Influence of bone related cells on leukemic cells
Project/Area Number |
21591201
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Hematology
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Research Institution | Saga University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
FUKUSHIMA Noriyasu 佐賀大学, 医学部, 講師 (20346894)
HISATOMI Takashi 佐賀大学, 医学部, 助教 (10398125)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 白血病 / 骨 / ニッチ / 骨芽細胞 / 破骨細胞 / 慢性骨髄性白血病 / ナノチャンバー / ABLチロシンキナーゼ |
Research Abstract |
We have established co-culture system with osteoblasts, osteoclasts, bones and leukemic cells to investigate the influence of bone related cells on leukemic cells. With this system, we found that osteoblasts stimulated the proliferation of leukemic cells, and leukemic cells which were introduced to quiescent phase by TGF-・that was released from bone via osteoclasts acquired the resistance to ABL tyrosine kinase inhibitors.
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Report
(4 results)
Research Products
(57 results)
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[Journal Article] Rapid automated detection of ABL kinase domain mutations in imatinib-resistant patients2011
Author(s)
Tanaka R, Kimura S, Ashihara E, Yoshimura M, Takahashi N, Wakita H, Itoh K, Nishiwaki K, Suzuki K, Nagao R, Yao H, Hayashi Y, Satake S, Hirai H, Sawada K, Ottmann OG, Melo JV, Maekawa T.
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Journal Title
Cancer Lett
Volume: 312
Pages: 228-234
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[Journal Article] Growth inhibition of imatinib-resistant CML cells with the T315I mutation and hypoxia adaptation by AV65, a novel Wnt/β-catenin signaling inhibitor2011
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Nagao R, Ashihara E, Kimura S, Strovel JW, Yao H, Takeuchi M, Tanaka R, Hayashi Y, Hirai H, Padia J, Strand K, Maekawa T.
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Journal Title
Cancer Lett
Volume: 312
Pages: 91-100
NAID
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[Journal Article] A non-invasive system for monitoring resistance to EGFR tyrosine kinase inhibitors with plasma DNA2011
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Nakamura T, Sueoka-Aragane N, Iwanaga K, Sato A, Komiya K, Abe T, Ureshino N, Hayashi S, Hosomi T, Hirai M, Sueoka E, Kimura S.
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Journal Title
J Thorac Oncol
Volume: 6
Pages: 1639-1648
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[Journal Article] Fully Integrated, Automated and Rapid Detection System for KRAS Mutations2011
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Ureshino N, Sueoka-Aragane N, Nakamura T, Sato A, Komiya K, Iwanaga K, Mitsuoka M, Takeda Y, Hayashi S, Sueoka E, Kimura S.
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Journal Title
Oncol Rep
Volume: 26
Pages: 609-613
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[Journal Article] Rakicidin A effectively induces apoptosis in hypoxia adapted Bcr-Abl positive leukemic cells2011
Author(s)
Takeuchi M, Ashihara E, Yamazaki Y, Kimura S, Nakagawa Y, Tanaka R, Yao H, Nagao R, Hayashi Y, Hirai H, Maekawa T.
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Journal Title
Cencer Sci
Volume: 102
Pages: 591-596
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[Journal Article] Galectin-9 ameliorates acute GVH disease through the induction of T-cell apoptosis2011
Author(s)
Sakai K, Kawata E, Ashihara E, Nakagawa Y, Yamauchi A, Yao H, Nagao R, Tanaka R, Yokota A, Takeuchi M, Hirai H, Kimura S, Hirashima M, Yoshimura N, Maekawa T.
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Journal Title
Eur J Immunol
Volume: 41
Pages: 67-75
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[Journal Article] Combined effects of bisphosphonate and radiation on osteosarcoma cells2010
Author(s)
Ryu K, Murata H, Koto K, Horie N, Matsui T, Nishigaki Y, Sakabe T, Takeshita H, Itoi M, Kimura S, Ashihara E, Maekawa T, Fushiki S, Kubo T.
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Journal Title
Anticancer Res
Volume: 30
Pages: 2713-2720
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[Journal Article] Zoledronic acid inhibits proliferation of human fibrosarcoma cells with induction of apoptosis, and shows combined effects with other anticancer agents2010
Author(s)
Koto K, Murata H, Kimura S, Horie N, Matsui T, Nishigaki Y, Ryu K, Sakabe T, Ashihara E, Maekawa T, Fushiki S, Kubo T.
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Journal Title
Oncol Rep
Volume: 24
Pages: 233-239
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[Journal Article] Activity of the multi-targeted kinase inhibitor, AT9283, in imatinib-resistant BCR-ABL positive leukemic cells2010
Author(s)
Tanaka R, Squires MS, Kimura S, Yokota A, Nagao R, Yamauchi T, Takeuchi M, Yao H, Reule M, Smyth T, Lyon JF, Thompson NT, Ashihara E, Ottmann OG, Maekawa T.
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Journal Title
Blood
Volume: 116
Pages: 2089-2095
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[Journal Article] A combination of a DNA-chimera 1 siRNA against PLK-1 and zoledronic acid suppresses the growth of malignant mesothelioma cells in vitro2010
Author(s)
Kawata E, Ahihara E, Nakagawa Y, Kiuchi T, Ogura M, Yao H, Sakai K, Tanaka R, Nagao R, Yokota A, Takeuchi M, Kimura S, Hirai H, Maekawa T.
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Journal Title
Cancer Lett
Volume: 294
Pages: 245-253
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[Journal Article] Glyoxalase-I is a novel target against Bcr-Abl+ leukemic cells acquiring stem-like characteristics in hypoxic environment2010
Author(s)
Takeuchi M, Kimura S, Kuroda J, Ashihara E, Kawatani M, Osada H, Umezawa K, Yasui E, Imoto M, Tsuruo T, Yokota A, Tanaka R, Nagao R, Nakahara T, Fujiyama Y, Maekawa T.
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Journal Title
Cell Death Diff
Volume: 17
Pages: 1211-1220
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[Journal Article] Osteoclasts are involved in the maintenance of dormant leukemic cells2010
Author(s)
Yokota A, Kimura S, Tanaka R, Takeuchi M, Yao H, Sakai K, Nagao R, Kuroda J, Kamitsuji Y, Kawata E, Ashihara E, Maekawa T.
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Journal Title
Leuk Res
Volume: 34
Pages: 793-799
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[Journal Article] Isolation of mesenchymal stem cells from bone marrow in the closed system using a new device made by non-woven fabrics2010
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Ito K, Aoyama T, Fukiage K, Otsuka S, Furu M, Jin Y, Nasu A, Ueda M, Kasai Y, Ashihara E, Kimura S, Maekawa T, Kobayashi A, Yoshida S, Otsuka T, Nakamura T, Toguchida J.
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Tissue Eng Part C Methods
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Hamaguchi M, Seno T, Yamamoto A, Kohno M, Kadoya M, Ishino H, Ashihara E, Kimura S, Tsubakimoto Y, Takata H, Yoshikawa T, Maekawa T, Kawahito Y.
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Journal Title
JClin Biochem Nutr
Volume: 47
Pages: 138-147
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[Journal Article] β-catenin siRNA successfully suppressed progression of multiple myeloma in a mouse model2009
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Ashihara E, Kawata E, Nakagawa Y, Shimazaski C, Kuroda J, Tanaka R, Yokota A, Murotani Y, Takeuchi M, Kamitsuji Y, Inaba T, Taniwaki T, Kimura S, Maekawa T.
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Journal Title
Clin Cancer Res
Volume: 15
Pages: 2731-2738
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[Journal Article] Clinically relevant dose of zoledronic acid inhibits spontaneous lung metastasis in a murine osteosarcoma model2009
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Koto K, Horie N, Kimura S, Murata H, Sakabe T, Matsui T, Watanabe M, Adachi S, Maekawa T, Fushiki S, Kubo T.
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Journal Title
Cancer Lett
Volume: 274
Pages: 271-278
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