The variety of concepts in mood disorders and pharmaco-image-Molecular approach

• Project/Area Number: 21591494
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: NAKAMURA Jun 産業医科大学, 医学部, 教授 (40148804)
• Co-Investigator(Renkei-kenkyūsha): YOSIMURA Reiji 産業医科大学, 医学部, 准教授 (90248568) ; HORI Hikaru 産業医科大学, 医学部, 助教 (50421334) ; SUGITA Atuko 産業医科大学, 医学部, 助教 (40421333) ; NAKONO Wakako 産業医科大学, 医学部, 助教 (30461552)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
• Keywords: うつ病 / MRI / DTI / 脳由来栄養因子(BDNF) / 血漿中MHPG / 血漿中HVA / NOx濃度 / γ-アミノ酪酸(GABA) / NOx / γ-アミノ酪酸 / 脳由来栄養因子 / NO_X濃度 / GABA

Research Abstract

1.We investigated the molecular-pharmacological and neuroimaging study in depressed patients, and we found the following results.
2.Brain NAA level in PO regions with depressed group is significantly lower than that with healthy control.
3.No difference is observed in Glx level between depressed group and healthy control.
4.Serum MHPG is significantly higher in depressed group than that in healthy control.
5.A trend for increase is found in depressed group compared with healthy group.

Research Products

• [Journal Article] Reliability, validity and clinical utility of a Japanese version of the Social Adaptation Self-evaluation Scale as calibrated using the Beck Depression (2011)
  • Author(s): Ueda, N.・A. Suda・M. Nakagawa・Nakano, H.・Nakano, W.・Sugita, A.・Hori, H.・Yoshimura, R. Nakamura, J
  • Journal Title: Inventory Psychiatry and Clinical Neurosciences Volume: 65(7) Pages: 624-629
• [Journal Article] Introducing the concept of modern depression in Japan ; an international case vignette survey (2011)
  • Author(s): Kato TA・Shinfuku N・Fujisawa D・Tateno M・Ishida T・Akiyama T・Sartorius N・Teo AR・Choi TY・Wand AP・Balhara YP・Chang JP・Chang RY・Shadloo B・Ahmed HU・Lerthattasilp T・Nakano W.・Horikawa H・Matsumoto R・Kuga H
  • Journal Title: J Affect Disord Volume: 135(1-3) Pages: 66-76
• [Journal Article] 産業領域におけるうつ状態 (2011)
  • Author(s): 中村純・新開隆弘
  • Journal Title: 治療 Volume: 93(12) Pages: 2395-2399
• [Journal Article] Three polymorphisms of the eNOS gene and plasma levels of metabolites of nitric oxide in depressed Japanese patients a preliminary report (2011)
  • Author(s): Nakano, W.・Yoshimura R・Chiharu Yoshii・Sugita, A.・Yoshimura, R.・Taro Kishi・Nakano, W.・Hori, H.・Hayashi, K.・Katsuki, A.・Ueda, N.・Nakao Iwata・Nakamura, J
  • Journal Title: Human Psycho-pharmacology Volume: 26(7) Pages: 531-534
• [Journal Article] Possible association between ubiquitin-specific peptidase 46 gene and major depressive disorders in the Japanese population (2011)
  • Author(s): Fukuo Y・Kishi T・Kushima I・Yoshimura, R.・Okochi T・Kitajima T・Matsunaga S・Kawashima K・Nakano, W.・Naitoh H・Inada T・Nakamura, J.・Ozaki N・Iwata N
  • Journal Title: J Affect Disord Volume: 133(1-2) Pages: 150-157
• [Journal Article] A case of discontinuation syndrome following the discontinuation of low-dose mirtazapine therapy in malignant lymphoma Clinical (2011)
  • Author(s): Sugita, A.・Yoshimura, R.・Nakamura, J
  • Journal Title: Neuropsychopharmacology and Therapeutics Volume: 2 Pages: 30-31
• [Journal Article] The clock gene and mood disorders : A case-control study and meta-analysis (2011)
  • Author(s): Kishi, T.・Yoshimura, R.・Fukuno, Y.・Kitajima, T.・Okochi, T.・Matsunaga, S.・Inada, T.・Kunugi, H.・Kato, T.・Yoshikawa, T.・Ujike, H・Nakano, W.・Nakamura, J.・Ozaki, N・Serretti, A・Correll, C.・Iwata, N
  • Journal Title: Chronobiology international Volume: 28(9) Pages: 825-833
• [Journal Article] A case of a depressive patient with alcohol and nicotine dependence successfully treated with sertraline (2011)
  • Author(s): Nakano, W.・Yoshimura, R.・Katsuki, A.・Nakamura, J
  • Journal Title: Clinical Neuropsycho-pharmacology and Therapeutics Volume: 2 Pages: 24-26
  • NAID: 130000961134
• [Journal Article] The brain-derived neurotrophic(BDNF) polymorphism Val66Met is associated with neither serum BDNF level nor response to selective serotonin reuptake inhibitors in depressed Japanese patients (2011)
  • Author(s): Yoshimura, R.・Kishi T・Suzuki A・Nakano, W.・Sugita, A.・Hori, H.・Otani K・Iwata N・Nakamura, J
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry Volume: 35(4) Pages: 1022-1025
• [Journal Article] うつ病での脳由来神経栄養因子(BDNF)の血中動態 (2011)
  • Author(s): 吉村玲児
  • Journal Title: 日本生物学的精神医学会誌 Volume: 22(2) Pages: 83-87
  • NAID: 10029785531
• [Journal Article] Type A behavior pattern hyperthymic temperament (2011)
  • Author(s): Yumei Wang・Terao, T・Hoaki, N・Goto, S・Tsuchiyama, K・Iwata, N・Yoshimura, R.・Nakamura, J
  • Journal Title: Possible association with bipolarIVdisorder Journal of Affective Disorders Volume: 133(1-2) Pages: 22-28
• [Journal Article] 気分障害の生化学的マーカー (2011)
  • Author(s): 中野和歌子・吉村玲児・中村純
  • Journal Title: 精神科 Volume: 18(5) Pages: 495-498
• [Journal Article] Relationships between stress, social adaptation, personality traits, brain-derived neurotrophic factor and 3-methoxy-4-hydroxyphenylglycol plasma concentrations in employees at a publishing company in Japan (2011)
  • Author(s): Okuno, K.・Yoshimura, R.・Ueda, N.・Sugita, A.・Nakano, W.・Hori, H.・Hayashi, K.・Katsuki, A.・Chen, HI.・Nakamura, J
  • Journal Title: Psychiatry Res Volume: 186(2-3) Pages: 326-332
• [Journal Article] Association between the DAOA/G72 gene and bipolar disorder and meta-analyses in bipolar disorder and schizophrenia (2011)
  • Author(s): Muller DJ・Zai CC・Shinkai, T.・Strauss J・Kennedy JL
  • Journal Title: Bipolar Disord Volume: 13(2) Pages: 198-207
• [Journal Article] うつ病の病態にBDNFはどのように関わるか (2011)
  • Author(s): 吉村玲児・中村純
  • Journal Title: カレントテラピー Volume: 29(3 Pages: 48-51
• [Journal Article] うつ病患者の社会復帰に関するSocial Adaptation Self-evaluation Scale(SASS)日本語版の臨床的有用性 (2011)
  • Author(s): 中野英樹・上田展久・中野和歌子・杉田篤子・吉村玲児・中村純
  • Journal Title: 精神医学 Volume: 53(2) Pages: 185-190
  • NAID: 40017658523
• [Journal Article] うつ病患者の社会復帰に関するSocial Adaptation Self-evaluation Scale (SASS)日本語版の臨床的有用性 (2011)
  • Author(s): 中野英樹・上田展久・中野和歌子・杉田篤子・吉村玲児・中村純
  • Journal Title: 精神医学 Volume: 53 Pages: 185-190
  • NAID: 40017658523
  • Peer Reviewed
• [Journal Article] Association between the DAOA/G72 gene and bipolar disorder and metaanalyses in bipolar disorder and schizophrenia. Bipolar Disord (2011)
  • Author(s): Muller DJ・Zai CC・Shinkai, T.・Strauss J・Kennedy JL
  • Journal Title: Bipolar Disord Volume: 13(2) Pages: 198-207
  • Peer Reviewed
• [Journal Article] Comparison of brain N-acetylaspartate levels and serum brain-derived neurotrophic factor (BDNF) levels between patients with first-episode schizophrenia psychosis and healthy controls (2011)
  • Author(s): Goto, N.・Yoshimura, R.・Kakeda, S.・Moriya, J.・Hayashi, K.・Sugita, A.・Nakano, W.・Hori, H.・Ueda, N.・Korogi, Y.・Nakamura, J.
  • Journal Title: Eur Psychiatry Volume: 26(1) Pages: 57-63
  • Peer Reviewed
• [Journal Article] Relationships between stress, social adaptation, personality traits, brain-derived neurotrophic factor and 3-methoxy-4-hydroxyphenylglycol plasmaconcentrations in employees at a publishing company in Japan (2011)
  • Author(s): Okuno, K.・Yoshimura, R.・Ueda, N.・Sugita, A.・Nakano, W.・Hori, H.・Hayashi, K.・Katsuki, A.・Chen, HI.・Nakamura, J.
  • Journal Title: Psychiatry Res Volume: 186(2-3) Pages: 326-332
  • Peer Reviewed
• [Journal Article] Type A behavior pattern hyperthymic temperament : Possible association with bipolar IV disorder (2011)
  • Author(s): Yumei Wang・Terao, T・Hoaki, N・Goto, S・Tsuchiyama, K・Iwata, N・Yoshimura, R.・Nakamura, J.
  • Journal Title: Journal of Affective Disorders Volume: 133(1-2) Pages: 22-28
  • Peer Reviewed
• [Journal Article] The brain-derived neurotrophic (BDNF) polymorphism Val66Met is associated with neither serum BDNF level nor response to selective serotonin reuptake inhibitors in depressed Japanese patients (2011)
  • Author(s): Yoshimura, R.・Kishi T・Suzuki A・Nakano, W.・Sugita, A.・Hori, H.・Otani K・Iwata N・Nakamura, J.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry Volume: 35(4) Pages: 1022-1025
  • Peer Reviewed
• [Journal Article] 抗うつ薬の潜在的有害事象-賦活症状を中心に- (2011)
  • Author(s): 中村純
  • Journal Title: 最新精神医学 Volume: 16(4) Pages: 459-466
  • Peer Reviewed
• [Journal Article] A case of a depressive patient with alcohol and nicotine dependence successfully treated with sertraline (2011)
  • Author(s): Nakano, W.・Yoshimura, R.・Katsuki, A.・Nakamura, J.
  • Journal Title: Clinical Neuropsychopharmacology and Therapeutics Volume: 2 Pages: 24-26
  • NAID: 130000961134
  • Peer Reviewed
• [Journal Article] 症状による抗うつ薬の使い方 (2011)
  • Author(s): 吉村玲児・中野和歌子・中村純
  • Journal Title: Depression Strategyうつ病治療の新たなストラテジー Volume: 1(1) Pages: 4-6
  • NAID: 40019351452
• [Journal Article] A case of discontinuation syndrome following the discontinuation of low-dose mirtazapine therapy in malignant lymphoma (2011)
  • Author(s): Sugita, A.・Yoshimura, R.・Nakamura, J.
  • Journal Title: Clinical Neuropsychopharmacology and Therapeutics Volume: 2 Pages: 30-31
  • NAID: 130000961136
  • Peer Reviewed
• [Journal Article] ムードスタビライザーとしてのバルプロ酸・carbamazepineの位置付け (2011)
  • Author(s): 中野和歌子・吉村玲児・堀輝・中村純
  • Journal Title: 臨床精神薬理 Volume: 14(9) Pages: 1471-1477
  • Peer Reviewed
• [Journal Article] Effect of treatment with atypical drugs for 6months on brain levels of N-acetylaspartate or serum levels of brain-derived neurotrophic factor i early-stage first-episode schizophrenia-a preliminary study (2011)
  • Author(s): Goto, N.・Yoshimura, R.・Hayashi, K.・Hori, H.・Sugita, A.・Nakano, W.・Katsuki, A.・Atake, K.・Korogi, Y.・Nakamura, J.
  • Journal Title: Clinical Neuropsychopharmacology and Therapeutics Volume: 2 Pages: 34-42
  • Peer Reviewed
• [Journal Article] 剤形選択から考える統合失調症患者の服薬アドヒアランス向上 (2011)
  • Author(s): 堀輝・中村純
  • Journal Title: 臨床精神薬理 Volume: 14(10) Pages: 1607-1613
  • Peer Reviewed
• [Journal Article] 内科医に知ってほしいうつ状態・うつ病の概念と治療指針 (2011)
  • Author(s): 堀輝・中村純
  • Journal Title: Medical Practice Volume: 28(10) Pages: 1720-1729
• [Journal Article] Three polymorphisms of the eNOS gene and plasma levels of metabolites of nitric oxide in depressed Japanese patients : a preliminary report (2011)
  • Author(s): Sugita, A.・Yoshimura, R.・Taro Kishi・Nakano, W.・Hori, H.・Hayashi, K.・Katsuki, A.・Ueda, N.・Nakao Iwata・Nakamura, J.
  • Journal Title: Human Psychopharmacology Volume: 26(7) Pages: 531-534
  • Peer Reviewed
• [Journal Article] 内科医のためのうつ病治療へのアプローチその1内科医のための基礎知識と治療指針内科医に知ってほしいうつ状態・うつ病の概念と治療指針 (2011)
  • Author(s): 堀輝・中村純
  • Journal Title: Medical Practice Volume: 28(10) Pages: 1720-1729
• [Journal Article] Several prescription patterns of antipsychotic drugs influence cognitive functions in Japanese chronic schizophrenia patients (2011)
  • Author(s): Hori, H.・Yoshimura, R.・Katsuki, A.・Hayashi, K.・Sugita, A.・Nakano, W.・Nakamura, J.
  • Journal Title: International journal of Psychiatry in Clinical Practice Volume: (in press)
  • Peer Reviewed
• [Journal Article] Reliability, validity and clinical utility of a Japanese version of the Social Adaptation Self-evaluation Scale as calibrated using the Beck Depression Inventory (2011)
  • Author(s): Ueda, N.・Sudaari, A・Nakano, H.・Nakano, W.・Sugita, A.・Hori, H.・Yoshimura, R.・Nakamura, J.
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 65(7) Pages: 624-629
  • Peer Reviewed
• [Journal Article] うつ病患者の社会復帰に関するSocial Adaptation Self-evaluation Scale(SASS)日本語版の臨床的有用性 (2011)
  • Author(s): 中野英樹, 上田展久, 中野和歌子, 杉田篤子, 吉村玲児, 中村純
  • Journal Title: 精神医学 Volume: 53 Pages: 185-190
  • NAID: 40017658523
  • Peer Reviewed
• [Journal Article] 各新規抗うつ薬の臨床薬理学的特徴と位置づけ (2010)
  • Author(s): 吉村玲児・中野和歌子・杉田篤子・堀輝・中村純
  • Journal Title: 臨床精神薬理 Volume: 13(12) Pages: 2253-2258
• [Journal Article] 福岡県下の多施設調査-うつ病治療の現状- (2010)
  • Author(s): 中野和歌子・吉村玲児・中村純
  • Journal Title: 臨床精神薬理 Volume: 13(12) Pages: 2237-5244
• [Journal Article] 気分障害とBDNF (2010)
  • Author(s): 吉村玲児・杉田篤子・堀輝・中野和歌子・香月あすか・林健司・阿竹聖和・上田展久・中村純
  • Journal Title: 日本神経精神薬理学雑誌 Volume: 30(5-6) Pages: 181-184
  • NAID: 10029093680
• [Journal Article] Plasma levels of brain-derived neurotrophic factor and interleukin-6 in patients with dysthymic disorder comparison with age-and sex-matched major depressed patients and healthy controls (2010)
  • Author(s): Yoshimura, R.・Nakano, W.・Hoshuyama, T.・Sugita, A.・Hori, H.・Katsuki, A.・Hayashi, K.・Atake, K.・Nakamura, J
  • Journal Title: Hum Psychopharmacol Volume: 25(7-8) Pages: 566-569
• [Journal Article] SIRT1 gene is associated with major depressive disorder in the Japanese population (2010)
  • Author(s): Kishi, T.・Yoshimura, R.・Kitajima, T.・Okochi, T.・Okumura, T.・Tsunoka, T.・Yamanouchi, Y.・Kinoshita, Y.・Kawashima, K.・Fukuo, Y.・Naitoh, H.・Nakano, W.・Inada, T.・Nakamura, J.・Ozaki, N.・Iwata, N
  • Journal Title: J Affect Disord Volume: 126(1-2) Pages: 167-173
• [Journal Article] 神経栄養因子BDNF仮説の検証 (2010)
  • Author(s): 吉村玲児・杉田篤子・堀輝・中野和歌子・林健司・香月あすか・上田展久・中村純
  • Journal Title: 精神神経学雑誌 Volume: 112(10) Pages: 982-985
  • NAID: 10028059789
• [Journal Article] HTR2A is Associated with SSRI Response in Major Depressive Disorder in a Japanese (2010)
  • Author(s): Kishi, T.・Yoshimura, R.・Kitajima, T.・Okochi, T.・Okumura, T.・Tsunoka, T.・Yamanouchi, Y.・Kinoshita, Y.・Kawashima, K.・Naitoh, H.・Nakamura, J.・Ozaki, N.・Iwata, N
  • Journal Title: Cohort Neuromolecular Med Volume: 12(3) Pages: 237-242
• [Journal Article] No difference in adherence to paroxetine between depressed patients with early remission and those with late remission based on monitoring of plasma paroxetine concentrations (2010)
  • Author(s): Yoshimura, R.・Nakano, W.・Ueda, N.・Sugita, A.・Hori, H.・Katsuki, A.・Hayashi, K.・Miyamoto, K.・Kodama, Y.・Nakamura, J
  • Journal Title: Hum Psychopharmacol Volume: 25(6) Pages: 487-490
• [Journal Article] Pharmacogenetic study of serotonin 6 receptor gene with antidepressant response in major depressive disorder in the Japanese population (2010)
  • Author(s): Kishi, T.・Fukuo, Y.・Yoshimura, R.・Okochi, T.・Kitajima, T.・Naitoh, H.・Nakano, W.・Nakamura, J.・Ozaki, N.・Iwata, N
  • Journal Title: Hum Psychopharmacol Volume: 25(6) Pages: 481-486
• [Journal Article] Relationships between stress, social adaptation, personality traits, brain-derived neurotrophic factor and 3-methoxy-4-hydroxyphenylglycol plasma concentrations in employees at a publishing company in Japan (2010)
  • Author(s): Kanae O・Yoshimura, R.・Nobuhisa Ueda・Sugita, A.・Nakano, W.・Hori, H.・Hayashi, K.・Katsuki, A.・Hsin-I Chen・Nakamura, J
  • Journal Title: Psychiatry Research Volume: 186 Pages: 326-332
• [Journal Article] Serotonin 6 receptor gene and mood disorders : case-control study and meta-analysis (2010)
  • Author(s): Fukuo, Y.・Kishi, T.・Yoshimura, R.・Kitajima, T.・Okochi, T.・Yamanouchi, Y.・Kinoshita, Y.・Kawashima, K.・Naitoh, H.・Nakano, W.・Inada, T.・Kunugi, H.・Kato, T.・Yoshikawa, T.・Ujike, H.・Nakamura, J.・Ozaki, N.・Iwata, N
  • Journal Title: Neurosci Res Volume: 67(3) Pages: 250-255
• [Journal Article] Association analysis of SIGMAR1 with major depressive disorder and SSRI response (2010)
  • Author(s): Kishi, T.・Yoshimura, R.・Okochi, T.・Fukuo, Y.・Kitajima, T.・Okumura, T.・Tsunoka, T.・Kawashima, K.・Yamanouchi, Y.・Kinoshita, Y.・Nakano, W.・Naitoh, H.・Nakamura, J.・Ozaki, N.・Iwata, N
  • Journal Title: Neuropharmacology Volume: 58(7) Pages: 1168-1173
• [Journal Article] Nonadherence to paroxetine : a study based on monitoring plasma paroxetine levels (2010)
  • Author(s): Yoshimura, R.・Sugita, A.・Nakano, W.・Hori, H.・Ueda, N.・Nakamura, J
  • Journal Title: J Clin Psychopharmacol Volume: 30(1) Pages: 82-83
• [Journal Article] Adding a low dose atypical antipsychotic drug to an antidepressant induced a rapid increase of plasma brain-derived neurotrophic factor levels in patients with treatment-resistant depression (2010)
  • Author(s): Yoshimura, R.・Sugita, A.・Hori, H.・Nakano, W.・Katsuki, A.・Hayashi, K.・Ueda, N.・Nakamura, J
  • Journal Title: Prog Neropsychopharmacol Biol Volume: 34(2) Pages: 308-312
• [Journal Article] Predictive factors for responding to sertraline treatment : views fromPlasma catecholamine metabolites and serotonin transporter polymorphism. (2010)
  • Author(s): Umene-Nakano W., Yoshimura R, Ueda N, Suzuki A, Ikenouchi-Sugita A, Hori H, Otani K, Nakamura J
  • Journal Title: Journal of Psychopharmacology Volume: 24 Pages: 1764-1771
  • Peer Reviewed
• [Journal Article] Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia : integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches. (2010)
  • Author(s): Ikeda M, Yasuyuki T, Mouri A, Koga M, Okochi T, Yoshimura R, Yamanouchi Y, Kinoshita Y, Hashimoto R, Williams HJ, Takeda M, Nakamura J, et al.
  • Journal Title: Biolological Psychiatry Volume: 67 Pages: 263-269
  • Peer Reviewed
• [Journal Article] Nonadherence to paroxetine : a study based on monitoring plasmaparoxetine levels. (2010)
  • Author(s): Yoshimura R, Sugita A, Nakano W, Hori H, Ueda N, Nakamura J.
  • Journal Title: J Clin Psychopharmacol Volume: 30(1) Pages: 82-83
  • Peer Reviewed
• [Journal Article] Association between plasma nitric oxide metabolites levels and negative symptoms of schizophrenia : a pilot study. (2010)
  • Author(s): Nakano Y, Yoshimura R, Nakano H, Sugita A, Hori H, Nakano W, Ueda N, Nakamura, J
  • Journal Title: Human Psychopharmacology Clinical and Experimental Volume: 25 Pages: 139-144
  • Peer Reviewed
• [Journal Article] Gray and white matter volumetric and diffusion tensor imaging (DTI)analyses in the early stage of first-episode schizophrenia. (2010)
  • Author(s): Moriya J, Kakeda S, Abe O, Goto N, Yoshimura R, Hori H, Ohnari N, Sato T, Aoki S, Ohtomo K, Nakamura J, Korogi Y.
  • Journal Title: Schizophrenia Research Volume: 116 Pages: 196-203
  • Peer Reviewed
• [Journal Article] Different patterns of longitudinal changes in plasma levels of catecholamine metabolites and brain-derived neurotrophic factor after administration of atypical antipsychotics in first episode untreated schizophrenic patients. (2010)
  • Author(s): Yoshimura R, Ueda N, Hori H, Sugita A, Nakano W, Nakamura J
  • Journal Title: World Journal of Biological Psychiatry Volume: 11 Pages: 256-261
  • Peer Reviewed
• [Journal Article] Varenichne does not increase serum BDNF levels in patients with nicotine dependence. (2010)
  • Author(s): Nakano W, Yoshimura R, Yoshii C, Hoshuyama T, Hayashi K, Hori H, Katsuki A, Sugita A, Nakamura J
  • Journal Title: Human Psychopharmacology Clinical and Experimental Volume: 25 Pages: 276-279
  • Peer Reviewed
• [Journal Article] Adding a low dose atypical antipsychotic drug to an antidepressant induced a rapid increase of plasma brain-derived neurotrophic factor levels inpatients with treatment-resistant depression. (2010)
  • Author(s): Yoshimura R, Sugita A, Hori H, Nakano W, Katsuki A, Hayashi K, Ueda N, Nakamura J
  • Journal Title: Progress in Nero-Psychopharmacology and Biological Psychiatry Volume: 34 Pages: 308-312
  • Peer Reviewed
• [Journal Article] Serum brain-derived neurotrophic factor levels as a novel biological marker for the activities of psychiatric symptoms in systemic lupus erythematosus. (2010)
  • Author(s): Ikenouchi-Sugita A, Yoshimura R, Okamoto T, Umene-Nakano W, Ueda N, Hori H, Katsuki A, Saito K, Tanaka Y, Nakamura J
  • Journal Title: World Journal of Biological Psychiatry Volume: 11
  • Peer Reviewed
• [Journal Article] Association analysis of SIGMAR1 with major depressive disorder and SSRI response. (2010)
  • Author(s): Kishi T, Yoshimura R, Okochi T, Fukuo Y, Kitajima T, Okumura T, Nakano W., Naitoh H, Nakamura J, Ozaki N, Iwata N
  • Journal Title: Neuropharmacology Volume: 58 Pages: 1168-1173
  • Peer Reviewed
• [Journal Article] Storage of GABA in chromaffin granules and not in synaptic-like microvesicles in rat adrenal medullary cells. (2010)
  • Author(s): Harada K, Matsuoka H, Nakamura J, Fukuda M, Inoue M
  • Journal Title: J Neurochem Volume: 114(2) Pages: 617-626
  • Peer Reviewed
• [Journal Article] Serotonin 6 receptor gene and mood disorders : case-control study and meta-analysis. (2010)
  • Author(s): Fukuo Y, Kishi T, Yoshimura R, Kitajima T, Okochi T, Yamanouchi Y, Kinoshita Y, Kawashima K, Naitoh H, Nakano W, Inada T, Kunugi H, Kato T, Yoshikawa T, Ujike H, Nakamura J, Ozaki N, Iwata N
  • Journal Title: Neuroscience Research Volume: 67 Pages: 250-255
  • Peer Reviewed
• [Journal Article] Pharmacogenetic study of serotonin 6 receptor gene with antidepressant response in major depressive disorder in the Japanese population. (2010)
  • Author(s): Kishi T, Fukuo Y, Yoshimura R, Okochi T, Kitajima T, Naitoh H, Nakano W, Nakamura J, Ozaki N, Iwata, N
  • Journal Title: Human Psychopharmacology Clinical and Experimental Volume: 25 Pages: 481-486
  • Peer Reviewed
• [Journal Article] No difference in adherence to paroxetine between depressed patients with early remission and those with late remission based on monitoring of plasma paroxetine concentrations. (2010)
  • Author(s): Yoshimura R, Nakano W, Ueda N, Sugita A, Hori H, Katsuki A, Hayashi K, Miyamoto K, Kodama Y, Nakamura J.
  • Journal Title: Human Psychopharmacology Clinical and Experimental Volume: 25 Pages: 487-490
  • Peer Reviewed
• [Journal Article] HTR2A is associated with SSRI response in major depressive disorder in a Japanese cohort. (2010)
  • Author(s): Kishi T, Yoshimura R, Kitajima T, Okochi T, Okumura T, Tsunoka T, Yamanouchi Y, Kinoshita Y, Kawashima K, Naitoh H, Nakamura J, Ozaki N, Iwata N.
  • Journal Title: Neuromolecular Medicine Volume: 12 Pages: 237-242
  • Peer Reviewed
• [Journal Article] Lack of association between MAGEL2 and schizophrenia and mood disorders in the Japanese population. (2010)
  • Author(s): Fukuo Y, Kishi T, Okochi T, Kitajima T, Tsunoka T, Okumura T, Kinoshita Y, Kawashima K, Yamanouchi Y, Nakano W, Naitoh H, Inada T, Yoshimura R, Nakamura J, Ozaki N, Iwata N
  • Journal Title: Neuromelecular Medicine Volume: 12 Pages: 285-291
  • Peer Reviewed
• [Journal Article] SIRT1 gene is associated with major depressive disorder in the Japanese population. (2010)
  • Author(s): Kishi T, Yoshimura R, Kitajima T, Okochi T, Okumura T, Tsunoka T, Yamanouchi Y, Kinoshita Y, Kawashima K, Fukuo Y, Naitoh H, Umene-Nakano W, Inada T, Nakamura J, Ozaki N, Iwata N
  • Journal Title: Journal of Affective Disorder Volume: 126 Pages: 167-173
  • Peer Reviewed
• [Journal Article] Critical examination of a correlation between brain gamma- aminobutyricacid(GABA)concentrations and a personality trait of extroversion in healthy volunteers as measured by a 3Tesla proton magnetic resonance spectroscopy study. (2010)
  • Author(s): Goto N, Yoshimura R, Moriya J, Kakeda S, Hayashi K, Ueda N, Sugita, A, Nakano W, Ohnari N, Korogi Y, Nakamura J
  • Journal Title: Psychiatry Research Volume: 182 Pages: 53-57
  • Peer Reviewed
• [Journal Article] Relationships between stress, social adoptation, personality traits, brain-derived neurotrophic factor and 3-methoxy-4-hydroxyphenylglycol plasma concentrations in employees at a publishing company in Japan. (2010)
  • Author(s): Okuno K, Yoshimura R, Ueda N, Ikenouchi-Sugita A, Umene-Nakano W, Hori H, Hayashi K, Katsuki A, Chen HI, Nakamura J
  • Journal Title: Psychiatry Research Volume: Sep 8(Pubmed ahead of print)
  • Peer Reviewed
• [Journal Article] No alteratios of brain GABA after 6 months treatment with atypical antipsychotic drugs in early-stage first-episode schizophrenia. (2010)
  • Author(s): Goto N, Yoshimura R, Kakeda S, Moriya J, Hori H, Hayashi K, Ikenouchi-Sugita A, Nakano-Umene W, Katsuki A, Nishimura J, Korogi Y, Nakamura J
  • Journal Title: Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume: 34 Pages: 1480-1483
  • Peer Reviewed
• [Journal Article] Plasma levels of brain-derived neurotrophic factor and interleukin-6 in patients with dysthymic disorder : comparison with age-and sex-matched major depressed patients and healthy controls. (2010)
  • Author(s): Yoshimura R, Umene-Nakano W, Hoshuyama T, Atsuko Ikenouchi-Sugita, Hikaru Hori, Asuka Katsuki, Kenji Hayashi, Kiyokazu Atake, Jun Nakamura
  • Journal Title: Human Psychycopharmacology Clinical and Experimental Volume: In Press
  • Peer Reviewed
• [Journal Article] Adding a low dose atypical antipsychotic drug to an antidepressant Induced a rapid increase of plasma brain-derived neurotrophic factor levels in patients with treatment-resistant depression. (2010)
  • Author(s): Yoshimura R., at al.
  • Journal Title: Progress in Neuro-Psychopharmacology & Biol. Psychiatry 34(2) Pages: 308-312
  • Peer Reviewed
• [Journal Article] Opposite effects of milnacipran, a serotonin norepinephrine reuptake inhibitor, on the levels of nitric oxide and brain-derived neurotrophic factor in mouse brain cortex (2009)
  • Author(s): Sugita, A.・Toyohira, Y.・Ueno, S.・Tsutsui, M.・Nakamura, J.・Yanagihara, N
  • Journal Title: Naunyn Schmiedebergs Arch Pharmacol Volume: 380(6) Pages: 479-486
• [Journal Article] Effects of antidepressants on plasma metabolites of nitric oxide in major depressive disorder (2009)
  • Author(s): Sugita, A.・Yoshimura, R.・Hori, H.・Nakano, W.・Ueda, N.・Nakamura, J
  • Journal Title: Comparison between milnacipran and paroxetine Prog Neuropsychopharmacol Biol Psychiatry Volume: 33(8) Pages: 1451-1453
• [Journal Article] Tricholliomania responding to low-dose fluvoxamine (2009)
  • Author(s): Sugita, A.・Yoshimura, R.・Ueda, N.・Nakamura, J
  • Journal Title: Psychiatry Clin Neurosci Volume: 63(5) Pages: 701-702
• [Journal Article] 難治性うつ病に対する非定型抗精神病薬の効果 (2009)
  • Author(s): 上田展久・中村純
  • Journal Title: 臨床精神医学 Volume: 38(10) Pages: 1521-1528
• [Journal Article] アルコールとうつ:カテコールアミンと脳由来神経栄養因子からの検討 (2009)
  • Author(s): 吉村玲児・中野和歌子・中村純
  • Journal Title: 精神神経学雑誌 Volume: 111(7) Pages: 825-828
  • NAID: 10026307595
• [Journal Article] うつ病とアルコール依存症との合併 (2009)
  • Author(s): 中野和歌子・吉村玲児
  • Journal Title: 日本アルコール精神医学雑誌 Volume: 16(1) Pages: 19-26
• [Journal Article] Rapid response to paroxetine is associated with plasma paroxetine levels at 4 but not 8 weeks of treatment, and is independent of serotonin transporter promoter polymorphism in Japanese depressed patients (2009)
  • Author(s): Yoshimura, R.・Nakano, W.・Suzuki, A.・Ueda, N.・Miyamoto, K.・Sugita, A.・Hori, H.・Otani, K.・Nakamura, J
  • Journal Title: Hum Psychopharmacol Volume: 24(6) Pages: 489-494
• [Journal Article] Serum levels of brain-derived neurotrophic factor in comorbidity of depression and alcohol dependence (2009)
  • Author(s): Nakano, W.・Yoshimura, R.・Sugita, A.・Hori, H.・Hayashi, K.・Ueda, N.・Nakamura, J
  • Journal Title: Hum Psychopharmacol Volume: 24(5) Pages: 409-413
• [Journal Article] 尿閉、前立腺肥大を有する患者に対する抗うつ薬 (2009)
  • Author(s): 上田展久・中村純
  • Journal Title: 精神科治療学 Volume: 24(7) Pages: 809-812
• [Journal Article] Higher plasma interleukin-6(1L-6) level is associated with SSRI-or SNRI-refractory depression (2009)
  • Author(s): Yoshimura, R.・Hori, H.・Sugita, A.・Nakano, W.・Ueda, N.・Nakamura, J
  • Journal Title: Prog Neuropsychophamacol Biol Psychiatry Volume: 33(4) Pages: 722-726
• [Journal Article] How many well vs. unwell days can you expect over 10 years, once you become depressed (2009)
  • Author(s): Furukawa, TA.・Yoshimura, R.・Harai, H.・Imaizumi, T.・Takeuchi, H.・Kitamura, T.・Takahashi, K
  • Journal Title: Acta Psychiatr Scand Volume: 119(4) Pages: 290-297
• [Journal Article] 非定型抗精神病薬の難治性うつ病への適用:血漿中脳由来神経栄養因子からの検討 (2009)
  • Author(s): 吉村玲児
  • Journal Title: 臨床精神薬理 Volume: 12(4) Pages: 25-31
• [Journal Article] Grapefruit juice alters plasma sertraline levels after single ingestion of sertraline in healthy volunteers (2009)
  • Author(s): Ueda, N.・Yoshimura, R.・Nakano, W.・Sugita, A.・Hori, H.・Hayashi, K.・Nakamura, J
  • Journal Title: World J Biol Psychiatry Volume: 10(4) Pages: 832-835
• [Journal Article] A case with occurring adverse effects when cross-over titration from fluvoxamine to paroxetine associated with increasing the plasma fluvoxamine level in major depressive disorder (2009)
  • Author(s): Hori, H.・Yoshimura, R.・Ueda, N.・Sugita, A.・Nakano, W.・Nakamura, J
  • Journal Title: World J Biol Psychiatry Volume: 10(4) Pages: 620-622
• [Journal Article] Effects of antidepressants on plasma metabolites of nitric oxide in major depressive disorder : comparison between milnacipran and paroxetine (2009)
  • Author(s): Ikenouchi-Sugita A., et al
  • Journal Title: Progress in Neuro-Psychopharmacology & Biol. Psychiatry 33(8) Pages: 1451-1453
  • Peer Reviewed
• [Journal Article] Higher plasma interleukin-6 (IL-6) level is associated with SSRI-or SNRI-refractory depression. (2009)
  • Author(s): Yoshimura R., et al.
  • Journal Title: Progress in Neuro-Psychopharmacology & Biol. Psychiatry 33(4) Pages: 722-726
  • Peer Reviewed
• [Journal Article] Predictive factors for responding to sertraline treatment : view from plasma catecholamine metabolites and serotonin transporter polymorphism (2009)
  • Author(s): Umene-Nakano, et al.
  • Journal Title: J Psychopharmacology
  • Peer Reviewed
• [Presentation] BDNF polymorphism (Val66Met) is associated with neither serum BDNF level nor response to SSRIs in depressed Japanese patients (2011)
  • Author(s): 中野和歌子
  • Organizer: 第32回日本臨床薬理学会年会
  • Place of Presentation: アプトシティー浜松(静岡)(招待講演)
  • Year and Date: 2011-12-01
• [Presentation] 各抗うつ薬の血中-酸化窒素動態への影響 (2011)
  • Author(s): 杉田篤子・吉村玲児・香月あすか・阿竹聖和・堀輝・中野和歌子・中村純
  • Organizer: 第21回日本臨床精神神経薬理学会・第41回日本神経精神薬理学会合同年会
  • Place of Presentation: 京王プラザホテル(東京)
  • Year and Date: 2011-10-27
• [Presentation] 多様なうつ病の治療と病態 (2011)
  • Author(s): 中村純
  • Organizer: 第21回日本臨床精神神経薬理学会・第41回日本神経精神薬理学会合同年会
  • Place of Presentation: 京王プラザホテル(東京)(招待講演)
  • Year and Date: 2011-10-27
• [Presentation] Duloxetineの血中カテコラミン代謝産物濃度への影響 (2011)
  • Author(s): 阿竹聖和・香月あすか・林健司・中野和歌子・杉田篤子・堀輝・吉村玲児・中村純
  • Organizer: 第21回日本臨床精神神経薬理学会第41回日本神経精神薬理学会合同年会
  • Place of Presentation: 京王プラザホテル(東京)
  • Year and Date: 2011-10-27
• [Presentation] Deloxetine投与中に幻覚妄想を呈した2症例 (2011)
  • Author(s): 柴田裕香・山田健治・堀輝・鎌田壇・新開隆弘・中村純
  • Organizer: 第64回九州精神神経学会
  • Place of Presentation: 福岡国際会議場(福岡)
  • Year and Date: 2011-10-16
• [Presentation] No Association between Responses to the Addition of an Atypical Antipsychotic Drug a SSRI or SNRI and BDNF (Val66Met) Polymorphism in Refractory Major Depressive Disorder in Japanese Patients (2011)
  • Author(s): Yoshimura, R.・Kishi, T・Nakano, W.・Sugita, A.・Hori, H.・Katsuki, A.・Iwta, N・Nakamura, J.
  • Organizer: 2^<nd> Congress of Asian college of Neuro Psychopharmacology
  • Place of Presentation: Grand Hilton, Seoul(韓国)
  • Year and Date: 2011-09-23
• [Presentation] 統合失調症患者における多剤併用療法と認知機能障害～新規抗精神病薬同士の併用療法は有効か?～ (2011)
  • Author(s): 香月あすか・堀輝・吉村玲児・中村純
  • Organizer: 第6回日本統合失調症学会
  • Place of Presentation: 札幌コンベンションセンター(北海道)
  • Year and Date: 2011-07-18
• [Presentation] 統合失調症患者の認知機能障害とカテコールアミン代謝産物、脳由来神経栄養因子との関連 (2011)
  • Author(s): 堀輝・吉村玲児・香月あすか・林健司・杉田篤子・中野和歌子・阿竹聖和・中村純
  • Organizer: 第6回日本統合失調症学会
  • Place of Presentation: 札幌コンベンションセンター(北海道)
  • Year and Date: 2011-07-18
• [Presentation] 多様な抑うつ状態と職場復帰 (2011)
  • Author(s): 中村純
  • Organizer: 第39回日本精神科病院協会精神医学会
  • Place of Presentation: 札幌コンベンションセンター(北海道)(招待講演)
  • Year and Date: 2011-07-14
• [Presentation] 自殺患者と抗うつ薬使用 (2011)
  • Author(s): 中村純
  • Organizer: 第8回日本うつ病学会総会
  • Place of Presentation: 大阪国際交流センター(大阪府天王寺)(招待講演)
  • Year and Date: 2011-07-01
• [Presentation] 生物学的分類;見果てぬ夢 (2011)
  • Author(s): 吉村玲児・中村純
  • Organizer: 第8回日本う病つ学会総会
  • Place of Presentation: 大阪国際交流センター(大阪府天王寺)(招待講演)
  • Year and Date: 2011-07-01
• [Presentation] 「抑うつ関連病名」の社会における使われ方の課題 (2011)
  • Author(s): 中村純
  • Organizer: 第8回日本うつ病学会総会
  • Place of Presentation: 大阪国際交流センター(大阪府天王寺)(招待講演)
  • Year and Date: 2011-07-01
• [Presentation] ミルタザピンは早期から血清BDNF濃度を増加させる (2011)
  • Author(s): 香月あすか・吉村玲児・杉田篤子・堀輝・中野和歌子・中村純
  • Organizer: 第8回日本うつ病学会総会
  • Place of Presentation: 大阪国際交流センター(大阪府天王寺)
  • Year and Date: 2011-07-01
• [Presentation] うつ病勤労者の復職継続群と復職失敗群のおける復職決定時における差異～精神症状、社会適応度、認知機能、背景情報からの検討～ (2011)
  • Author(s): 堀輝・香月あすか・林健司・守田義平・吉村玲児・中村純
  • Organizer: 第8回日本うつ病学会総会
  • Place of Presentation: 大阪国際交流センター(大阪府天王寺)
  • Year and Date: 2011-07-01
• [Presentation] Plasma catecholamine metabolite levels and the activities of psychiatric symptoms in systemic lupus erythematosus (2011)
  • Author(s): Sugita, A.・Yoshimura, R.・Nakano, W.・Hori, H.・Katsuki, A.・Ueda, N.・Nakamura, J.
  • Organizer: 10th World Congress of Biological Psychiatry
  • Place of Presentation: Prague Coungress Center(チェコ共和国Praha)
  • Year and Date: 2011-05-29
• [Presentation] Iowa gambling task in schizophrenia patients : Views from serum brain-derived neurotrophic factor (2011)
  • Author(s): Hori, H.・Yoshimura, R.・Katsuki, A.・Hayashi, K.・Sugita, A.・Nakano, W.・Nakamura, J.
  • Organizer: 10th World Congress of Biologocal Psychiatry
  • Place of Presentation: Prague Coungress Center(チェコ共和国Praha)
  • Year and Date: 2011-05-29
• [Presentation] Comparison of brain N-acetylaspartate levels and blood levels of brain-derived neurotrophic factor (BDNF) between first-episode schizophrenic patients and healthy controls (2011)
  • Author(s): Goto, N.・Yoshimura, R.・Kakeda, S・Hayashi, K.・Sugita, A.・Nakano, W.・Hori, H.・korogi, Y・Nakamura, J.
  • Organizer: 10th World Congress of Biological Psychiatry
  • Place of Presentation: Prague Coungress Center(チェコ共和国Praha)
  • Year and Date: 2011-05-29
• [Presentation] Effect of varenicline on plasma leves of HVA and MHPG in nicotine de pendent patients (2011)
  • Author(s): 中野和歌子・吉村玲児・吉井千春・林健司・杉田篤子・香月あすか・堀輝・中村純
  • Organizer: 第33回日本生物学的精神医学会
  • Place of Presentation: ホテルグランパシフィックLE DAIBA(東京)
  • Year and Date: 2011-05-21
• [Presentation] うつ病の生物学的マーカー:脳由来神経栄養因子(BDNF)を中心に (2011)
  • Author(s): 中野和歌子
  • Organizer: 第33回日本生物学的精神医学学会
  • Place of Presentation: ホテルグランパシフィックLE DAIBA(東京)(招待講演)
  • Year and Date: 2011-05-21
• [Presentation] 職域における精神障害の現状 (2011)
  • Author(s): 中村純
  • Organizer: 第24回日本総合病院精神医学会総会
  • Place of Presentation: 福岡
• [Presentation] 各種抗うつ薬の血中一酸化窒素動態への影響 (2011)
  • Author(s): 杉田篤子・吉村玲児・香月あすか・阿竹聖和・堀輝・中野和歌子・中村純
  • Organizer: 第21回日本臨床精神神経薬理学会・第41回日本神経精神薬理学会
  • Place of Presentation: 東京
• [Presentation] 多様なうつ病の病態と治療 (2011)
  • Author(s): 中村純
  • Organizer: 第21回日本臨床精神神経薬理学会・第41回日本神経精神薬理学会
  • Place of Presentation: 東京
• [Presentation] 各抗うつ薬の血中一酸化窒素動態への影響 (2011)
  • Author(s): 杉田篤子・吉村玲児・香月あすか・阿竹聖和・堀輝・中野和歌子・中村純
  • Organizer: 第21回日本臨床精神神経薬理学会第41回日本神経精神薬理学会合同年会
  • Place of Presentation: 東京
• [Presentation] No Association between Responses to the Addition of an Atypical Antipsychotic Drug a SSRI or SNRI and BDNF(Val66Met) polymorphism in refractory major depressive disorder in Japanese patients (2011)
  • Author(s): Yoshimura, R.・Kishi, T・Nakano, W.・Sugita, A.・Hori, H.・Katsuki, A.・Iwta, N・Nakamura, J
  • Organizer: 2nd AsCNP
  • Place of Presentation: 韓国
• [Presentation] 多様な抑うつ状態と職場復帰 (2011)
  • Author(s): 中村純
  • Organizer: 第39回日本精神科病院協会精神医学会
  • Place of Presentation: 札幌
• [Presentation] なかなか治らないうつの時代～三環系抗うつ薬は消滅していいのか?～ (2011)
  • Author(s): 中村純
  • Organizer: 第8回日本うつ病学会総会
  • Place of Presentation: 大阪
• [Presentation] 自殺患者と抗うつ薬使用 (2011)
  • Author(s): 中村純
  • Organizer: 第8回日本うつ病学会総会
  • Place of Presentation: 大阪
• [Presentation] うつ病勤労者の復職継続群と復職失敗群のおける復職決定時における差異～精神症状、社会適応度、認知機能、背景情報からの検討～ (2011)
  • Author(s): 堀輝・香月あすか・林健司・守田義平・吉村玲児・中村純
  • Organizer: 第8回日本うつ病学会総会
  • Place of Presentation: 大阪
• [Presentation] ミルタザピンは早期から血清BDNF濃度を増加させる (2011)
  • Author(s): 香月あすか・吉村玲児・杉田篤子・堀輝・中野和歌子・中村純
  • Organizer: 第8回日本うつ病学会総会
  • Place of Presentation: 大阪
• [Presentation] 福岡県のうつ病治療の現状に関する多施設調査 (2011)
  • Author(s): 中野和歌子・吉村玲児・中村純
  • Organizer: 第8回日本うつ病学会総会
  • Place of Presentation: 大阪
• [Presentation] 生物学的分類;見果てぬ夢 (2011)
  • Author(s): 吉村玲児・中村純
  • Organizer: 第8回日本うつ病学会総会
  • Place of Presentation: 大阪
• [Presentation] うつ病の生物学的マーカー:脳由来神経栄養因子(BDNF)を中心に (2011)
  • Author(s): 中野和歌子
  • Organizer: 第33回日本生物学的精神医学学会
  • Place of Presentation: 東京
• [Presentation] 精神疾患の生物学的マーカー-われわれの教室の研究から- (2010)
  • Author(s): 中村純
  • Organizer: 第32回日本生物学的精神医学会
  • Place of Presentation: 北九州市(リーガロイヤルホテル小倉)(会長講演)
  • Year and Date: 2010-10-08
• [Presentation] Plasma homovanillic acid levels and 5-HTTLPR gene polymorphism are predictive factors for sertraline in Japanese depressed patients. (2010)
  • Author(s): Nakano W, Yoshimura R, Ueda N, Suzuki A, Ikenouchi-Sugita A, Hori H, Otani K, Nakamura J
  • Organizer: 23rd European Neuro-psychopharmacologicum Congress
  • Place of Presentation: Amsterdam RAI Exhibition and Convention Centre THE NETHERLAND
  • Year and Date: 2010-09-01
• [Presentation] Effects of mirtazapine on brain-derived neurotrophic factor (BDNF) and catecholamine metabolites. (2010)
  • Author(s): Katsuki A, Yoshimura R, Sugita A, Hori H, Nakano W, Hayashi K, Nakamura J
  • Organizer: 23rd European Neuro-psychopharmacologicum Congress
  • Place of Presentation: Amsterdam RAI Exhibition and Convention Centre THE NETHERLAND
  • Year and Date: 2010-09-01
• [Presentation] Cognitive functions and dosage of antipsychotic drugs in Japanese schizophrenia patients. (2010)
  • Author(s): Hori H, Yoshimura R, Katsuki A, Hayashi K, Sugita A, Nakano W, Nakamura J
  • Organizer: 23rd European Neuro-psychopharmacologicum Congress
  • Place of Presentation: Amsterdam RAI Exhibition and Convention Centre THE NETHERLAND
  • Year and Date: 2010-09-01
• [Presentation] The characteristics of pharmacotherapy for inpatients with schizophrenia : amulticentre comparitive study in Asia. (2010)
  • Author(s): Nakano W, Yoshimura R, Yang N, Shinfuku N, Fujii S, Hoshuyama T, Sim K, Chong M, Tan C, Nakamura J
  • Organizer: 23rd European Neuro-psychopharmacologicum Congress
  • Place of Presentation: Amsterdam RAI Exhibition and Convention Centre THE NETHERLAND
  • Year and Date: 2010-09-01
• [Presentation] Three polymorphisms of endothelial nitric oxide synthase (eNOS) gene andplasma N03 levels. (2010)
  • Author(s): Ikenouchi-Sugita A, Yoshimura R, Tishi T, Umene-Nakano W, Hori H, Hayashi K, Katsuki A, Iwata N, Nakamura J
  • Organizer: 23rd European Neuro-psychopharmacologicum
  • Place of Presentation: Amsterdam RAI Exhibition and Convention Centre THE NETHERLAND
  • Year and Date: 2010-08-31
• [Presentation] Nonadherence to paroxetine ; comparison between early-remitters and late-remitters. (2010)
  • Author(s): Nakamura J, Yoshimura R, Ikenouchi-Sugita A, Hori H, Umene-Nakano W, Katsuki A, Ueda N
  • Organizer: 23rd European Neuro-psychopharmacologicum Congress
  • Place of Presentation: Amsterdam RAI Exhibition and Convention Centre THE NETHERLAND
  • Year and Date: 2010-08-31
• [Presentation] Adding an atypical antipsychotic drug induced a rapid increase of plasma BDNF levels in refractory depression., 2010 (2010)
  • Author(s): Yoshimura R, Ikenouchi-Sugita A, Hori H, Umene-Nakano W, Katsuki A, Hayashi K, Nakamura J
  • Organizer: 23rd European Neuro-psychopharmacologicum Congress
  • Place of Presentation: Amsterdam RAI Exhibition and Convention Centre THE NETHERLAND
  • Year and Date: 2010-08-31
• [Presentation] Higher plasma interleukin-6(IL-6)level is associated with SSRI- orSNRI-refractory depression. (2010)
  • Author(s): Yoshimura R, Hori H, Sugita A, Nakano W, Hayashi K, Katsuki A, Nakamura J
  • Organizer: 27th Collegium Internationale Neuro-psychopharmacologicum Congress
  • Place of Presentation: Hong Kong, Convention and Exhibition Centre CHINA
  • Year and Date: 2010-06-06
• [Presentation] Nonadherence to SSRI ; a study based on monitoring plasma levels of antidepressant. (2010)
  • Author(s): Nakamura J, Yoshimura R, Sugita A, Hori H, Nakano W
  • Organizer: 27th Collegium Internationale Neuro-psychopharmacologicum Congress
  • Place of Presentation: Hong Kong, Convention and Exhibition Centre CHINA
  • Year and Date: 2010-06-06
• [Presentation] Plasma homovanillic acid levels and 5-HTTLPR gene polymorphism are predictive factors for sertraline in Japanese depressed patients. (2010)
  • Author(s): Chen HI, Shinkai T, Sakata S, Utsunomiya K, Yamada K, Ohmori O, Nakamura J
  • Organizer: 27th Collegium Internationale Neuro-psychopharmacologicum Congress
  • Place of Presentation: Hong Kong, Convention and Exhibition Centre CHINA
  • Year and Date: 2010-06-06
• [Presentation] 精神疾患の生物学的マーカー-われわれの教室の研究から-(会長講演) (2010)
  • Author(s): 中村純
  • Organizer: 第32回日本生物学的精神医学会
  • Place of Presentation: 北九州
• [Presentation] ミルタザピンの4週間投与は血清BDNF濃度を増加させる可能性がある (2010)
  • Author(s): 香月あすか・吉村玲児・杉田篤子・堀輝・中野和歌子・林健司・中村純
  • Organizer: 第32回日本生物学的精神医学会
  • Place of Presentation: 北九州
• [Presentation] セルトラリンの治療反応予測:血漿HVA濃度、セロトニントランスポータープロモーター領域遺伝子多型から (2010)
  • Author(s): 中野和歌子・吉村玲児・上田展久・鈴木昭仁・杉田篤子・堀輝・大谷浩一・中村純
  • Organizer: 第32回日本生物学的精神医学会
  • Place of Presentation: 北九州
• [Presentation] うつ病での脳由来神経栄養因子の血中動態 (2010)
  • Author(s): 吉村玲児・杉田篤子・堀輝・中野和歌子・中村純
  • Organizer: 第32回日本生物学的精神医学会
  • Place of Presentation: 北九州
• [Presentation] 統合失調症、うつ病でのアルコール・ニコチン依存の合併とその治療 (2010)
  • Author(s): 吉村玲児・中野和歌子・中村純
  • Organizer: 第45回日本アルコール・薬物医学会第22回日本アルコール精神医学会第13回ニコチン・薬物依存研究フォーラム;平成22年度アルコール・薬物依存関連学会合同学術総会
  • Place of Presentation: 北九州
• [Presentation] アルコール依存症とうつ病の合併症に関する臨床薬理学的観点からの検討 (2010)
  • Author(s): 中野和歌子・吉村玲児・中村純
  • Organizer: 第45回日本アルコール・薬物医学会第22回日本アルコール精神医学会第13回ニコチン・薬物依存研究フォーラム;平成22年度アルコール・薬物依存関連学会合同学術総会
  • Place of Presentation: 北九州
• [Presentation] Effects of mirtazapine on brain-derived neurotrophic factor(BDNF) and catecholamine metabolites (2010)
  • Author(s): Katsuki, A.・Yoshimura, R.・Sugita, A.・Hori, H.・Nakano, W.・Hayashi, K.・Nakamura, J
  • Organizer: European Neuropsychopharmacology
  • Place of Presentation: Amsterdam
• [Presentation] Plasma homovanillic acid levels and 5-HTTLPR gene polymorphism are predictive factors for sertraline in Japanese depressed patients (2010)
  • Author(s): Nakano, W.・Yoshimura, R.・Ueda, N.・Suzuki, A.・Sugita, A.・Hori, H.・Otani, K.・Nakamura, J
  • Organizer: European Neuropsychopharmacology
  • Place of Presentation: Amsterdam
• [Presentation] Adding an atypical antipsychotic drug induced a rapid increase of flasma BDNF levels in refractory depression (2010)
  • Author(s): Yoshimura, R.・Sugita, A.・Hori, H.・Nakano, W.・Katsuki, A.・Hayashi, K.・Nakamura, J
  • Organizer: European Neuropsychopharmacology
  • Place of Presentation: Amsterdam
• [Presentation] Nonadherence to paroxetine ; comparison between early-remitters and late-remitters (2010)
  • Author(s): Nakamura, J.・Yoshimura, R.・Sugita, A.・Hori, H.・Nakano, W.・Katsuki, A.・Ueda, N
  • Organizer: European Neuropsychopharmacology
  • Place of Presentation: Amsterdam
• [Presentation] Three polymorphisms of endothelial nitric oxide synthase(eNOS) gene and plasma NO3 levels (2010)
  • Author(s): Sugita, A.・Yoshimura, R.・Kishi, T.・Nakano, W.・Hori, H.・Hayashi, K.・Katsuki, A.・Iwata, N.・Nakamura, J
  • Organizer: European Neuropsychopharmacology
  • Place of Presentation: Amsterdam
• [Presentation] Sertralineとlithium併用中に出現したPisa症候群の1例 (2010)
  • Author(s): 林健司・堀輝・吉村玲児・中村純
  • Organizer: 第20回日本臨床精神神経薬理学会
  • Place of Presentation: 仙台
• [Presentation] Efficacies of a low dose atypical antipsychotic drug addition to an antidepressant and its effects on plasma brain-derived neurotrophic factor levels in refractory depression (2010)
  • Author(s): Yoshimura, R.・Sugita, A.・Hori, H.・Nakano, W.・Katsuki, A.・Hayashi, K.・Ueda, N.・Nakamura, J
  • Organizer: 第20回日本臨床精神神経薬理学会
  • Place of Presentation: 仙台
• [Presentation] セルトラリンの反応性予測因子:血漿中カテコラミン代謝産物及びセロトニントランスポーター遺伝子多型からの検討 (2010)
  • Author(s): 中野和歌子・吉村玲児・中村純, 他5名
  • Organizer: 第20回日本臨床精神神経薬理学会
  • Place of Presentation: 仙台
• [Presentation] Nonadherence to SSRI ; a study based on monitoring plasma levels of antidepressant (2010)
  • Author(s): Nakamura, J.・Yoshimura, R.・Sugita, A.・Hori, H.・Nakano, W
  • Organizer: XXVII CINP CONGRESS
  • Place of Presentation: Hong Kong
• [Presentation] Higherplasmainterleukin-6(IL-6) level is associated with SSRI-or SNRI-refracto (2010)
  • Author(s): Yoshimura, R.・Hori, H.・Sugita, A.・Nakano, W. Nakamura, J
  • Organizer: XXVII CINP CONGRESS
  • Place of Presentation: Hong Kong
• [Presentation] うつ病患者におけるeNOS遺伝子多型と血中NOx濃度の関連 (2010)
  • Author(s): 杉田篤子・吉村玲児・岸太郎・中野和歌子・堀輝・中村純, 他3名
  • Organizer: 第29回躁うつ病の薬理・生化学的研究懇話会
  • Place of Presentation: 箱根
• [Presentation] ミルタザピンの血清BDNFと血漿カテコラミン代謝産物への影響 (2010)
  • Author(s): 香月あすか・吉村玲児・杉田篤子・堀輝・中野和歌子・中村純
  • Organizer: 第29回躁うつ病の薬理・生化学的研究懇談会
  • Place of Presentation: 箱根
• [Presentation] Augmentation of a low dose atypical antipsychotic drug to an antidepressant induced a rapid increase of plasma brain-derived neurotrophic factor levels in patients with refractory depression (2010)
  • Author(s): Yoshimura, R.・Sugita, A.・Hori, H.・Nakano, W・Nakamura, J
  • Organizer: 第29回躁うつ病の薬理・生化学的研究懇話会
  • Place of Presentation: 箱根
• [Presentation] 神経栄養因子BDNF仮説の検証 (2010)
  • Author(s): 吉村玲児・杉田篤子・中村純
  • Organizer: 第106回日本精神神経学会学術総会
  • Place of Presentation: 広島
• [Presentation] アルコール依存と脳由来神経栄養因子(BDNF) (2009)
  • Author(s): 吉村玲児、中野和歌子、中村純
  • Organizer: 第21回日本アルコール精神医学会
  • Place of Presentation: 横浜(パシフィコ横浜)
  • Year and Date: 2009-09-07
• [Presentation] うつ病寛解後の抗うつ薬の服薬コンプライアンス:血中薬物濃度を指標とした検討 (2009)
  • Author(s): 吉村玲児、杉田篤子、堀輝、中野和歌子、上田展久、中村純
  • Organizer: 第6回日本うつ病学会総会
  • Place of Presentation: 東京(品川プリンスホテル)
  • Year and Date: 2009-07-31
• [Presentation] 抗うつ薬が脳内一酸化窒素及び脳由来神経因子の発現に与える影響 (2009)
  • Author(s): 杉田篤子、吉村玲児、豊平由美子, 他
  • Organizer: 第31回 日本生物学的精神医学会
  • Place of Presentation: 京都(京都国際会議場)
  • Year and Date: 2009-04-23
• [Presentation] Alcohol dependence and depression-views from dynamics of brain-Derived neurotrophic factor and catecholamines (2009)
  • Author(s): Nakano W, Yoshimura R, Nakamura J
  • Organizer: Korean Society of Biological Psychiatry
  • Place of Presentation: Soul, Korea (Palace Hotel)
  • Year and Date: 2009-04-03
• [Presentation] Serum amyloid beta protein in young and elderly depression (2009)
  • Author(s): Yoshimura, R.・Hori, H.・Sugita, A.・Nakano, W.・Ueda, N.・Nakamura, J
  • Organizer: 第19回日本臨床精神神経薬理学会
  • Place of Presentation: 京都
• [Presentation] The effectiveness of low dose of fluvoxamine on trichotilliomania (2009)
  • Author(s): Sugita, A.・Yoshimura, R.・Ueda, N.・Nakamura, J
  • Organizer: 第19回日本臨床精神神経薬理学会
  • Place of Presentation: 京都
• [Presentation] 血漿インターロイキン(IL-6)濃度の高値がSSRI抵抗性うつ病と関連する (2009)
  • Author(s): 吉村玲児
  • Organizer: 第19回日本臨床精神神経薬理学会
  • Place of Presentation: 京都
• [Presentation] Social Adaptation Self-evaluation Scale(SASS)日本語版のうつ病患者における臨床的有用性の検討 (2009)
  • Author(s): 中野英樹・上田展久・中野和歌子・杉田篤子・吉村玲児・中村純
  • Organizer: 第105回日本精神神経学会学術総会
  • Place of Presentation: 神戸
• [Presentation] うつ病寛解後の抗うつ薬の服薬コンプライアンス:血中薬物濃度を指標とした検討 (2009)
  • Author(s): 吉村玲児・杉田篤子・堀輝・中野和歌子・上田展久・中村純
  • Organizer: 第6回日本うつ病学会総会
  • Place of Presentation: 東京
• [Presentation] うつ病とアルコール依存症合併例での抗うつ症状に対する抗うつ薬の効果:臨床精神薬理学的予備検討 (2009)
  • Author(s): 中野和歌子・吉村玲児・中村純, 他3名
  • Organizer: 第31回日本生物学的精神医学会
  • Place of Presentation: 京都
• [Presentation] 脳内GABA濃度は外向性・開放性性格と関連する:3T[1H] MRSを用いた健常者での検討 (2009)
  • Author(s): 吉村玲児・後藤直樹・中村純, 他7名
  • Organizer: 第31回日本生物学的精神医学会
  • Place of Presentation: 京都
• [Presentation] 抗うつ薬が脳内一酸化窒素及び脳由来神経栄養因子の発現に与える影響 (2009)
  • Author(s): 杉田篤子・吉村玲児・中村純, 他2名
  • Organizer: 第31回日本生物学的精神医学会
  • Place of Presentation: 京都
• [Book] うつ病今日の診療のためにガイドライン外来診療 (2011)
  • Author(s): 吉村玲児・中村純
  • Publisher: 日経メディカル東京
• [Book] うつ病治療は寛解を目指すべきか?EBM精神疾患の治療中外医学社東京 (2011)
  • Author(s): 中村純
  • Publisher: 中外医学社東京
• [Book] 抗うつ薬の選択の仕方と基本的な使用法向精神薬のリスク・ベネフィット (2011)
  • Author(s): 中村純・吉村玲児
  • Publisher: 中山書店東京
• [Book] 新規抗うつ薬と気分安定剤精神医学キーワード辞典 (2011)
  • Author(s): 中村純
  • Publisher: 中山書店東京
• [Remarks]
  • URL: http://www.uoeh-u.ac.jp/kouza/seisin/homepage/m_gyouseki.html