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Regulation of lipid composition of breast milk during lactation

Research Project

Project/Area Number 21591336
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionOsaka Medical College

Principal Investigator

TAKITANI Kimitaka  大阪医科大学, 医学部, 助教 (80319540)

Co-Investigator(Kenkyū-buntansha) TAMAI Hiroshi  大阪医科大学, 医学部, 教授 (30179874)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords母乳 / 脂質 / ビタミンE / 核内受容体
Research Abstract

Nutrition of breast-feeding is the most appropriate of all available milks for human infants. Human milk contains secretary IgA antibodies, lysozyme, and lactofarin, which provide gastrointestinal immunity. The composition of breast milk including minerals, prorotein and fats is changed during laction, however, the regulation of them have remained to be elucidated. In the study, the ligand of liver X receptor(LXR), one of nuclear receptor superfamily may affect the lipid contents of breast milk. This result The transcriptional factors including nuclear receptors may involve components of breast milk during lactation.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (32 results)

All 2011 2010 2009

All Journal Article (21 results) (of which Peer Reviewed: 7 results) Presentation (7 results) Book (4 results)

  • [Journal Article] Acute Monoblastic Leukemia That Switched Lineage at Relapse to Acute Lymphoblastic Leukemia : A Case Report2011

    • Author(s)
      Inoue A, Kawakami C, Takitani K, Ikemoto T, Tamai H.
    • Journal Title

      J Pediatr Hematol Oncol

    • Related Report
      2011 Final Research Report
  • [Journal Article] Induction of apoptosis by γ-tocotrienol in human cancer cell lines and leukemic blasts from patients : dependency on Bid, cytochrome c, and caspase pathway2011

    • Author(s)
      Inoue A, Takitani K, Koh M, Kawakami C, Kuno T, Tamai H.
    • Journal Title

      Nutr Cancer

      Volume: 63(5) Pages: 763-70

    • Related Report
      2011 Final Research Report
  • [Journal Article] Altered expression of both β-carotene 15, 15' monooxygenase and lecithin : retinol acyltransferase in obese Zucker rats2011

    • Author(s)
      Takitani K, Miyazaki H, Fukunishi S, Takaya R, Yoden A, Higuchi K, Tamai H.
    • Journal Title

      J Nutr Sci Vitaminol

      Volume: 57(1) Pages: 108-13

    • NAID

      10028106443

    • Related Report
      2011 Final Research Report
  • [Journal Article] Acute monocytic leukemia blasts with cuplike nuclear morphology : a case report2011

    • Author(s)
      Kawakami C, Inoue A, Takitani K, Ikemoto T, Yonetani N, Takubo T, Tamai H.
    • Journal Title

      Pediatr Hematol Oncol

      Volume: 28(2) Pages: 147-9

    • Related Report
      2011 Final Research Report
  • [Journal Article] X-linked agammaglobulinemia complicated with endobronchial tuberculosis2011

    • Author(s)
      Takitani K, Kanegane H, Miyawaki T, Tamai H.
    • Journal Title

      Acta Paediatr

      Volume: 100(3) Issue: 3 Pages: 466-8

    • DOI

      10.1111/j.1651-2227.2010.02071.x

    • Related Report
      2011 Final Research Report
  • [Journal Article] Induction of apoptosis by γ-tocotrienol in human cancer cell lines and leukemic blasts from patients : dependency on Bid, cytochrome c, and caspase pathway2011

    • Author(s)
      Inoue A, Takitani K, Koh M, Kawakami C, Kuno T, Tamai H
    • Journal Title

      Nutr Cancer

      Volume: 63 Pages: 763-770

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered expression of both β-carotene 15,15'monooxygenase and lecithin : retinol acyltransferase in obese Zucker rats2011

    • Author(s)
      Takitani K, Miyazaki H, Fukunishi S, et al
    • Journal Title

      J Nutr Sci Vitaminol

      Volume: 57 Pages: 108-113

    • NAID

      10028106443

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute monocytic leukemia blasts with cuplike nuclear morphology : a case report2011

    • Author(s)
      Kawakami C, Inoue A, Takitani K, et al
    • Journal Title

      Pediatr Hematol Oncol

      Volume: 28 Pages: 147-149

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] X-linked agammaglobulinemia complicated with endobronchial tuberculosis2011

    • Author(s)
      Kawakami C,Inoue A, Takitani K, et al
    • Journal Title

      Acta Paediatr

      Volume: 100 Pages: 466-468

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Successful treatment of acute monocytic leukemia with intracranial hemorrhage as the first manifestation2010

    • Author(s)
      Kawakami C, Inoue A, Takitani K, Yuki M, Tamai H.
    • Journal Title

      Pediatr Int

      Volume: 52(4) Issue: 4

    • DOI

      10.1111/j.1442-200x.2010.03138.x

    • Related Report
      2011 Final Research Report
  • [Journal Article] Peroxisome proliferation activation receptor alpha modulation of Ca2+-regulated exocytosis via arachidonic acid in guinea-pig antral mucous cells2010

    • Author(s)
      Sawabe Y, Shimamoto C, Sakai A, Kuwabara H, Saad AH, Nakano T, Takitani K, Tamai H, Mori H, Marunaka Y, Nakahari T.
    • Journal Title

      Exp Physiol

      Volume: 95(8) Pages: 858-68

    • Related Report
      2011 Final Research Report
  • [Journal Article] Anorectal and urinary anomalies and aberrant retinoic acid metabolism in cytochrome P450 oxidoreductase deficiency2010

    • Author(s)
      Fukami M, Nagai T, Mochizuki H, Muroya K, Yamada G, Takitani K, Ogata T.
    • Journal Title

      Mol Genet Metab

      Volume: 100(3) Pages: 269-73

    • Related Report
      2011 Final Research Report
  • [Journal Article] ビタミンEとその分画2010

    • Author(s)
      瀧谷公隆、玉井浩
    • Journal Title

      日本臨床

      Volume: 68増刊1 Pages: 184-187

    • Related Report
      2011 Final Research Report
  • [Journal Article] 基本的薬剤の選び方・使い方ビタミン薬2010

    • Author(s)
      瀧谷公隆、玉井浩
    • Journal Title

      小児内科

      Volume: 42増刊 Pages: 223-227

    • Related Report
      2011 Final Research Report
  • [Journal Article] Peroxisome proliferation activation receptor alpha modulation of Ca2+-regulated exocytosis via arachidonic acid in guinea-pig antral mucous cells2010

    • Author(s)
      Sawabe Y, et al.
    • Journal Title

      Exp Physiol

      Volume: 95 Pages: 858-868

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anorectal and urinary anomalies and aberrant retinoic acid metabolism in cytochrome P450 oxidoreductase deficiency.2010

    • Author(s)
      Fukami M, et al.
    • Journal Title

      Mol Genet Metab

      Volume: 100 Pages: 269-273

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 急性前骨髄性白血病を発症したクローン病患児のレチノイン酸薬物動態2009

    • Author(s)
      瀧谷公隆、井上彰子、河上千尋、井上敬介、宮崎敬士、青松友槻、余田篤、玉井浩
    • Journal Title

      日小臨薬誌

      Volume: 22 Pages: 104-107

    • Related Report
      2011 Final Research Report
  • [Journal Article] Children's toxicology from bench to bed-Liver Injury(2): Mechanism of antioxidant therapy for nonalcoholic fatty liver disease2009

    • Author(s)
      Takitani K, Miyazaki H, Yoden A, Tamai H.
    • Journal Title

      J Toxicol Sci

      Volume: 34 Pages: 223-8

    • Related Report
      2011 Final Research Report
  • [Journal Article] Three brothers of X-linked agammaglobulinemia : the relation between phenotype and neutropenia2009

    • Author(s)
      Kawakami C, Inoue A, Koh M, Takitani K, Kanegane H, Miyawaki T, Tamai H.
    • Journal Title

      Int J Hematol

      Volume: 90(1) Pages: 117-9

    • NAID

      10025162704

    • Related Report
      2011 Final Research Report
  • [Journal Article] Mechanism of antioxidant therapy for nonalcoholic fatty liver disease2009

    • Author(s)
      Takitani K, et al.
    • Journal Title

      J Toxicol Sci. 34

    • NAID

      110007337717

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Reduced plasma all-trans retinoic acid level in a Crohn's disease patient with acute promyelocytic leukemia2009

    • Author(s)
      Takitani K, et al.
    • Journal Title

      Leukemia Lymphoma 50

      Pages: 300-3022

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 母乳分泌におけるビタミンE濃度調節機構の解析2011

    • Author(s)
      瀧谷公隆
    • Organizer
      第14回Vitamin E UpDate Forum
    • Place of Presentation
      東京
    • Year and Date
      2011-08-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 1型糖尿病モデルラットにおけるレチノール代謝に関する検討2011

    • Author(s)
      瀧谷公隆
    • Organizer
      第63回日本ビタミン学会
    • Place of Presentation
      広島
    • Year and Date
      2011-06-04
    • Related Report
      2011 Final Research Report
  • [Presentation] Dehydroepiandrosterone alters retinol levels and expression of retinol related proteins2011

    • Author(s)
      Takitani K.
    • Organizer
      Multisciplinary approaches to modern therapeutics
    • Place of Presentation
      モントリオール、カナダ
    • Year and Date
      2011-05-25
    • Related Report
      2011 Final Research Report
  • [Presentation] Dehydroepiandrosterone alters retinol levels and expression of retinol related proteins2011

    • Author(s)
      Takitani K, Miyazaki H, Tamai H
    • Organizer
      The 2011 Annual Meeting of the Canadian Society of Pharmacology and Therapeutics
    • Place of Presentation
      Montreal, Canada
    • Related Report
      2011 Annual Research Report
  • [Presentation] 脂肪肝モデルラットにおけるレチノール代謝に関する検討2010

    • Author(s)
      瀧谷公隆
    • Organizer
      第62回日本ビタミン学会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-06-12
    • Related Report
      2011 Final Research Report
  • [Presentation] Reduced Plasma All-trans Retinoic Acid Levels In Acute Promyelocytic Leukemia Patients With Gastrointestinal Complications.2010

    • Author(s)
      TakitaniK, et al.
    • Organizer
      The 2010 Annual Meeting of the Canadian Society of Phannacology and Therapeutics
    • Place of Presentation
      Toronto, Canada
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肥満症モデルZuckerラットにおけるレチノール代謝に関する検討2009

    • Author(s)
      瀧谷公隆、宮崎敬士、玉井浩
    • Organizer
      第61回日本ビタミン学会
    • Place of Presentation
      亀岡
    • Year and Date
      2009-05-31
    • Related Report
      2011 Final Research Report
  • [Book] 小児臨床栄養学2011

    • Author(s)
      瀧谷公隆、玉井浩
    • Publisher
      診断と治療社
    • Related Report
      2011 Final Research Report
  • [Book] ビタミン欠乏症と過剰症2011

    • Author(s)
      瀧谷公隆、玉井浩
    • Publisher
      文光堂
    • Related Report
      2011 Final Research Report
  • [Book] 除外すべき各種基礎疾患と検査法2010

    • Author(s)
      瀧谷公隆
    • Publisher
      中山書店
    • Related Report
      2011 Final Research Report
  • [Book] ビタミンE臨床2010

    • Author(s)
      瀧谷公隆、玉井浩
    • Publisher
      朝倉書店
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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