Analysis of neurofibromatosis generation mechanism and identification of malignant factors using proteomics techniques
| Project/Area Number |
21591441
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | National Institute of Radiological Sciences (2011)
Jichi Medical University (2009-2010) |
|---|
Principal Investigator |
GOTOH Takaya 独立行政法人放射線医学総合研究所, 緊急被ばく医療研究センター, 主任研究員 (80284355)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
岩本 禎彦 自治医科大学, 医学部, 教授 (10232711)
中山 一大 自治医科大学, 医学部, 助教 (90433581)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
OHTA Arihito 東京慈恵会医科大学, 医学部, 講師 (20168933)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 皮膚腫瘍学 / 神経線維腫 / 病態医化学 / 皮膚病理 / 病理学 / 皮膚腫瘍 / プロテオーム / 細胞内情報伝達 / 神経系維腫症 / プロテオミクス |
|---|
| Research Abstract |
We analyzed using pathological specimens obtained from neurofibromatosis patients. The protein samples from tumor tissue and normal tissue that exist in periphery of the tumor were labeled with fluorescence dye respectively. First dimension, and the second dimension electrophoresis for the sample performed on same gels. And we compared expressed protein amounts as the fluorescence intensity and color difference. From comparison of the portion spots of normal tissues with spots of the tumor portion, we identified and analyze protein that may be related to malignancy. However, it is impossible to explain the pathological biology of NF1 from the molecule that we identify. We have to study more detail for these molecules that may concern to malignancy.
|
Report
(4 results)
Research Products
(38 results)
-
-
-
-
[Journal Article] Phenotype-dependent production of des-γ-carboxy prothrombin in hepatocellular carcinoma2011
Author(s)
Suzuki H, Murata K, Gotoh T, Kusano M, Okano H, Oyamada T, Yasuda Y, Imamura M, Kudo M, Mizokami M, Sakamoto A
-
Journal Title
J Gastroenterol
Volume: 46(10)
Pages: 1219-29
NAID
Related Report
-
[Journal Article] Depot-specific expression of lipolytic genes in human adipose tissues--association among CES1 expression, triglyceride lipase activity and adiposity2011
Author(s)
Nagashima S, Yagyu H, Takahashi N, Kurashina T, Takahashi M, Tsuchita T, Tazoe F, Wang XL, Bayasgalan T, Sato N, Okada K, Nagasaka S, Gotoh T, Kojima M, Hyodo M, Horie H, Hosoya Y, Okada M, Yasuda Y, Fujiwara H, Ohwada M, Iwamoto S, Suzuki M, Nagai H, Ishibashi S
-
Journal Title
J Atheroscler Thromb
Volume: 18(3)
Pages: 190-9
NAID
Related Report
-
-
-
-
-
-
-
[Journal Article] A single nucleotide polymorphism in the FADS1/FADS2 gene is associated with plasma lipid profiles in two genetically similar Asian ethnic groups with distinctive differences in lifestyle2010
Author(s)
Nakayama K, Bayasgalan T, Tazoe F, Yanagisawa Y, Gotoh T, Yamanaka K, Ogawa A, Munkhtulga L, Chimedregze U, Kagawa Y, Ishibashi S, Iwamoto S
-
Journal Title
Hum Genet
Volume: 127(6)
Pages: 685-90
Related Report
-
[Journal Article] Regulatory SNP in the RBP4 gene modified the expression in adipocytes and associated with BMI2010
Author(s)
Munkhtulga L, Nagashima S, Nakayama K, Utsumi N, Yanagisawa Y, Gotoh T, Omi T, Kumada M, Zolzaya K, Lkhagvasuren T, Kagawa Y, Fujiwara H, Hosoya Y, Hyodo M, Horie H, Kojima M, Ishibashi S, Iwamoto S
-
Journal Title
Obesity (Silver Spring)
Volume: 18(5)
Pages: 1006-14
Related Report
-
-
-
-
-
-
[Journal Article] Jichi Community Genetics Team (JCOG). Large scale replication analysis of lociassociated with lipid concentrations in a Japanese population.2009
Author(s)
Nakayama K, Bayasgalan T, Yamanaka K, Kumada M, Gotoh T, Utsumi N, Yanagisawa Y, Okayama M, Kajii E, Ishibashi S, Iwamoto S
-
Journal Title
J Med Genet
Volume: 46(6)
Pages: 370-4
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
