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2011 Fiscal Year Final Research Report

Clinical and immunological studies of autoimmune Hashimoto's encephalopathy associated with chronic thyroiditis

Research Project

  • PDF
Project/Area Number 21591171
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Endocrinology
Research InstitutionUniversity of Fukui

Principal Investigator

YONEDA Makoto  福井大学, 医学部, 准教授 (70270551)

Co-Investigator(Kenkyū-buntansha) TAKAMURA Toshinari  金沢大学, 医学系, 准教授 (00324111)
Project Period (FY) 2009 – 2011
Keywords橋本脳症 / 自己抗体 / プロテオミクス / 臨床解析
Research Abstract

Hashimoto' encephalopathy(HE) is a distinct clinical entity which is associated with chronic thyroiditis, and presents with various neuropsychological features. We recently developed a novel diagnostic marker, anti-NAE autoantibodies, in sera from HE patients. We have analyzed over 1, 350 patients, and revealed clinical and immunological characters of HE. Furthermore, we have investigated the pathogenic mechanisms such as changes in the synaptic transmission and proteomes, supplemented by the sera from HE patients.

  • Research Products

    (14 results)

All 2012 2011 2010 2009

All Journal Article (7 results) (of which Peer Reviewed: 4 results) Presentation (5 results) Book (2 results)

  • [Journal Article] Hashimoto's encephalopathy presenting with micrographia as atypical feature of parkinsonism2012

    • Author(s)
      Inoue, K, Kitamura, J, Yoneda, M, Imamura, E, Tokinobu, H
    • Journal Title

      Neurol Sci

      Volume: 33 Pages: 395-397

    • Peer Reviewed
  • [Journal Article] 橋本脳症-小脳失調型を中心に-2011

    • Author(s)
      松永晶子, 米田誠
    • Journal Title

      最新医学

      Volume: 66巻 Pages: 1039-1044

  • [Journal Article] 甲状腺脳症2011

    • Author(s)
      米田誠
    • Journal Title

      神経眼科

      Volume: 28巻 Pages: 335-341

  • [Journal Article] 抗N末端α-エノラーゼ抗体をみとめた急性小脳失調症の1例2010

    • Author(s)
      山本幹枝, 和田健二, 米田誠, 土井浩二, 古和久典, 中島健二
    • Journal Title

      臨床神経

      Volume: 50巻 Pages: 581-583

    • Peer Reviewed
  • [Journal Article] 橋本脳症.精神科医が知っておくべき神経内科の新知識.2009

    • Author(s)
      米田誠
    • Journal Title

      精神治療学

      Volume: 24巻 Pages: 1385-1390

  • [Journal Article] Unique clinicopathological features and PrP profiles in the first autopsied case of dura matter graft-associated Creutzfeldt-Jakob disease with codon 219 lysine allele observed in Japanese population2009

    • Author(s)
      Ikawa M, Yoneda M, Matsunaga A, Nakagawa H, Kazama-Suzuki A, Miyashita N, Naiki H, Kitamoto T, Kuriyama M
    • Journal Title

      J Neurol Sci

      Volume: 285 Pages: 265-267

    • Peer Reviewed
  • [Journal Article] Acute on chronic subdural hematoma as a rare complication in a microscopic polyangiitis patient receiving antithrombotic treatment2009

    • Author(s)
      Takahashi N, Kimura H, Kitai R, Sato M, Yoneda M, Yamamoto C, Mikami D, Kuriyama M, Kubota T, Itoh H, Yoshida H.
    • Journal Title

      Clin Nephrol

      Volume: 72 Pages: 211-215

    • Peer Reviewed
  • [Presentation] 橋本脳症.シンポジウム:中枢神経を侵す難治性炎症性疾患の治療法の選択と最適化2012

    • Author(s)
      米田誠
    • Organizer
      第53回日本神経学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-05-25
  • [Presentation] 橋本脳症.小脳失調型を中心に-.シンポジウム:脳炎・脳症における最近の話題2012

    • Author(s)
      米田誠
    • Organizer
      第53回日本神経学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-05-25
  • [Presentation] 橋本脳症.シンポジウムII「甲状腺異常に伴う眼・脳合併症」2011

    • Author(s)
      米田誠
    • Organizer
      第48回日本神経眼科学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      20111126-27
  • [Presentation] 自己免疫介在性脳炎.教育講演2011

    • Author(s)
      米田誠
    • Organizer
      第29回日本神経治療学会総会
    • Place of Presentation
      福井
    • Year and Date
      2011-11-18
  • [Presentation] 橋本脳症.2010

    • Author(s)
      米田誠
    • Organizer
      日本神経学会北海道地区生涯教育講演会
    • Place of Presentation
      札幌
    • Year and Date
      2010-03-07
  • [Book] 橋本脳症の治療,今日の精神疾患治療指針2012

    • Author(s)
      米田誠
    • Total Pages
      429-430
    • Publisher
      医学書院
  • [Book] 日本臨床増刊2010

    • Author(s)
      松永晶子,米田誠,栗山勝
    • Total Pages
      648-650

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Published: 2013-07-31  

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