Involvement of selectins and their ligands in wound healing

• Project/Area Number: 21591469
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: The University of Tokyo
• Principal Investigator: SATO Shinichi 東京大学, 医学部附属病院, 教授 (20215792)
• Co-Investigator(Kenkyū-buntansha): OGAWA Fumihide 長崎大学, 医学部・歯学部付属病院, 講師 (10333519) ; YOSHIZAKI Ayumu 長崎大学, 医学部・歯学部付属病院, 講師 (40530415)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 細胞接着分子 / PSGL-1 / P-selectin / 創傷治癒 / 皮膚免疫学

Research Abstract

Cell adhesion molecules are critical to wound healing through leukocyte recruitment. To clarify a role of P-selectin glycoprotein ligand-1(PSGL-1), one of cell adhesion molecules, in wound healing, we investigated cutaneous wound healing in PSGL-1-deficient mice. The results suggest that PSGL-1 contributes to wound healing predominantly as a P-selectin ligand and partly as an E-selectin ligand by mediating infiltration of inflammatory cells.