The efficacy of anti-Aβoligomer antibody to the toxicity of Aβto neuronal cells
| Project/Area Number |
21591524
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
EBIHARA Kousuke 宮崎大学, 医学部, 助教 (20510720)
HUNAHASHI Hideki 宮崎大学, 医学部, 助教 (10404435)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | アルツハイマー型認知症 / βアミロイド / オリゴマー / 神経細胞保護 |
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| Research Abstract |
The most popular type of dementia is Alzheimer's disease(AD). The cause of AD is thought that amyloid beta protein(Aβ) cleaved from amyloid precursor protein(APP) which is expressing on the neuronal cell membranes has neurotoxicity and induce neuronal cell death. Recently some researchers found the soluble oligomer form had toxicity to the synapses and induce cognitive decline. We thought that anti-oligomer antibody has neuroprotective effect. We investigated the mechanisms of neuroprotective effect of anti-oligomer antibody against neuronal cells from Aβtoxicity. We investigated whether or not anti-oligomer antibody reduce the amount of free radical formation when Aβaggregate themselves. The amount of free radical formation was reduced compared with control solution. The viability of PC12 cells was higher when culture medium was added anti-oligomer antibody with Aβ. We found some changes of amount of NMDA receptor in PC12 when added Aβto culture medium with anti-oligomer antibody. We did not confirm whether the effect of anti-oligomer antibody against NMDA receptor was direct or indirect effect. We thought that there are some relations between two properties.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] アルツハイマー型認知症の周辺症状(BPSD)に対する抑肝散の効果-日常診療下における検討:入院患者における部分集団解析-2010
Author(s)
林要人, 石田康, 井上輝彦, 宇田川充隆, 竹内康三, 木上幸一郎, 二宮嘉正, 河野次郎, 鮫島哲郎, 川原岳, 後藤勇, 首藤謙二, 倉山茂樹, 中村純五, 岡原一徳, 三山吉夫
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Journal Title
Geriatric Medicine(老年医学)
Volume: 48巻6号
Pages: 831-838
Related Report
Peer Reviewed
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[Journal Article] Treatment of behavioral and psychological symptoms of Alzheimer-type dementia with Yokukansan in clinical practice2010
Author(s)
Hayashi Y, Ishida Y, Inoue T, Udagawa M, Takeuchi K, Yoshimuta H, Kiue K, Ninomiya Y, Kawano J, Sameshima T, Kawahara T, Goto I, Shudo K, Kurayama S, Nakamura J, Okahara K, Mitsuyama Y
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Journal Title
Prog Neuropsychopharmacol Biol Psychiatry
Volume: 34-3
Pages: 541-5
Related Report
Peer Reviewed
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[Journal Article] Effects of Yokukansan on behavioral and psychological symptoms of dementia in regular treatment for Alzheimer's disease2010
Author(s)
Okahara K, Ishida Y, Hayashi Y, Inoue T, Tsuruta K, Takeuchi K, Yoshimuta H, Kiue K, Ninomiya Y, Kawano J, Yoshida K, Noda S, Tomita S, Fujimoto M, Hosomi J, Mitsuyama Y
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Journal Title
Prog Neuropsychopharmacol Biol Psychiatry.
Volume: 34-3
Pages: 532-6
Related Report
Peer Reviewed
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