Regulation of carbohydrate and lipid metabolism in regard to purine metabolism in skeletal muscle
| Project/Area Number |
21591167
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
MORISAKI Takayuki 独立行政法人国立循環器病研究センター, 分子生物学部, 部長 (30174410)
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| Co-Investigator(Renkei-kenkyūsha) |
MORISAKI Hiroko 独立行政法人国立循環器病研究センター, 分子生物学部, 室長 (40311451)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | プリン代謝 / 骨格筋 / 糖代謝 / 脂質代謝 / AMP / AMPK / アデニンヌクレオチド / 代謝調節 / 糖脂質代謝 / ヌクレオチド代謝 / 遺伝子改変動物 / 代謝異常 |
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| Research Abstract |
In this study, we revealed changes in nucleotide levels, phosphorylated AMPK and other relating molecules in AMPD1 knock-out(muscle AMPD deficient) mice, indicating the close relationship between adenine nucleotide and carbohydrate/lipid metabolism. Also, we studied the relationship between AMPD deficiency and renal glomerular function.
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Report
(4 results)
Research Products
(21 results)
