| Project/Area Number |
21591256
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Aichi Cancer Center Research Institute |
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Principal Investigator |
AKATSUKA Yoshiki 愛知県がんセンター(研究所), 腫瘍免疫学部, 客員研究員 (70333391)
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| Co-Investigator(Kenkyū-buntansha) |
KUZUSHIMA Kiyotaka 愛知県がんセンター研究所, 腫瘍免疫学部, 部長 (30311442)
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| Research Collaborator |
OGAWA Seishi 東京大学, 医学部附属病院, 特任准教授 (60292900)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 同種造血細胞移植 / 白血病 / 腫瘍免疫 / 遺伝子多型 / 国際HapMapプロジェクト / オンラインソフトウエア / バイオテクノロジー / 免疫学 / SNP / HapMap / パイオテクノロジー |
|---|
| Research Abstract |
Minor histocompatibility antigens(H) are polymorphic proteins targeted by donor immune cells to cure hematological malignancies following allogeneic hematopoietic cell transplantation. This immune response utilizes rejection reaction due to genetic disparities between individuals. In this study, we developed a software that can efficiently identify single nucleotide polymorphisms(SNPs) responsible for generation of minor H antigens among large number of SNPs and have made the software available via internet as researcher-friendly interactive manners.
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