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An subclinical investigation and a preliminary categorization of bipolar mood liability in childhood

Research Project

Project/Area Number 21591504
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionGunma University

Principal Investigator

UEHARA Toru  群馬大学, 健康支援総合センター, 准教授 (60303145)

Co-Investigator(Kenkyū-buntansha) SUDA Masashi  群馬大学, 医学部, 医員 (30553747)
Research Collaborator ISHIGE Yoko  群馬大学, 医学部, 大学院生
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords児童・思春期精神医学 / 双極性障害 / スクリーニング / 気分障害 / 解離 / 前頭前野 / 軽躁 / 児童青年 / 大学生 / 近赤外線分光法 / 脳機能 / 気分変調 / うつ状態 / メンタルヘルス / 若年期
Research Abstract

This study aimed to clarify bipolar mood swings in youth, and in the first fiscal the authors conducted a structured interview to university students with high-risk on mental health screening. It was revealed 22% with history or current symptoms of bipolar mood liability from childhood. In the next fiscal, by adding elevated mood and irritability items in the screening, the authors examined relationships among the other mental problems. It was demonstrated 1% positive for elevated mood, 1-2% for irritability, and 0.3-0.5% for both item. These two items were correlated with depression, referential idea, eating problems, and disability of daily life significantly. In the last fiscal, the authors investigated frontal functioning using near infrared spectroscopy associated with bipolar mood scores (MDQ) or psychological features. During word fluency task, spread blood volume changes in frontal lobe were shown, but high MDQ group indicated relative lower activation. The MDQ was significantly correlated with deactivation in left lateral portion. And dissociative tendencies were associated with frontal pole deactivations. In youths, subclinical bipolar mood liability or dissociations could be related to lower prefrontal activations, and left lateral dysfunction might be linked with bipolar spectrums.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (20 results)

All 2012 2011 2010 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (4 results) Book (2 results) Remarks (4 results)

  • [Journal Article] A new proposed factor structure : reliability and validity of the diagnostic and statistical manual for mental disorders scale for depression2011

    • Author(s)
      Uehara T, Takeuchi K, Roberts RE
    • Journal Title

      Journal of Psychiatry Psychology, and Mental health

      Volume: No.3,issue 1

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Screening features associated with depression in first-year university students2011

    • Author(s)
      Uehara T, Takeuchi K, Kubota F, Oshima K, Ishikawa O
    • Journal Title

      Psychiatry Research Journal

      Volume: No.11, issue 4 Pages: 325-334

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 大学生における双極性気分変調に関する報告:自記式スクリーニングを用いた検討2011

    • Author(s)
      上原徹, 石毛陽子
    • Journal Title

      精神医学

      Volume: 53巻 Pages: 647-654

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 大学生における双極性気分変調に関する報告:第一報2011

    • Author(s)
      上原徹, 大島喜八, 石川治
    • Journal Title

      Campus Health

      Volume: 48巻 Pages: 181-185

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A new proposed factor structure : reliability and validity of the diagnostic and statistical manual for mental disorders scale for depression2011

    • Author(s)
      Uehara T(上原徹)
    • Journal Title

      Journal of Psychiatry Psychology and Mental health

      Volume: 3(Open access)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 大学生における双極性気分変調に関する報告:第一報2011

    • Author(s)
      上原徹、大島喜八、石川治
    • Journal Title

      Campus Health

      Volume: 48(In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Screening features associated with depression in first-year university students.2011

    • Author(s)
      Uehara T, Takeuchi K, Kubota F, Oshima K, Ishikawa O.?
    • Journal Title

      Psychiatry Research Journal

      Volume: 1(4)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 大学生における双極性気分変調に関する報告:自記式スクリーニングを用いた検討.2011

    • Author(s)
      上原徹、石毛陽子
    • Journal Title

      精神医学

      Volume: 53(In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Annual transition of major depressive episode in university students using a structured self-rating questionnaire2010

    • Author(s)
      Uehara T, Takeuchi K, Kubota F, Oshima K, Ishikawa O
    • Journal Title

      Asia-Pacific Psychiatry

      Volume: No.2,Vo.1 Pages: 99-104

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Annual transition of major depressive episode in university students using a structured self-rating questionnaire.?2010

    • Author(s)
      Uehara T, Takeuchi K, Kubota F, Oshima K, Ishikawa O.
    • Journal Title

      Asia-Pacific Psychiatry

      Volume: 2 Pages: 99-124

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Bipolar mood tendency and frontal activations using a multichannel near-infrared spectroscopy2012

    • Author(s)
      Uehara T, Ishige Y, Fuuda M
    • Organizer
      The World Psychiatric Association (WPA) Regional Meeting : Mental Health and Disaster : Beyond Emergency Response
    • Place of Presentation
      バリ・ハイアットホテル(Bali, Indonesia)
    • Related Report
      2011 Final Research Report
  • [Presentation] Bipolar mood tendency and frontal activations using a multichannel near infrared spectroscopy2012

    • Author(s)
      Uehara T(上原徹)
    • Organizer
      World Psychiatric Association Regional Meeting(世界精神医学会アジア地域会議)
    • Place of Presentation
      バリ・ハイアットホテル、Bali, Indonesia(受理済)(発表確定)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Dissociative tendency, anger expression, and frontal activations during a verbal fluency task2011

    • Author(s)
      Uehara T(上原徹)
    • Organizer
      14^<th> international congress of European Society of Child and Adolescent Psychiatry(第14回欧州児童青年精神医学会国際会議)
    • Place of Presentation
      フィンランディアホール、Helsinki, Finland
    • Year and Date
      2011-06-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Dissociative tendency, anger expression, and frontal activation during a verbal fluency task2011

    • Author(s)
      Uehara T, Ishige Y, Suda M
    • Organizer
      14th International Congress of European Society for Child and Adolescent Psychiatry
    • Place of Presentation
      フィンランディアホール (Helsinki, Finland)
    • Related Report
      2011 Final Research Report
  • [Book] Dissociative tendency, anger expression, and frontal activation during a verbal fluency task2011

    • Author(s)
      Uehara T, Ishige Y, Suda M
    • Publisher
      IN Psychiatric Disorders-Worldwide Advances (Uehara T, edt), In Tech, Croatia
    • Related Report
      2011 Final Research Report
  • [Book] Psychiatric Disorders-Worldwide Advances/Dissociative tendency, anger expression, and frontal activation during a verbal fluency task2011

    • Author(s)
      Uehara T(上原徹)
    • Publisher
      In Tech社
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://ghsc.aramaki.gunma-u.ac.jp/uehara/work.php

    • Related Report
      2011 Final Research Report
  • [Remarks] 臨床カンファレンス資料集上原徹、黒崎成男:児童青年期の双極性気分変調をめぐる臨床的対話、p1-12、2011年7月作成

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://ghsc.aramaki.gunma-u.ac.jp/uehara/work.php

    • Related Report
      2010 Annual Research Report
  • [Remarks] 今後、研究内容の紹介や被検者リクルート、チェックリスト検査などに使用する予定である

    • URL

      http://ghsc.aramaki.gunma-u.ac.jp/

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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