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Therapeutic effect of donepezil administration for patients with Alzheimer's disease as shown by [11C]-donepezil PET

Research Project

Project/Area Number 21591543
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionTohoku University

Principal Investigator

MEGURO Kenichi  東北大学, 大学院・医学系研究科, 教授 (90239559)

Co-Investigator(Kenkyū-buntansha) OKAMURA Nobuyuki  東北大学, 大学院・医学系研究科, 准教授 (40361076)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywordsドネペジル / PET / アルツハイマー病 / 注意力
Research Abstract

The aim of the study was to predict donepezil responders among patients with Alzheimer disease(AD)based on cognitive tests and PET. [11C]-Donepezil PET examinations were performed before and after treatment for 30 randomly selected patients. The distribution volume(DV), which indicates the density of donepezil binding sites, was calculated using Logan graphical analysis. The DV at baseline and %DV change in the responders were found to be higher than in the non-responders, and these drug-responders were also good responders to psychosocial intervention such as group reminiscence therapy and reality orientation.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (3 results)

All 2011 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Book (1 results)

  • [Journal Article] Greater responsiveness to donepezil in Alzheimer patients with higher levels of acetylcholinesterase based on attention task scores and a donepezil PET study2011

    • Author(s)
      Masashi Kasuya, Kenichi Meguro, Nobuyuki Okamura, Yoshihito Funaki, Hiroyasu Ishikawa, Naofumi Tanaka, Ren Iwata, Kazuhiko Yanai
    • Journal Title

      Alzheimer Disease & Associated Disorders

      Volume: Jun 9(Epub)

    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Greater responsiveness to donepezil in Alzheimer patients with higher levels of acetylcholinesterase based on attention task scores and a donepezil PET study Alzheimer Disease & Associated Disorders

    • Author(s)
      Masashi Kasuya, Kenichi Meguro, Nobuyuki Okamura, Yoshihito Funaki, Hiroyasu Ishikawa, Naofumi Tanaka, Ren Iwata, Kazuhiko Yanai
    • Journal Title

      Epub

      Volume: 2011

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Book] 認知症医療学:自治体における認知症対策のために-田尻プロジェクトからの提言2011

    • Author(s)
      目黒謙一
    • Publisher
      新興医学出版社
    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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