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Analysis of bacterial diversity in hospital environments and application for infection control using metagenomics

Research Project

Project/Area Number 21591291
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Infectious disease medicine
Research InstitutionGunma University

Principal Investigator

TOKUE Yutaka  群馬大学, 医学部, 准教授 (80292275)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsメタゲノミクス / 16S rRNA / 病院環境 / 感染対策 / 院内感染対策 / 環境検査 / メタゲノム / 16SrRNA
Research Abstract

Sequencing of the 16S rRNA gene is recognized as an effective method for bacterial identification. For the control of hospital infections, we compared culture method and of bacterial diversity in the hospital environments where drug-resistant bacteria were isolated. Molecular biological analysis was more sensitive than culture method. This culture-independent analysis was able to detect some bacteria from sample of dried surface, so it was suggested to be available as an index of contaminated environment.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (18 results)

All 2012 2011 2010 2009

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (11 results)

  • [Journal Article] Antibacterial activity of carbapenems against clinical isolates of respiratory bacterial pathogens in the northeastern region of Japan in 20072011

    • Author(s)
      Gomi K, Fujimura S, Fuse K, Takane H, Nakano Y, Kariya Y, Kikuchi T, Kurokawa I, Tokue Y, Watanabe A
    • Journal Title

      J Infect Chemother

      Volume: 17 Pages: 200-206

    • NAID

      10028171398

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Criteria for safety evaluation of antimicrobial agents2011

    • Author(s)
      Watanabe A, Tokue Y, Aoki N, Matsumoto T, Yanagihara K, Higa F, Tsuge H, Nagashima M, Matsuoka H, Sasagawa Y, Matsumoto M, Fujimaki K, Taguchi K, Ariyasu M, Yamamoto N, Kunii O, Shiba K
    • Journal Title

      J Infect Chemother

      Volume: 17 Pages: 47-139

    • NAID

      10027817022

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Criteria for safety evaluation of antimicrobial agents2011

    • Author(s)
      Watanab A, Tokue Y, et al
    • Journal Title

      J Infect Chemother

      Volume: 17 Pages: 139-147

    • NAID

      10027817022

    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antibacterial activity of carbapenems against clinical isolates of respiratory bacterial pathogens in the northeasten region of Japan in 20072011

    • Author(s)
      Gomi K, Tokue Y, et al
    • Journal Title

      J Infect Chemother

      Volume: 17 Pages: 200-206

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antibacterial activity of carbapenems against clinical isolates of respiratory bacterial pathogens in the northeastern region of Japan in 20072010

    • Author(s)
      Gomi K, Tokue Y, et al
    • Journal Title

      J Infect Chemother

      Volume: publish on line

    • NAID

      10028171398

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between Mycobacterial genotypes and disease progression in Mycobacterium avium pulmonary infection2009

    • Author(s)
      Kikuchi T, Watanabe A, Gomi K, Sakakibara T, Nishimori K, Daito H, Fujimura S, Tazawa R, Inoue A, Ebina M, Tokue Y, Kaku M, Nukiwa T
    • Journal Title

      Thorax

      Volume: 64 Pages: 901-907

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association between Mycobacterial genotypes and disease progression in Mycobacterium avium pulmonary infection.2009

    • Author(s)
      Kikuchi T, Tokue Y, et al
    • Journal Title

      Thorax 64

      Pages: 901-907

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 呼吸器感染症の治療~レスピラトリーキノロンを中心に~2012

    • Author(s)
      徳江豊
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] 教育講演2「ニューキノロン系抗菌薬の使い分け」2011

    • Author(s)
      徳江豊
    • Organizer
      第60回日本感染症学会東日本地方会、第58回日本化学療法学会東日本支部総会合同学会
    • Place of Presentation
      山形
    • Year and Date
      2011-10-27
    • Related Report
      2011 Final Research Report
  • [Presentation] ニューキノロン系抗菌薬の使い分け2011

    • Author(s)
      徳江豊
    • Organizer
      日本化学療法学会・感染症学会東日本合同学会
    • Place of Presentation
      山形
    • Year and Date
      2011-10-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] 教育講演「病院感染対策の実際アウトブレイクへの対応2011

    • Author(s)
      徳江豊
    • Organizer
      日本呼吸器学会東北地方会
    • Place of Presentation
      仙台
    • Year and Date
      2011-03-05
    • Related Report
      2011 Final Research Report
  • [Presentation] 教育講演「病院感染対策の実際-アウトブレイクへの対応-」2011

    • Author(s)
      徳江豊
    • Organizer
      第92回日本呼吸器学会東北地方会
    • Place of Presentation
      フォレスト仙台(宮城県)
    • Year and Date
      2011-03-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] シンポジウム5抗菌薬を使用しても改善しない!抗菌薬とホスト因子感染症におけるホスト因子の役割2010

    • Author(s)
      徳江豊
    • Organizer
      第58回日本化学療法学会
    • Place of Presentation
      長崎
    • Year and Date
      2010-06-03
    • Related Report
      2011 Final Research Report
  • [Presentation] シンポジウム「抗菌薬を使用しても改善しない!抗菌薬とホスト因子」感染症におけるホスト因子の役割2010

    • Author(s)
      徳江豊
    • Organizer
      第58回日本化学療法学会総会
    • Place of Presentation
      長崎ブリックホール(長崎県)
    • Year and Date
      2010-06-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] シンポジウム4 NICU病院感染予防のためのガイドライン ガイドラインの検証-感染管理担当者(基礎)の立場から2010

    • Author(s)
      徳江豊
    • Organizer
      第25回日本環境感染学会
    • Place of Presentation
      東京
    • Year and Date
      2010-02-05
    • Related Report
      2011 Final Research Report
  • [Presentation] 教育セミナー10抗菌薬の適正使用を含めた病院感染対策2010

    • Author(s)
      徳江豊
    • Organizer
      第25回日本環境感染学会
    • Place of Presentation
      東京
    • Year and Date
      2010-02-05
    • Related Report
      2011 Final Research Report
  • [Presentation] NICU病院感染興望のためのガイドラインガイドラインの検証-感染管理担当者(基礎)の立場から2010

    • Author(s)
      徳江豊
    • Organizer
      環境感染学会
    • Place of Presentation
      東京
    • Year and Date
      2010-02-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] ICD講習会院内感染における耐性菌の現状とその対策細菌感染症の動向とその対策2009

    • Author(s)
      徳江豊
    • Organizer
      第18回日本口腔感染症学会
    • Place of Presentation
      足利
    • Year and Date
      2009-11-14
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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