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Analysis of neurofibromatosis generation mechanism and identification of malignant factors using proteomics techniques

Research Project

Project/Area Number 21591441
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionNational Institute of Radiological Sciences (2011)
Jichi Medical University (2009-2010)

Principal Investigator

GOTOH Takaya  独立行政法人放射線医学総合研究所, 緊急被ばく医療研究センター, 主任研究員 (80284355)

Co-Investigator(Kenkyū-buntansha) 岩本 禎彦  自治医科大学, 医学部, 教授 (10232711)
中山 一大  自治医科大学, 医学部, 助教 (90433581)
Co-Investigator(Renkei-kenkyūsha) OHTA Arihito  東京慈恵会医科大学, 医学部, 講師 (20168933)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords皮膚腫瘍学 / 神経線維腫 / 病態医化学 / 皮膚病理 / 病理学 / 皮膚腫瘍 / プロテオーム / 細胞内情報伝達 / 神経系維腫症 / プロテオミクス
Research Abstract

We analyzed using pathological specimens obtained from neurofibromatosis patients. The protein samples from tumor tissue and normal tissue that exist in periphery of the tumor were labeled with fluorescence dye respectively. First dimension, and the second dimension electrophoresis for the sample performed on same gels. And we compared expressed protein amounts as the fluorescence intensity and color difference. From comparison of the portion spots of normal tissues with spots of the tumor portion, we identified and analyze protein that may be related to malignancy. However, it is impossible to explain the pathological biology of NF1 from the molecule that we identify. We have to study more detail for these molecules that may concern to malignancy.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (38 results)

All 2012 2011 2010 2009 Other

All Journal Article (22 results) (of which Peer Reviewed: 6 results) Presentation (10 results) Remarks (6 results)

  • [Journal Article] Vitronectin improves cell survival after radiation injury in human umbilical vein endothelial cells2012

    • Author(s)
      Hazawa M
    • Journal Title

      FEBS Open Bio

      Volume: 2 Pages: 334-338

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 右肘部に生じたグロムス腫瘍の1例2011

    • Author(s)
      高坂美帆,石地尚興,山田英明,伊東秀記,松尾光馬,太田有史,中川秀己
    • Journal Title

      日本皮膚科学会雑誌

      Volume: 121巻14号 Pages: 3414-3414

    • Related Report
      2011 Final Research Report
  • [Journal Article] Phacomatosis Pigmentokeratoticaに合併した腎芽腫の1男児例2011

    • Author(s)
      奥山舞,山岡正慶,横川裕一,寺尾陽子, 横井健太郎,秋山政晴,田嶼朝子, 田知本寛,太田有史,井田博幸
    • Journal Title

      日本小児科学会雑誌

      Volume: 115巻11号 Pages: 1827-1827

    • Related Report
      2011 Final Research Report
  • [Journal Article] Phenotype-dependent production of des-γ-carboxy prothrombin in hepatocellular carcinoma2011

    • Author(s)
      Suzuki H, Murata K, Gotoh T, Kusano M, Okano H, Oyamada T, Yasuda Y, Imamura M, Kudo M, Mizokami M, Sakamoto A
    • Journal Title

      J Gastroenterol

      Volume: 46(10) Pages: 1219-29

    • NAID

      10030294539

    • Related Report
      2011 Final Research Report
  • [Journal Article] Depot-specific expression of lipolytic genes in human adipose tissues--association among CES1 expression, triglyceride lipase activity and adiposity2011

    • Author(s)
      Nagashima S, Yagyu H, Takahashi N, Kurashina T, Takahashi M, Tsuchita T, Tazoe F, Wang XL, Bayasgalan T, Sato N, Okada K, Nagasaka S, Gotoh T, Kojima M, Hyodo M, Horie H, Hosoya Y, Okada M, Yasuda Y, Fujiwara H, Ohwada M, Iwamoto S, Suzuki M, Nagai H, Ishibashi S
    • Journal Title

      J Atheroscler Thromb

      Volume: 18(3) Pages: 190-9

    • NAID

      130004444498

    • Related Report
      2011 Final Research Report
  • [Journal Article] 神経線維腫症のカフェオレ斑に対するQスイッチルビーレーザーの治療効果2011

    • Author(s)
      小林康隆,太田有史,中川秀己,堀和彦
    • Journal Title

      日本皮膚科学会雑誌

      Volume: 121巻5号 Pages: 920-920

    • Related Report
      2011 Final Research Report
  • [Journal Article] Depot-specific expression of lipolytic genes in human adipose tissues--association among CES1 expression, triglyceride lipase activity and adiposity2011

    • Author(s)
      Nagashima S
    • Journal Title

      J Atheroscler Thromb

      Volume: 18 Pages: 190-199

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phenotype-dependent production of des-γ-carboxy prothrombin in hepatocellular carcinoma2011

    • Author(s)
      Suzuki H
    • Journal Title

      J Gastroentero

      Volume: 46 Issue: 10 Pages: 1219-1229

    • DOI

      10.1007/s00535-011-0432-8

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] レックリングハウゼン病の分子標的治療2010

    • Author(s)
      太田有史
    • Journal Title

      日本レックリングハウゼン病学会雑誌

      Volume: 1巻1号 Pages: 21-24

    • Related Report
      2011 Final Research Report
  • [Journal Article] 神経線維腫症1型のモザイクの親から神経線維腫症1型の子供が生まれた4家族2010

    • Author(s)
      谷戸克己,太田有史,中川秀己,新村眞人,澤田 俊一
    • Journal Title

      日本レックリングハウゼン病学会雑誌

      Volume: 1巻1号 Pages: 30-34

    • Related Report
      2011 Final Research Report
  • [Journal Article] Gastrointestinal stromal tumor(GIST)を合併した神経線維腫症1型の1例2010

    • Author(s)
      小林光,延山嘉眞,松尾光馬,太田有史,中川秀己,三木淳
    • Journal Title

      西日本皮膚科

      Volume: 72巻3号 Pages: 299-299

    • Related Report
      2011 Final Research Report
  • [Journal Article] A single nucleotide polymorphism in the FADS1/FADS2 gene is associated with plasma lipid profiles in two genetically similar Asian ethnic groups with distinctive differences in lifestyle2010

    • Author(s)
      Nakayama K, Bayasgalan T, Tazoe F, Yanagisawa Y, Gotoh T, Yamanaka K, Ogawa A, Munkhtulga L, Chimedregze U, Kagawa Y, Ishibashi S, Iwamoto S
    • Journal Title

      Hum Genet

      Volume: 127(6) Pages: 685-90

    • Related Report
      2011 Final Research Report
  • [Journal Article] Regulatory SNP in the RBP4 gene modified the expression in adipocytes and associated with BMI2010

    • Author(s)
      Munkhtulga L, Nagashima S, Nakayama K, Utsumi N, Yanagisawa Y, Gotoh T, Omi T, Kumada M, Zolzaya K, Lkhagvasuren T, Kagawa Y, Fujiwara H, Hosoya Y, Hyodo M, Horie H, Kojima M, Ishibashi S, Iwamoto S
    • Journal Title

      Obesity (Silver Spring)

      Volume: 18(5) Pages: 1006-14

    • Related Report
      2011 Final Research Report
  • [Journal Article] 成人発症したLipoid proteinosisの1例2010

    • Author(s)
      相馬孝光,竹内紋子,太田有史,中川秀己,濱田 尚宏
    • Journal Title

      日本皮膚科学会雑誌

      Volume: 120巻5号 Pages: 1061-1061

    • Related Report
      2011 Final Research Report
  • [Journal Article] びまん性神経線維腫内への出血に対し血管内塞栓術が奏功した1例2010

    • Author(s)
      梶井崇行,吉田寿斗志,延山嘉眞,松尾光馬,太田有史, 石地尚興,中川秀己,蘆田浩一,貞岡 俊一
    • Journal Title

      日本皮膚科学会雑誌

      Volume: 120巻1号 Pages: 80-80

    • Related Report
      2011 Final Research Report
  • [Journal Article] Regulatory SNP in RBP4 gene modified the expression in adipocytes and associated with BMI2010

    • Author(s)
      Munkhtulga L
    • Journal Title

      Obesity (Silver Spring)

      Volume: 18(5) Pages: 1006-14

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A single nucleotide polymorphism in the FADS1/FADS2 gene is associated with plasma lipid profiles in two genetically similar Asian ethic Groups with distinctive difference in lifestyle.2010

    • Author(s)
      Nakayama K
    • Journal Title

      Human Genet

      Volume: 127(6) Pages: 685-690

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PDI(Psoriasis Disability Index) 日本語版の検討2009

    • Author(s)
      福地 修,太田有史,石地尚興, 本田まりこ,上出良一, 中川秀己,長谷川友紀
    • Journal Title

      日本皮膚科学会雑誌

      Volume: 119巻6号 Pages: 110-110

    • Related Report
      2011 Final Research Report
  • [Journal Article] Jichi Community Genetics Team (JCOG). Large scale replication analysis of lociassociated with lipid concentrations in a Japanese population.2009

    • Author(s)
      Nakayama K, Bayasgalan T, Yamanaka K, Kumada M, Gotoh T, Utsumi N, Yanagisawa Y, Okayama M, Kajii E, Ishibashi S, Iwamoto S
    • Journal Title

      J Med Genet

      Volume: 46(6) Pages: 370-4

    • Related Report
      2011 Final Research Report
  • [Journal Article] Regulatory SNP in the RBP4 Gene Mondified the Expression in Adipocytes and Associated with BMI2009

    • Author(s)
      Munkhtulga L, Nakayama K, et.Al.
    • Journal Title

      Obesity(Silver Spring) 1022

      Pages: 257-261

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 扁平母斑・von Recklinghausen 病・McCune-Albright 症候群2009

    • Author(s)
      谷戸克己
    • Journal Title

      小児科診療 72(11)

      Pages: 2105-2111

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 液体窒素凍結療法が有効であったeccrinesyringofibroadenomaの1例

    • Author(s)
      片山宏賢, 川瀬正昭, 太田有史, 中川秀己
    • Journal Title

      臨床皮膚科(0021-4973)

      Volume: 63巻1号

    • Related Report
      2011 Final Research Report
  • [Presentation] 若年発症した悪性末梢神経鞘腫の1例2011

    • Author(s)
      東福有佳里
    • Organizer
      第3回 日本レックリングハウゼン病学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-13
    • Related Report
      2011 Final Research Report
  • [Presentation] 神経線維腫症のカフェオレ斑に対するQスイッチルビーレーザーの治療効果2011

    • Author(s)
      小林康隆
    • Organizer
      日本皮膚科学会学術大会
    • Place of Presentation
      震災により中止となり紙上発表のみ
    • Related Report
      2011 Final Research Report
  • [Presentation] アジア・太平洋地域の人類集団におけるスカベンジャー受容体ファミリーの遺伝的多様性2010

    • Author(s)
      中山一大
    • Organizer
      日本人類遺伝学会
    • Place of Presentation
      さいたま市
    • Year and Date
      2010-10-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Gastrointestinal stromal tumor(GIST)を併した神経線維腫症1型の1例2010

    • Author(s)
      小林光
    • Organizer
      第62回 日本皮膚科西部支部学術大会
    • Place of Presentation
      倉敷
    • Year and Date
      2010-10-24
    • Related Report
      2011 Final Research Report
  • [Presentation] 糖感受性エレメントのTRIB1遺伝子脂質異常症関連領域へのマッピングと遺伝子機能解析2010

    • Author(s)
      岩本禎彦
    • Organizer
      日本遺伝子診療学会
    • Place of Presentation
      津市
    • Year and Date
      2010-08-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] びまん性神経線維腫内への出血に対し血管内塞栓術が奏功した1例2010

    • Author(s)
      梶井崇行
    • Organizer
      日本皮膚科学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-04-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 神経線維腫症1型のモザイクの親から神経線維腫症1型の子供が生まれた4家族2009

    • Author(s)
      谷戸克己
    • Organizer
      第1回 日本レックリングハウゼン病学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-15
    • Related Report
      2011 Final Research Report
  • [Presentation] レックリングハウゼン病の分子標的治療2009

    • Author(s)
      太田有史
    • Organizer
      第1回 日本レックリングハウゼン病学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-15
    • Related Report
      2011 Final Research Report
  • [Presentation] 神経線維腫症1型のモザイクの親から神経線維腫症1型の子供が生まれた4家族2009

    • Author(s)
      谷戸克己, 他
    • Organizer
      日本レックリングハウゼン病学会
    • Place of Presentation
      東京慈恵会医科大学(東京)
    • Year and Date
      2009-11-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] レックリングハウゼン病の分子標的治療2009

    • Author(s)
      太田有史, 他
    • Organizer
      日本レックリングハウゼン病学会
    • Place of Presentation
      東京慈恵会医科大学(東京)
    • Year and Date
      2009-11-15
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.jichi.ac.jp/gotoh/NF/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.recklinghausen.jp/index.html

    • Related Report
      2011 Final Research Report
  • [Remarks] 日本レックリングハウゼン病学会

    • URL

      http://www.recklinghausen.jp/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks] 神経線維腫症の完治へ

    • URL

      http://www.jichi.ac.jp/gotoh/NF/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.jichi.ac.jp/gotoh/NF

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.recklinghausen.jp

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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