2011

    • Author(s)
      岡田朱美、金井恵理
    • Journal Title

      プチナース疾患別看護過程

      Pages: 43-60

    • Related Report
      2011 Annual Research Report
  • [Journal Article] p53 and TIGAR regulate cardiac myocyte energy homeostasis under hypoxic stress2010

    • Author(s)
      Kimata M, Matoba S, Iwai-Kanai E, Nakamura H, Hoshino A, Nakaoka M, Katamura M, Okawa Y, Mita Y, Okigaki M, Ikeda K, Tatsumi T, Matsubara H.
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: 299(6) Pages: 1908-16

    • Related Report
      2011 Final Research Report
  • [Journal Article] Paracrine osteogenic signals via bone morphogenetic protein-2 accelerate the atherosclerotic intimal calcification in vivo2010

    • Author(s)
      Nakagawa Y, Ikeda K, Akakabe Y, Koide M, Uraoka M, Yutaka KT, Kurimoto-Nakano R, Takahashi T, Matoba S, Yamada H, Okigaki M, Matsubara H.
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 30(10) Pages: 1908-15

    • Related Report
      2011 Final Research Report
  • [Journal Article] AMI-Kyoto Multi-Center Risk Study Group. Clinical manifestations and effects of primary percutaneous coronary intervention for patients with delayed pre-hospital time in acute myocardial infarction2010

    • Author(s)
      Nomura T, Tatsumi T, Sawada T, Kojima A, Urakabe Y, Enomoto-Uemura S, Nishikawa S, Keira N, Nakamura T, Matoba S, Yamada H, Matsumuro A, Shirayama T, Shiraishi J, Kohno Y, Kitamura M, Furukawa K, Matsubara H
    • Journal Title

      J Cardiol

      Volume: 56(2) Pages: 204-10

    • Related Report
      2011 Final Research Report
  • [Journal Article] p53 and TIGAR regulate cardiac myocyte energy homeostasis under hypoxic stress2010

    • Author(s)
      Kimata M, Matoba S, Iwai-Kanai E, Nakamura H, Hoshino A, Nakaoka M, Katamura M, Okigaki M, Tatsumi T, Matsubara H
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: 299(6)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Granulocyte colony-stimulating factor protects cardiac mitochondria in the early phase of cardiac injury2010

    • Author(s)
      Hiraumi Y, Iwai-Kanai E, Baba S, Yui Y, Kamitsuji Y, Mizushima Y, Matsubara H, Watanabe M, Watanabe K, Toyokuni S, Matsubara H, Nakahata T, Adachi S
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: 296(3)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Granulocyte colony-stimulating factor protects cardiac mitochondria in the early phase of cardiac injury2009

    • Author(s)
      Hiraumi Y, Iwai-Kanai E, Baba S, Yui Y, Kamitsuji Y, Mizushima Y, Matsubara H, Watanabe M, Watanabe K, Toyokuni S, Matsubara H, Nakahata T, Adachi S.
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: 296(3) Pages: 23-32

    • Related Report
      2011 Final Research Report
  • [Journal Article] Prorenin induces ERK activation in endothelial cells to enhance neovascularization independently of the renin-angiotensin system2009

    • Author(s)
      Uraoka M, Ikeda K, Nakagawa Y, Koide M, Akakabe Y, Nakano-Kurimoto R, Takahashi T, Matoba S, Yamada H, Okigaki M, Matsubara H.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 390(4) Pages: 1202-7

    • Related Report
      2011 Final Research Report
  • [Journal Article] Pressure-mediated hypertrophy and mechanical stretch induces IL-1 release and subsequent IGF-1 generation to maintain compensative hypertrophy by affecting Akt and JNK pathways2009

    • Author(s)
      Honsho S, Nishikawa S, Amano K, Zen K, Adachi Y, Kishita E, Matsui A, Katsume A, Yamaguchi S, Nishikawa K, Isoda K, Riches DW, Matoba S, Okigaki M, Matsubara H.
    • Journal Title

      Circ Res

      Volume: 105(11) Pages: 1149-58

    • Related Report
      2011 Final Research Report
  • [Journal Article] Replicative senescence of vascular smooth muscle cells enhances the calcification through initiating the osteoblastic transition2009

    • Author(s)
      Nakano-Kurimoto R, Ikeda K, Uraoka M, Nakagawa Y, Yutaka K, Koide M, Takahashi T, Matoba S, Yamada H, Okigaki M, Matsubara H.
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: 297(5) Pages: 1673-84

    • Related Report
      2011 Final Research Report
  • [Journal Article] Granulocyte colony-stimulating factor protects cardiac mitochondria in the early phase of cardiac injury2009

    • Author(s)
      Hiraumi Y, Iwai-Kanai E, et.al.
    • Journal Title

      Am J Physiol Heart Circ Physiol. 296(3)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apoptosis regulator through modulating IAP expression(ARIA) controls the PI3K/Akt pathway in endothelial and endothelial progenitor cells

    • Author(s)
      Koide M, Ikeda K, Akakabe Y, Kitamura Y, Ueyama T, Matoba S, Yamada H, Okigaki M, Matsubara H.
    • Journal Title

      Proc Natl Acad Sci USA.

    • Related Report
      2011 Final Research Report
  • [Journal Article] LPS-induced autophagy is mediated by oxidative signaling in cardiomyocytes and is associated with cytoprotection

    • Author(s)
      Yuan H, Perry CN, Huang C, Iwai-Kanai E, Carreira RS, Glembotski CC, Gottlieb RA.
    • Related Report
      2011 Final Research Report
  • [Presentation] Granulocyte colony-stimulating factor(G-CSF) protects cardiac myocytes against doxorubicin induced injury via the stabilization of MDM22012

    • Author(s)
      Mita Y, Iwai-Kanai E, Matoba S, Nakaoka M, Kimata M, Nakamura H, Hoshino A, Katamura M, Okawa Y, Matsubara H.
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2011 Final Research Report
  • [Presentation] Curcumin protect mice heart against doxorubicin induced cardiomyopathy thorough the induction of autophagy2012

    • Author(s)
      Katamura M, Matoba S, Iwai-Kanai E, Kimata M, Nakamura H, Nakaoka M, Hoshino A, Okawa Y, Mita Y, Matsubara H.
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2011 Final Research Report
  • [Presentation] Granulocyte colony-stimulating factor (G-CSF) protects cardiac myocytes against doxorubicin induced injury via the stabilization of MDM22012

    • Author(s)
      Mita Y, Iwai-Kanai E, Matoba S, Nakaoka M, Kimata M, Nakamura H, Hoshino A, Katamura M, Okawa Y, Matsubara H
    • Organizer
      第76回日本循環器学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2011 Annual Research Report
  • [Presentation] Curcumin protect mice heart against doxorubicin induced cardio myopathy thorough the induction of autophagy2012

    • Author(s)
      Katamura M, Matoba S, Iwai-Kanai E, Kimata M, Nakamura H, Nakaoka M, Hoshino A, Okawa Y, Mita Y, Matsubara H
    • Organizer
      第76回日本循環器学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2011 Annual Research Report
  • [Presentation] P53 promotes cardiac aging through the inhibition of parkin mediated mitochondrial quality control2011

    • Author(s)
      Hoshino A, Matoba S, Iwai-Kanai E, Kimata M, Nakamura H, Nakaoka M, Katamura M, Mita Y, Matsubara H.
    • Organizer
      The 84th Scientific Sessions of the American Heart Association
    • Place of Presentation
      Orlando, U. S. A
    • Related Report
      2011 Final Research Report
  • [Presentation] P53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia2011

    • Author(s)
      Hoshino A, Matoba S, Iwai-Kanai E, Kimata M, Nakamura H, Katamura M, Mita Y, Matsubara H.
    • Organizer
      The 84th Scientific Sessions of the American Heart Association
    • Place of Presentation
      Orlando, U. S. A
    • Related Report
      2011 Final Research Report
  • [Presentation] Mitochondrial Respiration-Mediated ROS Generation and Lipid Accumulation2011

    • Author(s)
      Nakamura H, Matoba S, Iwai-Kanai E, Kimata M, Hoshino A, Katamura M, Adachi S, Matsubara H.
    • Organizer
      The 84th Scientific Sessions of the American Heart Association
    • Place of Presentation
      Orlando, U. S. A
    • Related Report
      2011 Final Research Report
  • [Presentation] G-CSFによる心筋保護効果と抗がん作用への影響2011

    • Author(s)
      三田雄一郎、的場聖明、松原弘明、木股正樹、中村英夫、星野温、中岡幹彦、片村真紀、大川善文、三田雄一郎、金井恵理
    • Organizer
      第20回日本Cell Death学会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] ドキソルビシン心筋障害に対しクルクミンは心筋保護作用を示す2011

    • Author(s)
      片村真紀、的場聖明、松原弘明、木股正樹、中村英夫、中岡幹彦、星野温、大川善文、三田雄一郎、金井恵理
    • Organizer
      第20回日本Cell Death学会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] P53 promotes cardiac aging through the inhibition of parkin mediated mitochondrial quality control. The 84th Scientific Sessions of the American Heart Association2011

    • Author(s)
      Hoshino A, Matoba S, Iwai-Kanai E, Kimata M, Nakamura H, Nakaoka M, Katamura M, Mita Y, Matsubara H
    • Organizer
      The 84th Scientific Sessions of the American Heart Association
    • Place of Presentation
      Orlando, U.S.A.
    • Related Report
      2011 Annual Research Report
  • [Presentation] P53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia2011

    • Author(s)
      Hoshino A, Matoba S, Iwai-Kanai E, Kimata M, Nakamura H, Katamura M, Mita Y, Matsubara H
    • Organizer
      The 84th Scientific Sessions of the American Heart Association
    • Place of Presentation
      Orlando, U.S.A
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mitochondrial Respiration-Mediated ROS Generation and Lipid Accumulation2011

    • Author(s)
      Nakamura H, Matoba S, Iwai-Kanai E, Kimata M, Hoshino A, Katamura M, Adachi S, Matsubara H
    • Organizer
      The 84th Scientific Sessions of the American Heart Association
    • Place of Presentation
      Orlando, U.S.A
    • Related Report
      2011 Annual Research Report
  • [Presentation] p53-Mediated Inactivation of Bnip3 Reduces Mitophagy to Aggravate Cardiac Damage after Ischemic Injury2011

    • Author(s)
      Hoshino A, Matoba S, Iwai-Kanai E, Kimata M, Nakamura H, Katamura M, Mita Y, Matsubara H
    • Organizer
      第75回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2010 Annual Research Report
  • [Presentation] p53 and SCO2 (Synthesis of Cytochrome c Oxidase 2) Augment the Progression of Diabetic Cardiomyopathy2011

    • Author(s)
      Nakamura H, Matoba S, Iwai-Kanai E, Kimata M, Hoshino A, Nakaoka M, Katamura M, Tatsumi T, Matsubara H
    • Organizer
      第75回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2010 Annual Research Report
  • [Presentation] Hypoxia-Induced p53 Deteriorates Cardiac Energetics and Apoptotic Cell Death via TIGAR (TP53-Induced Glycolysis and Apoptosis Regulator)2011

    • Author(s)
      Kimata M, Matoba S, Iwai-Kanai E, Nakamura H, Hoshino A, Nakaoka M, Katamura M, Tatsumi T, Matsubara H
    • Organizer
      第75回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2010 Annual Research Report
  • [Presentation] Differential roles of Akt and Extracellular signal-regulated kinase signaling pathways on autophagy during alphal-adrenergic agonist mediated cardioprotection2011

    • Author(s)
      Nakaoka M, Iwai-Kanai E, Matoba S, Kimata M, Nakamura H, Hoshino A, Katamura M, Adachi S, Matsubara H
    • Organizer
      第75回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2010 Annual Research Report
  • [Presentation] The effects of glanulocyte colony-stimulating factor on cardiac mitochondria.2010

    • Author(s)
      Iwai-Kanai E.
    • Organizer
      Protein and Peptide Conference
    • Place of Presentation
      Beijing, china
    • Year and Date
      2010-03-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新型インフルエンザAHlpdmの動向と心筋炎2010

    • Author(s)
      Iwai-Kanai E.
    • Organizer
      日本循環器学会学術集会モーニングレクチャー
    • Place of Presentation
      京都
    • Year and Date
      2010-03-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] p53 Inhibits Autophagy and Accelerates Apoptotic Cell Death through Mitochondrial Redox Signal in Ischemic Myocardium2010

    • Author(s)
      Hoshino A, Matoba S, Iwai-Kanai E, et.al.
    • Organizer
      日本循環器学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] p53 promotes heart failure in diabetic cardiomyopathy2010

    • Author(s)
      Nakamura H, Matoba S, Iwai-Kanai E, et.al.
    • Organizer
      日本循環器学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] The role of autophagy in diastolic failing state of heart failure2010

    • Author(s)
      Iwai-Kanai E.
    • Organizer
      日本循環器学会学術集会シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2010-03-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Contribution of Cardiac Autophagy to Alpha1-Adrenergic Agonist-Mediated Cardioprotection2010

    • Author(s)
      Nakaoka M, Iwai-Kanai E, et.al.
    • Organizer
      日本循環器学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] p53-Mediated Decrease in ROS Signal Reduces Mitophagy via Inactivation of Bnip3 to Aggravate Cardiac Damage After Ischemic Injury2010

    • Author(s)
      Hoshino A, Matoba S, Iwai-Kanai E, Kimata M, Nakamura H, Nakaoka M, Katamura M, Mita Y, Matsubara H.
    • Organizer
      American Heart Association Scientific Sessions
    • Place of Presentation
      Chicago, Illinois, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] p53-mediated Acceleration of Mitochondrial Oxygen Consumption Promotes Lipotoxicity via SCO2 in Diabetic Mice2010

    • Author(s)
      Nakamura H, Matoba S, Iwai-Kanai E, Kimata M, Hoshino A, Katamura M, Adachi S, Matsubara H.
    • Organizer
      American Heart Association Scientific Sessions
    • Place of Presentation
      Chicago, Illinois, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Imaging oxidative stress in unstable atherosclerotic plaque with iodine-125-labeled 4-hydroxy-2-nonenal in vivo2010

    • Author(s)
      Doue T, Iwai-Kanai E, Ohtsuki K, Matoba S, Ogawa K, Matsubara H.
    • Organizer
      American Heart Association Scientific Sessions
    • Place of Presentation
      Chicago, Illinois, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] G-CSF protects cardiac mitochondria2010

    • Author(s)
      Iwai-Kanai E. Hiraumi Y, Matoba S, Adachi S, Matsubara H
    • Organizer
      Mitochondrial Conference of NIH
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] p53発現抑制におけるオートファジーを介した虚血心筋保護効果2010

    • Author(s)
      星野温、的場聖明、金井恵理、中岡幹彦、木股正樹、中村英夫、片村真紀、堂上友紀、松原弘明
    • Organizer
      第19回日本cell death学会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 交感神経刺激による心筋アポトーシス、オートファジーの制御2010

    • Author(s)
      中岡幹彦、金井恵理、的場聖明、木股正樹、中村英夫、星野温、片村真紀、堂上友紀、松原弘明
    • Organizer
      第19回日本cell death学会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 新型インフルエンザAH1pdmの動向と心筋炎2010

    • Author(s)
      Iwai-Kanai E
    • Organizer
      第74回日本循環器学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] The Role of Autophagy in Diastolic Heart Failing State of Heart Failure2010

    • Author(s)
      Iwai-Kanai E, Hiraumi Y, Matoba S, Adachi S, Matsubara H.
    • Organizer
      第74回日本循環器学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] p53 and SCO2(Synthesis of Cytochrome c Oxidase 2) Augment the Progression of Diabetic Cardiomyopathy2010

    • Author(s)
      Nakamura H, Matoba S, Iwai-Kanai E, Kimata M, Hoshino A, Katamura M, Adachi S, Matsubara H.
    • Organizer
      第74回日本循環器学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] Hypoxia-Induced p53 Deteriorates Cardiac Energetics and Apoptotic Cell Death via TIGAR(TP53-Induced Glycolysis and Apoptosis Regulator)2010

    • Author(s)
      Kimata M, Matoba S, Iwai-Kanai E, Nakamura H, Hoshino A, Nakaoka M, Katamura M, Okawa Y, Mita Y, Okigaki M, Ikeda K, Tatsumi T, Matsubara H.
    • Organizer
      第74回日本循環器学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] Differential roles of Akt and Extracellular signal-regulated kinase signaling pathways on autophagy during alpha1-adrenergic agonist mediated cardioprotection2010

    • Author(s)
      Nakaoka M, Iwai-Kanai E, Matoba S, Kimata M, Nakamura H, Hoshino A, Katamura M, Adachi S, Matsubara H.
    • Organizer
      第74回日本循環器学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] G-CSF protects cardiac myocytes in the progress of heart failure2010

    • Author(s)
      Iwai-Kanai E
    • Organizer
      Protein Peptide Conference
    • Place of Presentation
      Beijing, China
    • Related Report
      2011 Final Research Report
  • [Presentation] 心不全の進展における心筋細胞死とオートファジーによる心保護のメカニズム2010

    • Author(s)
      Nakaoka M, Iwai-Kanai E, et. al.
    • Organizer
      第18回日本Cell Death学会
    • Place of Presentation
      長崎
    • Related Report
      2011 Final Research Report
  • [Presentation] 心筋虚血におけるp53と心筋2010

    • Author(s)
      Hoshino A, Iwai-Kanai E, et. al
    • Organizer
      第18回日本Cell Death学会
    • Place of Presentation
      長崎
    • Related Report
      2011 Final Research Report
  • [Presentation] p53-Mediated Decrease in ROS Signal Reduces Mitophagy via Inactivation of Bnip3 to Aggravate Cardiac Damage After Ischemic Injury2010

    • Author(s)
      Atsushi Hoshino, Satoaki Matoba, Eri Iwai-Kanai, Masaki Kimata, Hideo Nakamura, Mikihiko Nakaoka, Yoshifumi Okawa, Maki Katamura, Hiroaki Matsubara
    • Organizer
      American Heart Association Scientific Sessions2010
    • Place of Presentation
      Chicago, Illinois, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] p53-mediated Acceleration of Mitochondrial Oxygen Consumption Promotes Lipotoxicity via SCO2 in Diabetic Mice2010

    • Author(s)
      Hideo Nakamura, Satoaki Matoba, Eri Iwai-Kanai, Masaki Kimata, Hideo Nakamura, Atsushi Hoshino, Mikihiko Nakaoka, Yoshifumi Okawa, Maki Katamura, Hiroaki Matsubara
    • Organizer
      American Heart Association Scientific Sessions2010
    • Place of Presentation
      Chicago, Illinois, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Imaging oxidative stress in unstable atherosclerotic plaque with iodine-125-labeled 4-hydroxy-2-nonenal in vivo2010

    • Author(s)
      Tomoki Doue, Eri Iwai-Kanai, Katsuichi Ohtsuki, Satoaki Matoba, Kazuma Ogawa, Hiroaki Matsubara
    • Organizer
      American Heart Association Scientific Sessions2010
    • Place of Presentation
      Chicago, Illinois, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Differential role of Akt and ERK signaling pathways on autophagy during alpha-1 adrenergic agonist-mediated cardioprotection2009

    • Author(s)
      Nakaoka M, Iwai-Kanai E, et.al.
    • Organizer
      2010 American Heart Association Scientific Sessions
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2009-11-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 交感神経の亢進による心筋オートファジーの誘導2009

    • Author(s)
      Nakaoka M, Iwai-Kanai E, et.al.
    • Organizer
      日本高血圧学会
    • Place of Presentation
      大津
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] P53/TIGARはグルコース代謝を抑えて心筋アポトーシスを誘導する2009

    • Author(s)
      Kimata M, Matoba S, Iwai-Kanai E, et.al.
    • Organizer
      日本高血圧学会
    • Place of Presentation
      大津
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高齢予備世代の高血圧患者とMRI集団健診を用いたハイリスクアプローチ:京都府乙訓地域における疫学研究2009

    • Author(s)
      Iwai-Kanai E, et.al.
    • Organizer
      日本高血圧学会
    • Place of Presentation
      大津
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 心筋虚血におけるp53と心筋2009

    • Author(s)
      Hoshino A, Iwai-Kanai E, et.al.
    • Organizer
      日本Cel Death学会
    • Place of Presentation
      長崎
    • Year and Date
      2009-08-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 心不全の進展における心筋細胞死とオートファジーによる心保護のメカニズム2009

    • Author(s)
      Nakaoka M, Iwai-Kanai E, et.al.
    • Organizer
      日本Cell Death学会
    • Place of Presentation
      長崎
    • Year and Date
      2009-08-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高齢予備世代の高血圧患者とMRI集団健診を用いたハイリスクアプローチ:京都府乙訓地域における疫学研究2009

    • Author(s)
      Iwai-Kanai E, et. al.
    • Organizer
      第32回日本高血圧学会
    • Place of Presentation
      大津
    • Related Report
      2011 Final Research Report
  • [Presentation] 交感神経の亢進による心筋オートファジーの誘導2009

    • Author(s)
      Nakaoka M, Iwai-Kanai E, et. al
    • Organizer
      第32回日本高血圧学会
    • Place of Presentation
      大津
    • Related Report
      2011 Final Research Report
  • [Presentation] P53/TIGARはグルコース代謝を抑えて心筋アポトーシスを誘導する2009

    • Author(s)
      Kimata M, Matoba S, Iwai-Kanai E, et. al.
    • Organizer
      第32回日本高血圧学会
    • Place of Presentation
      大津
    • Related Report
      2011 Final Research Report
  • [Book] 心不全.プチナース疾患別看護過程2012

    • Author(s)
      麹谷康子、金井恵理
    • Publisher
      照林社
    • Related Report
      2011 Final Research Report
  • [Book] 肥大型心筋症.最新治療「循環器疾患」2012

    • Author(s)
      金井恵理、松森昭
    • Publisher
      文光堂
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Book] 心臓MRS.磁気共鳴スペクトルの医学応用-基礎から臨床までー2012

    • Author(s)
      金井恵理
    • Publisher
      株インナービジョン
    • Related Report
      2011 Final Research Report
  • [Book] 心筋梗塞.プチナース疾患別看護過程2011

    • Author(s)
      岡田朱美、金井恵理
    • Publisher
      照林社
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.f.kpu-m.ac.jp/k/med2/group/cardio/kenkyu-07.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.f.kpu-m.ac.jp/k/med2/group/cardio/kenkyu-07.html

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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