Identification of novel acylated proteins regulating insulin secretion and exploration of their physiological significance
| Project/Area Number |
21591128
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KABURAGI Yasushi 国立国際医療研究センター, 代謝疾患研究部病態代謝研究室, 室長 (40342927)
NODA Mitsuhiko 国立国際医療研究センター, 代謝症候群診療部, 部長 (90237850)
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| Project Period (FY) |
2009 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | インスリン分泌 / ブドウ糖 / インクレチン / cAMP / アシル化蛋白 |
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| Research Abstract |
Insulin deficiency is an important pathophysiological feature in the evolution of type 2 diabetes. In the processes of insulin release from pancreatic beta-cells, glucose-induced closure of KATP channels is known to be essential. However, we established the experimental model using rat pancreatic islets that glucose triggered acute insulin release in the presence of incretin signaling in a KATP channel -independent manner.
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Report
(5 results)
Research Products
(16 results)
