| Project/Area Number |
21590960
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
|
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| Research Institution | Fukuoka University |
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Principal Investigator |
SAKU Keijiro 福岡大学, 医学部, 教授 (40183371)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OHTA Takao 琉球大学, 医学部, 教授 (70185271)
MIURA Shinichiro 福岡大学, 医学部, 准教授 (20343709)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | ApoA-I模倣ペプチド / HDL / コレステロール引き抜き能 / preβ-HDL / リン脂質 / ApoA-1模倣ペプチド / コレステロール逆転送系 / 心筋梗塞 / 抗炎症作用 / 高比重リポ蛋白 / 引き抜き能 / turn over study / アポリポ蛋白 / A-I Mimetic Petide / 一酸化窒素 |
|---|
| Research Abstract |
Recently, HDL targeted therapy has been attracting attention to prevent atherosclerosis. First, we proved that newly developed ApoA-I mimetic peptide containing phospholipids showed a strong anti-atherosclerotic effect in rabbit model of atherosclerosis. Next, we developed new ApoA-I mimetic peptide without phospholipids which forms strong.-helix structure. We found the mimetic peptide increased preβ-HDL and showed a strong anti-atherosclerotic effect in an in vivo and in vitro.
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