Clinical and immunological studies of autoimmune Hashimoto's encephalopathy associated with chronic thyroiditis

• Project/Area Number: 21591171
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Endocrinology
• Research Institution: University of Fukui
• Principal Investigator: YONEDA Makoto 福井大学, 医学部, 准教授 (70270551)
• Co-Investigator(Kenkyū-buntansha): TAKAMURA Toshinari 金沢大学, 医学系, 准教授 (00324111) ; 栗山 勝 福井大学, 医学部, 教授 (80107870)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 橋本脳症 / 自己抗体 / プロテオミクス / 臨床解析 / 2D-DIGE / 小脳失調

Research Abstract

Hashimoto' encephalopathy(HE) is a distinct clinical entity which is associated with chronic thyroiditis, and presents with various neuropsychological features. We recently developed a novel diagnostic marker, anti-NAE autoantibodies, in sera from HE patients. We have analyzed over 1, 350 patients, and revealed clinical and immunological characters of HE. Furthermore, we have investigated the pathogenic mechanisms such as changes in the synaptic transmission and proteomes, supplemented by the sera from HE patients.

Research Products

• [Journal Article] Hashimoto's encephalopathy presenting with micrographia as atypical feature of parkinsonism (2012)
  • Author(s): Inoue, K, Kitamura, J, Yoneda, M, Imamura, E, Tokinobu, H
  • Journal Title: Neurol Sci Volume: 33 Pages: 395-397
  • Peer Reviewed
• [Journal Article] 橋本脳症-小脳失調型を中心に- (2011)
  • Author(s): 松永晶子, 米田誠
  • Journal Title: 最新医学 Volume: 66巻 Pages: 1039-1044
  • NAID: 130004505165
• [Journal Article] 甲状腺脳症 (2011)
  • Author(s): 米田誠
  • Journal Title: 神経眼科 Volume: 28巻 Pages: 335-341
• [Journal Article] 甲状腺眼症 (2011)
  • Author(s): 米田誠
  • Journal Title: 神経眼科 Volume: 28 Pages: 335-341
• [Journal Article] 抗N末端α-エノラーゼ抗体をみとめた急性小脳失調症の1例 (2010)
  • Author(s): 山本幹枝, 和田健二, 米田誠, 土井浩二, 古和久典, 中島健二
  • Journal Title: 臨床神経 Volume: 50巻 Pages: 581-583
  • NAID: 10027705681
  • Peer Reviewed
• [Journal Article] Posterior reversible encephalopathy syndrome following measles vaccination. (2010)
  • Author(s): Tadanori Hamano, Tomoko Takeda, Hiroshi Morita, Tomoko Muramatsu, Makoto Yoneda, Hirohiko Kimura, Masar u Kuriyama.
  • Journal Title: J Neurol Sci Volume: 298 Pages: 124-126
  • Peer Reviewed
• [Journal Article] 航N末端α-エノラーゼ抗体をみとめた急性小脳失調症の1例 (2010)
  • Author(s): 山本幹枝, 和田健二, 米田誠, 土井浩二, 古和久典, 中島健二
  • Journal Title: 臨床神経 Volume: 50 Pages: 581-583
  • Peer Reviewed
• [Journal Article] 抗N末端αエノラーゼ抗体 (2010)
  • Author(s): 松永晶子, 米田誠, 栗山勝
  • Journal Title: 日本臨床増刊 Volume: 6 Pages: 648-650
• [Journal Article] 橋本脳症.精神科医が知っておくべき神経内科の新知識. (2009)
  • Author(s): 米田誠
  • Journal Title: 精神治療学 Volume: 24巻 Pages: 1385-1390
• [Journal Article] Unique clinicopathological features and PrP profiles in the first autopsied case of dura matter graft-associated Creutzfeldt-Jakob disease with codon 219 lysine allele observed in Japanese population (2009)
  • Author(s): Ikawa M, Yoneda M, Matsunaga A, Nakagawa H, Kazama-Suzuki A, Miyashita N, Naiki H, Kitamoto T, Kuriyama M
  • Journal Title: J Neurol Sci Volume: 285 Pages: 265-267
  • Peer Reviewed
• [Journal Article] Acute on chronic subdural hematoma as a rare complication in a microscopic polyangiitis patient receiving antithrombotic treatment (2009)
  • Author(s): Takahashi N, Kimura H, Kitai R, Sato M, Yoneda M, Yamamoto C, Mikami D, Kuriyama M, Kubota T, Itoh H, Yoshida H.
  • Journal Title: Clin Nephrol Volume: 72 Pages: 211-215
  • Peer Reviewed
• [Journal Article] Acute on chronic subdural hematoma as a rare complication in a microscopic polyangitis patient receiving antithrombotic treatment (2009)
  • Author(s): Naoki Takahashi, et al.
  • Journal Title: Clin Nephrol 72 Pages: 211-215
  • Peer Reviewed
• [Journal Article] Unique clinicopathological features and PrP profiles in the first autopsied case of data matter graft-associated Creutzfeldt-Jakob disease with codon 219 lysine allele observed in Japanese population (2009)
  • Author(s): Masamichi Ikawa, et al.
  • Journal Title: J Neurol Sci 285 Pages: 265-267
  • Peer Reviewed
• [Journal Article] 橋本脳症. 精神科医が知っておくべき神経内科の新知識 (2009)
  • Author(s): 米田誠
  • Journal Title: 精神科治療学 24 Pages: 1385-1390
• [Presentation] 橋本脳症.シンポジウム:中枢神経を侵す難治性炎症性疾患の治療法の選択と最適化 (2012)
  • Author(s): 米田誠
  • Organizer: 第53回日本神経学会総会
  • Place of Presentation: 東京
  • Year and Date: 2012-05-25
• [Presentation] 橋本脳症.小脳失調型を中心に-.シンポジウム:脳炎・脳症における最近の話題 (2012)
  • Author(s): 米田誠
  • Organizer: 第53回日本神経学会総会
  • Place of Presentation: 東京
  • Year and Date: 2012-05-25
• [Presentation] 自己免疫介在性脳炎.教育講演 (2011)
  • Author(s): 米田誠
  • Organizer: 第29回日本神経治療学会総会
  • Place of Presentation: 福井
  • Year and Date: 2011-11-18
• [Presentation] 橋本脳症.シンポジウムII「甲状腺異常に伴う眼・脳合併症」 (2011)
  • Author(s): 米田誠
  • Organizer: 第48回日本神経眼科学会総会
  • Place of Presentation: 名古屋
• [Presentation] 自己免疫介在性脳炎 (2011)
  • Author(s): 米田誠
  • Organizer: 第29回日本神経治療学会総会
  • Place of Presentation: 福井市
• [Presentation] 橋本脳症. (2010)
  • Author(s): 米田誠
  • Organizer: 日本神経学会北海道地区生涯教育講演会
  • Place of Presentation: 札幌
  • Year and Date: 2010-03-07
• [Presentation] 橋本脳症 (2010)
  • Author(s): 米田誠
  • Organizer: 日本神経学会北海道地区生涯教育講演会
  • Place of Presentation: 北海道大学
  • Year and Date: 2010-03-07
• [Presentation] シンポジウムII「甲状腺異常に伴う眼・脳合併症」 (2010)
  • Author(s): 米田誠
  • Organizer: 第48回日本神経眼科学会総会
  • Place of Presentation: 名古屋
• [Book] 橋本脳症の治療,今日の精神疾患治療指針 (2012)
  • Author(s): 米田誠
  • Publisher: 医学書院
• [Book] 今日の精神疾患治療指針 (2012)
  • Author(s): 米田誠
  • Publisher: 医学書院
• [Book] 日本臨床増刊 (2010)
  • Author(s): 松永晶子,米田誠,栗山勝