The relationship of cutaneous carcinogenesis and polymorphisms in the pigment-regulating genes including MC1R and P

• Project/Area Number: 21591449
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: Kinki University
• Principal Investigator: OISO Naoki 近畿大学, 医学部, 講師 (10419814)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 遺伝子 / 癌 / がん

Research Abstract

The aging society in Japan brings increased affected number of individuals with malignant cutaneous tumors. Sun exposure is the most essential environmental factor inducing cutaneous precancerosis and malignant tumors. Recent studies for inherited pigment anomalies identified the genes regulating skin color. We are currently investigating the relationship of cutaneous carcinogenesis and polymorphisms in the pigment-regulating genes including MC1R and P. This study would identify the Japanese subgroup to be recommended to protect sun exposure more intensively.

Research Products

• [Journal Article] 線状IgA水疱症の1例 (2012)
  • Author(s): 石橋淳子, 他
  • Journal Title: 皮膚科の臨床 Volume: 54 Pages: 91-94
  • Peer Reviewed
• [Journal Article] Clinical effectiveness of levofloxacin for inflammatory acne with high concentrations in the lesions (2012)
  • Author(s): Kawada A, et al
  • Journal Title: J Dermatol Volume: 39 Issue: 1 Pages: 94-96
  • DOI: 10.1111/j.1346-8138.2011.01216.x
  • Peer Reviewed
• [Journal Article] Nail isthmus : a distinct region of the nail apparatus (2012)
  • Author(s): Oiso N, et al
  • Journal Title: Dermatol Res Pract Volume: 2,012 Pages: 925-023
  • DOI: 10.1155/2012/925023
  • Peer Reviewed
• [Journal Article] Unusual exophytic inclusion warts as a cutaneous horn on the dorsum of the hand (2012)
  • Author(s): Oiso N, et al
  • Journal Title: Eur J Dermatol Volume: 22 Issue: 1 Pages: 152-153
  • DOI: 10.1684/ejd.2011.1597
  • Peer Reviewed
• [Journal Article] Coexisting pustular and ulcerative pyoderma gangrenosum (2012)
  • Author(s): Nakano S, et al
  • Journal Title: Eur J Dermatol Volume: 22 Issue: 1 Pages: 153-154
  • DOI: 10.1684/ejd.2011.1594
  • Peer Reviewed
• [Journal Article] Renbok phenomenon in a patient with alopecia areata universalis and psoriasis (2012)
  • Author(s): Oiso N, et al
  • Journal Title: J Dermatol Volume: 39 Issue: 3 Pages: 288-289
  • DOI: 10.1111/j.1346-8138.2011.01438.x
  • NAID: 10031184890
  • Peer Reviewed
• [Journal Article] Efficacy and safety of low-energy double-pass 1450-nm diode laser for the treatment of acne scars (2012)
  • Author(s): Wada T, et al
  • Journal Title: Photomed Laser Surg Volume: 30 Issue: 2 Pages: 107-111
  • DOI: 10.1089/pho.2011.3063
  • Peer Reviewed
• [Journal Article] Cellulitis with leukocytopenica as an initial sign of acute promyelocytic leukemia (2012)
  • Author(s): Sakamoto S, et al
  • Journal Title: Case Rep Dermatol Volume: 4 Issue: 1 Pages: 47-49
  • DOI: 10.1159/000337195
  • Peer Reviewed
• [Journal Article] The histopathological feature of the nail isthmus in an ectopic nail (2011)
  • Author(s): Oiso N, Kurokawa I, Tsuruta D, et al.
  • Journal Title: Am J Dermatopathol Volume: 33 Pages: 841-844
  • Peer Reviewed
• [Journal Article] Generalized vitiligo and associated autoimmune diseases in Japanese patients and their families (2011)
  • Author(s): Narita T, Oiso N, Fukai K, et al.
  • Journal Title: Allergol Int Volume: 60 Pages: 505-508
  • NAID: 130004477112
  • Peer Reviewed
• [Journal Article] Repigmantation of leukoderma of piebald patient associated with a novel mutation, G592E of tyrosine kinase domain within the c-kit gene (2011)
  • Author(s): Arase N, Wataya-Kaneda M, Oiso N, et al.
  • Journal Title: J Dermatol Sci Volume: 64 Pages: 147-149
  • Peer Reviewed
• [Journal Article] Skin ulcer mimicking pyoderma gangrenosum in a patient with incontinentia pigmenti (2011)
  • Author(s): Yoshida M, Oiso N, Kimura M, et al.
  • Journal Title: J Dermatol Volume: 38 Pages: 1019-1021
  • NAID: 10031147123
  • Peer Reviewed
• [Journal Article] The diagnostic usefulness of dermoscopy for nevus depigmentosus (2011)
  • Author(s): Oiso N, Kawada A
  • Journal Title: Eur J Dermatol Volume: 21 Pages: 639-640
  • Peer Reviewed
• [Journal Article] Superimposed linear graft-versus-host disease and secondary cutaneous involvement of anaplastic large cell lymphoma (2011)
  • Author(s): Oiso N, Tatsumi Y, Rai S, et al.
  • Journal Title: Eur J Dermatol Volume: 21 Pages: 636-638
  • Peer Reviewed
• [Journal Article] Consequences of two different amino acid substitutions at the same codon in KRT14 indicate definitive roles of structural distortion in epidermolysis bullosa simplex pathogenesis (2011)
  • Author(s): Natsuga K, Nishie W, Smith BJ, et al.
  • Journal Title: J Invest Dermatol Volume: 131 Pages: 1869-1876
  • Peer Reviewed
• [Journal Article] Non-segmental vitiligo and autoimmune mechanism (2011)
  • Author(s): Oiso N, Suzuki T, Fukai K, et al.
  • Journal Title: Dermatol Res Pract Pages: 518090-518090
  • Peer Reviewed
• [Journal Article] Two children with a mild or moderate piebaldism phenotype and a father with no leukoderma in a family with the same recurrent missense mutation in the kinase domain of KIT (2011)
  • Author(s): Narita T, Oiso N, Fukai K, et al.
  • Journal Title: Eur J Dermatol Volume: 21 Pages: 446-447
  • Peer Reviewed
• [Journal Article] Hyperpigmented spots within and partly around a hypopigmented macule (2011)
  • Author(s): Oiso N, Amatsu A, Kawada A
  • Journal Title: Int J Dermatol Volume: 50 Pages: 795-797
  • Peer Reviewed
• [Journal Article] Melanocytic nevi in nevus depigmentosus in a region of the body exposed to sunlight (2011)
  • Author(s): Oiso N, Kawada A
  • Journal Title: J Eur Acad Dermatol Venereol Volume: 25 Pages: 491-492
  • Peer Reviewed
• [Journal Article] Dermoscopic features in a case of dyschromatosis symmetrica hereditaria (2011)
  • Author(s): Oiso N, Murata I, Hayashi M, et al.
  • Journal Title: J Dermatol Volume: 38 Pages: 91-93
  • NAID: 10027902883
  • Peer Reviewed
• [Journal Article] Review of allergic and photoallergic contact dermatitis from an ingredient in a medicament vehicle consisting of a compress, poultice, plaster and tape (2011)
  • Author(s): Oiso N, et al
  • Journal Title: J Allergy (Cairo) Volume: 2,011 Pages: 169-432
  • DOI: 10.1155/2011/169432
  • Peer Reviewed
• [Journal Article] Dermoscopy for tick bite : reconfirmation of the usefulness for the initial diagnosis (2011)
  • Author(s): Matsuda M, et al
  • Journal Title: Case Rep Dermatol Volume: 3 Issue: 1 Pages: 94-97
  • DOI: 10.1159/000328181
  • Peer Reviewed
• [Journal Article] Disseminated superficial actinic porokeratosis in a patient with a long-term narrow-band UVB for psoriasis (2011)
  • Author(s): Kawara S, et al
  • Journal Title: J Dermatol Volume: 2,011 Issue: 6 Pages: 585-587
  • DOI: 10.1111/j.1346-8138.2010.01099.x
  • Peer Reviewed
• [Journal Article] The dermoscopic features in disseminated superficial actinic porokeratosis (2011)
  • Author(s): Oiso N, et al
  • Journal Title: Eur J Dermatol Volume: 21 Issue: 3 Pages: 439-440
  • DOI: 10.1684/ejd.2011.1337
  • Peer Reviewed
• [Journal Article] Dermoscopy of pyogenic granuloma on the lip : the differing appearances of vascular structures with and without pressure (2011)
  • Author(s): Oiso N, et al
  • Journal Title: Eur J Dermatol Volume: 21 Issue: 3 Pages: 441-441
  • DOI: 10.1684/ejd.2011.1338
  • Peer Reviewed
• [Journal Article] 全身性エリテマトーデス患者にみられた皮膚クリプトコッカス症の1例 (2011)
  • Author(s): 東森倫子, 他
  • Journal Title: 皮膚の科学 Volume: 10 Pages: 159-163
  • Peer Reviewed
• [Journal Article] Skin typing, sun exposure, and sunscreen use in a population of Japanese females using an online interview (2011)
  • Author(s): Kawada A, et al
  • Journal Title: 香粧会誌 Volume: 35 Pages: 89-92
  • Peer Reviewed
• [Journal Article] Non-segmental vitiligo and autoimmune mechanism (2011)
  • Author(s): Oiso N, et al
  • Journal Title: Dermatol Res Pract Volume: 2,011 Pages: 518-090
  • DOI: 10.1155/2011/518090
  • Peer Reviewed
• [Journal Article] Preoperative assessment using magnetic resonance imaging for subungual exostosis beneath the proximal region of the nail plate (2011)
  • Author(s): Higuchi K, et al
  • Journal Title: Case Rep Dermatol Volume: 3 Issue: 2 Pages: 155-157
  • DOI: 10.1159/000330894
  • Peer Reviewed
• [Journal Article] The dermoscopic features in infantile hemangioma (2011)
  • Author(s): Oiso N, et al
  • Journal Title: Pediatr Dermatol Volume: 28 Issue: 5 Pages: 591-593
  • DOI: 10.1111/j.1525-1470.2011.01385.x
  • Peer Reviewed
• [Journal Article] A dermoscopic figure of polymorphous atypical vessels with color gradation : a quiz (2011)
  • Author(s): Oiso N, et al
  • Journal Title: Acta Derm Venereol Volume: 91 Issue: 6 Pages: 737-740
  • DOI: 10.2340/00015555-1105
  • Peer Reviewed
• [Journal Article] 白斑の基礎と臨床 (2011)
  • Author(s): 大磯直毅
  • Journal Title: 日皮会誌 Volume: 121 Pages: 3084-3085
  • NAID: 10031165124
• [Journal Article] Eotaxin-3/CC chemokine ligand 26 is a functional ligand for CX3CR1 (2010)
  • Author(s): Nakayama T, Watanabe Y, Oiso N, et al.
  • Journal Title: J Immunol Volume: 185 Pages: 6472-6479
  • Peer Reviewed
• [Journal Article] The effectiveness of intense pulsed light for possible Riehl's melanosis (2010)
  • Author(s): Oiso N, Tsuruta D, Imanishi H, et al.
  • Journal Title: Dermatol Ther Volume: 23 Pages: 561-563
  • Peer Reviewed
• [Journal Article] Mutation Analysis of Patients with Dyschromatosis Symmetrica Hereditaria : Five Novel Mutations of the ADAR1 Gene (2010)
  • Author(s): Murata I, Hayashi M, Hozumi Y, et al.
  • Journal Title: J Dermatol Sci Volume: 58 Pages: 518-520
  • Peer Reviewed
• [Journal Article] A case of amelanotic vulvar melanoma with intratumor histological heterogeneity (2010)
  • Author(s): Oiso N, Yoshida M, Kawara S, et al.
  • Journal Title: J Dermatol Volume: 37 Pages: 537-541
  • Peer Reviewed
• [Journal Article] Phylloid hypermelanosis and melanocytic nevi with aggregated and disfigured melanosomes : causal relationship between the phylloid pigment distribution and chromosome 13 abnormalities (2010)
  • Author(s): Oiso N, Tsuruta D, Imanishi H, et al.
  • Journal Title: Dermatology Volume: 220 Pages: 169-172
  • Peer Reviewed
• [Journal Article] Phylloid hypermelanosis and melanocytic nevi with aggregated and disfigured melanosomes : causal relationship between the phvlloid pigment distribution and chromosome 13 abnormalities. (2010)
  • Author(s): Oiso N, et al.
  • Journal Title: Dermatology Volume: 220 Pages: 169-172
  • Peer Reviewed
• [Journal Article] The effectiveness of intense pulsed light for possible Riehl's melanosis. (2010)
  • Author(s): Oiso N, et al.
  • Journal Title: Dermatologic Therapy Volume: 23 Pages: 561-563
  • Peer Reviewed
• [Journal Article] A case of amelanotic vulvar melanoma with intratumor histological heterogeneity. (2010)
  • Author(s): Oiso N, et al.
  • Journal Title: The Journal of Dermatology Volume: 37 Pages: 537-541
  • Peer Reviewed
• [Journal Article] A Japanese piebald patient with auburn hair color associated with a novel mutation p. P832L in the KIT gene and a homozygous variant p. I120T in the MC1R gene (2009)
  • Author(s): Oiso N, Kishida K, Fukai K, et al.
  • Journal Title: Brit J Dermatol Volume: 161 Pages: 468-469
  • Peer Reviewed
• [Journal Article] Pigmented spots as a sign of mammary Paget disease (2009)
  • Author(s): Oiso N, Kawara S, Inui H, et al.
  • Journal Title: Clin Exp Dermatol Volume: 34 Pages: 36-38
  • Peer Reviewed
• [Journal Article] Pigmentary mosaicism with hyperpigmented streaks on the palmoplantar lesion associated with balanced X ; autosome translocations t(X ; 9)(p11.21 ; q34.1) (2009)
  • Author(s): Oiso N, Amatsu A, Kawara S, et al.
  • Journal Title: J Eur Acad Dermatol Venereol Volume: 23 Pages: 359-361
  • Peer Reviewed
• [Journal Article] A Japanese piebald patient with auburn hair color associated with a novel mutation p.P832L in the KIT gene and a homozygous variant p.I120T in the MC1R gene (2009)
  • Author(s): Oiso N, et al.
  • Journal Title: British Journal of Dermatology 161 Pages: 359-361
  • Peer Reviewed
• [Presentation] A case of superimposed linear graft-versus-host disease in secondary cutaneous involvement of anaplastic large cell lymphoma (2012)
  • Author(s): Narita T, et al.(3人中2番目)
  • Organizer: American Academy of Dermatology 70th Annual Meeting
  • Place of Presentation: San Diego, California, USA
• [Presentation] シンポジウム:「アレルギー疾患診療医間のパートナーシップの向上～総合アレルギー医を目指して～」皮膚科医の立場から (2011)
  • Author(s): 大磯直毅
  • Organizer: 第67回臨床アレルギー研究会
  • Place of Presentation: 大阪市
  • Year and Date: 2011-06-25
• [Presentation] 「アレルギー疾患診療医間のパートナーシップの向上～総合アレルギー医を目指して～」3.皮膚科医の立場から (2011)
  • Author(s): 大磯直毅
  • Organizer: 第67回臨床アレルギー研究会(関西)
  • Place of Presentation: 大阪市中央区大日本住友製薬株式会社本社7階ホール)(シンポジウム)(招待講演)
  • Year and Date: 2011-06-25
• [Presentation] Epidemiologic evaluation for non-segmental vitiligo and related autoimmune disorders in the Japanese population (2011)
  • Author(s): Oiso N, Fukai K, Narita T, et al.
  • Organizer: The 36th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: Kyoto, Japan
• [Presentation] Blastic plasmacytoid dendritic cell neoplasm caused by loss of genomic DNA copy numbers in the p18, p16, p27 and RB loci (2011)
  • Author(s): Oiso N, Tatsumi Y, Arao T, et al.
  • Organizer: The 12th International Congress of Human Genetics & The American Society of Human Genetics 61st Annual Meeting
  • Place of Presentation: Montreal, Canada
• [Presentation] Generalized vitiligo and related autoimmune disorders in Japanese patients and their families (2011)
  • Author(s): Oiso N, Fukai K, Narita T, et al.
  • Organizer: XXIst International Pigment Cell Conference
  • Place of Presentation: Bordeaux, France
• [Presentation] シンポジウムTreatment strategies for mucocutaneous side effects caused by chemotherapeutic agents of small molecules and mononuclonal antibodies (2011)
  • Author(s): Oiso N
  • Organizer: 第9回日本臨床腫瘍学会学術大会
  • Place of Presentation: 横浜市
• [Presentation] The diagnostic application of dermoscopy for six-legged larval ticks (2011)
  • Author(s): Oiso N, Wada T, Yamamoto H, et al.
  • Organizer: 22nd Would Congress of Dermatology
  • Place of Presentation: Seoul, Korea
• [Presentation] 教育講演白斑の基礎と臨床 (2011)
  • Author(s): 大磯直毅
  • Organizer: 第110回日本皮膚科学会総会
  • Place of Presentation: 横浜市
• [Presentation] 白斑の基礎と臨床 (2011)
  • Author(s): 大磯直毅
  • Organizer: 第110回日本皮膚科学会総会
  • Place of Presentation: 横浜市西区(パシフィコ横浜)(教育講演)(招待講演)
• [Presentation] 右頬部皮下硬結で初発したblastic plasmacytoid dendritic cell neoplasm (2011)
  • Author(s): 大磯直毅, 他
  • Organizer: 第110回日本皮膚科学会総会
  • Place of Presentation: 横浜市西区(パシフィコ横浜)
• [Presentation] 円形脱毛症患者における甲状腺および膵島自己免疫疾患合併例の検討 (2011)
  • Author(s): 朴忠勇, 他
  • Organizer: 第84回日本内分泌学会学術総会
  • Place of Presentation: 神戸市中央区(神戸国際会議場・神戸国際展示場)
• [Presentation] Efficacy and safety of a low-energy double-pulse 1450 nm diode laser for treatment of acne scars (2011)
  • Author(s): Wada T, et al
  • Organizer: 22nd Would Congress of Dermatology
  • Place of Presentation: Seoul, Korea
• [Presentation] Clinical effectiveness of once-daily levofloxacin for inflammatory acne with high concentrations in the lesions (2011)
  • Author(s): Kawada A, et al
  • Organizer: 22nd Would Congress of Dermatology
  • Place of Presentation: Seoul, Korea
• [Presentation] An investigation of clinical efficacy of faropenem for inflammatory lesions of acne vulgaris (2011)
  • Author(s): Hirao A, et al
  • Organizer: 22nd Would Congress of Dermatology
  • Place of Presentation: Seoul, Korea
• [Presentation] Clinical effectiveness of intense pulsed light therapy for solar lentigines of the hands : an open study (2011)
  • Author(s): Yamamoto H, et al
  • Organizer: 22nd Would Congress of Dermatology
  • Place of Presentation: Seoul, Korea
• [Presentation] The effectiveness of a combination of narrowband ultraviolet B phototherapy, topical corticosteroids and an antihistamine for a case of lichen amyloidosis associated with atopic dermatitis (2011)
  • Author(s): Oiso N, et al
  • Organizer: 22nd Would Congress of Dermatology
  • Place of Presentation: Seoul, Korea
• [Presentation] Treatment strategies for mucocutaneous side effects caused by chemotherapeutic agents of small molegules and mononuclonal antibodies (2011)
  • Author(s): Oiso N
  • Organizer: 第9回日本臨床腫瘍学会学術大会
  • Place of Presentation: 横浜市西区(パシフィコ横浜)(シンポジウム)(招待講演)
• [Presentation] 自己免疫疾患の臓器特異性を規定する体質に関する検討:円形脱毛症に合併する甲状腺および膵島自己免疫の実態と遺伝解析 (2011)
  • Author(s): 朴忠勇, 他
  • Organizer: 第61回日本体質医学会総会
  • Place of Presentation: 東京都中央区TKP東京駅日本橋ビジネスセンター
• [Presentation] Clinical effectiveness of once-daily levofloxacin for inflammatory acne with high concentrations in the lesions (2011)
  • Author(s): Kawada A, et al
  • Organizer: 20th Congress of the European Academy of Dermatology and Venereology
  • Place of Presentation: Kisbon, Portugal
• [Presentation] Sunscreen use and sun exposure in a population of Japanese females (2011)
  • Author(s): Nakano S, et al
  • Organizer: 20th Congress of the European Academy of Dermatology and Venereology
  • Place of Presentation: Kisbon, Portugal
• [Presentation] A Japanese piebald patient with auburn hair colour caused by a novel mutation p.p8321 in the kit gene and a homozygous variant p.i120t in the mclr gene (2011)
  • Author(s): Hirao A, et al
  • Organizer: 20th Congress of the European Academy of Dermatology and Venereology
  • Place of Presentation: Kisbon, Portugal
• [Presentation] Epidermiologic evaluation for non-segmental vitiligo and related autoimmune disorders in the Japanese population (2011)
  • Author(s): Oiso N, et al
  • Organizer: The 36th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: Kyoto, Japan (Kyoto International Conference Center)
• [Presentation] Histopathological and ultrastracural study for a Japanese female child case of erythema dyschromicum perstans (2010)
  • Author(s): Oiso N, Tsuruta D, Imanishi H, et al.
  • Organizer: The 35th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: Wakayama, Japan
• [Presentation] ランチョンセミナー「白斑の治療」汎発型尋常性白斑の疾患感受性遺伝子と治療 (2010)
  • Author(s): 大磯直毅
  • Organizer: 第23回日本色素細胞学会学術大会
  • Place of Presentation: 東京都
• [Presentation] Dyschromatosis symmetrica hereditaria : consideration of the pathogenesis with dermoscopic features (2010)
  • Author(s): Oiso N, Murata I, Hayashi M, et al.
  • Organizer: The American Society of Human Genetics 60th Annual Meeting
  • Place of Presentation: Washington DC, USA
• [Presentation] Pigmented spots on the nipple : a sign of mammatory Paget disease (2010)
  • Author(s): Oiso N, Kawara S, Kawaka A
  • Organizer: The First Eastern Asia Dermatology Congress
  • Place of Presentation: Fukuoka, Japan
• [Presentation] シンポジウム白斑とシミ尋常性白斑の疾患感受性遺伝子と治療 (2010)
  • Author(s): 大磯直毅
  • Organizer: 第61回日本皮膚科学会中部支部学術大会
  • Place of Presentation: 大阪市
• [Presentation] 教育講演新しい検査(エコー・発汗検査を含む)新しい遺伝子検査と診断への応用 (2010)
  • Author(s): 大磯直毅
  • Organizer: 第109回日本皮膚科学会総会
  • Place of Presentation: 大阪市
• [Presentation] 新しい検査(エコー・発汗検査を含む)新しい遺伝子検査と診断への応用 (2010)
  • Author(s): 大磯直毅
  • Organizer: 第109回日本皮膚科学会総会
  • Place of Presentation: 大阪市
• [Presentation] Mild phenotype of the dominant negative mutation in the tyrosine kinase domain of KIT may suggest a second modifier gene for piebaldism (2009)
  • Author(s): Oiso N, Suzuki T, Fukai K, et al.
  • Organizer: The American Society of Human Genetics 59th Annual Meeting
  • Place of Presentation: Honolulu, Hawaii, USA
• [Book] 皮膚科診療カラ-アトラス大系7 (2011)
  • Author(s): 大磯直毅
  • Total Pages: 160
  • Publisher: 講談社
• [Book] The Stage of Melanogenesis in Amelanotic Melanoma. Melanoma in the Clinic. Diagnosis, management and Complications of Malignancy (2011)
  • Author(s): Oiso N, Kawada A, Murph M
  • Publisher: INTECH
• [Book] 正中菱形舌炎.皮膚科診療カラーアトラス大系7(全8巻+別巻1)(編集鈴木啓之・神埼保) (2011)
  • Author(s): 大磯直毅
  • Total Pages: 1
  • Publisher: 株式会社講談社(東京都文京区)
• [Book] The Stage of Melanogenesis in Amelanotic Melanoma. In : Melanoma in the Clinic-Diagnosis, management and Complications of Malignancy(Murph M (ed)) (2011)
  • Author(s): Oiso N, Kawada A
  • Total Pages: 10
  • Publisher: InTech (Rijeka, Croatia)