Basic study of the development of an evidence based early drug intervention for neuro-developmental diseases

• Project/Area Number: 21591335
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Nippon Medical School
• Principal Investigator: NAGANO Masatoshi 日本医科大学, 医学部, 講師 (60271350)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Hidenori 日本医科大学, 大学院・医学研究科, 教授 (30221328) ; SAKAI Atsushi 日本医科大学, 医学部, 助教 (30386156) ; HANEDA Eisuke 日本医科大学, 大学院・医学研究科, ポストドクター (30453921)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 発達小児科学 / 脳・神経 / ストレス / セロトニン / 早期介入 / SSRI / セロトニン1A受容体 / 発達障害

Research Abstract

We found that prenatal dexamethasone(DEX) exposure, which mimics some aspects of prenatal stress, induced anxiety-related behaviors in male offspring when they reached adulthood. Before the emergence of behavioral changes, abnormalities occurred in the serotonin(5-HT) signaling in the brain. During postnatal 3 week treatment with a selective serotonin reuptake inhibitor or a 5-HT1A receptor agonist prevented the emergence of behavioral abnormalities in the prenatally DEX-exposed offspring.

Research Products

• [Journal Article] Early intervention with fluoxetine reverses abnormalities in the serotonergic system and behavior of rats exposed prenatally to dexamethasone (2012)
  • Author(s): Masatoshi Nagano, Mingyan Liu, Hirofumi Inagaki, Tomoyuki Kawada
  • Journal Title: Hidenori Suzuki Neuropharmacology Volume: (in press) Issue: 2 Pages: 292-300
  • DOI: 10.1016/j.neuropharm.2012.03.027
  • Peer Reviewed
• [Journal Article] Distribution and pharmacological characterization of primate NK-2 tachykinin receptor in the central nervous system of the rhesus monkey (2011)
  • Author(s): Nagano M, Oishi T, Suzuki H
  • Journal Title: Neurosci Lett Volume: 503 Issue: 1 Pages: 23-26
  • DOI: 10.1016/j.neulet.2011.07.057
  • Peer Reviewed
• [Journal Article] Effects of early intervention with fluoxetine on anxiety-related behaviors induced in prenatally glucocorticoid exposed rats (2010)
  • Author(s): M.Nagano., M.Liu., H Ozawa., H.Suzuki.
  • Journal Title: Basic & clinical pharmacology & toxicology Volume: 107 Supple S1 Pages: 481-481
• [Journal Article] Chronic stress enhances synaptic plasticity due to disinhibition in the anterior cingulated cortex and induces hyper-locomotion in mice (2010)
  • Author(s): H.Ito., M.Nagano., H.Suzuki., T.Murakosi
  • Journal Title: Neuropharmacology 58 Pages: 746-757
  • Peer Reviewed
• [Presentation] Effects of early intervention with fluoxetine on anxiety-related behaviors induced in prenatally glucocorticoid exposed rats (2012)
  • Author(s): M. Nagano.M. Liu., H Ozawa., H. Suzuki.
  • Organizer: 16th World congress on basic and clinical pharmacology(World Pharma2012)
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2012-07-20
• [Presentation] 生後のフルオキセチン投与は妊娠期デキサメサゾン暴露により仔ラットに誘導される行動異常を改善する (2011)
  • Author(s): 永野昌俊、劉明妍、永野玲子、鈴木秀典
  • Organizer: 第84回日本薬理学会年会
  • Place of Presentation: 横浜(震災による誌上開催)
  • Year and Date: 2011-03-24
• [Presentation] マカクザルtachykinin受容体NK-1、NK-2、NK-3の中枢での発現分布と薬理学的性質 (2011)
  • Author(s): 永野昌俊、大石高生、林基治、鈴木秀典
  • Organizer: 第85回日本薬理学会年会
  • Place of Presentation: 京都
  • Year and Date: 2011-03-16
• [Presentation] Effects of early intervention with fluoxetine on anxiety-related behaviors induced in prenatally glucocorticoid exposed rats (2010)
  • Author(s): M.Nagano., M.Liu., H Ozawa., H.Suzuki.
  • Organizer: 16th World congress on basic and clinical pharma-cology (World Pharma2010)
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2010-07-20
• [Presentation] 母体ストレスが児の神経発達に与える影響 (2010)
  • Author(s): 永野昌俊
  • Organizer: 早稲田大学応用脳化学研究所・人間総合研究センター共催シンポジウム
  • Place of Presentation: 早稲田大学国際会議場
  • Year and Date: 2010-03-20
• [Presentation] 母体ストレスが児の神経発達に与える影響 (2010)
  • Author(s): 永野昌俊
  • Organizer: 早稲田大学 応用脳化学研究所・人間総合研究センター共催シンポジウム
  • Place of Presentation: 早稲田大学国際会議場
  • Year and Date: 2010-03-20
• [Presentation] 妊娠期ストレスと発達障害 (2009)
  • Author(s): 永野昌俊
  • Organizer: 第3回日本医科大学-早稲田大学合同シンポジウム
  • Place of Presentation: 日本医科大学橘桜会館
  • Year and Date: 2009-11-21
• [Presentation] 妊娠期ストレスと発達障害 (2009)
  • Author(s): 永野昌俊
  • Organizer: 第3回 日本医科大学-早稲田大学合同シンポジウム
  • Place of Presentation: 日本医科大学橘桜会館
  • Year and Date: 2009-11-21