Drug development for ALS using astrocytes derived from patient-specific iPSCs

• Project/Area Number: 21591079
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurology
• Research Institution: Kyoto University
• Principal Investigator: INOUE Haruhisa 京都大学, iPS細胞研究所, 准教授 (70332327)
• Co-Investigator(Kenkyū-buntansha): TAKAHASHI Ryosuke 京都大学, 医学研究科, 教授 (90216771) ; TAKAHASHI Kazutoshi 京都大学, iPS細胞研究所, 講師 (80432326)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 神経内科学 / 神経科学 / 幹細胞

Research Abstract

We have generated ALS astrocytes using patient-specific iPS cells with mutant SOD1, and identified an existing drug that down-regulated SOD1 level in ALS astrocytes. The drug treatment also attenuated the clinical phenotypes of mutant SOD1 transgenic mice. Furthrmore we found that specific molecular pathways were activated in ALS astrocytes.

Research Products

• [Journal Article] RNA結合タンパク質の機能と神経変性疾患iPS細胞を用いた疾患病態の再現とRNAプロセシング治療の可能性 (2011)
  • Author(s): 江川斉宏, 井上治久
  • Journal Title: Dmentia Japan Volume: 25(2) Pages: 137-144
• [Journal Article] 再生医療とiPS細胞 (2011)
  • Author(s): 近藤孝之, 高橋良輔, 井上治久
  • Journal Title: Clinical Neuroscience Volume: 29(9) Pages: 1055-105
• [Journal Article] iPS細胞技術の神経疾患研究での有用性および今後の課題 (2011)
  • Author(s): 北岡志保, 井上治久
  • Journal Title: 脳21 Volume: 14(3) Pages: 20-24
• [Journal Article] iPS細胞作製技術を用いたALS治療法開発 (2011)
  • Author(s): 井上治久
  • Journal Title: 日本ALS協会会報JALSA Volume: 82 Pages: 7-9
• [Journal Article] 天からの蜘蛛の糸を生かすには (2011)
  • Author(s): 井上治久
  • Journal Title: 日経サイエンス Volume: 41(6) Pages: 72-72
• [Journal Article] Chemical library screening identifies a small molecule that down regulates SOD1 transcription for drugs to treat ALS (2011)
  • Author(s): Murakami G, Inoue H, Tsukita K, Asai Y, Amagai Y, Aiba K, Shimogawa H, Uesugi M, Nakatsuji N, Takahashi R
  • Journal Title: The Journal of Biomolecular Screening Volume: 16(4) Pages: 405-414
  • Peer Reviewed
• [Journal Article] The Use of Induced Pluripotent Stem Cells in Drug Development (2011)
  • Author(s): Inoue H, Yamanaka S
  • Journal Title: Clinical Pharmacology & Therapeutics Volume: 89(5) Pages: 655-661
  • NAID: 120004873781
  • Peer Reviewed
• [Journal Article] RNA結合タンパク質の機能と神経変性疾患iPS細胞を用いた疾患病態の再現とRNAプロセシング治癒の可能性 (2011)
  • Author(s): 江川斉宏, 井上治久
  • Journal Title: Dmentia Japan Volume: 25(2) Pages: 137-144
• [Journal Article] Neurodegenerative disease-specific induced pluripotent stem cell research. (2011)
  • Author(s): Inoue, H.
  • Journal Title: Journal of Pharmacological Sciences Volume: 115,Supplement 1
  • NAID: 130004504826
• [Journal Article] Neurodegenerative disease-specific induced pluripotent stem cell research (2010)
  • Author(s): Inoue H
  • Journal Title: Experimental Cell Research Volume: 316(16) Pages: 2560-2564
  • NAID: 130004504826
  • Peer Reviewed
• [Journal Article] iPS細胞作製技術を用いた神経変性疾患の研究 (2010)
  • Author(s): 井上治久
  • Journal Title: 第1回ALSフォーラム～ALS最前線～記録集 Pages: 13-15
  • NAID: 130005395507
• [Journal Article] 筋萎縮性側索硬化症(ALS)の治療戦略 (2009)
  • Author(s): 村上学, 井上治久, 高橋良輔
  • Journal Title: ファルマシア Volume: 45 Pages: 1009-1112
• [Journal Article] 筋萎縮性側索硬化症(ALS)の治療戦略 (2009)
  • Author(s): 村上学、井上治久、高橋良輔
  • Journal Title: ファルマシア 45
• [Journal Article] Research on neurodegenerative diseases using induced pluripotent cells
  • Author(s): Imamura K, Inoue H
  • Journal Title: Psychogeriatrics Volume: (In press)
  • Peer Reviewed
• [Journal Article] iPS細胞作製技術を応用した神経疾患病因機構の解明と創薬開発への取り組み
  • Author(s): 八幡直樹, 井上治久
  • Journal Title: 遺伝子医学MOOK Volume: 22(In press)
• [Journal Article] Research on neurodegenerative diseases using induced pluripotent cells
  • Author(s): Imamura K., Inoue H.
  • Journal Title: Psychogeriatrics Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] iPS細胞作製技術を応用した神経疾患病因機構の解明と創薬開発への取り組み
  • Author(s): 八幡直樹, 井上治久
  • Journal Title: 遺伝子医学MOOK Volume: 22(印刷中)
• [Journal Article] Chemical library screening identifies a small molecule that downregulates SOD1 transcription for drugs to treat ALS
  • Author(s): Murakami, G., Inoue, H., Tsukita, K., Asai, Y., Amagai, Y., Aiba, K., Shimogawa, H., Uesugi, M., Nakatsuji, N., Takahashi, R.
  • Journal Title: The Journal of Biomolecular Screening Volume: (In press)
  • Peer Reviewed
• [Journal Article] The Use of Induced Pluripotent Stem Cells in Drug Development.
  • Author(s): Inoue, H., Yamanaka, S.
  • Journal Title: Clinical Pharmacology & Therapeutics Volume: (In press)
  • NAID: 120004873781
  • Peer Reviewed
• [Presentation] Establishment of iPS cells from amyotrophic lateral sclerosis model mice and motor neuronal differentiation (2011)
  • Author(s): Komatsu K., Inoue H., Kondo T., Kitaoka S., Takahashi R
  • Organizer: The XXth World Congress of Neurology
  • Place of Presentation: Marrakesh, Morocco
  • Year and Date: 2011-11-16
• [Presentation] 神経変性症としての前頭側頭葉変性症:症候から分子病態解明の新展開まで (2011)
  • Author(s): 井上治久
  • Organizer: 第29回日本認知症学会学術集会
  • Place of Presentation: 愛知.(招待)
  • Year and Date: 2011-11-05
• [Presentation] iPS細胞技術を用いた神経変性疾患の研究 (2011)
  • Author(s): 井上治久
  • Organizer: 日本ALS協会徳島支部第12回定例会
  • Place of Presentation: 徳島(招待)
  • Year and Date: 2011-10-30
• [Presentation] iPS細胞技術を用いた神経変性疾患の研究 (2011)
  • Author(s): 井上治久
  • Organizer: 日本ALS協会徳島支部第12回定例会
  • Place of Presentation: 徳島(招待講演)
  • Year and Date: 2011-10-30
• [Presentation] 難治性神経変性疾患特異的iPS細胞を用いた研究 (2011)
  • Author(s): 井上治久
  • Organizer: 第38回ヒューマンサイエンス総合研究セミナー
  • Place of Presentation: 東京(招待)
  • Year and Date: 2011-10-03
• [Presentation] 難治性神経変性疾患特異的iPS細胞を用いた研究 (2011)
  • Author(s): 井上治久
  • Organizer: 第38回ヒューマンサイエンス総合研究セミナー
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-10-03
• [Presentation] Induction of astrocyte differentiation from human induced pluripotent stem cells carrying mutant SOD1 (2011)
  • Author(s): Kitaoka S, Tsukita K, Takahashi K, Okita K, Kondo T, Yoshikawa K, Yamawaki S, Naitoh M, Suzuki S, Izumi Y, Kaji R, Takuma H, Tamaoka A, Morita M, Nakano I, Kawata A, Nakahata T, Takahashi R, Yamanaka S, Inoue H
  • Organizer: The 34th Annual Meeting of the Japan Neuroscience Society. Neuroscience of the Mind
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2011-09-16
• [Presentation] Induction of astrocyte differentiation from human induced pluripotent stem cells carrying Mutant SOD1 (2011)
  • Author(s): Kitaoka S., Tsukita K., Takahashi K., Okita K., Kondo T., Yoshikawa K., Yamawaki S., Naitoh M., Suzuki S., Izumi Y., Kaji R., Takuma H., Tamaoka A., Morita M., Nakano I., Kawata A., Nakahata T., Takahashi R., Yamanaka S., Inoue H.
  • Organizer: The 34 th Annual Meeting of the Japan Neuroscience Society-Neuroscience of the Mind-
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2011-09-16
• [Presentation] Chemical library screening identifies a small molecule that down regulates SOD1 transcription for drugs to treat amyotrophic lateral sclerosis (2011)
  • Author(s): Murakami G, Inoue H, Tsukita K, Asai Y, Amagai Y, Aiba K, Shimogawa H, Uesugi M, Nakatsuji N, Takahashi R
  • Organizer: The 34th Annual Meeting of the Japan Neuroscience Society. Neuroscience of the Mind
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2011-09-15
• [Presentation] Establishment of iPS cells from amyotrophic lateral sclerosis model mice and motor neuronal differentiation (2011)
  • Author(s): Komatsu K., Inoue H., Kondo I, Kitaoka S., Takahashi K., Yamanaka S., Takahashi R.
  • Organizer: The 34th Annual Meeting of the Japan Neuroscience Society-Neuroscience of the Mind-
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2011-09-15
• [Presentation] Chemical library screening identifies a small Molecule that downregulates SOD1 transcription for drugs to treat amyotrophic lateral sclerosis (2011)
  • Author(s): Murakami G., Inoue H., Tsukita K., Asai Y., Amagai Y., Aiba K., Shimogawa H., Uesugi M., Nakatsuji N., Takahashi R.
  • Organizer: The 34th Annual Meeting of the Japan Neuroscience Society-Neuroscience of the Mind-
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2011-09-15
• [Presentation] iPS細胞技術を用いた神経難病の研究 (2011)
  • Author(s): 井上治久
  • Organizer: 熊本県難病相談・支援センター6周年記念医療講演会
  • Place of Presentation: 熊本(招待)
  • Year and Date: 2011-07-15
• [Presentation] iPS細胞技術を用いた神経難病の研究 (2011)
  • Author(s): 井上治久
  • Organizer: 熊本県難病相談・支援センター6周年記念医療講演会
  • Place of Presentation: 熊本(招待講演)
  • Year and Date: 2011-07-15
• [Presentation] 患者由来iPS細胞を用いた神経変性疾患バイオマーカー同定と病態解明 (2011)
  • Author(s): 井上治久
  • Organizer: 第53回日本老年医学会学術集会
  • Place of Presentation: 東京(招待)
  • Year and Date: 2011-06-17
• [Presentation] 患者由来iPS細胞を用いた神経変性疾患バイオマーカー同定と病態解明 (2011)
  • Author(s): 井上治久
  • Organizer: 第53回日本老年医学会学術集会ノバルティス老化および老年医学研究基金2009年度受賞講演
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-06-17
• [Presentation] iPS細胞作製技術を用いた神経変性疾患の研究 (2011)
  • Author(s): 井上治久
  • Organizer: 日本老年精神医学会
  • Place of Presentation: 東京(招待)
  • Year and Date: 2011-06-16
• [Presentation] iPS細胞作製技術を用いた神経変性疾患の研究 (2011)
  • Author(s): 井上治久
  • Organizer: 日本老年精神医学会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-06-16
• [Presentation] iPS細胞作製技術を用いた神経変性疾患の研究 (2011)
  • Author(s): 井上治久
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋(招待)
  • Year and Date: 2011-05-20
• [Presentation] iPS細胞作製技術を用いた神経変性疾患の研究 (2011)
  • Author(s): 井上治久
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋(招待講演)
  • Year and Date: 2011-05-20
• [Presentation] 転写を標的とした家族性筋萎縮性側索硬化症新規治療法の開発 (2011)
  • Author(s): 村上学, 井上治久, 月田香代子, 淺井康行, 饗庭一博, 天貝裕地, 下川浩輝, 上杉志成, 中辻憲夫, 高橋良輔
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-05-19
• [Presentation] 変異SOD1を有するALS患者由来iPS細胞の樹立とアストロサイトへの分化 (2011)
  • Author(s): 北岡志保, 井上治久, 月田香代子, 高橋和利, 近藤孝之, 吉川勝宇, 山脇聖子, 内藤素子, 鈴木茂彦, 伊東秀文, 和泉唯信, 梶龍兒, 宅間浩, 玉岡晃, 森田光哉, 中野今治, 川田明広, 中畑龍俊, 高橋良輔, 山中伸弥
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-05-19
• [Presentation] 筋萎縮性側索硬化症モデルマウスiPS細胞の樹立および運動ニューロンへの分化 (2011)
  • Author(s): 小松研一, 井上治久, 近藤孝之, 北岡志保, 一阪朋子, 高橋和利, 山中伸弥, 高橋良輔
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-05-19
• [Presentation] 疾患モデルと創薬スクリーニング (2011)
  • Author(s): 井上治久
  • Organizer: バイオファイナンスギルド第9期第10回セミナー
  • Place of Presentation: 東京.(招待)
  • Year and Date: 2011-05-13
• [Presentation] 疾患モデルと創薬スクリーニング (2011)
  • Author(s): 井上治久
  • Organizer: バイオファイナンスギルド第9期第10回セミナー
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-05-13
• [Presentation] Neurodegenerative disease-specific induced pluripotent stem cell research (2011)
  • Author(s): 井上治久
  • Organizer: 日本薬理学会
  • Place of Presentation: 横浜.(招待)
  • Year and Date: 2011-03-22
• [Presentation] Neurodegenerative disease-specific induced pluripotent stem cell research. (2011)
  • Author(s): 井上治久
  • Organizer: 日本薬理学会
  • Place of Presentation: 横浜(招待講演)
  • Year and Date: 2011-03-22
• [Presentation] 神経疾患とiPS細胞研究 (2011)
  • Author(s): 井上治久
  • Organizer: 第2回iPS細胞研究講演会
  • Place of Presentation: 長野.(招待)
  • Year and Date: 2011-03-15
• [Presentation] 神経疾患とiPS細胞研究 (2011)
  • Author(s): 井上治久
  • Organizer: 第2回iPS細胞研究講演会
  • Place of Presentation: 長野(招待講演)
  • Year and Date: 2011-03-15
• [Presentation] iPS Cell Technology and Motor Neuron Disease (2011)
  • Author(s): Inoue H
  • Organizer: International Symposium on Motor Neuron Disease and Perry Syndrome in Tokyo
  • Place of Presentation: Tokyo, Japan.(招待)
  • Year and Date: 2011-02-22
• [Presentation] iPS Cell Technology and Motor Neuron Disease. (2011)
  • Author(s): Inoue, H.
  • Organizer: International Symposium on Motor Neuron Disease and Perry Syndrome in Tokyo
  • Place of Presentation: Tokyo, Japan(招待講演)
  • Year and Date: 2011-02-22
• [Presentation] iPS細胞作製技術を用いた神経変性疾患の研究 (2011)
  • Author(s): 井上治久
  • Organizer: 札幌神経再生医療研究会
  • Place of Presentation: 札幌.(招待)
  • Year and Date: 2011-02-08
• [Presentation] iPS細胞作製技術を用いた神経変性疾患の研究 (2011)
  • Author(s): 井上治久
  • Organizer: 札幌神経再生医療研究会
  • Place of Presentation: 札幌(招待講演)
  • Year and Date: 2011-02-08
• [Presentation] iPS細胞作製技術を用いた神経変性疾患の研究 (2011)
  • Author(s): 井上治久
  • Organizer: 第2回関西北陸神経免疫研究会
  • Place of Presentation: 京都.(招待)
  • Year and Date: 2011-01-22
• [Presentation] iPS細胞作製技術を用いた神経変性疾患の研究 (2011)
  • Author(s): 井上治久
  • Organizer: 第2回関西北陸神経免疫研究会
  • Place of Presentation: 京都(招待講演)
  • Year and Date: 2011-01-22
• [Presentation] iPS細胞作製技術を用いた神経変性疾患の研究 (2010)
  • Author(s): 井上治久
  • Organizer: 鳥取医療センター
  • Place of Presentation: 鳥取.(招待)
  • Year and Date: 2010-12-08
• [Presentation] iPS細胞作製技術を用いた神経変性疾患の研究 (2010)
  • Author(s): 井上治久
  • Organizer: 鳥取医療センター
  • Place of Presentation: 鳥取(招待講演)
  • Year and Date: 2010-12-08
• [Presentation] 疾患特異的iPS細胞を用いた神経変性疾患の研究 (2010)
  • Author(s): 井上治久
  • Organizer: 第26回Wakoワークショップ
  • Place of Presentation: 東京.(招待)
  • Year and Date: 2010-11-26
• [Presentation] 疾患特異的iPS細胞を用いた神経変性疾患の研究 (2010)
  • Author(s): 井上治久
  • Organizer: 第26回Wakoワークショップ
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2010-11-26
• [Presentation] Transcription-targeted drug discovery for SOD1-mediated ALS using high-throughput screening technique (2010)
  • Author(s): Murakami G, Inoue H, Tsukita K, Asai Y, Amagai Y, Aiba K, Uesugi M, Nakatsuji N, Takahashi R
  • Organizer: The 40th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, USA
  • Year and Date: 2010-11-17
• [Presentation] iPSC Cell Banking facilitating Disease-specific iPSC research (2010)
  • Author(s): Inoue H
  • Organizer: CIRM iPS Cell Banking Workshop
  • Place of Presentation: San Francisco, USA.(招待)
  • Year and Date: 2010-11-17
• [Presentation] Analysis of motor neurons derived from induced pluripotent stem cells from ALS patients (2010)
  • Author(s): Kitaoka S, Inoue H, Tsukita K, Kawada M, Naitoh M, Takahashi K, Yoshikawa K, Kondo T, Yamawaki S, Watanabe D, Suzuki S, Takahashi R, Yamanaka S
  • Organizer: The 40th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, USA.
  • Year and Date: 2010-11-17
• [Presentation] iPSC Cell Banking facilitating Disease-specific iPSC research. CIRM iPS Cell Banking Workshop. (2010)
  • Author(s): Inoue, H.
  • Organizer: CIRM iPS Cell Banking Workshop.
  • Place of Presentation: San Francisco, USA(招待講演)
  • Year and Date: 2010-11-17
• [Presentation] Analysis of motor neurons derived from induced pluripotent stem cells from ALS patients. (2010)
  • Author(s): Kitaoka, S., Inoue, H., Tsukita, K., Kawada, M., Naitoh, M., Takahashi, K., Yoshikawa, K., Kondo, T., Yamawaki, S., Watanabe, D., Suzuki, S., Takahashi, R., Yamanaka, S.
  • Organizer: The 40th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, USA
  • Year and Date: 2010-11-17
• [Presentation] Transcription-targeted drug discovery for SOD1-mediated ALS using high-throughput screening technique. (2010)
  • Author(s): Murakami, G., Inoue, H., Tsukito, K., Asai, Y., Amagai, Y., Aiba, K., Uesugi, M., Nakatsuji, N., Takahashi, R.
  • Organizer: The 40th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, USA
  • Year and Date: 2010-11-17
• [Presentation] 変性疾患モデルとしてのiPS細胞 (2010)
  • Author(s): 井上治久
  • Organizer: 第29回日本認知症学会学術集会,シンポジウム3「神経変性症としての前頭側頭葉変性症:症候から分子病態解明の新展開まで」
  • Place of Presentation: 愛知(招待講演)
  • Year and Date: 2010-11-05
• [Presentation] Neurodegenerative disease-specific induced Pluripotent Stem cells research (2010)
  • Author(s): Inoue H
  • Organizer: Kick off symposium Science Research on Innovative Area"Foundation of Synapse and Neurocircuit Pathology."
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2010-10-27
• [Presentation] Neurodegenerative disease-specific induced Pluripotent Stem cells research. (2010)
  • Author(s): Inoue, H.
  • Organizer: Kick off symposium Science Research on Innovative Area "Foundation of Synapse and Neurocircuit Pathology."
  • Place of Presentation: Tokyo, Japan(招待講演)
  • Year and Date: 2010-10-27
• [Presentation] 疾患特異的iPS細胞を用いた神経変性疾患の研究 (2010)
  • Author(s): 井上治久
  • Organizer: 第32回日本生物学的精神医学会
  • Place of Presentation: 福岡.(招待)
  • Year and Date: 2010-10-08
• [Presentation] 疾患特異的iPS細胞を用いた神経変性疾患の研究 (2010)
  • Author(s): 井上治久
  • Organizer: 第32回日本生物学的精神医学会
  • Place of Presentation: 福岡(招待講演)
  • Year and Date: 2010-10-08
• [Presentation] 次世代の精神薬理の研究手法Research approaches for the new strategy of psychopharmacology. (2010)
  • Author(s): 成田年、永井拓、橋本恵理、今井哲司、井上治久、岡野ジェイムス洋尚、池田和隆
  • Organizer: 第20回日本臨床精神神経薬理学会・第40回日本神経精神薬理学会合同年会スタディグループ6
  • Place of Presentation: 仙台(招待講演)
  • Year and Date: 2010-09-16
• [Presentation] Differentiation of induced pluripotent stem cells from ALS patients generates motor neurons (2010)
  • Author(s): Kitaoka S, Inoue H, Tsukita K, Kawada M, Naitoh M, Takahashi K, Yoshikawa K, Kondo T, Yamawaki S, Watanabe D, Suzuki S, Nakahata T, Takahashi R, Yamanaka S
  • Organizer: The 33rd Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2010-09-02
• [Presentation] Differentiation of induced pluripotent stem cells from ALS patients generates motor neurons. (2010)
  • Author(s): Kitaoka, S., Inoue, H, Tsukita, K., Kawada, M., Naitoh, M., Takahashi, K., Yoshikawa, K., Kondo T., Yamawaki, S., Watanabe, D., Suzuki, S., Nakahata, T., Takahashi, R., Yamanaka, S.
  • Organizer: The 33rd Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2010-09-02
• [Presentation] Establishment of iPS cells from amyotrophic lateral sclerosis model mice. (2010)
  • Author(s): Komatsu, K., Inoue, H., Kondo, T., Kitaoka, S., Ichisaka, T., Takahashi, K., Yamanaka, S., Takahashi, R.
  • Organizer: The 33rd Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2010-09-02
• [Presentation] iPS細胞作製技術を用いた神経変性疾患の研究 (2010)
  • Author(s): 井上治久
  • Organizer: 第1回ALSフォーラム
  • Place of Presentation: 東京.(招待)
  • Year and Date: 2010-08-28
• [Presentation] iPS細胞作製技術を用いた神経変性疾患の研究 (2010)
  • Author(s): 井上治久
  • Organizer: 第1回ALSフォーラム
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2010-08-28
• [Presentation] 変異SOD1を有するALS患者由来iPS細胞の樹立と脊髄運動ニューロンへの分化 (2010)
  • Author(s): 北岡志保、井上治久、月田香代子、川田三代、高橋和利、近藤孝之、吉川勝宇、山脇聖子、内藤素子、鈴木茂彦、伊東秀文、和泉唯信、森田光哉、中野今治、川田明広、中畑龍俊、高橋良輔、山中伸弥
  • Organizer: 第51回日本神経学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-05-21
• [Presentation] 疾患特異的iPS細胞を用いた神経変性疾患の研究 (2010)
  • Author(s): 井上治久
  • Organizer: 梅田神経懇話会
  • Place of Presentation: 大阪.(招待)
  • Year and Date: 2010-04-28
• [Presentation] 疾患特異的iPS細胞を用いた神経変性疾患の研究 (2010)
  • Author(s): 井上治久
  • Organizer: 梅田神経懇話会
  • Place of Presentation: 大阪(招待講演)
  • Year and Date: 2010-04-28
• [Presentation] PS細胞作製技術を用いた神経変性疾患の研究 (2010)
  • Author(s): 井上治久
  • Organizer: 第3回iPS細胞産学合同研究会
  • Place of Presentation: 京都.(招待)
  • Year and Date: 2010-04-12
• [Presentation] iPS細胞作製技術を用いた神経変性疾患の研究 (2010)
  • Author(s): 井上治久
  • Organizer: 第3回iPS細胞産学合同研究会
  • Place of Presentation: 京都(招待講演)
  • Year and Date: 2010-04-12
• [Presentation] Functional Neuro Muscular Culture Derived From Human Ips Cells. (2010)
  • Author(s): Baba, S., Hua, E., Nakamura, K., Sears, M., Inoue, H., Conklin, B.R.
  • Organizer: ISSCR 8th Annual Meeting
  • Place of Presentation: San Francisco, USA
• [Presentation] Neurodegenerative disease-specific induced Pluripotent Stem cells research (2009)
  • Author(s): Inoue H
  • Organizer: Joint iPS Meeting
  • Place of Presentation: Toronto, CANADA.(招待)
  • Year and Date: 2009-10-28
• [Presentation] Neurodegenerative disease-specific induced Pluripotent Stem cells research (2009)
  • Author(s): Inoue H.
  • Organizer: Joint iPS Meeting
  • Place of Presentation: Toronto, CANADA.
  • Year and Date: 2009-10-28
• [Presentation] Neurodegenerative disease-specific induced Pluripotent Stem cells research (2009)
  • Author(s): Inoue H
  • Organizer: Gladstone Institute of Cardiovascular Disease : Seminar
  • Place of Presentation: San Francisco, USA.(招待)
  • Year and Date: 2009-10-26
• [Presentation] Neurodegenerative disease-specific induced Pluripotent Stem cells research (2009)
  • Author(s): Inoue H.
  • Organizer: Gladstone Institute of Cardiovascular Disease : Ceminar
  • Place of Presentation: San Francisco, USA.
  • Year and Date: 2009-10-26
• [Presentation] 疾患特異的iPS細胞を用いた神経変性疾患研究 (2009)
  • Author(s): 井上治久
  • Organizer: 倉敷神経内科疾患フォーラム
  • Place of Presentation: 倉敷(招待)
  • Year and Date: 2009-10-02
• [Presentation] 疾患特異的iPS細胞を用いた神経変性疾患研究 (2009)
  • Author(s): 井上治久
  • Organizer: 倉敷神経内科疾患フォーラム
  • Place of Presentation: 倉敷
  • Year and Date: 2009-10-02
• [Presentation] Neurodegenerative disease-specific induced Pluripotent Stem cells research (2009)
  • Author(s): Inoue H
  • Organizer: 5th Symposium sur la SLA
  • Place of Presentation: Quebec, CANADA.(招待)
  • Year and Date: 2009-09-25
• [Presentation] Neurodegenerative disease-specific induced Pluripotent Stem cells resarch (2009)
  • Author(s): Inoue H.
  • Organizer: 5th Symposium sur la SLA
  • Place of Presentation: Quebec, CANADA.
  • Year and Date: 2009-09-25
• [Presentation] Neurodegenerative disease-specific induced Pluripotent Stem cells research (2009)
  • Author(s): Inoue H
  • Organizer: The 32nd Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Nagoya, Japan.(招待)
  • Year and Date: 2009-09-16
• [Presentation] Neurodegenerative disease-specific induced Pluripotent Stem cells research (2009)
  • Author(s): Inoue H.
  • Organizer: The 32nd Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Nagoya, Japan.
  • Year and Date: 2009-09-16
• [Presentation] Translational Neurosceience based on iPS cell Technology iPS細胞作製技術を用いた神経科学研究 (2009)
  • Author(s): 井上治久
  • Organizer: 第30回再生医療・臓器再建医学コースミーティング
  • Place of Presentation: 京都
  • Year and Date: 2009-09-11
• [Presentation] Neurodegenerative disease-specific induced Pluripotent Stem cells research (2009)
  • Author(s): Inoue H
  • Organizer: Seweden-Japan Joint Colloquim : Advances in Cellular Reprogramming and Stem Cell Biology
  • Place of Presentation: Stockholm, Sweden(招待)
  • Year and Date: 2009-09-05
• [Presentation] Neurodegenerative disease-specific induced Pluripotent Stem cells research (2009)
  • Author(s): Inoue H.
  • Organizer: Seweden-Japan Joint Colloquim : Advances in Cellular Reprogramming and Stem Cell Biology
  • Place of Presentation: Stockholm, Sweden.
  • Year and Date: 2009-09-05
• [Presentation] 疾患iPS細胞の樹立から臨床応用へ (2009)
  • Author(s): 井上治久
  • Organizer: 第2回iPS細胞樹立・維持培養の講習会
  • Place of Presentation: 京都(招待)
  • Year and Date: 2009-08-26
• [Presentation] 疾患iPS細胞の樹立から臨床応用へ (2009)
  • Author(s): 井上治久
  • Organizer: 第2回iPS細胞樹立・維持培養の講習会
  • Place of Presentation: 京都
  • Year and Date: 2009-08-26
• [Presentation] Neurodegenerative disease-specific induced Pluripotent Stem cells research (2009)
  • Author(s): Inoue H
  • Organizer: International Symposium : New Approach for Molecular Neuropathology
  • Place of Presentation: Tokyo, Japan.(招待)
  • Year and Date: 2009-08-13
• [Presentation] Nzurodegenerative disease-specific induced Pluripotent Stem cells research (2009)
  • Author(s): Inoue H.
  • Organizer: International Symposium : New Approach for Molecular Neuronathology
  • Place of Presentation: Tokyo, Japan.
  • Year and Date: 2009-08-13
• [Presentation] 疾患特異的iPS細胞を用いたALS研究 (2009)
  • Author(s): 井上治久
  • Organizer: 放射線分子疫学セミナー
  • Place of Presentation: 広島(招待)
  • Year and Date: 2009-07-02
• [Presentation] 疾患特異的iPS細胞を用いたALS研究 (2009)
  • Author(s): 井上治久
  • Organizer: 放射線分子疫学セミナー
  • Place of Presentation: 広島
  • Year and Date: 2009-07-02
• [Presentation] Neurodegenerative disease-specific induced Pluripotent Stem cells research (2009)
  • Author(s): Inoue H
  • Organizer: The Workshop
  • Place of Presentation: San Francisco, USA.(招待)
  • Year and Date: 2009-06-08
• [Presentation] Neurodegenerative disease-specific induced Pluripotent Stem cells research (2009)
  • Author(s): Inoue H.
  • Organizer: The Workshop
  • Place of Presentation: San Francisco, USA.
  • Year and Date: 2009-06-08
• [Presentation] 運動ニューロン疾患におけるiPS細胞の可能性 (2009)
  • Author(s): 井上治久
  • Organizer: SMA家族の会
  • Place of Presentation: 京都(招待)
  • Year and Date: 2009-05-16
• [Presentation] 運動ニューロン疾患におけるiPS細胞の可能性 (2009)
  • Author(s): 井上治久
  • Organizer: SMA家族の会
  • Place of Presentation: 京都
  • Year and Date: 2009-05-16
• [Book] Stem Cells and Cancer Stem Cells (2011)
  • Author(s): Kondo T, Takahashi R, Inoue H.
  • Publisher: Springer
• [Book] Induced Stem Cells (2011)
  • Author(s): Kitaoka S, Kondoh H, Inoue H
  • Publisher: Nova Science Publishers Inc
• [Book] Annual Review神経2012 (2011)
  • Author(s): 今村恵子, 井上治久
  • Publisher: 中外医学社
• [Book] 認知症学(上) (2011)
  • Author(s): 八幡直樹, 井上治久
  • Publisher: 日本臨牀社
• [Book] Stem Cells and Cancer Stem Cells (2011)
  • Author(s): Kondo I., Takahashi R., Inoue H.
  • Total Pages: 8
  • Publisher: Springer
• [Book] Induced Stem Cells (2011)
  • Author(s): Kitaoka S., Kondoh H., Inoue H.
  • Total Pages: 14
  • Publisher: Nova Science Publishers Inc
• [Book] 認知症学(上) (2011)
  • Author(s): 八幡直樹, 井上治久
  • Total Pages: 4
  • Publisher: 日本臨休社
• [Book] 再生医療叢書第7巻
  • Author(s): 近藤孝之, 井上治久, 高橋良輔
  • Publisher: 朝倉書店
• [Book] 再生医療叢書第7巻
  • Author(s): 近藤孝之, 井上治久, 高橋良輔
  • Publisher: 朝倉書店(印刷中)
• [Remarks] ホームページ
  • URL: http://www.cira.kyoto-u.ac/j/index.html
• [Remarks] 報道iPSで薬の効き方評価創薬に応用へ.日本経済新聞(2011. 12. 26朝刊)京大研、ALS患者からiPS細胞作製神経細胞誘導に成功.京都新聞(2012. 2. 24朝刊)
  • URL: http://www.cira.kyoto-u.ac.jp/inoue/
• [Remarks] iPSで薬の効き方評価創薬に応用へ.日本経済新聞(2011.12.26朝刊)
  • URL: http://www.cira.kyoto-u.ac/j/index.html
• [Remarks] 京大研、ALS患者からiPS細胞作製神経細胞誘導に成功.京都新聞(2012.2.24朝刊)
  • URL: http://www.cira.kyoto-u.ac.jp/inoue/
• [Remarks]
  • URL: http://www.cira.kyoto-u.ac/j/index.html
• [Remarks]
  • URL: http://www.cira.kyoto-u.ac.jp/inoue/
• [Remarks]
  • URL: http://www.cira.kyoto-u.ac.jp/j/index.html