Identification of novel acylated proteins regulating insulin secretion and exploration of their physiological significance

• Project/Area Number: 21591128
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Shinshu University
• Principal Investigator: KOMATSU Mitsuhisa 信州大学, 医学部, 教授 (90221978)
• Co-Investigator(Kenkyū-buntansha): KABURAGI Yasushi 国立国際医療研究センター, 代謝疾患研究部病態代謝研究室, 室長 (40342927) ; NODA Mitsuhiko 国立国際医療研究センター, 代謝症候群診療部, 部長 (90237850)
• Project Period (FY): 2009 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: インスリン分泌 / ブドウ糖 / インクレチン / cAMP / アシル化蛋白

Research Abstract

Insulin deficiency is an important pathophysiological feature in the evolution of type 2 diabetes. In the processes of insulin release from pancreatic beta-cells, glucose-induced closure of KATP channels is known to be essential. However, we established the experimental model using rat pancreatic islets that glucose triggered acute insulin release in the presence of incretin signaling in a KATP channel -independent manner.

Research Products

• [Journal Article] Glucose-stimulated insulin secretion: A newer perspective (2013)
  • Author(s): Komatsu M, Takei M, Ishii H, Sato Y.
  • Journal Title: J Diabetes Invest Volume: 4 Issue: 6 Pages: 511-516
  • DOI: 10.1111/jdi.12094
  • Peer Reviewed
• [Journal Article] A new experimental model of ATP-sensitive K+channel-independent insulinotropic action of glucose: a permissive role of cAMP for triggering of insulin release from rat pancreatic beta-cells. (2013)
  • Author(s): Takei M, Dezaki K, Ishii H, Nishio SI, Sato Y, Suzuki S, Yada T, Komatsu M
  • Journal Title: Endocrine journal. Volume: 60 Pages: 599-607
  • Peer Reviewed
• [Journal Article] A new experimental model of ATP-sensitive K⁺ channel-independent insulinotropic action of glucose: a permissive role of cAMP for triggering of insulin release from rat pancreatic β-cells (2013)
  • Author(s): Masahiro Takei
  • Journal Title: Endocrine Journal Volume: 60 Issue: 5 Pages: 599-607
  • DOI: 10.1507/endocrj.EJ12-0388
  • NAID: 10031184527
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed
• [Journal Article] Bariatric surgery on type 2 dizbetes mellitus patients in Japan. Shinshu (2011)
  • Author(s): Mori J, Sato Y, Ishii H, Komatsu M.
  • Journal Title: Med J Volume: 59(4) Pages: 273-279
  • Peer Reviewed
• [Journal Article] Glucose-incretin interaction revisited. (2011)
  • Author(s): Ishii H, Sato Y, Takei M, Nishio S, Komatsu M.
  • Journal Title: Endocr J Volume: 58(7) Pages: 519-525
  • NAID: 10029589169
  • Peer Reviewed
• [Journal Article] Glucose-incretin interaction revisited [Review] (2011)
  • Author(s): Ishii H, Sato Y, Takei M, Nishio S, Komatsu M
  • Journal Title: Endocrine Journal Volume: 58 Issue: 7 Pages: 519-525
  • DOI: 10.1507/endocrj.EJ11-0064
  • NAID: 10029589169
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed
• [Journal Article] Transient polyuria related to central diabetes insipidus caused by lymphocytic infundibulo‐neurohypophysitis in a patient treated for Graves'disease (2010)
  • Author(s): Yamazaki M, Sato A, Nishio S, Uehara T, Komatsu M
  • Journal Title: Intern Med Volume: 49 Pages: 1885-1890
  • Peer Reviewed
• [Journal Article] closed-loopとopen-loopによる血糖制御 (2010)
  • Author(s): 駒津光久
  • Journal Title: 内分泌・糖尿病・代謝内科 Volume: 30 Pages: 591-595
  • NAID: 40017666413
• [Journal Article] 機能的膵β細胞量を標的としたあらたな糖尿病治療-GLP-1治療の展望 (2010)
  • Author(s): 駒津光久
  • Journal Title: International Review of Diabetes Volume: 2 Pages: 24-25
• [Journal Article] Distinct Clinical Courses in Type 1 Diabetes Mellitus Induced by Peg-interferon-alpha Treatment for Chronic Hepatitis C (2010)
  • Author(s): Yamazaki M, Sato A, Takeda T, Komatsu M
  • Journal Title: Intern Med 49 Pages: 403-407
  • NAID: 130000251685
  • Peer Reviewed
• [Journal Article] Cold-induced sweating syndrome with neonatal features of Crisponi syndrome : Longitudinal observation of a patient homozygous for a CRLF1 mutation (2010)
  • Author(s): Yamazaki M, et al.(11番目)
  • Journal Title: Am J Med Genet A 152A Pages: 764-769
  • Peer Reviewed
• [Journal Article] Enhancement of the incretin pathway in response to bariatric surgery is important for restoration of beta cell function (2009)
  • Author(s): Komatsu M, Aizawa T
  • Journal Title: Diabetologia 52 Pages: 374-375
  • Peer Reviewed
• [Presentation] Combinationtherapy with low dose glimepiride and sitagliptin is reasonably effective for poorly controlled type 2 diabetes patients (2012)
  • Author(s): Ishii H, Takei M, Nisio S, Sato Y, Suzuki S, Komatsu M.
  • Organizer: 第48回ヨーロッパ糖尿病学会
  • Place of Presentation: ベルリン、ドイツ
  • Year and Date: 2012-10-01
• [Presentation] Acute triggering of insulin release concomitant with a decrease in cytosolic free Ca^ concentration by a combination of glucose and cAMP. (2011)
  • Author(s): Takei M, Ishii H, Nisio S, Sato Y, Komatsu M.
  • Organizer: 第47回ヨーロッパ糖尿病学会
  • Place of Presentation: リスボン、ポルトガル
  • Year and Date: 2011-09-16
• [Presentation] Acute triggering of insulin release concomitant with a decrease in cytosolic free Ca2+concentration by a combination of glucose and cAMP (2011)
  • Author(s): M.Takei, H.Ishii, S Nisio, Y.Sato, M.Komatsu
  • Organizer: 第47回欧州糖尿病学会
  • Place of Presentation: リスボン(ポルトガル)
  • Year and Date: 2011-09-15
• [Book] Bariatric surgery on obese type 2 diabetes patients. Advanced Bariatric and Metabolic Surgery (2012)
  • Author(s): Mori J, Sato Y, Komatsu M
  • Publisher: Edited by Chin-Kun Huang, In Tech