The investigation of the effect of transplantation of neural crest derived cells to murine focal cerebral ischemia model

• Project/Area Number: 21591119
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurology
• Research Institution: Keio University
• Principal Investigator: TOMITA Yutaka 慶應義塾大学, 医学部, 講師(非常勤) (60276251)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 神経堤細胞 / 脳梗塞 / Confocal顕微鏡 / Matlab software / Matlab Software

Research Abstract

The aim of the study was to monitor in vivo and noninvasively the fate of neural crest cells transplanted into the ischemic brain of unirradiated mice. In vivo imaging was performed through a closed cranial window following cell transplantation, using laser-scanning confocal fluorescence microscopy. Repeated in vivo imaging revealed that transplanted cells survived within the ischemic and peri-ischemic cortex, migrated significantly towards the lesion, proliferated. This study indicates that confocal fluorescence microscopy is a reliable and unique tool to repeatedly assess with cellular resolution the in vivo dynamic fate of fluorescent cells transplanted into a mouse brain.

Research Products

• [Journal Article] Repeated longitudinal in vivo imaging of neuro-glio-vascular unit at the peripheral boundary of ischemia in mouse cerebral cortex (2012)
  • Author(s): Masamoto K, Tomita Y, Toriumi H, Unekawa M, Takuwa H, Itoh Y, Suzuki N, Kanno I
  • Journal Title: Neuroscience Volume: (in press)
  • Peer Reviewed
• [Journal Article] Suppressive effect of chronic peroral topiramate on potassium-induced cortical spreading depression in rats (2012)
  • Author(s): Unekawa M, Tomita Y, Toriumi H, Suzuki N
  • Journal Title: Cephalalgia Volume: (in press)
  • Peer Reviewed
• [Journal Article] Sustained decrease and remarkable increase in red blood cell velocity in intraparenchymal capillaries associated with potassium-induced cortical spreading depression (2012)
  • Author(s): Unekawa M, Tomita M, Tomita Y, Toriumi H, Suzuki N
  • Journal Title: Microcirculation Volume: 19(2) Pages: 166-174
  • Peer Reviewed
• [Journal Article] Repeated Longitudinal in vivo Imaging of Neuro-glio-vascular Unit at the Peripheral Boundary of Ischemia in Mouse Cerebral Cortex (2012)
  • Author(s): Masamoto K, Tomita Y, Toriumi H, Unekawa M, Takuwa H, Itoh Y, Suzuki N, Kanno I
  • Journal Title: Neuroscience Volume: (in press)
  • Peer Reviewed
• [Journal Article] Long-term, repeated measurements of mouse cortical microflow at the same region of interest with high spatial resolution (2011)
  • Author(s): Tomita Y, Pinard E, Tran-Dinh A, Schiszler I, Kubis N, Tomita M, Suzuki N, Seylaz J
  • Journal Title: Brain Research Volume: 1372 Pages: 59-69
  • Peer Reviewed
• [Journal Article] Developmental and circulatory profile of the diploic veins (2011)
  • Author(s): Toriumi H, Shimizu T, Shibata M, Unekawa M, Tomita Y, Tomita M, Suzuki N
  • Journal Title: Microvascular Research Volume: 81 Pages: 97-102
  • Peer Reviewed
• [Journal Article] Oscillating neuro-capillary coupling during cortical spreading depression as observed by tracking of FITC-labeled RBCs in single capillaries (2011)
  • Author(s): Tomita M, Tomita Y, Unekawa M, Toriumi H, Suzuki N
  • Journal Title: NeuroImage Volume: 56(3) Pages: 1001-1010
  • Peer Reviewed
• [Journal Article] Capillary remodeling and collateral growth without angiogenesis after unilateral common carotid artery occlusion in mice (2011)
  • Author(s): Guo H, Itoh Y, Toriumi H, Yamada S, Tomita Y, Hoshino H, Suzuki N
  • Journal Title: Microcirculation Volume: 18(3) Pages: 221-227
  • Peer Reviewed
• [Journal Article] Long-term, repeated measurements of mouse cortical microflow at the same region of interest with high spatial resolution. (2011)
  • Author(s): Tomita Y, Pinard E, Tran-Dinh A, Schiszler I, Kubis N, Tomita M, Suzuki N, Seylaz J
  • Journal Title: Brain Research Volume: 1372 Pages: 59-69
  • Peer Reviewed
• [Journal Article] Developmental and circulatory profile of the diploic veins. (2011)
  • Author(s): Toriumi H, Shimizu T, Shibata M, Unekawa M, Tomita Y, Tomita M, Suzuki N
  • Journal Title: Microvascular Research Volume: 81 Pages: 97-102
  • Peer Reviewed
• [Journal Article] Oscillating neuro-capillary coupling during cortical spreading depression as observed by tracking of FITC-labeled RBCs in single capillaries. (2011)
  • Author(s): Tomita M, Tomita Y, Unekawa M, Toriumi H, Suzuki N
  • Journal Title: NeuroImage Volume: 1;56(3) Pages: 1001-1010
  • Peer Reviewed
• [Journal Article] Capillary remodeling and collateral growth without angiogenesis after unilateral common carotid artery occlusion in mice. (2011)
  • Author(s): Guo H, Itoh Y, Toriumi H, Yamada S, Tomita Y, Hoshino H, Suzuki N
  • Journal Title: Microcirculation Volume: 18(3) Pages: 221-227
  • Peer Reviewed
• [Journal Article] RBC velocities in single capillaries of mouse and rat brains are the same, despite 10-fold difference in body size (2010)
  • Author(s): Unekawa M, Tomita M, Tomita Y, Toriumi H, Miyaki K, Suzuki N
  • Journal Title: Brain Res Volume: 1320 Pages: 69-73
  • Peer Reviewed
• [Journal Article] Exogenous nitric oxide increases microflow but decreases RBC attendance in single capillaries in rat cerebral cortex. (2010)
  • Author(s): Tomita M, Osada T, Unekawa M, Tomita Y, Toriumi H, Suzuki N
  • Journal Title: Microvasc.Rev.Commun. Volume: 3(1) Pages: 11-16
  • NAID: 130004467805
  • Peer Reviewed
• [Journal Article] RBC velocities in single capillaries of mouse and rat brains are the same, despite 10-fold difference in body size. (2010)
  • Author(s): Unekawa M, Tomita M, Tomita Y, Toriumi H, Miyaki K, Suzuki N
  • Journal Title: Brain Research Volume: 1320 Pages: 69-73
  • Peer Reviewed
• [Journal Article] Association of a cyclin-dependent kinase 5 regulatory subunit-associated protein 1-like 1 (CDKAL1) polymorphism with elevated hemoglobin A_1(c) levels and the prevalence of metabolic syndrome in Japanese men : interaction with dietary energy intake. (2010)
  • Author(s): Miyaki K, Oo T, Song Y, Lwin H, Tomita Y, Hoshino H, Suzuki N, Muramatsu M
  • Journal Title: Am J Epidemiol. Volume: 1;172(9) Pages: 985-991
  • Peer Reviewed
• [Journal Article] RBC velocities in single capillaries of mouse and rat brains are the same, despite 10-fold difference in body size (2010)
  • Author(s): Unekawa M, Tomita M, Tomita Y, Toriumi H, Miyaki K, Suzuki N
  • Journal Title: Brain Research 1320 Pages: 69-73
  • Peer Reviewed
• [Journal Article] Exogenous nitric oxide increases microflow but decreases RBC attendance in single capillaries in rat cerebral cortex (2010)
  • Author(s): Tomita M, Osada T, Unekawa M, Tomita Y, Toriumi H, Suzuki N
  • Journal Title: Microvasc.Rev.Commun. 3 Pages: 11-16
  • NAID: 130004467805
  • Peer Reviewed
• [Journal Article] Exogenous nitric oxide increases microflow but decreases RBC attendance in single capillaries in rat cerebral cortex (2009)
  • Author(s): Tomita M, Osada T, Unekawa M, Tomita Y, Toriumi H, Suzuki N
  • Journal Title: Microvasc Rev Commun Volume: 3 Pages: 11-16
  • NAID: 130004467805
  • Peer Reviewed
• [Journal Article] Dually supplied T-junctions in arteriolo-arteriolar anastomosis in mice : key to local hemodynamic homeostasis in normal and ischemic states (2009)
  • Author(s): Toriumi H, Tatarishvili J, Tomita M, Tomita Y, Unekawa M, Suzuki N
  • Journal Title: Stroke Volume: 40 Pages: 3378-3383
  • Peer Reviewed
• [Journal Article] Dually Supplied T-Junctions in Arteriolo-Arteriolar Anastomosis in Mice.Key to Local Hemodynamic Homeostasis in Normal and Ischemic States? (2009)
  • Author(s): Toriumi H, Tatarishvili J, Tomita M, Tomita Y, Unekawa M, Suzuki N
  • Journal Title: Stroke 40 Pages: 3378-3383
  • Peer Reviewed
• [Journal Article] Artificial RBC transiently improved microcirculatory derangement produced by blood-loss hypotension or MCA occlusion in mice (2009)
  • Author(s): Tomita Y, Toriumi H, Hattori H, Unekawa M, Tomita M, Itoh Y, Hoshino H, Sakai H, Tsuchida E, Horinouchi H, Kobayashi K, Suzuki N
  • Journal Title: J.Cereb.Blood Flow Metab. 29
  • Peer Reviewed
• [Journal Article] Transient hemiparesis after topical application of 0.3 M KCl to the sensorimotor cortex in awake unrestricted mice (2009)
  • Author(s): Hattori H, Tomita M, Toriumi H, Tomita Y, Unekawa M, Suzuki N
  • Journal Title: J.Cereb.Blood Flow Metab. 29
  • Peer Reviewed
• [Journal Article] When does angiogenesis accompanied with RBC flow develop in ischemit tissue after permanent MCA occlusion in C57BL/6J mice? (2009)
  • Author(s): Tomita M, Tatarishvili J, Toriumi H, Tomita Y, Unekawa M, Hattori H, Suzuki N
  • Journal Title: J.Cereb.Blood Flow Metab. 29
  • Peer Reviewed
• [Journal Article] FITC-labeled RBC tracking in arteriolo-arteriolar anastomoses in control state and during ischemia after MCA occlusion in mice (2009)
  • Author(s): Toriumi H, Tatarishvili J, Tomita M, Tomita Y, Hattori H, Unekawa M, Suzuki N
  • Journal Title: J.Cereb.Blood Flow Metab. 29
  • Peer Reviewed
• [Journal Article] Shift of frequency distribution of RBC velocity in parenchymal capillaries during potassium-induced cortical spreading depression in rats (2009)
  • Author(s): Unekawa M, Tomita M, Tomita Y, Toriumi H, Hattori H, Suzuki N
  • Journal Title: J.Cereb.Blood Flow Metab. 29
  • Peer Reviewed
• [Presentation] Changes in diameter of cerebral microvessels and blood flow associated with potassium-induced cortical spreading depression in anesthetized mice (2012)
  • Author(s): 畝川美悠紀, 冨田裕, 鳥海春樹, 海老根妙子, 正本和人, 伊藤義彰, 菅野巌, 鈴木則宏
  • Organizer: 第37回日本微小循環学会総会
  • Place of Presentation: 盛岡
  • Year and Date: 2012-03-16
• [Presentation] K^+による大脳皮質性拡延性抑制誘発時の局所脳血流と軟膜動脈血管口径の変化 (2011)
  • Author(s): 畝川美悠紀, 冨田裕, 鳥海春樹, 正本和人, 伊藤義彰, 菅野巌, 鈴木則宏
  • Organizer: 第23回日本脳循環代謝学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-04
• [Presentation] マウス一側総頸動脈閉塞後に観察された血管新生を伴わない毛細血管の動脈化と側副血行路の発達: Capillary arterialization and collateral growth without angiogenesis after carotid artery occlusion in mice (2011)
  • Author(s): Guo H, Itoh Y, Toriumi H, Yamada S, Tomita Y, Hoshino H, Suzuki N
  • Organizer: 第36回日本脳卒中学会総会
  • Place of Presentation: 京都
  • Year and Date: 2011-07-30
• [Presentation] マウス一側総頸動脈閉塞後に観察された血管新生を伴わない毛細血管の動脈化と側副血行路の発達:Capillary arterialization and collateral growth without angiogenesis after carotid artery occlusion in mice (2011)
  • Author(s): Guo H, Itoh Y, Toriumi H, Yamada S, Tomita Y, Hoshino H, Suzuki N
  • Organizer: 第36回日本脳卒中学会総会
  • Place of Presentation: 京都
  • Year and Date: 2011-07-30
• [Presentation] Effect of injection of artificial RBCs on murine hemorrhagic hypotension model (2011)
  • Author(s): Tomita Y, Unekawa M, Toriumi H, Masamoto K, Sakai H, Tsuchida E, Horinouchi H, Kobayashi K, Kanno I, Suzuki N
  • Organizer: XIII International Symposium on Blood Substitutes and Oxygen Therapeutics
  • Place of Presentation: Boston
  • Year and Date: 2011-07-29
• [Presentation] Effect of injection of artificial rbcs on murine hemorrhagic hypotension model (2011)
  • Author(s): Tomita Y, Unekawa M, Toriumi H, Masamoto K, Sakai H, Tsuchida E, Horinouchi H, Kobayashi K, Kanno I, Suzuki N.
  • Organizer: XIII International Symposium on Blood Substitutes and Oxygen Therapeutics
  • Place of Presentation: Boston, USA
  • Year and Date: 2011-07-29
• [Presentation] The effect of Artificial RBCS injection for hemorrhagic hypotension in mice (2011)
  • Author(s): Tomita Y, Unekawa M, Toriumi H, Masamoto K, Sakai H, Tsuchida E, Horinouchi H, Kobayashi K, Kanno I, Suzuki N
  • Organizer: Brain 11 ; 25th International Symposium on Cerebral Blood Flow, Metabolism & Function
  • Place of Presentation: Barcelona
  • Year and Date: 2011-05-28
• [Presentation] Prolonged moderate hypoxia impairs neuro-glia-vascular coupling in the somatosensory cortex accompanied by parenchymal microvessel dilation and astroglia swelling in mice (2011)
  • Author(s): Kanno I, Masamoto K, Takuwa H, Kawaguchi H, Tomita Y, Suzuki N, Obata T
  • Organizer: Brain 11
  • Place of Presentation: Barcelona
  • Year and Date: 2011-05-26
• [Presentation] Cerebral blood flow restoration mechanisms after unilateral common carotid artery occlusion in mice (2011)
  • Author(s): Yamada S, Guo H, Itoh Y, Toriumi H, Tomita Y, Hoshino H, Suzuki N
  • Organizer: Brain 11
  • Place of Presentation: Barcelona
  • Year and Date: 2011-05-26
• [Presentation] Resident endothelial cells surrounding damaged arterial endothelium reendothelialize the lesion without any involvement of foreign progenitor cells (2011)
  • Author(s): Itoh Y, Toriumi H, Yamada S, Tomita Y, Hoshino H, Suzuki N
  • Organizer: Brain 11
  • Place of Presentation: Barcelona
  • Year and Date: 2011-05-26
• [Presentation] Transhemispheric effect of cortical spreading depression : electroencephalogram was suppressed but erythrocyte velocity in intraparenchymal capillaries was not affected in rat (2011)
  • Author(s): Unekawa M, Tomita Y, Toriumi H, Masamoto K, Kanno I, Suzuki N
  • Organizer: Brain 11
  • Place of Presentation: Barcelona
  • Year and Date: 2011-05-26
• [Presentation] The effect of Artificial RBCs injection for hemorrhagic hypotension in mice (2011)
  • Author(s): Tomita Y, Unekawa M, Toriumi H, Masamoto K, Sakai H, Tsuchida E, Horinouchi H, Kobayashi K, Kanno I, Suzuki N
  • Organizer: Brain 11
  • Place of Presentation: Barcelona
  • Year and Date: 2011-05-26
• [Presentation] Prolonged moderate hypoxia impairs neuro-glia-vascular coupling in the somatosensory cortex accompanied by parechymal microvessel dilation and astroglia swelling in mice (2011)
  • Author(s): Kanno I, Masamoto K, Takuwa H, Kawaguchi H, Tomita Y, Suzuki N, Obata T
  • Organizer: Brain 11 ; 25th International Symposium on Cerebr al Blood Flow, Metabolism & Function
  • Place of Presentation: Barcelona
  • Year and Date: 2011-05-26
• [Presentation] Cerebral blood flow restoration mechanisms after unilateral common carotid artery occlusion in mice (2011)
  • Author(s): Yamada S, Guo H, Itoh Y, Toriumi H, Tomita Y, Hoshino H, Suzuki N
  • Organizer: Brain 11 ; 25th International Symposium on Cerebral Blood Flow, Metabolism & Function
  • Place of Presentation: Barcelona
  • Year and Date: 2011-05-26
• [Presentation] Resident endothelial cells surrounding damaged arterial endothelium reend othelialize the lesion without any involvement of foreign progenitor cells (2011)
  • Author(s): Itoh Y, Toriumi H, Yamada S, Tomita Y, Hoshino H, Suzuki N
  • Organizer: Brain 11 ; 25th International Symposium on Cerebral Blood Flow, Metabolism & Function
  • Place of Presentation: Barcelona
  • Year and Date: 2011-05-26
• [Presentation] Transhemispheric effect of cortical spreading depression : electroencephalogram was suppressed but erythrocyte velocity in intraparenchymal capillaries was not affected in rat (2011)
  • Author(s): Unekawa M, Tomita Y, Toriumi H, Masamoto K, Kanno I, Suzuki N
  • Organizer: Brain 11 ; 25th International Symposium on Cerebral Blood Flow, Metabolism & Function
  • Place of Presentation: Barcelona
  • Year and Date: 2011-05-26
• [Presentation] Longitudinal imaging of glio-vascular remodeling induced by chronic hypoxia in mouse somatosensory cortex (2011)
  • Author(s): Masamoto K, Tomita Y, Takuwa H, Unekawa M, Toriumi H, Itoh Y, Suzuki N. Kanno I
  • Organizer: Brain 11
  • Place of Presentation: Barcelona
  • Year and Date: 2011-05-24
• [Presentation] Longitudinal imaging of glio-vascular remodeling induced by chronic hypoxia in mouse somatosensory cortex (2011)
  • Author(s): Masamoto K, Tomita Y, Takuwa H, Unekawa M, Toriumi H, Itoh Y, Suzuki N., Kanno I
  • Organizer: Brain 11 ; 25th International Symposium on Cerebr al Blood Flow, Metabolism & Function
  • Place of Presentation: Barcelona
  • Year and Date: 2011-05-24
• [Presentation] Potassium-induced cortical spreading depression suppressed transhemispheric electroencephalogram but did not affect on red blood cell velocity in intraparenchymal capillaries in rats (2011)
  • Author(s): 畝川美悠紀, 冨田裕, 鳥海春樹, 正本和人, 伊藤義彰, 菅野巖, 鈴木則宏
  • Organizer: 第36回日本微小循環学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-02-11
• [Presentation] K^+による大脳皮質性拡延性抑制誘発時の毛細血管内赤血球速度および脳波に対する持続的効果 (2010)
  • Author(s): 畝川美悠紀, 冨田稔, 冨田裕, 鳥海春樹, 菅野巌, 鈴木則宏
  • Organizer: 第22回日本脳循環代謝学会総会
  • Place of Presentation: 大阪(口演)
  • Year and Date: 2010-11-26
• [Presentation] マウス中大脳動脈閉塞モデルにおける虚血周辺領域の微小血管およびアストロサイトの経時的形態観察 (2010)
  • Author(s): 鳥海春樹, 正本和人, 冨田裕, 畝川美悠紀, 田桑弘之, 伊藤義彰, 菅野巌, 鈴木則宏
  • Organizer: 第22回日本脳循環代謝学会総会
  • Place of Presentation: 大阪(口演)
  • Year and Date: 2010-11-26
• [Presentation] マウス大脳皮質における微小血管-アストログリア構造の長期追跡イメージング法 (2010)
  • Author(s): 正本和人, 冨田裕, 田桑弘之, 畝川美悠紀, 鳥海春樹, 小畠隆行, 鈴木則宏, 菅野巌
  • Organizer: 第22回日本脳循環代謝学会総会
  • Place of Presentation: 大阪(口演)
  • Year and Date: 2010-11-26
• [Presentation] マウス中大脳動脈・永久閉塞モデルと虚血再灌流モデルとのin vivo脳微小循環動態の比較 (2010)
  • Author(s): 冨田裕, 安部貴人, 畝川美悠紀, 鳥海春樹, 正本和人, 菅野巌, 鈴木則宏
  • Organizer: 第22回日本脳循環代謝学会総会
  • Place of Presentation: 大阪(口演)
  • Year and Date: 2010-11-26
• [Presentation] K^+による大脳皮質性拡延性抑制誘発反応に対する慢性トピラマート投与の影響 (2010)
  • Author(s): 畝川美悠紀, 冨田裕, 鳥海春樹, 鈴木則宏
  • Organizer: 第38回日本頭痛学会総会
  • Place of Presentation: 東京(口演)
  • Year and Date: 2010-11-19
• [Presentation] In vivo visualization of mouse cerebral microcirculation during middle cerebral artery occlusion induced by the suture method. (2010)
  • Author(s): Tomita Y, Abe T, Unekawa M, Toriumi H, Masamoto K, Kanno I, Suzuki N
  • Organizer: 7th World Stroke Congress
  • Place of Presentation: Seoul Korea
  • Year and Date: 2010-11-13
• [Presentation] Long-term in vivo investigation of mouse cerebral microcirculation after middle cerebral artery ischemia-reperfusion induced by the suture method. (2010)
  • Author(s): Tomita Y, Abe T, Unekawa M, Toriumi H, Masamoto K, Kanno I, Suzuki N
  • Organizer: 9th World Congress for Microcirculation
  • Place of Presentation: Paris France(口演)
  • Year and Date: 2010-10-25
• [Presentation] Significance of arterio-venous shunt in the diploic veins in mice. (2010)
  • Author(s): Toriumi H, Shimizu T, Shibata M, Tomita M, Tomita Y, Unekawa M, Kanno I, Suzuki N
  • Organizer: 9th World Congress for Microcirculation
  • Place of Presentation: Paris France(ポスター)
  • Year and Date: 2010-10-25
• [Presentation] Sustained decrease of red blood cell velocity in intraparenchymal capillaries against potassium-induced cortical spreading depression in rats. (2010)
  • Author(s): Unekawa M, Tomita M, Tomita Y, Toriumi H, Kanno I, Suzuki N
  • Organizer: 9th World Congress for Microcirculation
  • Place of Presentation: Paris France(ポスター)
  • Year and Date: 2010-10-25
• [Presentation] In vivo visualization of mouse cerebral microcirculation during middle cerebral artery occlusion induced by the suture method (2010)
  • Author(s): Tomita Y, Abe T, Unekawa M, Toriumi H, Masamoto K, Kanno I, Suzuki N
  • Organizer: 7th World Stroke Congress
  • Place of Presentation: Korea
  • Year and Date: 2010-10-13
• [Presentation] Cilostazol inhibits leukocyte rolling/adhesion onto the cerebral vessel wall after recirculation (2010)
  • Author(s): Itoh Y, Toriumi H, Koizumi K, Yamada S, Guo H, Tomita Y, Hoshino H, Suzuki N
  • Organizer: 7th World Stroke Congress
  • Place of Presentation: Korea
  • Year and Date: 2010-10-13
• [Presentation] Long-term in vivo investigation of mouse cerebral microcirculation after middle cerebral artery ischemia-reperfusion induced by the suture method (2010)
  • Author(s): Tomita Y, Abe T, Unekawa M, Toriumi H, Masamoto K, Kanno I, Suzuki N
  • Organizer: The 9th World Congress for Microcirculation
  • Place of Presentation: Paris
  • Year and Date: 2010-09-28
• [Presentation] Sustained decrease of red blood cell velocity in intraparenchymal capillaries against potassium-induced cortical spreading depression in rats (2010)
  • Author(s): Unekawa M, Tomita M, Tomita Y, Toriumi H, Kanno I, Suzuki N
  • Organizer: The 9th World Congress for Microcirculation
  • Place of Presentation: Paris
  • Year and Date: 2010-09-28
• [Presentation] Significance of arterio-venous shunt in the diploic veins in mice (2010)
  • Author(s): Toriumi H, Shimizu T, Shibata M, Tomita M, Tomita Y, Unekawa M, Kanno I, Suzuki N
  • Organizer: The 9th World Congress for Microcirculation
  • Place of Presentation: Paris
  • Year and Date: 2010-09-28
• [Presentation] Brain microcirculation during cortical spreading depression (2010)
  • Author(s): 冨田裕
  • Organizer: 第35回日本微小循環学会総会
  • Place of Presentation: 埼玉
  • Year and Date: 2010-02-27
• [Presentation] Variation of red blood cell velocities in intraparenchymal capillaries on potassium-induced cortical spreading depression in anesthetized rats (2010)
  • Author(s): 畝川美悠紀, 冨田稔, 冨田裕, 鳥海春樹, 鈴木則宏
  • Organizer: 第35回日本微小循環学会総会
  • Place of Presentation: 埼玉
  • Year and Date: 2010-02-26
• [Presentation] Neuro-capillary coupling during cortical spreading depression (2010)
  • Author(s): 冨田稔, 冨田裕, 畝川美悠紀, 鳥海春樹, 鈴木則宏
  • Organizer: 第35回日本微小循環学会総会
  • Place of Presentation: 埼玉
• [Presentation] マウス局所脳虚血モデルにおける長期皮質微小循環の高空間分解能in vivo定量的測定 (2009)
  • Author(s): 冨田裕
  • Organizer: 第46回日本臨床生理学会総会
  • Place of Presentation: 盛岡
  • Year and Date: 2009-10-22
• [Presentation] Artificial RBCs Transiently improved microcirculatory derangement produced by MCA occlusion or hemorrhagic hypotension in mice (2009)
  • Author(s): Tomita Y, Toriumi H, Hattori H, Unekawa M, Tomita M, Itoh Y, Hoshino H, Sakai H, Tsuchida E, Horinouchi H, Kobayashi K, Suzuki N
  • Organizer: Brain 09
  • Place of Presentation: Chicago
  • Year and Date: 2009-07-02
• [Presentation] FITC-Labeled RBC tracking in arteriolo-arteriolar anastomoses in control state and during ischemia after MCA occlusion in mice (2009)
  • Author(s): Toriumi H, Tatarishvili J, Tomita M, Tomita Y, Hattori H, Unekawa M, Suzuki N
  • Organizer: Brain 09
  • Place of Presentation: Chicago
  • Year and Date: 2009-07-02
• [Presentation] A hypothesis : Virchow-Robin space as an integrating cleft of cerebrocortical local arteriolar responses (2009)
  • Author(s): Tomita M, Tomita Y, Unekawa M, Toriumi H, Hattori H, Suzuki N
  • Organizer: The 10^<th> International Symposium on Vasodilatation
  • Place of Presentation: 松島
  • Year and Date: 2009-06-02
• [Presentation] 虚血性脳血管疾患あるいは出血性ショック時の人工酸素運搬体投与の効果について (2009)
  • Author(s): 冨田裕
  • Organizer: 平成20年度 厚生労働省科学研究費補助金・研究成果発表会.人工血液をつくる(9)
  • Place of Presentation: 東京
  • Year and Date: 2009-02-11
• [Presentation] 麻酔下および覚醒時のK^+誘発性皮質性拡延性抑制によるDC電位の変化および片麻痺 (2009)
  • Author(s): 畝川美悠紀, 冨田稔, 冨田裕, 鳥海春樹, 鈴木則宏
  • Organizer: 第37回日本頭痛学会総会
  • Place of Presentation: 宇都宮
• [Presentation] 片頭痛発作時の血流変化に関する検討-硬膜動脈と板間静脈の血管構造とA-Vシャント (2009)
  • Author(s): 鳥海春樹, 冨田稔, 冨田裕, 清水利彦, 畝川美悠紀, 鈴木則宏
  • Organizer: 第37回日本頭痛学会総会
  • Place of Presentation: 宇都宮
• [Presentation] ラットK^+による脳皮質性拡延性抑制伝播の際の赤血球速度、DC電位、脳波、酸素分圧、脳血流の相互関係 (2009)
  • Author(s): 畝川美悠紀, 冨田稔, 冨田裕, 鳥海春樹, 鈴木則宏
  • Organizer: 第21回日本脳循環代謝学会総会
  • Place of Presentation: 大阪
• [Presentation] When does angiogenesis accompanied with RBC flow develop in ischemic tissue after permanent MCA occlusion in C57BL/6J mice (2009)
  • Author(s): Tomita M, Tatarishvili J, Toriumi H, Tomita Y, Unekawa M, Hattori H, Suzuki N
  • Organizer: Brain 09
  • Place of Presentation: Chicago
• [Presentation] Artificial RBC transiently improved microcirculatory derangement produced by blood-loss hypotension or MCA occlusion in mice (2009)
  • Author(s): Tomita Y, Toriumi H, Hattori H, Unekawa M, Tomita M, Itoh Y, Hoshino H, Sakai H, Tsuchida E, Horinouchi H, Kobayashi K, Suzuki N
  • Organizer: Brain 09
  • Place of Presentation: Chicago
• [Presentation] Transient hemiparesis after topical application of 0.3 M KCl to the sensorimotor cortex in awake unrestricted mice (2009)
  • Author(s): 服部英典, 冨田稔, 鳥海春樹, 冨田裕, 畝川美悠紀, 鈴木則宏
  • Organizer: Brain 09
  • Place of Presentation: Chicago
• [Presentation] When does angiogenesis accompanied with RBC flow develop in ischemic tissue after permanent MCA occlusion in C57BL/6J mice? (2009)
  • Author(s): 冨田稔, Tatarishvili J, 鳥海春樹, 冨田裕, 畝川美悠紀, 服部英典, 鈴木則宏
  • Organizer: Brain 09
  • Place of Presentation: Chicago
• [Presentation] FITC-labeled RBC tracking in arteriolo-arteriolar anastomoses in control state and during ischemia after MCA occlusion in mice (2009)
  • Author(s): 鳥海春樹, Tatarishvili J, 冨田稔, 冨田裕, 服部英典, 畝川美悠紀, 鈴木則宏
  • Organizer: Brain 09
  • Place of Presentation: Chicago
• [Presentation] Shift of frequency distribution of RBC velocity in parenchymal capillaries during potassium-induced cortical spreading depression in rats (2009)
  • Author(s): 畝川美悠紀, 冨田稔, 冨田裕, 鳥海春樹, 服部英典, 鈴木則宏
  • Organizer: Brain 09
  • Place of Presentation: Chicago
• [Presentation] A hypothesis : Virchow-Robin space as an integrating "cleft" of cerebrocortical local arteriolar response.10th International Symposium on Mechanisms of Vasodilatation (2009)
  • Author(s): 冨田稔, 冨田裕, 鳥海春樹, 畝川美悠紀, 服部英典, 鈴木則宏
  • Organizer: 10th International Symposium on Mechanisms of Vasodilatation
  • Place of Presentation: Matsushima, Sendai
• [Presentation] 大脳皮質動脈において血管内皮障害後の修復過程で認められた移植単核球の効果 (2009)
  • Author(s): 伊藤義彰, 鳥海春樹, 山田哲, 木村浩晃, 冨田裕, 星野晴彦, 鈴木則宏
  • Organizer: 第34回日本脳卒中学会総会
  • Place of Presentation: 島根
• [Presentation] 脳虚血周辺部微小血管の血管新生-経時的形態的変化と赤血球流速よりみたアプローチ脳虚血周辺部微小血管の血管新生-経時的形熊的変化と赤血球流速よりみたアプローチ (2009)
  • Author(s): 冨田稔, Tatarishvili J, 鳥海春樹, 冨田裕, 畝川美悠紀, 服部英典, 鈴木則宏
  • Organizer: 第34回日本卒中学会総会
  • Place of Presentation: 島根
• [Presentation] 麻酔下および覚醒時のK^+誘発性皮質性拡延性抑制によるDC電位の変化および片麻痺麻酔下および覚醒時のK+誘発性皮質性拡延性抑制によるDC電位の変化および片麻痺 (2009)
  • Author(s): 畝川美悠紀, 冨田稔, 冨田裕, 鳥海春樹, 鈴木則宏
  • Organizer: 第37回日本頭痛学会総会
  • Place of Presentation: 宇都宮
• [Presentation] 片頭痛発作時の血流変化に関する検討―硬膜動脈と板間静脈の血管構造とA-Vシャント片頭痛発作時の血流変化に関する検討―硬膜動脈と板間静脈の血管構造とA-V シャント (2009)
  • Author(s): 鳥海春樹, 冨田稔, 冨田裕, 清水利彦, 畝川美悠紀, 鈴木則宏
  • Organizer: 第37回日本頭痛学会総会
  • Place of Presentation: 宇都宮