Translational approach to identifying cell specific expression and function of thyroid hormone transporters
| Project/Area Number |
21591320
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MOHRI Ikuko 大阪大学, 連合小児発達学研究科, 准教授 (70399351)
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| Research Collaborator |
ABE Sanae 大阪大学, 歯学研究科, 大学院生
FUJIWARA Makoto 大阪大学, 医学系研究科, 大学院生 (50625697)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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|---|
| Keywords | 甲状腺ホルモントランスポーター / 軟骨細胞 / 成長軟骨 / 成長障害 / 乏突起膠細胞 / トランスレーショナルリサーチ / Allan-Herndon-Dudley症候群 / MCT8 / MCT10 |
|---|
| Research Abstract |
The Allan-Herndon-Dudley syndrome(AHDS), caused by monocarboxylate transporter 8(MCT8) mutations, is characterized by severe psychomotor retardation. We focused on two symptoms, delayed myelination and relatively normal growth compared to patients with congenital hypothyroidism and demonstrated that# 1) oligodendrocyte precursor cells express MCT8 and# 2) Monocarboxylate transporter 10(MCT10) plays a role in growth plate chondrocyte proliferation and differentiation
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Increased type 3 iodothyronine deiodinase activity in a regrown hepatic hemangioma with consumptive hypothyroidism2010
Author(s)
Bessho K, Etani Y, Ichimori H, Miyoshi Y, Namba N, Yoneda A, Ooue T, Chihara T, Morii E, Aoki T, Murakami M, Mushiake S, Ozono K.
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Journal Title
Eur J Pediatr
Volume: 169(2)
Pages: 215-221
Related Report
Peer Reviewed
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[Presentation] 成長と骨2011
Author(s)
難波範行
Organizer
宮崎小児内分泌講演会
Place of Presentation
宮日会館(宮崎)(招待講演)
Year and Date
2011-10-28
Related Report
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[Presentation] Monocarboxylate Transporter8(MCT8) Expression in Oligodendrocytes May Account for the Delayed Myelination in MCT8-Deficient Patients2009
Author(s)
Namba N, Mohri I, Abe S, Kitaoka T, Miura K, Hirai H, Kitai Y, Sakai N, Taniike M, Ozono K.
Organizer
The Endocrine Society' s 91st Annual Meeting
Place of Presentation
Washington, DC, USA
Year and Date
2009-06-13
Related Report
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