Comparison analysis of two different human regulatory T cell populations

• Project/Area Number: 21591277
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: The University of Tokyo
• Principal Investigator: FUJIO Keishi 東京大学, 医学部附属病院, 助教 (70401114)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 免疫寛容 / リンパ球 / サイトカイン / 獲得免疫 / 免疫制御 / 制御性T細胞 / レトロウイルスベクター / 移植拒絶反応 / 炎症性腸疾患

Research Abstract

The functions of two newly identified regulatory T cells subsets were evaluated. Regulatory activities of human tonsilar CD4+CD25-CD45RO-cells and CD4+CD25-LAG3+cells were confirmed in graft-versus-host disease(GVHD) model induced by the transfer of human peripheral blood mononuclear cells(PBMC) to immunodeficient NOG mice.

Research Products

• [Journal Article] Regulatory T cell-mediated control of autoantibody-induced inflammation (2012)
  • Author(s): Fujio K, Okamura T, Sumitomo S, Yamamoto K.
  • Journal Title: Frontiers in Immunology Volume: 3 Pages: 28-28
  • Peer Reviewed
• [Journal Article] Roles of LAG3 and EGR2 in regulatory T cells (2012)
  • Author(s): Okamura T, Fujio K, Sumitomo S, Yamamoto K.
  • Journal Title: Ann Rheum Dis Volume: 71
  • Peer Reviewed
• [Journal Article] A genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese (2012)
  • Author(s): 岡田随象
  • Journal Title: PLoS Genetics Volume: (掲載確定) Issue: 1 Pages: 1002455-1002455
  • DOI: 10.1371/journal.pgen.1002455
  • NAID: 120005906866
  • Peer Reviewed
• [Journal Article] Regulatory T cell-associated cytokines in systemic lupus erythematosus (2011)
  • Author(s): Okamoto A, Fujio K, Okamura T, Yamamoto K.
  • Journal Title: J Biomed Biotechnol Volume: 2011 Pages: 463412-463412
  • Peer Reviewed
• [Journal Article] Detection of autoantibodies to citrullinated BiP in rheumatoid arthritis patients and pro-inflammatory role of citrullinated BiP in collagen-induced arthritis (2011)
  • Author(s): Shoda H, Fujio K, Shibuya M, Okamura T, Sumitomo S, Okamoto A, Sawada T, et al.
  • Journal Title: Arthritis Res Ther Volume: 13 Issue: 6 Pages: 1-12
  • DOI: 10.1186/ar3520
  • Peer Reviewed
• [Journal Article] Regulatory T-cell-associated cytokines in systemic lupus erythematosus (2011)
  • Author(s): Okamoto A, Fujio K, Okamura T, Yamamoto K
  • Journal Title: J Biomed Biotechnol Volume: 2011 Issue: 1 Pages: 463412-463412
  • DOI: 10.1155/2011/463412
  • Peer Reviewed
• [Journal Article] The future of lupus therapy modulating autoantigen recognition (2010)
  • Author(s): Okamoto A, Fujio K, Yamamoto K.
  • Journal Title: Lupus Volume: 19 Pages: 1474-1474
  • Peer Reviewed
• [Journal Article] The family of IL-10 secreting CD4+T cells (2010)
  • Author(s): Fujio K, Okamura T, Yamamoto K.
  • Journal Title: Adv Immunol Volume: 105 Pages: 99-99
  • Peer Reviewed
• [Journal Article] Regulatory polymorphisms in EGR2 are associated with susceptibility to systemic lupus erythematosus (2010)
  • Author(s): Myouzen K, Kochi Y, Shimane K, Fujio K, Okamura T, Okada Y, Suzuki A, Atsumi T, Ito S, Takada K, Mimori A, Ikegawa S, Yamada R, Nakamura Y, Yamamoto K.
  • Journal Title: Hum Mol Genet Volume: 19 Pages: 2313-2313
  • Peer Reviewed
• [Journal Article] The Family of IL-10-secreting CD4+ T cells. (2010)
  • Author(s): Fujio K, Okamura T, Yamamoto K.
  • Journal Title: Adv lmmunol Volume: 105 Pages: 99-130
  • Peer Reviewed
• [Journal Article] Regulatory polymorphisms in EGR2 are associated with susceptibility to systemic lupus erythematosus. (2010)
  • Author(s): Myouzen K, Kochi Y, Shimane K, Fujio K, Okamura T, Okada Y, Suzuki A, Atsumi T, Ito S, Takada K, Mimori A, Ikegawa S, Yamada R, Nakamura Y, Yamamoto K
  • Journal Title: Hum Mol Genet Volume: 19 Pages: 2313-2320
  • Peer Reviewed
• [Journal Article] The future of lupus therapy modulating autoantigen recognition. (2010)
  • Author(s): Okamoto A, Fujio K, Yamamoto K.
  • Journal Title: Lupus. Volume: 19 Pages: 1474-1481
  • Peer Reviewed
• [Journal Article] Regulatory polymorphisms in EGR2 are associated with susceptibility to systemic lupus erythematosus. (2010)
  • Author(s): Myouzen K, Kochi Y, Shimane K, Fujio K, Okamura T, Okada Y, Suzuki A, Atsumi T, Ito S, Takada K, Mimori A, Ikegawa S, Yamada R, Nakamura Y, Yamamoto K
  • Journal Title: Human Molecular Genetics (E-Pvb)
  • Peer Reviewed
• [Journal Article] CD4+CD25-LAG3+regulatory T cells controlled by the transcription factor Egr-2 (2009)
  • Author(s): Okamura T, Fujio K, Shibuya M, Sumitomo S, Shoda H, Sakaguchi S, Yamamoto K.
  • Journal Title: Proc Natl Acad Sci USA. Volume: 106 Pages: 13974-13974
  • Peer Reviewed
• [Journal Article] CD4+CD25-LAG3+ regulatory T cells controlled by the trans cription factor Egr-2. (2009)
  • Author(s): Okamura T, Fujio K, Shibuya M, Sumitomo S, Shoda H, Sakaguchi S, Yamamoto K
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America 106 Pages: 13974-13979
  • Peer Reviewed
• [Presentation] CD4+CD25-LAG3+regulatory T cells and autoimmunity (2012)
  • Author(s): Keishi Fujio
  • Organizer: 8^<th> International Congress on Autoimmunity
  • Place of Presentation: グラナダ、スペイン
  • Year and Date: 2012-05-10
• [Presentation] 制御性T細胞と自己免疫 (2012)
  • Author(s): 藤尾圭志
  • Organizer: 日本リウマチ学会、第56回日本リウマチ学会学術総会シンポジウム
  • Place of Presentation: グランドプリンスホテル新高輪、東京、日本
  • Year and Date: 2012-04-27
• [Presentation] CD4+CD25-LAG3+regulatory T cells and autoimmune disease (2011)
  • Author(s): 藤尾圭志
  • Organizer: 第40回日本免疫学会学術総会
  • Place of Presentation: 幕張メッセ、千葉、日本
  • Year and Date: 2011-11-29
• [Presentation] CD4+CD25+LAG3+regulatory T cells and autoimmune disease (2011)
  • Author(s): KEISHI FUJIO
  • Organizer: 第40回日本免疫学会学術総会シンポジウム
  • Place of Presentation: 幕張メッセ(招待講演)
  • Year and Date: 2011-11-29
• [Presentation] CD4+CD25-LAG3+regulatory T cells and autoimmunity (2011)
  • Author(s): Keishi Fujio
  • Organizer: Autoimmunity Congress Asia 2011
  • Place of Presentation: シンガポール、シンガポール
  • Year and Date: 2011-11-18
• [Presentation] CD4陽性CD25陰性LAG3陽性制御性T細胞と自己免疫疾患 (2011)
  • Author(s): 藤尾圭志
  • Organizer: 第39回日本臨床免疫学会総会
  • Place of Presentation: 東京、日本
  • Year and Date: 2011-09-17
• [Presentation] Immunological intervention strategies aimed at regulatory T cells (2010)
  • Author(s): Keishi Fujio
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2010-08-23
• [Presentation] The similarity between human tonsil CD4+CD25-LAG3+ T cells and mouse CD4+CD25-LAG3+ regulatory T cells (2009)
  • Author(s): Sumitomo S, Fujio K, Okamura T, Shoda H, Yamamoto K
  • Organizer: 第39回日本免疫学会総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-12-03
• [Remarks]
  • URL: http://plaza.umin.ac.jp/~areriu18/
• [Remarks]
  • URL: http://plaza.umin.ac.jp/~areriu18/
• [Remarks]
  • URL: http://plaza.umin.ac.jp/~rareriu18/
• [Remarks]
  • URL: http://plaza.umin.ac.jp/%7Eareriul8/