Peptdes and antbodes therapy by acute exacerbaton of idiopathic pumonary fbross-reated autoantgens

• Project/Area Number: 21590982
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Chiba University
• Principal Investigator: KUROSU Katsushi 千葉大学, 医学部・附属病院, 講師 (20291106)
• Co-Investigator(Kenkyū-buntansha): TAKIGUCHI Yuuichi 千葉大学, 大学院・医学研究院, 教授 (30272321) ; TATSUMI Koichiro 千葉大学, 大学院・医学研究院, 教授 (10207061)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 肺線維症 / ELISPOT解析 / 細胞内サイトカインアッセイ / SEREX法 / 間質性肺炎 / 自己抗体

Research Abstract

Apoptosis-related autoantibodies were elevated in acute exacerbated patients with idiopathic pulmonary fibrosis (IPF). Anti-annexin 1 and anti-Bax inhibitor 1 antibodies were elevated in poor prognosis patients with acute exacerbated IPF. Anti-Bid antibodies were elevated in good prognosis patients. By ELISPOT analysis and intra cytokine assay, autoantibodies enhanced TH2 immune reaction on peripheral lymphocytes and suppressed phagocytosis of apoptotic cells.

Research Products

• [Presentation] 特発性肺線維症急性増悪における抗アネキシン1抗体の関与について (2010)
  • Author(s): 黒須克志, 滝口裕一, 黒田文伸, 坂尾誠一郎, 多田裕司, 笠原靖紀, 田邊信宏, 巽浩一郎
  • Organizer: 日本内科学会総会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2010-04-09
• [Presentation] 特発性肺線維症急性増悪特異的抗アネキシン1抗体の検討 (2009)
  • Author(s): 黒須克志, 滝口裕一, 湯本典夫, 岡田修, 黒田文伸, 坂尾誠一郎, 多田裕司, 笠原靖紀, 田邊信宏, 栗山喬之, 巽浩一郎
  • Organizer: 日本呼吸器学会総会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2009-06-12