Conprehensive identification of important genes related to growing and maintaining the hair using knock down mice.

• Project/Area Number: 21591474
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: Keio University
• Principal Investigator: SHIBUYA Kazunori 慶應義塾大学, 医学部, 助教 (90296723)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 毛髪 / 成長期 / ノックダウンマウス / 毛包 / miRNA / 毛周期

Research Abstract

Many people hold a trouble of hair becoming thin with aging.
Then, the experiment which searches for the gene which maintains and grows up hair using a genetically engineered mouse was conducted.
As a result, the phenotype which has change in hair which was expected although it succeeded in producing a genetically engineered mouse was not observed.