| Project/Area Number |
21591492
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
OZEKI Yuji 獨協医科大学, 医学部, 准教授 (90303768)
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| Co-Investigator(Kenkyū-buntansha) |
FUJII Kumiko 獨協医科大学, 医学部, 講師 (70314151)
SHIMODA Kazutaka 獨協医科大学, 医学部, 教授 (30196555)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 統合失調症 / L-セリン合成 / ホスホセリンアミノトランスフェラーゼ / ホスホセリンホスファターゼ / ホスホグリセリン酸デヒドロゲナーゼ / L-セリン / L-グルタミン酸 / phosphoserin aminotransferase / phosphoserine phospatase / phosphoglycerate dehydrogenase / PSAT1 / D-セリン / グルタミン酸 / 染色体均衡転座 |
|---|
| Research Abstract |
In the schizophrenic patient, the enzyme activity of phosphoserine phospatase(PSP), which is one of L-serine synthetase, was increased as compared with the healthy comparisons. Plasma concentration of L-serine and the severity of illness were significantly related. Furthermore, the amount of mRNA of phosphoglycerate dehydrogenase(one of L-serine synthetase) was decreased and the amount of PSP was increased in schizophrenic patients compared with healthy comparisons. Therefore, abnormality of L-serine synthesis was found in schizophrenic patients.
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