Drug development for ALS using astrocytes derived from patient-specific iPSCs
| Project/Area Number |
21591079
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Kyoto University |
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Principal Investigator |
INOUE Haruhisa 京都大学, iPS細胞研究所, 准教授 (70332327)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Ryosuke 京都大学, 医学研究科, 教授 (90216771)
TAKAHASHI Kazutoshi 京都大学, iPS細胞研究所, 講師 (80432326)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 神経内科学 / 神経科学 / 幹細胞 |
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| Research Abstract |
We have generated ALS astrocytes using patient-specific iPS cells with mutant SOD1, and identified an existing drug that down-regulated SOD1 level in ALS astrocytes. The drug treatment also attenuated the clinical phenotypes of mutant SOD1 transgenic mice. Furthrmore we found that specific molecular pathways were activated in ALS astrocytes.
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Report
(4 results)
Research Products
(119 results)
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[Journal Article] Chemical library screening identifies a small molecule that downregulates SOD1 transcription for drugs to treat ALS
Author(s)
Murakami, G., Inoue, H., Tsukita, K., Asai, Y., Amagai, Y., Aiba, K., Shimogawa, H., Uesugi, M., Nakatsuji, N., Takahashi, R.
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Journal Title
The Journal of Biomolecular Screening
Volume: (In press)
Related Report
Peer Reviewed
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[Presentation] Induction of astrocyte differentiation from human induced pluripotent stem cells carrying mutant SOD12011
Author(s)
Kitaoka S, Tsukita K, Takahashi K, Okita K, Kondo T, Yoshikawa K, Yamawaki S, Naitoh M, Suzuki S, Izumi Y, Kaji R, Takuma H, Tamaoka A, Morita M, Nakano I, Kawata A, Nakahata T, Takahashi R, Yamanaka S, Inoue H
Organizer
The 34th Annual Meeting of the Japan Neuroscience Society. Neuroscience of the Mind
Place of Presentation
Yokohama, Japan
Year and Date
2011-09-16
Related Report
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[Presentation] Induction of astrocyte differentiation from human induced pluripotent stem cells carrying Mutant SOD12011
Author(s)
Kitaoka S., Tsukita K., Takahashi K., Okita K., Kondo T., Yoshikawa K., Yamawaki S., Naitoh M., Suzuki S., Izumi Y., Kaji R., Takuma H., Tamaoka A., Morita M., Nakano I., Kawata A., Nakahata T., Takahashi R., Yamanaka S., Inoue H.
Organizer
The 34 th Annual Meeting of the Japan Neuroscience Society-Neuroscience of the Mind-
Place of Presentation
Yokohama, Japan
Year and Date
2011-09-16
Related Report
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[Presentation] Chemical library screening identifies a small molecule that down regulates SOD1 transcription for drugs to treat amyotrophic lateral sclerosis2011
Author(s)
Murakami G, Inoue H, Tsukita K, Asai Y, Amagai Y, Aiba K, Shimogawa H, Uesugi M, Nakatsuji N, Takahashi R
Organizer
The 34th Annual Meeting of the Japan Neuroscience Society. Neuroscience of the Mind
Place of Presentation
Yokohama, Japan
Year and Date
2011-09-15
Related Report
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[Presentation] Chemical library screening identifies a small Molecule that downregulates SOD1 transcription for drugs to treat amyotrophic lateral sclerosis2011
Author(s)
Murakami G., Inoue H., Tsukita K., Asai Y., Amagai Y., Aiba K., Shimogawa H., Uesugi M., Nakatsuji N., Takahashi R.
Organizer
The 34th Annual Meeting of the Japan Neuroscience Society-Neuroscience of the Mind-
Place of Presentation
Yokohama, Japan
Year and Date
2011-09-15
Related Report
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[Presentation] 変異SOD1を有するALS患者由来iPS細胞の樹立とアストロサイトへの分化2011
Author(s)
北岡志保, 井上治久, 月田香代子, 高橋和利, 近藤孝之, 吉川勝宇, 山脇聖子, 内藤素子, 鈴木茂彦, 伊東秀文, 和泉唯信, 梶龍兒, 宅間浩, 玉岡晃, 森田光哉, 中野今治, 川田明広, 中畑龍俊, 高橋良輔, 山中伸弥
Organizer
第52回日本神経学会学術大会
Place of Presentation
名古屋
Year and Date
2011-05-19
Related Report
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[Presentation] Analysis of motor neurons derived from induced pluripotent stem cells from ALS patients2010
Author(s)
Kitaoka S, Inoue H, Tsukita K, Kawada M, Naitoh M, Takahashi K, Yoshikawa K, Kondo T, Yamawaki S, Watanabe D, Suzuki S, Takahashi R, Yamanaka S
Organizer
The 40th Annual Meeting of the Society for Neuroscience
Place of Presentation
San Diego, USA.
Year and Date
2010-11-17
Related Report
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[Presentation] Analysis of motor neurons derived from induced pluripotent stem cells from ALS patients.2010
Author(s)
Kitaoka, S., Inoue, H., Tsukita, K., Kawada, M., Naitoh, M., Takahashi, K., Yoshikawa, K., Kondo, T., Yamawaki, S., Watanabe, D., Suzuki, S., Takahashi, R., Yamanaka, S.
Organizer
The 40th Annual Meeting of the Society for Neuroscience
Place of Presentation
San Diego, USA
Year and Date
2010-11-17
Related Report
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[Presentation] Transcription-targeted drug discovery for SOD1-mediated ALS using high-throughput screening technique.2010
Author(s)
Murakami, G., Inoue, H., Tsukito, K., Asai, Y., Amagai, Y., Aiba, K., Uesugi, M., Nakatsuji, N., Takahashi, R.
Organizer
The 40th Annual Meeting of the Society for Neuroscience
Place of Presentation
San Diego, USA
Year and Date
2010-11-17
Related Report
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[Presentation] Differentiation of induced pluripotent stem cells from ALS patients generates motor neurons2010
Author(s)
Kitaoka S, Inoue H, Tsukita K, Kawada M, Naitoh M, Takahashi K, Yoshikawa K, Kondo T, Yamawaki S, Watanabe D, Suzuki S, Nakahata T, Takahashi R, Yamanaka S
Organizer
The 33rd Annual Meeting of the Japan Neuroscience Society
Place of Presentation
Kobe, Japan
Year and Date
2010-09-02
Related Report
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[Presentation] Differentiation of induced pluripotent stem cells from ALS patients generates motor neurons.2010
Author(s)
Kitaoka, S., Inoue, H, Tsukita, K., Kawada, M., Naitoh, M., Takahashi, K., Yoshikawa, K., Kondo T., Yamawaki, S., Watanabe, D., Suzuki, S., Nakahata, T., Takahashi, R., Yamanaka, S.
Organizer
The 33rd Annual Meeting of the Japan Neuroscience Society
Place of Presentation
Kobe, Japan
Year and Date
2010-09-02
Related Report
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[Presentation] Establishment of iPS cells from amyotrophic lateral sclerosis model mice.2010
Author(s)
Komatsu, K., Inoue, H., Kondo, T., Kitaoka, S., Ichisaka, T., Takahashi, K., Yamanaka, S., Takahashi, R.
Organizer
The 33rd Annual Meeting of the Japan Neuroscience Society
Place of Presentation
Kobe, Japan
Year and Date
2010-09-02
Related Report
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[Presentation] Functional Neuro Muscular Culture Derived From Human Ips Cells.2010
Author(s)
Baba, S., Hua, E., Nakamura, K., Sears, M., Inoue, H., Conklin, B.R.
Organizer
ISSCR 8th Annual Meeting
Place of Presentation
San Francisco, USA
Related Report
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