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Identification of novel acylated proteins regulating insulin secretion and exploration of their physiological significance

Research Project

Project/Area Number 21591128
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Metabolomics
Research InstitutionShinshu University

Principal Investigator

KOMATSU Mitsuhisa  信州大学, 医学部, 教授 (90221978)

Co-Investigator(Kenkyū-buntansha) KABURAGI Yasushi  国立国際医療研究センター, 代謝疾患研究部病態代謝研究室, 室長 (40342927)
NODA Mitsuhiko  国立国際医療研究センター, 代謝症候群診療部, 部長 (90237850)
Project Period (FY) 2009 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsインスリン分泌 / ブドウ糖 / インクレチン / cAMP / アシル化蛋白
Research Abstract

Insulin deficiency is an important pathophysiological feature in the evolution of type 2 diabetes. In the processes of insulin release from pancreatic beta-cells, glucose-induced closure of KATP channels is known to be essential. However, we established the experimental model using rat pancreatic islets that glucose triggered acute insulin release in the presence of incretin signaling in a KATP channel -independent manner.

Report

(5 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (16 results)

All 2013 2012 2011 2010 2009

All Journal Article (12 results) (of which Peer Reviewed: 10 results) Presentation (3 results) Book (1 results)

  • [Journal Article] Glucose-stimulated insulin secretion: A newer perspective2013

    • Author(s)
      Komatsu M, Takei M, Ishii H, Sato Y.
    • Journal Title

      J Diabetes Invest

      Volume: 4 Issue: 6 Pages: 511-516

    • DOI

      10.1111/jdi.12094

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A new experimental model of ATP-sensitive K+channel-independent insulinotropic action of glucose: a permissive role of cAMP for triggering of insulin release from rat pancreatic beta-cells.2013

    • Author(s)
      Takei M, Dezaki K, Ishii H, Nishio SI, Sato Y, Suzuki S, Yada T, Komatsu M
    • Journal Title

      Endocrine journal.

      Volume: 60 Pages: 599-607

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A new experimental model of ATP-sensitive K<sup>+</sup> channel-independent insulinotropic action of glucose: a permissive role of cAMP for triggering of insulin release from rat pancreatic &beta;-cells2013

    • Author(s)
      Masahiro Takei
    • Journal Title

      Endocrine Journal

      Volume: 60 Issue: 5 Pages: 599-607

    • DOI

      10.1507/endocrj.EJ12-0388

    • NAID

      10031184527

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bariatric surgery on type 2 dizbetes mellitus patients in Japan. Shinshu2011

    • Author(s)
      Mori J, Sato Y, Ishii H, Komatsu M.
    • Journal Title

      Med J

      Volume: 59(4) Pages: 273-279

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Glucose-incretin interaction revisited.2011

    • Author(s)
      Ishii H, Sato Y, Takei M, Nishio S, Komatsu M.
    • Journal Title

      Endocr J

      Volume: 58(7) Pages: 519-525

    • NAID

      10029589169

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Glucose-incretin interaction revisited [Review]2011

    • Author(s)
      Ishii H, Sato Y, Takei M, Nishio S, Komatsu M
    • Journal Title

      Endocrine Journal

      Volume: 58 Issue: 7 Pages: 519-525

    • DOI

      10.1507/endocrj.EJ11-0064

    • NAID

      10029589169

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transient polyuria related to central diabetes insipidus caused by lymphocytic infundibulo‐neurohypophysitis in a patient treated for Graves'disease2010

    • Author(s)
      Yamazaki M, Sato A, Nishio S, Uehara T, Komatsu M
    • Journal Title

      Intern Med

      Volume: 49 Pages: 1885-1890

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] closed-loopとopen-loopによる血糖制御2010

    • Author(s)
      駒津光久
    • Journal Title

      内分泌・糖尿病・代謝内科

      Volume: 30 Pages: 591-595

    • NAID

      40017666413

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 機能的膵β細胞量を標的としたあらたな糖尿病治療-GLP-1治療の展望2010

    • Author(s)
      駒津光久
    • Journal Title

      International Review of Diabetes

      Volume: 2 Pages: 24-25

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Distinct Clinical Courses in Type 1 Diabetes Mellitus Induced by Peg-interferon-alpha Treatment for Chronic Hepatitis C2010

    • Author(s)
      Yamazaki M, Sato A, Takeda T, Komatsu M
    • Journal Title

      Intern Med 49

      Pages: 403-407

    • NAID

      130000251685

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cold-induced sweating syndrome with neonatal features of Crisponi syndrome : Longitudinal observation of a patient homozygous for a CRLF1 mutation2010

    • Author(s)
      Yamazaki M, et al.(11番目)
    • Journal Title

      Am J Med Genet A 152A

      Pages: 764-769

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of the incretin pathway in response to bariatric surgery is important for restoration of beta cell function2009

    • Author(s)
      Komatsu M, Aizawa T
    • Journal Title

      Diabetologia 52

      Pages: 374-375

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Combinationtherapy with low dose glimepiride and sitagliptin is reasonably effective for poorly controlled type 2 diabetes patients2012

    • Author(s)
      Ishii H, Takei M, Nisio S, Sato Y, Suzuki S, Komatsu M.
    • Organizer
      第48回ヨーロッパ糖尿病学会
    • Place of Presentation
      ベルリン、ドイツ
    • Year and Date
      2012-10-01
    • Related Report
      2012 Final Research Report
  • [Presentation] Acute triggering of insulin release concomitant with a decrease in cytosolic free Ca^ concentration by a combination of glucose and cAMP.2011

    • Author(s)
      Takei M, Ishii H, Nisio S, Sato Y, Komatsu M.
    • Organizer
      第47回ヨーロッパ糖尿病学会
    • Place of Presentation
      リスボン、ポルトガル
    • Year and Date
      2011-09-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Acute triggering of insulin release concomitant with a decrease in cytosolic free Ca2+concentration by a combination of glucose and cAMP2011

    • Author(s)
      M.Takei, H.Ishii, S Nisio, Y.Sato, M.Komatsu
    • Organizer
      第47回欧州糖尿病学会
    • Place of Presentation
      リスボン(ポルトガル)
    • Year and Date
      2011-09-15
    • Related Report
      2011 Annual Research Report
  • [Book] Bariatric surgery on obese type 2 diabetes patients. Advanced Bariatric and Metabolic Surgery2012

    • Author(s)
      Mori J, Sato Y, Komatsu M
    • Publisher
      Edited by Chin-Kun Huang, In Tech
    • Related Report
      2012 Final Research Report

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Published: 2009-04-01   Modified: 2019-07-29  

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