| Project/Area Number |
21591171
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
|
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| Research Institution | University of Fukui |
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Principal Investigator |
|
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| Co-Investigator(Kenkyū-buntansha) |
TAKAMURA Toshinari 金沢大学, 医学系, 准教授 (00324111)
栗山 勝 福井大学, 医学部, 教授 (80107870)
|
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
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| Keywords | 橋本脳症 / 自己抗体 / プロテオミクス / 臨床解析 / 2D-DIGE / 小脳失調 |
|---|
| Research Abstract |
Hashimoto' encephalopathy(HE) is a distinct clinical entity which is associated with chronic thyroiditis, and presents with various neuropsychological features. We recently developed a novel diagnostic marker, anti-NAE autoantibodies, in sera from HE patients. We have analyzed over 1, 350 patients, and revealed clinical and immunological characters of HE. Furthermore, we have investigated the pathogenic mechanisms such as changes in the synaptic transmission and proteomes, supplemented by the sera from HE patients.
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