| Project/Area Number |
21591120
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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|---|
| Research Institution | Juntendo University |
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Principal Investigator |
|
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| Co-Investigator(Kenkyū-buntansha) |
MOTIZUKI Hideki 大阪大学, 医学部, 教授 (90230044)
SHINOHARA Mitsuyo 順天堂大学, 医学部, 助教 (00301507)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | 睡眠時無呼吸症候群 / アルツハイマー病 / アミロイドベータ42 / 間欠的低酸素 |
|---|
| Research Abstract |
We showed that the ratio of amyloidβprotein subtypes Aβ42 to Aβ40(Aβ42/Aβ40) in the brain of Alzheimer's model mice increased through chronic intermittent hypoxia which is pathophysiologically characteristic of obstructive sleep apnea. Furthermore, compared to room air condition, intermittent hypoxia exposure induced the significant increase of Aβ42 levels and Aβ42/Aβ40 ratio Aβ42/Aβ40 in conditioned medium. of the human neuroblastoma cell line SH-SY5Y that stably expressing wild-type amyloid precursor protein. Hipoxic inducible factor-1α(HIF-1α) was not activated.
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