• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of novel identification methods of SNPs responsible for minor H antigens and open public internet software tool

Research Project

Project/Area Number 21591256
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionAichi Cancer Center Research Institute

Principal Investigator

AKATSUKA Yoshiki  愛知県がんセンター(研究所), 腫瘍免疫学部, 客員研究員 (70333391)

Co-Investigator(Kenkyū-buntansha) KUZUSHIMA Kiyotaka  愛知県がんセンター研究所, 腫瘍免疫学部, 部長 (30311442)
Research Collaborator OGAWA Seishi  東京大学, 医学部附属病院, 特任准教授 (60292900)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords同種造血細胞移植 / 白血病 / 腫瘍免疫 / 遺伝子多型 / 国際HapMapプロジェクト / オンラインソフトウエア / バイオテクノロジー / 免疫学 / SNP / HapMap / パイオテクノロジー
Research Abstract

Minor histocompatibility antigens(H) are polymorphic proteins targeted by donor immune cells to cure hematological malignancies following allogeneic hematopoietic cell transplantation. This immune response utilizes rejection reaction due to genetic disparities between individuals. In this study, we developed a software that can efficiently identify single nucleotide polymorphisms(SNPs) responsible for generation of minor H antigens among large number of SNPs and have made the software available via internet as researcher-friendly interactive manners.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (34 results)

All 2012 2011 2010 2009 Other

All Journal Article (11 results) (of which Peer Reviewed: 8 results) Presentation (19 results) Remarks (4 results)

  • [Journal Article] HapMap SNP Scanner : an online program to mine SNPs responsible for cell phenotype2012

    • Author(s)
      Yamamura T, Hikita J, Bleakley M, Hirosawa T, Sato-Otsubo A, Torikai H, Hamajima T, Nannya Y, Demachi-Okamura A, Maruya E, Saji H, Yamamoto Y, Takahashi T, Emi N, Morishima Y, Kodera Y, Kuzushima K, Riddell SR, Ogawa S, Akatsuka Y.
    • Journal Title

      Tissue Antigens

      Volume: (in press) Issue: 2 Pages: 119-125

    • DOI

      10.1111/j.1399-0039.2012.01883.x

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Glypican-3 could be an effective target for immunotherapy combined with chemotherapy against ovarian clear cell carcinoma2011

    • Author(s)
      Suzuki S, Yoshikawa T, Hirosawa T, Shibata K, Kikkawa F, Akatsuka Y, Nakatsura T.
    • Journal Title

      Cancer Sci

      Volume: 102 Issue: 9 Pages: 1622-9

    • DOI

      10.1111/j.1349-7006.2011.02003.x

    • NAID

      10030242806

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mismatched human leukocyte antigen class II-restricted CD8^+cytotoxic T cells may mediate selective graft-versus-leukemia effects following allogeneic hematopoietic cell transplantation2011

    • Author(s)
      Hirosawa T, Torikai H, Yanagisawa M, Kamei M, Imahashi N, Demachi-Okamura A, Tanimoto M, Shiraishi K, Ito M, Miyamura K, Shibata K, Kikkawa F, Morishima Y, Takahashi T, Emi N, Kuzushima K, Akatsuka Y.
    • Journal Title

      Cancer Sci

      Volume: 102 Issue: 7 Pages: 1281-6

    • DOI

      10.1111/j.1349-7006.2011.01949.x

    • NAID

      10029295003

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relapse of leukemia with loss of mismatched HLA resulting from uniparental disomy after haploidentical hematopoietic stem cell transplantation2010

    • Author(s)
      Villalobos IB, Takahashi Y, Akatsuka Y, Muramatsu H, Nishio N, Hama A, Yagasaki H, Saji H, Kato M, Ogawa S, Kojima S.
    • Journal Title

      Blood

      Volume: 115 Issue: 15 Pages: 3158-61

    • DOI

      10.1182/blood-2009-11-254284

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Therapy of relapsed leukemia after allogeneic hematopoietic cell transplantation with T cells specific for minor histocompatibility antigens2010

    • Author(s)
      Warren EH, Fujii N, Akatsuka Y, Chaney CN, Mito JK, Loeb KR, Gooley TA, Brown ML, Koo KK, Rosinski KV, Ogawa S, Matsubara A, Appelbaum FR, Riddell SR.
    • Journal Title

      Blood

      Volume: 115(19) Issue: 19 Pages: 3869-78

    • DOI

      10.1182/blood-2009-10-248997

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Modified ELISPOT assay may predict T-cell hyporesponsiveness to non-inherited maternal antigens2010

    • Author(s)
      Taniguchi K, Shimazaki C, Ochiai N, Maruya E, Akatsuka Y, Ashihara E, Maekawa T, Taniwaki M, Saji H.
    • Journal Title

      Int J Lab Hematol

      Volume: 32 Issue: 1p1

    • DOI

      10.1111/j.1751-553x.2008.01121.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relapse of leukemia with loss of mismatched HLA resulting from uniparental disomy after haploidentical hematopoietic stem cell transplantation.2010

    • Author(s)
      Villalobos IB, et al.
    • Journal Title

      Blood

      Volume: 115 Pages: 3158-3161

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 同種造血幹細胞移植とマイナー組織適合性抗原2010

    • Author(s)
      小川誠司, ら
    • Journal Title

      医学のあゆみ

      Volume: 233 Pages: 1217-1222

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Japan Marrow Donation Program(JMDP). Exploration of the genetic basis of GVHD by genetic association studies2009

    • Author(s)
      Ogawa S, Matsubara A, Onizuka M, Kashiwase K, Sanada M, Kato M, Nannya Y, Akatsuka Y, Satake M, Takita J, Chiba S, Saji H, Maruya E, Inoko H, Morishima Y, Kodera Y, Takehiko S
    • Journal Title

      Biol Blood Marrow Transplant

      Volume: 15 Issue: 1 Pages: 39-41

    • DOI

      10.1016/j.bbmt.2008.11.020

    • Related Report
      2011 Final Research Report
  • [Journal Article] マイナー抗原を標的とした造血器腫瘍に対する免疫療法.2009

    • Author(s)
      赤塚美樹
    • Journal Title

      血液フロンティア 19

      Pages: 559-566

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Therapy of relapsed leukemia after allogeneic hematopoietic cell transplant with T cells specific for minor histocompatibility antigens.

    • Author(s)
      Warren EH
    • Journal Title

      BLOOD (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] An online tool to scan single nucleotide polymorphisms for identification of novel minor antigens2011

    • Author(s)
      katsuka Y
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋国際会議場,名古屋市
    • Year and Date
      2011-10-14
    • Related Report
      2011 Final Research Report
  • [Presentation] An online tool to scan single nucleotide polymorphisms for identification of novel minor antigens2011

    • Author(s)
      Akatsuka Y, ら
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      国際会議場(名古屋)(ポスター#PS1-262)
    • Year and Date
      2011-10-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] マイナー組織適合抗原をコードする一塩基多型のオンライン検索ツール2011

    • Author(s)
      赤塚美樹
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋国際会議場名古屋市
    • Year and Date
      2011-10-03
    • Related Report
      2011 Final Research Report
  • [Presentation] マイナー組織適合抗原をコードする一塩基多型のオンライン検索ツール2011

    • Author(s)
      赤塚美樹, ら
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      国際会議場(名古屋)
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 同種移植後再発予防・治療を目的としたマイナー抗原ワクチン臨床試験2011

    • Author(s)
      赤塚美樹
    • Organizer
      第15回日本がん免疫学会総会
    • Place of Presentation
      千里ライフサイエンスセンター,大阪市
    • Year and Date
      2011-06-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 同種移植後再発予防・治療を目的としたマイナー抗原ワクチン臨床試験(中間報告)2011

    • Author(s)
      赤塚美樹, ら
    • Organizer
      第15回日本がん免疫学会総会
    • Place of Presentation
      千里ライフサイエンスセンタービル(大阪)(口演#39)
    • Year and Date
      2011-06-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] マイナー組織適合抗原の重要性2011

    • Author(s)
      赤塚美樹
    • Organizer
      第33回日本造血細胞移植学会・シンポジウム
    • Place of Presentation
      ひめぎんホール(愛媛県)
    • Year and Date
      2011-03-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Characterization And Clinical Application of Minor Histocompatibility Antigens2011

    • Author(s)
      Akatsuka Y
    • Organizer
      The 15th Annual Winter Meeting of the Korean Society of Blood and Marrow Transplantation
    • Place of Presentation
      Muju Resort、Muju, Korea
    • Year and Date
      2011-02-25
    • Related Report
      2011 Final Research Report
  • [Presentation] Characterization And Clinical Application of Minor Histocompatibility Antigens.2011

    • Author(s)
      Akatsuka Y, et al.
    • Organizer
      The 15th Annual Winter Meeting of the Korean Society of Blood and Marrow Transplantation
    • Place of Presentation
      Muju Resort (Muju, Korea)
    • Year and Date
      2011-02-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Development of an Online Tool to Scan Single Nucleotide Polymorphisms for Identification of Novel Minor Histocompatibility Antigens2011

    • Author(s)
      Yamamura T, et al
    • Organizer
      第17回BMT Tandem Meetings
    • Place of Presentation
      Hawaii Convention Center, Honolulu
    • Year and Date
      2011-02-19
    • Related Report
      2011 Final Research Report
  • [Presentation] Development of an Online Tool to Scan Single Nucleotide Polymorphisms for Identification of Novel Minor Histo-compatibility Antigens.2011

    • Author(s)
      Yamamura T, et al.
    • Organizer
      第17回BMT Tandem Meetings
    • Place of Presentation
      Hawaii Convention Center (Honolulu, USA)
    • Year and Date
      2011-02-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Identification of novel minor histocompatibility antigens using HAPMAP EBV-LCL panels transduced with restricting HLA cDNA retrovirally2010

    • Author(s)
      Akatsuka Y
    • Organizer
      第16回日本遺伝子治療学会総会
    • Place of Presentation
      栃木県総合文化センター,宇都宮市
    • Year and Date
      2010-07-01
    • Related Report
      2011 Final Research Report
  • [Presentation] Identification of novel minor histocompatibility antigens using HAPMAP EBV-LCL panels transduced with restricting HLA cDNA retrovirally.2010

    • Author(s)
      Akatsuka Y, et al.
    • Organizer
      第16回日本遺伝子治療学会総会
    • Place of Presentation
      栃木県総合文化センター(栃木県)
    • Year and Date
      2010-07-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] HLAクラスII不適合骨髄移植患者より樹立した不一致クラスII拘束性アロCD8+CTLクローンの解析2009

    • Author(s)
      鳥飼宏基
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      国立京都国際会館、京都市
    • Year and Date
      2009-10-25
    • Related Report
      2011 Final Research Report
  • [Presentation] HLAクラスII不適合骨髄移植患者より樹立した不一致クラスII拘束性アロCD8+CTLクローンの解析2009

    • Author(s)
      鳥飼宏基
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      京都(京都国際会議場)
    • Year and Date
      2009-10-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Clinical significance of CD8+CTL clone recognizing mismatched HLA class II2009

    • Author(s)
      Torikai H
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜,横浜市
    • Year and Date
      2009-10-02
    • Related Report
      2011 Final Research Report
  • [Presentation] Clinical significance of CD8+ CTL clone recognizing mismatched HLA class II.2009

    • Author(s)
      Torikai H
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 移植後再発白血病に対するマイナー抗原特異的CTL養子免疫療法後に重症肺GVHDの合併を来した標的抗原の同定2009

    • Author(s)
      赤塚美樹
    • Organizer
      第13回日本がん免疫学会総会
    • Place of Presentation
      北九州国際会議場,北九州市
    • Year and Date
      2009-06-24
    • Related Report
      2011 Final Research Report
  • [Presentation] 移植後再発白血病に対するマイナー抗原特異的CTL養子免疫療法後に重症肺GVHDの合併を来した標的抗原の同定2009

    • Author(s)
      赤塚美樹
    • Organizer
      第13回日本がん免疫学会総会
    • Place of Presentation
      北九州市(北九州国際会議場)
    • Year and Date
      2009-06-24
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://hapmap-scanner.fujita-hu.ac.jp/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://hapmap-scanner.fujita-hu.ac.jp/

    • Related Report
      2011 Annual Research Report
  • [Remarks] (報告時点では限定公開中)論文受理後に対話型ソフトウエアを公開予定

    • URL

      http://hapmap-scanner.fujita-hu.ac.jp/hms_ceu.html

    • Related Report
      2010 Annual Research Report
  • [Remarks] 論文受理後に対話型ソフトウエアを公開予定

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi