Elucidation of schizophrenia etiology and development of a cure by the analysis of PSAT1 which is a gene relevant to serine synthesis.
| Project/Area Number |
21591492
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
OZEKI Yuji 獨協医科大学, 医学部, 准教授 (90303768)
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| Co-Investigator(Kenkyū-buntansha) |
FUJII Kumiko 獨協医科大学, 医学部, 講師 (70314151)
SHIMODA Kazutaka 獨協医科大学, 医学部, 教授 (30196555)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 統合失調症 / L-セリン合成 / ホスホセリンアミノトランスフェラーゼ / ホスホセリンホスファターゼ / ホスホグリセリン酸デヒドロゲナーゼ / L-セリン / L-グルタミン酸 / phosphoserin aminotransferase / phosphoserine phospatase / phosphoglycerate dehydrogenase / PSAT1 / D-セリン / グルタミン酸 / 染色体均衡転座 |
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| Research Abstract |
In the schizophrenic patient, the enzyme activity of phosphoserine phospatase(PSP), which is one of L-serine synthetase, was increased as compared with the healthy comparisons. Plasma concentration of L-serine and the severity of illness were significantly related. Furthermore, the amount of mRNA of phosphoglycerate dehydrogenase(one of L-serine synthetase) was decreased and the amount of PSP was increased in schizophrenic patients compared with healthy comparisons. Therefore, abnormality of L-serine synthesis was found in schizophrenic patients.
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] A novel balanced chromosomal translocation found in subjects with schizophrenia and schizotypal personality disorder : altered l-serine level associated with disruption of PSAT1 gene expression2011
Author(s)
Yuji Ozeki, Benjamin S. Pickard, Shin-ichi Kano, Mary P. Malloy, Mariela Zeledon, Daniel Q. Sun, Kumiko Fujii, Keiko Wakui, Yukihiko Shirayama, Yoshimitsu Fukushima, Hiroshi Kunugi, Kenji Hashimoto, Walter J. Muir, Douglas H. Blackwood and Akira Sawa
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Journal Title
Neurosci Research
Volume: 69
Pages: 154-60
NAID
URL
Related Report
Peer Reviewed
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[Journal Article] Relationships between psychological distress, coping styles, and HPA axis reactivity in healthy adults2010
Author(s)
Hiroaki Hori, Yuji Ozeki, Toshiya Teraishi, Junko Matsuo, Yumiko Kawamoto, Yukiko Kinoshita, Shiho Suto, Sumio Terada, Teruhiko Higuchi, Hiroshi Kunugi
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Journal Title
Journal of Psychiatric Research
Volume: 44
Issue: 14
Pages: 865-73
DOI
Related Report
Peer Reviewed
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[Journal Article] QTc prolongation and antipsychotic medications in a sample of 1, 017 patients with schizophrenia2010
Author(s)
Yuji Ozeki, Kumiko Fujii, Naoki Kurimoto, Naoto Yamada, Masako Okawa, Takesuke Aoki, Jun Takahashi, Nobuya Ishida, Minoru Horie, Hiroshi Kunugi
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Journal Title
Progress in Neuro-Psychopharmacology & Biological Psychiatry
Volume: 34
Pages: 401-405
URL
Related Report
Peer Reviewed
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[Presentation] Low serum L-serine and glutamate in a schizophrenic patient and son with a chromosomal translocation affecting phosphoserine aminotransferase 1(PSAT1) mRNA expression2009
Author(s)
Yuji Ozeki, Benjamin S. Pickard, Kumiko Fujii, Mary P. Malloy, Keiko Wakuie, Yukihiko Shirayama, Yoshimitsu Fukushima, Hiroshi Kunugi, Kenji Hashimoto, Walter J. Muir, Douglas H. Blackwood and Akira Sawa
Organizer
39^<th> annual meeting of the Society for Neuroscience
Place of Presentation
Chicago USA
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