2011 Fiscal Year Final Research Report
Clinical and immunological studies of autoimmune Hashimoto's encephalopathy associated with chronic thyroiditis
| Project/Area Number |
21591171
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKAMURA Toshinari 金沢大学, 医学系, 准教授 (00324111)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 橋本脳症 / 自己抗体 / プロテオミクス / 臨床解析 |
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| Research Abstract |
Hashimoto' encephalopathy(HE) is a distinct clinical entity which is associated with chronic thyroiditis, and presents with various neuropsychological features. We recently developed a novel diagnostic marker, anti-NAE autoantibodies, in sera from HE patients. We have analyzed over 1, 350 patients, and revealed clinical and immunological characters of HE. Furthermore, we have investigated the pathogenic mechanisms such as changes in the synaptic transmission and proteomes, supplemented by the sera from HE patients.
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[Journal Article] Acute on chronic subdural hematoma as a rare complication in a microscopic polyangiitis patient receiving antithrombotic treatment2009
Author(s)
Takahashi N, Kimura H, Kitai R, Sato M, Yoneda M, Yamamoto C, Mikami D, Kuriyama M, Kubota T, Itoh H, Yoshida H.
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Journal Title
Clin Nephrol
Volume: 72
Pages: 211-215
Peer Reviewed
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