Prophylactic therapy of bronchial asthma utilizing TLR4 signaling.

• Project/Area Number: 21591283
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Saga University
• Principal Investigator: OHTA Shoichiro 佐賀大学, 医学部, 助教 (20346886)
• Co-Investigator(Kenkyū-buntansha): IZUHARA Kenji 佐賀大学, 医学部, 教授 (00270463) ; SUZUKI Shoichi 佐賀大学, 医学部, 助教 (40253695) ; SHIRAISHI Hiroshi 佐賀大学, 医学部, 助教 (80452837)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: アレルギー学 / 気管支喘息 / TLR4 / モノクローナル抗体 / LPSトレランス

Research Abstract

We elucidated a mechanism that the agonistic stimulation of TLR4 suppresses airway hyperreactivity in ovalbumin-sensitized mice. Expression of antigen presentation-associated molecules on dendritic cells is attenuated by LPS tolerance induced by agonistic stimulation of TLR4. Therefore, sensitization of CD4+ T cells is inhibited, leading to the suppression of airway inflammation and thereby airway hyperreactivity.

Research Products

• [Journal Article] The usefulness of combined measurements of squamous cell carcinoma antigens 1 and 2 in diagnosing atopic dermatitis (2012)
  • Author(s): Shoichiro Ohta, Rumiko Shibata, Yoshifumi Nakao, Yoshinori Azuma, Kazuto Taniguchi, Kazuhiko Arima, Shoichi Suzuki, Hiroshi Shiraishi, Tsuyoshi Iwasaka and Kenji Izuhara
  • Journal Title: Ann Clin Biochem Volume: 49 Pages: 277-284
• [Journal Article] Periostin, a matricellular protein, accelerates cutaneous wound repair by activating dermal fibroblasts (2012)
  • Author(s): Kanako Ontsuka, Yorihisa Kotobuki, Hiroshi Shiraishi, Satoshi Serada, Shoichiro Ohta, Atsushi Tanemura, Lingli Yang, Minoru Fujimoto, Kazuhiko Arima, Shoichi Suzuki, Hiroyuki Murota, Shuji Toda, Akira Kudo, Simon J. Conway, Yutaka Narisawa, Ichiro Katayam
  • Journal Title: Exp Dermatol Volume: 21 Pages: 331-336
• [Journal Article] The RP105/MD-1 complex is indispensable for TLR4/MD-2-dependent proliferation and IgM-secreting plasma cell differentiation of marginal zone B cells (2012)
  • Author(s): Yoshinori Nagai
  • Journal Title: International Immunology Volume: (in press) Issue: 6 Pages: 389-400
  • DOI: 10.1093/intimm/dxs040
  • Peer Reviewed
• [Journal Article] The usefulness of combined measurements of squamous cell carcinoma antigens 1 and 2 in diagnosing atopic dermatitis (2012)
  • Author(s): Shoichiro Ohta
  • Journal Title: Annals of Clinical Biochemistry Volume: (in press) Issue: 3 Pages: 277-284
  • DOI: 10.1258/acb.2011.011065
  • Peer Reviewed
• [Journal Article] Periostin, a matrix protein, is a novel biomarker for idiopathic interstitial pneumonias (2011)
  • Author(s): Masaki Okamoto, Tomoaki Hoshino, Yasuhiko Kitasato, Yuki Sakazaki, Tomotaka Kawayama, Kiminori Fujimoto, Koichi Ohshima, Hiroshi Shiraishi, Masaru Uchida, Junya Ono, Shoichiro Ohta, Seiya Kato, Kenji Izuhara, and Hisamichi Aizawa
  • Journal Title: Eur Respir J Volume: 37 Pages: 1119-1127
• [Journal Article] Periostin, a matrix protein, has potential as a novel serodiagnostic marker for cholangiocarcinoma (2011)
  • Author(s): Kiminori Fujimoto, Takumi Kawaguchi, Osamu Nakashima, Junya Ono, Shoichiro Ohta, Atsushi Kawaguchi, Tatsuyuki Tonan, Koichi Ohshima, Hirohisa Yano, Naofumi Hayabuchi, Kenji Izuhara, and Michio Sata
  • Journal Title: Oncol Rep Volume: 25 Pages: 1211-1216
• [Journal Article] Increased Expression of Periostin in Vitreous and Fibrovascular Membranes Obtained from Patients with Proliferative Diabetic Retin (2011)
  • Author(s): Shigeo Yoshida, Keijiro Ishikawa, Ryo Asato, Mitsuru Arima, Yukio Sassa, Ayako Yoshida, Hiroshi Yoshikawa, Keisuke Narukawa, Satoshi Obika, Junya Ono, Shoichiro Ohta, Kenji Izuhara, Toshihiro Kono, and Tatsuro Ishibashi
  • Journal Title: Invest Ophth Vis Sci Volume: 52 Pages: 5670-5678
• [Journal Article] Treatment in Chronic Renal Failure Patients with Dementia Receiving Hemodialysis : An Open Label Study (2011)
  • Author(s): Hidenori Sumiyoshi, Akio Mantani, Satoshi Nishiyama, Soh Fujiwaki, Shoichiro Ohta, Yoshikazu Masuda, Youhei Tomita, Naofumi Tarumoto, and Shigeto Yamawaki Yokukansan
  • Journal Title: Am J Geriatr Psych Volume: 19 Pages: 906-907
• [Journal Article] Periostin, a matrix protein, is a novel biomarker for idiopathic interstitial pneumonias (2011)
  • Author(s): Okamoto, M., Hoshino, T., 他
  • Journal Title: Eur Respir J Volume: 37 Issue: 5 Pages: 1119-27
  • DOI: 10.1183/09031936.00059810
  • Peer Reviewed
• [Journal Article] Periostin, a matrix protein, has potential as a novel serodiagnostic marker for cholangiocarcinoma (2011)
  • Author(s): Kiminori Fujimoto
  • Journal Title: Oncology Reports Volume: 25 Issue: 5 Pages: 1211-1216
  • DOI: 10.3892/or.2011.1194
  • Peer Reviewed
• [Journal Article] Increased Expression of Periostin in Vitreous and Fibrovascular Membranes Obtained from Patients with Proliferative Diabetic Retinopathy (2011)
  • Author(s): Shigeo Yoshida
  • Journal Title: Investigative Ophthalmology & Visual Science Volume: 52 Issue: 8 Pages: 5670-5678
  • DOI: 10.1167/iovs.10-6625
  • Peer Reviewed
• [Journal Article] Yokukansan Treatment in Chronic Renal Failure Patients with Dementia Receiving Hemodialysis : An Open Label Study (2011)
  • Author(s): Hidenori Sumiyoshi
  • Journal Title: American Journal of Geriatric Psychiatry Volume: 19 Issue: 10 Pages: 906-907
  • DOI: 10.1097/jgp.0b013e318227f88e
  • Peer Reviewed
• [Journal Article] Pendrin function in airway epithelia (2011)
  • Author(s): Charity Nofziger
  • Journal Title: Cellular Physiology and Biochemistry Volume: 28 Issue: 3 Pages: 571-578
  • DOI: 10.1159/000335115
  • Peer Reviewed
• [Journal Article] Epigen is induced during the interleukin-13-stimulated cell proliferation in murine primary airway epithelial cells (2011)
  • Author(s): Kazuto Taniguchi
  • Journal Title: Experimental Lung Research Volume: 37 Issue: 8 Pages: 461-470
  • DOI: 10.3109/01902148.2011.596894
  • Peer Reviewed
• [Journal Article] アトピー性皮膚炎「アトピー性皮膚炎のモデルマウス」 (2011)
  • Author(s): 増岡美穂
  • Journal Title: アレルギー・免疫 Volume: 18 Pages: 332-339
  • Peer Reviewed
• [Journal Article] Influences of %T>MIC Achievement Probability Due to the Difference of the MIC Measurement Concentration Range-Analysis of Meropenem for Pseudomonas aeruginosa (2011)
  • Author(s): 永沢善三
  • Journal Title: 臨床微生物迅速診断研究会誌 Volume: 22 Pages: 10-22
  • Peer Reviewed
• [Journal Article] Endotoxin tolerance attenuates airway allergic inflammation in model mice by suppression of the T-cell stimulatory effect of dendritic cells (2010)
  • Author(s): Hidetomo Matsushita, Shoichiro Ohta, Hiroshi Shiraishi, Shoichi Suzuki, Kazuhiko Arima, Shuji Toda, Hiroyuki Tanaka, Hiroichi Nagai, Masao Kimoto, Akira Inokuchi, and Kenji Izuhara
  • Journal Title: Int Immunol Volume: 22 Pages: 739-747
  • NAID: 10030913704
• [Journal Article] Endotoxin tolerance attenuates airway allergic inflammation in model mice by suppression of the T-cell stimulatory effect of dendritic cells. (2010)
  • Author(s): Hidetomo Matsushita
  • Journal Title: International Immunology Volume: 22 Pages: 739-747
  • Peer Reviewed
• [Journal Article] アレルギー疾患の生化学的検査方法 (2010)
  • Author(s): 出原賢治
  • Journal Title: 臨床と研究 Volume: 87 Pages: 221-225
• [Journal Article] 炎症メディエーター主なサイトカイン インターロイキン13 (2010)
  • Author(s): 出原賢治
  • Journal Title: 日本臨牀 Volume: 68 Pages: 141-144
• [Journal Article] アレルギー疾患の生化学的検査法 (2010)
  • Author(s): 出原賢治
  • Journal Title: 臨床と研究 87 Pages: 221-225
• [Journal Article] 炎症メディエーター 主なサイトカイン インターロイキン13 (2010)
  • Author(s): 出原賢治
  • Journal Title: 日本臨床 68 Pages: 141-144
• [Journal Article] Identification of four novel mutations in F5 associated with congenital factor V deficiency (2009)
  • Author(s): Sachiko Kanaji, Taisuke Kanaji, Miho Honda, Sachie Nakazato, Kazuo Wakayama, Yoshitomi Tabata, Shoichiro Shibata, Hisashi Gondo, Ikuko Nakamura, Koichi Node, Masanori Miura, Masaharu Miyahara, Takashi Okamura, Fumio Nagumo, Shoichiro Ohta, and Kenji Izuha
  • Journal Title: Int J Hematol Volume: 89 Pages: 71-75
• [Journal Article] Distinct structural requirements for IL-4 and IL-13 binding to the shared IL-13 receptor facilitate cellular tuning of cytokine responsiveness (2009)
  • Author(s): Takachika Ito, Shoichi Suzuki, Sachiko Kanaji, Hiroshi Shiraishi, Shoichiro Ohta, Kazuhiko Arima, Go Tanaka, Taro Tamada, Eijiro Honjo, K. Christopher Garcia, Ryota Kuroki, and Kenji Izuhara
  • Journal Title: J Biol Chemy Volume: 284 Pages: 4289-24296
• [Journal Article] The mechanism of mucus production in bronchial asthma (2009)
  • Author(s): Kenji Izuhara, Shoichiro Ohta, Hiroshi Shiraishi, Shoichi Suzuki, Kazuto Taniguchi, Shuji Toda, Tsuyoshi Tanabe, Yasuo M, Kubo K, Tomoaki Hoshino, and Hisamichi Aizawa
  • Journal Title: Curr Med Chem Volume: 16 Pages: 2867-2875
• [Journal Article] Identification of four novel mutations in F5 associated with congenital factor V deficiency. (2009)
  • Author(s): Sachiko Kanaji
  • Journal Title: Int J Hematol 89 Pages: 71-75
  • Peer Reviewed
• [Journal Article] Distinct structural requirements for IL-4 and IL-13 binding to the shared IL-13 receptor facilitate cellular tuning of cytokine responsiveness. (2009)
  • Author(s): Takachika Ito
  • Journal Title: J Biol Chem 284 Pages: 24289-24296
  • Peer Reviewed
• [Journal Article] The mechanism of mucus production in bronchial asthma. (2009)
  • Author(s): Kenji Izuhara
  • Journal Title: Curr Med Chem 16 Pages: 2867-2875
  • Peer Reviewed
• [Journal Article] IL-4/IL-13で誘導されるアレルギー性炎症 (2009)
  • Author(s): 出原賢治
  • Journal Title: 実験医学 27 Pages: 3297-3302
• [Journal Article] 基礎研究と応用研究との橋渡しへ (2009)
  • Author(s): 出原賢治
  • Journal Title: 呼吸 28 Pages: 339-340
• [Presentation] 細胞外マトリクスタンパク質「ペリオスチン」は、皮膚線維芽細胞の活性化を介して創傷治癒を促進する (2011)
  • Author(s): 御塚加奈子
  • Organizer: 第15回九州基礎皮膚科研究会
  • Place of Presentation: 福岡
  • Year and Date: 2011-12-03
• [Presentation] Enhanced expression of periostin in lungs and sera of idiopathic pulmonary fibrosis (2011)
  • Author(s): Tomoaki Hoshino, Masaki Okamoto, Yasuhiko Kitasato, Shoichiro Ohta, Hiroshi Shiraishi, Masaru Uchida, Seiya Kato, Koichi Ohshima, Kenji Izuhara, and Hisamichi Aizawa
  • Organizer: 14th Congress of the Asian Pacific Society of Respirology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2011-11-14
• [Presentation] Bacteriologyの核酸検査の現状と今後の方向性 (2011)
  • Author(s): 出原賢治
  • Organizer: 第6回九州遺伝子診断研究会
  • Place of Presentation: 長崎
  • Year and Date: 2011-09-10
• [Presentation] 特発性間質性肺炎(IIPs)における細胞外マトリクス蛋白ペリオスチン発現の解析 (2011)
  • Author(s): 第14回岡元昌樹
  • Organizer: 間質性肺炎細胞分子病態研究会
  • Place of Presentation: 東京
  • Year and Date: 2011-08-20
• [Presentation] 細胞外マトリクス蛋白ペリオスチンは、特発性間質性肺炎(IIPs)の新たなバイオマーカーとなり得る (2011)
  • Author(s): 岡元昌樹
  • Organizer: 第3回びまん性肺疾患バイオマーカー研究会
  • Place of Presentation: 東京
  • Year and Date: 2011-08-19
• [Presentation] Development of combined measurement of squamous cell carcinoma antigens 1 and 2 as a potential companion diagnostic for anti-IL-4/ IL-13 therapies in allergic diseases (2011)
  • Author(s): Shoichiro Ohta, Rumiko Shibata, Yoshifumi Nakao, Yoshinori Azuma, Kazuto Taniguchi, Kazuhiko Arima, Shoichi Suzuki, Hiroshi Shiraishi, Tsuyoshi Iwasaka, and Kenji Izuhara
  • Organizer: 21st International Congress of Clinical Chemistry and Laboratory Medicine
  • Place of Presentation: Berlin, Germany
• [Presentation] Yokukansan treatment of chronic renal failure patients receiving hemodialysis, with behavioral and psychological symptoms of dementia : An open-label study (2011)
  • Author(s): Makoto Hayashi, Akio Mantani, Hidenori Sumiyoshi, Satoshi Nishiyama, Soh Fujiwaki, Shoichiro Ohta, Yoshikazu Masuda, Youhei Tomita, Naofumi Tarumoto, and Shigeto Yamawaki
  • Organizer: 11th Annual Meeting of the International College of Geriatric Psychoneuropharmacology
  • Place of Presentation: Irvine, CA
• [Presentation] Pendrin and airway inflammation (2011)
  • Author(s): Kenji Izuhara
  • Organizer: ESF Exploratory workshop on tne peoteomics, epigenetics, and pharmacogenetics of pendrin
  • Place of Presentation: ザルツブルグ、オーストリア国
• [Presentation] Development of combined measurement of squamous cell carcinoma antigens 1 and 2 as a potential companion diagnostic for anti-IL-4/IL-13 therapies in allergic diseases (2011)
  • Author(s): Shoichiro Ohta
  • Organizer: 21st International Congress of Clinical Chemistry and Laboratory Medicine
  • Place of Presentation: ペルリン、ドイツ国
• [Presentation] Periostin is a critical mediator for acute lung injury induced by chemot herapeutic agents (2011)
  • Author(s): Masaru Uchida
  • Organizer: 2011 American Thoracic Society International Conference
  • Place of Presentation: デンバー、米国
• [Presentation] Yokukansan treatment of chronic renal failure patients receiving hemodialysis, with behavioral and psychological symptoms of dementia : An open-label study (2011)
  • Author(s): Makoto Hayashi
  • Organizer: 11th Annual Meeting of the International College of Geriatric Psychoneuropharmacology
  • Place of Presentation: アーバイン、米国
• [Presentation] 細胞外マトリックスを介したアトピー性皮膚炎の病態形成 (2011)
  • Author(s): 有馬和彦
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
• [Presentation] ペンドリンと気道炎症 (2011)
  • Author(s): 出原賢治
  • Organizer: 第84回日本内分泌学会学術総会
  • Place of Presentation: 神戸
• [Presentation] 好酸球性中耳炎におけるPeriostin (2011)
  • Author(s): 松原篤
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
• [Presentation] アレルギー疾患の新規バイオマーカーとしてのSCCA-アレルギー疾患における個の医療の実現に向けて- (2011)
  • Author(s): 太田昭一郎
  • Organizer: 第51回日本臨床化学会年次学術集会
  • Place of Presentation: 札幌
• [Presentation] 好酸球前駆細胞特異的なIL-25受容体発現の意義の解明 (2011)
  • Author(s): 續啓史
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
• [Presentation] ペジオスチンはインターロイキン6産生を介して表皮角化細胞の増殖・分化に関与する (2011)
  • Author(s): 谷口一登
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 千葉
• [Presentation] Inhibition of primary but not secondary himoral immune responses by pre-injection of an agonistic anti-TLR4/MD-2 antibody (2011)
  • Author(s): Nurlaely Mida Rachmawati
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 千葉
• [Presentation] 質量分析計MALDI Biotyperの同定性能評価-ATCC株を対象とした同定精度および血液培養ボトルからの迅速性- (2011)
  • Author(s): 宇木望
  • Organizer: 第58回日本臨床検査医学会学術集会
  • Place of Presentation: 岡山
• [Presentation] Periostin, a matrix protein, is a novel serodiagnostic marker for cholangiocarcinoma. (2010)
  • Author(s): Takumi Kawaguchi
  • Organizer: The 61th annual meeting of the American association for the study of Liver diseases
  • Place of Presentation: 米国サンフランシスコ市
  • Year and Date: 2010-10-29
• [Presentation] Inhibition mechanism of Interleukin-13(IL-13)signal by extracellular region of Interleukin-13 receptorα2 chain(IL-13Rα2) (2010)
  • Author(s): Fumiko Matsumoto
  • Organizer: 第48回日本生物物理学会年会
  • Place of Presentation: 仙台市
  • Year and Date: 2010-09-20
• [Presentation] 新規バイオマーカーとしての血清ペリオスチン値の測定意義 (2010)
  • Author(s): 小野純也
  • Organizer: 第57回日本臨床検査医学会学術集会
  • Place of Presentation: 東京都
  • Year and Date: 2010-09-11
• [Presentation] Periostin, an extracellular matrix protein, is a critical mediator for amplification and chronicity inflammation in atopic dermatitis. (2010)
  • Author(s): Miho Masuoka
  • Organizer: 14th International Congress of Immunolo
  • Place of Presentation: 神戸市
  • Year and Date: 2010-07-22
• [Presentation] The RP 105/MD-1 complex is required for TLR4/MD-2-dependent plasma cell differentiation and robust IgM production in marginal zone B cells (2010)
  • Author(s): Yoshinori Nagai
  • Organizer: 14th International Congress of Immunolo
  • Place of Presentation: 神戸市
  • Year and Date: 2010-07-22
• [Presentation] Enhanced expression of periostin in lungs and sera of idiopathic pulmonary fibrosis. (2010)
  • Author(s): Tomoaki Hoshino
  • Organizer: 2010 American Thoracic Society International Conference
  • Place of Presentation: 米国ニューオーリーンズ市
  • Year and Date: 2010-05-14
• [Presentation] Periostin, an extracellular matrix protein, acts as a master switch for the onset of inflammation in atopic dermatitis. (2010)
  • Author(s): Kenji Izuhara
  • Organizer: 28th Symposium of the collegium Internationale Allergologicum
  • Place of Presentation: イタリア国イスキア島
  • Year and Date: 2010-04-25
• [Presentation] a matrix protein, is a novel serodiagnostic marker for cholangiocarcinoma (2010)
  • Author(s): Takumi Kawaguchi, Kiminori Fujimoto, Osamu Nakashima, Shoichi Suzuki, Hiroshi Shiraishi, Shoichiro Ohta, Atsushi Kawaguchi, Tatsuyuki Tonan, Koichi Oshima, Hirohisa Yano, Naofumi Hayabuchi, Kenji Izuhara, Michio Sata Periostin
  • Organizer: The 61st annual meeting of the American association for the study of Liver diseases
  • Place of Presentation: San Francisco, CA
• [Presentation] Enhanced expression of periostin in lungs and sera of idiopathic pulmonary fibrosis (2010)
  • Author(s): Tomoaki Hoshino, Masaki Okamoto, Kitasato Y, Shoichiro Ohta, Masaru Uchida, Kato S, Kawayama T, Kenji Izuhara, Hiromichi Aizawa
  • Organizer: T2010 American Thoracic Society International Conference
  • Place of Presentation: New Orleans
• [Presentation] an extracellular matrix protein, acts as a master switch for the onset of inflammation in atopic dermatitis (2010)
  • Author(s): Kenji Izuhara, Miho Masuoka, Hiroshi Shiraishi, Shoichiro Ohta, Shoichi Suzuki Periostin
  • Organizer: 28th Symposium of the collegium Internationale Allergologicum
  • Place of Presentation: Ischia, Italy
• [Presentation] an extracellular matrix protein, is a critical mediator for amplification and chronicity inflammation in atopic dermatitis (2010)
  • Author(s): Miho Masuoka, Hiroshi Shiraishi, Shoichiro Ohta, Shoichi Suzuki, Hajime Sutoh, Naoki Inagaki, Masutaka Furue, Kenji Izuhara Periostin
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: Kobe, Japan
• [Presentation] The RP105/ MD-1 complex is required for TLR4/ MD-2-dependent plasma cell differentiation and robust IgM production in marginal zone B cells (2010)
  • Author(s): Yoshinori Nagai, Shoichiro Ohta, Masahi Ikutani, Ai kariyone, Kensuke Miyake, Kiyoshi Takatsu
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: Kobe, Japan
• [Presentation] A new paradigm in the pathogenesis of atopic dermatitis. (2009)
  • Author(s): Kenji Izuhara
  • Organizer: XXI World Allergy Congress
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 2009-12-08
• [Presentation] サイトカインとアレルギー疾患 (2009)
  • Author(s): 出原賢治
  • Organizer: 第46回日本小児アレルギー学会
  • Place of Presentation: 福岡市
  • Year and Date: 2009-12-05
• [Presentation] 気管支喘息における陰イオンチャンネルの役割 (2009)
  • Author(s): 谷口一登
  • Organizer: 第46回日本小児アレルギー学会
  • Place of Presentation: 福岡市
  • Year and Date: 2009-12-05
• [Presentation] Inhibitory effects of TLR4 signaling on allergic airway inflammation. (2009)
  • Author(s): Shoichiro Ohta
  • Organizer: 第39回日本免疫学会総会学術総会
  • Place of Presentation: 大阪市
  • Year and Date: 2009-12-04
• [Presentation] Distinct structural requirements for IL-4 and IL-13 binding to the shared IL-13 receptor facilitate cellular turning of cytokine responsiveness. (2009)
  • Author(s): Shoichi Suzuki
  • Organizer: 第39回日本免疫学会総会学術総会
  • Place of Presentation: 大阪市
  • Year and Date: 2009-12-04
• [Presentation] 細胞外マトリックスタンパク質であるペリオスチンはアトピー性皮膚炎の病態形成において重要な役割を果たしている (2009)
  • Author(s): Miho Masuoka
  • Organizer: 第39回日本免疫学会総会学術総会
  • Place of Presentation: 大阪市
  • Year and Date: 2009-12-03
• [Presentation] Periostin plays an important role in the pathogenesis of pulmonary fibrosis (2009)
  • Author(s): Masaru Uchida, Shoichiro Ohta, Hiroshi Shiraishi, Koichi Ohshima, Masaki Okamoto, Tomoaki Hoshino, Hisamichi Aizawa, Simon J. Conway, and Kenji Izuhara
  • Organizer: Allergy and Asthma, Fibrosis, Keystone Symposia
  • Place of Presentation: Keystone, CO
  • Year and Date: 2009-11-14
• [Presentation] Enhanced expression of periostin in lungs and sera of idiopathic pulmonary fibrosis. (2009)
  • Author(s): Tomoaki Hoshino
  • Organizer: 14th Congress of the Asian Pacific Society of Respirology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2009-11-14
• [Presentation] インターロイキン13受容体α2(IL-13R□2)の調製とその性質 (2009)
  • Author(s): 松本富美子
  • Organizer: 第47回日本生物物理学会年会
  • Place of Presentation: 徳島市
  • Year and Date: 2009-11-01
• [Presentation] アレルギー疾患の生化学的検査方法 (2009)
  • Author(s): 出原賢治
  • Organizer: 第59回日本アレルギー学会秋季学術大会
  • Place of Presentation: 秋田市
  • Year and Date: 2009-10-30
• [Presentation] 気管支喘息患者におけるIL-13遺伝子多型と気道リモデリング (2009)
  • Author(s): 長島広相
  • Organizer: 第59回日本アレルギー学会秋季学術大会
  • Place of Presentation: 秋田市
  • Year and Date: 2009-10-30
• [Presentation] 細胞外マトリックスタンパク質ペリオスチンを標的としたアトピー性皮膚炎の治療の試み (2009)
  • Author(s): 白石裕士
  • Organizer: 第59回日本アレルギー学会秋季学術大会
  • Place of Presentation: 秋田市
  • Year and Date: 2009-10-30
• [Presentation] オーダーメイド医療を目指したアレルギー疾患における病因診断システムの確立 (2009)
  • Author(s): 出原賢治
  • Organizer: 第56回日本臨床検査医学会学術集会
  • Place of Presentation: 札幌市
  • Year and Date: 2009-08-26
• [Presentation] Expression of periostin in small peripheral lung adenocarcinoma : Correlation with high-resolution CT findings, pathologic findings, and likelihood of tumor recurrence. (2009)
  • Author(s): Ryouji Iwamoto
  • Organizer: 13th world conference on lung cancer
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2009-08-01
• [Presentation] アレルギー疾患の発症機序における環境要因の役割 (2009)
  • Author(s): 出原賢治
  • Organizer: 第18回日本臨床環境医学会学術集会
  • Place of Presentation: 岡山市
  • Year and Date: 2009-07-04
• [Presentation] 特発性肺線維症(IPF)における細胞外マトリクス分子ペリオスチン発現の解析 (2009)
  • Author(s): 岡元昌樹
  • Organizer: 第49回日本呼吸器学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2009-06-14
• [Presentation] IL-4/IL-13拮抗剤選択に向けての新規バイオマーカーの開発 (2009)
  • Author(s): 太田昭一郎
  • Organizer: 第21回日本アレルギー学会春季臨床大会
  • Place of Presentation: 岐阜市
  • Year and Date: 2009-06-05
• [Presentation] TLR4/ MD-2 and RP105/ MD-1 differentially regulate LPS responsiveness in B cells (2009)
  • Author(s): Yoshinori Nagai, Shoichiro Ohta, Kensuke Miyake, Kiyoshi Takatsu
  • Organizer: The 96th Annual Meeting of The American Association of Immunologists
  • Place of Presentation: Seattle, WA
  • Year and Date: 2009-05-08
• [Presentation] TLR4/MD-2 and RP105/MD-1 differentially regulate LPS responsiveness in B cells. (2009)
  • Author(s): Yoshinori Nagai
  • Organizer: The 96th Annual Meeting of The American Association of Immunologists
  • Place of Presentation: Seattle, USA
  • Year and Date: 2009-05-08
• [Presentation] Inhibitory effects of TLR4 signals on allergic airway inflammation (2009)
  • Author(s): Hidetomo Matsushita, Shoichiro Ohta, Hiroshi Shiraishi, and Kenji Izuhara
  • Organizer: Allergy and Asthma, Fibrosis, Keystone Symposia
  • Place of Presentation: Keystone, CO
  • Year and Date: 2009-01-22
• [Presentation] TLR4/ MD-2 and RP105/ MD-1 differentially regulate LPS responsiveness in B cells (2009)
  • Author(s): Yoshinori Nagai, Shoichiro Ohta, Kensuke Miyake, Kiyoshi Takatsu
  • Organizer: The 9th World Congress on Inflammation
  • Place of Presentation: Tokyo, Japan
• [Book] Interleukin 4, interleukin 13, and interleukin 9. Inflammation and Allergy Drug Design (2011)
  • Author(s): Kenji Izuhara, Shoichiro Ohta, Hiroshi Shiraishi, and Shoichi Suzuki
  • Publisher: Blackwell Publishing
• [Book] Inflammation and Allergy Drug Design (2011)
  • Author(s): Kenji Izuhara
  • Publisher: Wiley-Blackwell, London
• [Book] 第30回六甲カンファレンス2010年における気管支喘息のすべて (2011)
  • Author(s): 出原賢治
  • Publisher: ライフサイエンス出版、東京
• [Book] 疾患モデルの作製と利用-免疫疾患 (2011)
  • Author(s): 出原賢治
  • Publisher: 株式会社エル・アイ・シー、東京
• [Book] Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease Environmental and Genetic Factors in Allergy and Clinical Immunology (2010)
  • Author(s): Kenji Izuhara, Sachiko Kanaji, Isao Nakao, Kazuhiko Arima, Aya Nakajima, Shoichiro Ohta, Hiroyuki Tanaka, and Hiroichi Nagai
• [Book] Environmental and Genetic factors in allergy and clinical immunology (2010)
  • Author(s): Kenji Izuhara
  • Publisher: Pacini editore medicina, Italy
• [Remarks]
  • URL: http://www.biomol.med.saga-u.ac.jp/medbiochem/index.php
• [Remarks]
  • URL: http://www.biomol.med.saga-u.ac.jp/medbiochem/index.php
• [Remarks]
  • URL: http://www.biomol.med.saga-u.ac.jp/medbiochem/index.php
• [Remarks]
  • URL: http://www.biomol.med.saga-u.ac.jp/medbiochem/index.php
• [Patent(Industrial Property Rights)] 気管支喘息の予防又は治療薬及びそのスクリーニング方法 (2012)
  • Inventor(s): 太田昭一郎、出原賢治、有馬和彦、鈴木章一、白石裕士
  • Industrial Property Rights Holder: 佐賀大学
  • Industrial Property Number: 2012-011838
  • Filing Date: 2012-01-24
• [Patent(Industrial Property Rights)] 気管支喘息の予防又は治療薬及びそのスクリーニング方法 (2012)
  • Inventor(s): 太田昭一郎
  • Industrial Property Rights Holder: 佐賀大学
  • Industrial Property Number: 2012-011838
  • Filing Date: 2012-01-24
• [Patent(Industrial Property Rights)] 慢性副鼻腔炎の検出方法 (2011)
  • Inventor(s): 太田昭一郎、出原賢治、有馬和彦、鈴木章一、白石裕士、太田伸男、石田晃弘、鈴木祐輔
  • Industrial Property Rights Holder: 佐賀大学、山形大学
  • Industrial Property Number: 2011-238913
  • Filing Date: 2011-10-31
• [Patent(Industrial Property Rights)] ペリオスチンの特定領域に結合する抗体、並びにこの抗体を用いるペリオスチンの測定方法、測定試薬及び計画性の改善方法 (2011)
  • Inventor(s): 太田昭一郎、出原賢治、有馬和彦、鈴木章一、白石裕士、星野友昭、東義則、小野純也
  • Industrial Property Rights Holder: 佐賀大学、久留米大学、株式会社シノテスト
  • Industrial Property Number: 2011-194323
  • Filing Date: 2011-09-06
• [Patent(Industrial Property Rights)] 慢性副鼻腔炎の検出方法 (2011)
  • Inventor(s): 太田昭一郎
  • Industrial Property Rights Holder: 佐賀大学
  • Industrial Property Number: 2011-238913
  • Filing Date: 2011-10-31
• [Patent(Industrial Property Rights)] ペリオスチンの特定領域に結合する抗体、並びにこの抗体を用いるペリオスチンの測定方法、測定試薬及び計画性の改善方法 (2011)
  • Inventor(s): 太田昭一郎
  • Industrial Property Rights Holder: 佐賀大学
  • Industrial Property Number: 2011-194323
  • Filing Date: 2011-09-06
• [Patent(Industrial Property Rights)] 胆管細胞癌の検出方法および予防・治療剤のスクリーニング方法 (2010)
  • Inventor(s): 出原賢治、太田昭一郎、白石裕士、鈴木章一、佐田通夫、藤本公則、中島収、川口巧
  • Industrial Property Rights Holder: 佐賀大学、久留米大学
  • Filing Date: 2010-12-02
  • Overseas
• [Patent(Industrial Property Rights)] ペリオスチン測定の正確性の改善方法 (2010)
  • Inventor(s): 出原賢治、太田昭一郎、有馬和彦、白石裕士、鈴木章一、佐田通夫、相澤久道、藤本公則、川口巧、星野友昭、岡元昌樹、東義則、小野純也
  • Industrial Property Rights Holder: 佐賀大学、久留米大学、株式会社シノテスト
  • Industrial Property Number: 2010-200564
  • Filing Date: 2010-09-08
• [Patent(Industrial Property Rights)] 増殖糖尿病網膜症の検出方法および予防・治療剤のスクリーニング方法 (2010)
  • Inventor(s): 出原賢治、太田昭一郎、有馬和彦、白石裕士、鈴木章一、佐田通夫、相澤久道、藤本公則、川口巧、星野友昭、岡元昌樹、東義則、小野純也
  • Industrial Property Rights Holder: 佐賀大学、久留米大学、九州大学、株式会社シノテスト
  • Industrial Property Number: 2010-093240
  • Filing Date: 2010-04-14
• [Patent(Industrial Property Rights)] 特発性間質性肺炎の検出方法 (2010)
  • Inventor(s): 太田昭一郎
  • Industrial Property Rights Holder: 佐賀大学
  • Filing Date: 2010-12-02
  • Overseas
• [Patent(Industrial Property Rights)] 特発性間質性肺炎の検出方法 (2010)
  • Inventor(s): 太田昭一郎
  • Industrial Property Rights Holder: 佐賀大学
  • Filing Date: 2010-11-29
  • Overseas
• [Patent(Industrial Property Rights)] 特発性間質性肺炎の検出方法 (2010)
  • Inventor(s): 太田昭一郎
  • Industrial Property Rights Holder: 佐賀大学
  • Industrial Property Number: 2010-515954
  • Filing Date: 2010-11-29
• [Patent(Industrial Property Rights)] 胆管細胞癌の検出方法および予防・治療剤のスクリーニング方法 (2010)
  • Inventor(s): 太田昭一郎
  • Industrial Property Rights Holder: 佐賀大学
  • Filing Date: 2010-12-02
  • Overseas
• [Patent(Industrial Property Rights)] ペリオスチン測定の正確性の改善方法 (2010)
  • Inventor(s): 太田昭一郎
  • Industrial Property Rights Holder: 佐賀大学
  • Industrial Property Number: 2010-200564
  • Filing Date: 2010-09-08
• [Patent(Industrial Property Rights)] 増殖糖尿病網膜症の検出方法および予防・治療剤のスクリーニング方法 (2010)
  • Inventor(s): 太田昭一郎
  • Industrial Property Rights Holder: 佐賀大学
  • Industrial Property Number: 2010-093240
  • Filing Date: 2010-04-14
• [Patent(Industrial Property Rights)] 胆管細胞癌の検出方法および予防・治療剤のスクリーニング方法 (2009)
  • Inventor(s): 出原賢治、太田昭一郎、白石裕士、鈴木章一、佐田通夫、藤本公則、中島収、川口巧
  • Industrial Property Rights Holder: 佐賀大学、久留米大学
  • Industrial Property Number: 2009-274873
  • Filing Date: 2009-12-02
• [Patent(Industrial Property Rights)] アトピー性皮膚炎の検出方法及び予防・治療薬のスクリーニング方法 (2009)
  • Inventor(s): 出原賢治、太田昭一郎、白石裕士、増岡美穂
  • Industrial Property Rights Holder: 佐賀大学
  • Industrial Property Number: 2009-174692
  • Filing Date: 2009-07-27
• [Patent(Industrial Property Rights)] 特発性間質性肺炎の検出方法 (2009)
  • Inventor(s): 出原賢治、太田昭一郎、白石裕士、相澤久道,星野友昭,岡元昌樹
  • Industrial Property Rights Holder: 佐賀大学、久留米大学
  • Filing Date: 2009-06-03
  • Overseas
• [Patent(Industrial Property Rights)] (2009)
  • Inventor(s): 太田昭一郎
  • Industrial Property Rights Holder: 佐賀大学
  • Industrial Property Number: 2009-274873
  • Filing Date: 2009-12-02
• [Patent(Industrial Property Rights)] 特発性間質性肺炎の検出方法 (2009)
  • Inventor(s): 太田昭一郎
  • Industrial Property Rights Holder: 太田昭一郎
  • Filing Date: 2009-06-03
• [Patent(Industrial Property Rights)] アトピー性皮膚炎の検出方法及び予防・治療薬のスクリーニング方法 (2009)
  • Inventor(s): 太田昭一郎
  • Industrial Property Rights Holder: 太田昭一郎
  • Filing Date: 2009-07-27
• [Patent(Industrial Property Rights)] 胆管細胞癌の検出方法および予防・治療剤のスクリーニング方法 (2009)
  • Inventor(s): 太田昭一郎
  • Industrial Property Rights Holder: 太田昭一郎
  • Filing Date: 2009-12-02