Therapeutic effect of antiangiogenic therapy and chemotherapy determined by molecular imaging

• Project/Area Number: 21591573
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Yokohama City University
• Principal Investigator: TATEISHI Ukihide 横浜市立大学, 医学部, 准教授 (20415524)
• Co-Investigator(Renkei-kenkyūsha): YAMADA Yasuhide 国立がん研究センター中央病院, 消化器内科, 医長
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 血管新生

Research Abstract

Integrin specific PET ligands were synthesized in order to visualize therapeutic effect of antiangiogenic agents in rat model. 68Ga-DOTA-PEG-RGDfK and 68Ga-DOTA-RGDfK, which are monomeric alpha(v) beta3 agonists were used to evaluate therapeutic effect of antiangiogenic drug in rat model. Integrin specific PET ligands were considered to be promising tool for monitering therapeutic effect of antiangiogenic agents.

Research Products

• [Journal Article] B細胞性悪性リンパ腫治療のパラダイムシフトB細胞リンパ腫診療におけるFDG-PETの意義 (2011)
  • Author(s): 立石宇貴秀
  • Journal Title: 血液フロンティア Volume: 21巻 Pages: 1411-1421
• [Journal Article] PET/CT allows stratification of responders to neoadjuvant chemotherapy for high-grade sarcoma : a prospective study (2011)
  • Author(s): 立石宇貴秀
  • Journal Title: Clin Nucl Med Volume: 36巻 Pages: 526-532
  • Peer Reviewed
• [Journal Article] Relevance of monitoring metabolic reduction in patients with relapsed or refractory follicular and mantle cell lymphoma receiving bendamustine : a multicenter study (2011)
  • Author(s): 立石宇貴秀
  • Journal Title: Cancer Sci Volume: 102巻 Pages: 414-418
  • NAID: 10029290273
  • Peer Reviewed
• [Journal Article] Relevance of monitoring metabolic reduction in patients with relapsed or refractory follicular and mantle cell lymphoma receiving bendamustine : a multicenter study (2011)
  • Author(s): 立石宇貴秀
  • Journal Title: Cancer Science Volume: 102 Pages: 414-418
  • NAID: 10029290273
  • Peer Reviewed
• [Journal Article] PET/CT allows stratification of responders to neoadjuvant chemotherapy for high-grade sarcoma : a prospective study (2011)
  • Author(s): 立石宇貴秀
  • Journal Title: Clinical Nuclear Medicine Volume: 36 Pages: 526-532
  • Peer Reviewed
• [Journal Article] GISTの画像診断 (2010)
  • Author(s): 立石宇貴秀
  • Journal Title: 外科治療 Volume: 102巻 Pages: 126-132
• [Journal Article] PET assessment of disease activity in children with juvenile idiopathic arthritis (2010)
  • Author(s): 立石宇貴秀
  • Journal Title: Pediatric Radiology Volume: 40巻 Pages: 1781-1788
  • Peer Reviewed
• [Journal Article] A meta-analysis of(18) F-Fluoride positron emission tomography for assessment of metastatic bone tumor (2010)
  • Author(s): 立石宇貴秀
  • Journal Title: Ann Nucl Med Volume: 24巻 Pages: 523-531
  • NAID: 10027659068
  • Peer Reviewed
• [Journal Article] A meta-analysis of(18)F-Fluoride positron emission tomography for assessment of metastatic bone tumor (2010)
  • Author(s): 立石宇貴秀
  • Journal Title: Annals of Nuclear Medicine Volume: 24 Pages: 523-531
  • NAID: 10027659068
  • Peer Reviewed
• [Journal Article] PET assessment of disease activity in children with juvenile idiopathic arthriti (2010)
  • Author(s): 立石宇貴秀
  • Journal Title: Pediatric Radiology Volume: 40 Pages: 1781-1788
  • Peer Reviewed
• [Journal Article] PET-CTを用いた癌の治療効果判定 (2009)
  • Author(s): 立石宇貴秀
  • Journal Title: 画像診断 Volume: 29巻 Pages: 1458-1465
  • Peer Reviewed
• [Journal Article] Comparative study of FDG PET/CT and conventional imaging in the staging of rhabdomyosarcoma (2009)
  • Author(s): 立石宇貴秀
  • Journal Title: Ann Nucl Med Volume: 23巻 Pages: 155-161
  • NAID: 10025135707
  • Peer Reviewed
• [Journal Article] Chronic thyroiditis in patients with advanced breast carcinoma : metabolic and morphologic changes on PET-CT (2009)
  • Author(s): 立石宇貴秀
  • Journal Title: Eur J Nucl Med Mol Imaging Volume: 36巻 Pages: 894-902
  • Peer Reviewed
• [Journal Article] Chronic thyroiditis in patients with advanced breast carcinoma : metabolic and morphologic changes on PET-CT (2009)
  • Author(s): 立石宇貴秀
  • Journal Title: Eur J Nucl Med Mol Imaging 36 Pages: 894-902
  • Peer Reviewed
• [Journal Article] Comparative study of FDG PET/CT and conventional imaging in the staging of rhabdomyosarcoma (2009)
  • Author(s): 立石宇貴秀
  • Journal Title: Ann Nucl Med 23 Pages: 155-161
  • NAID: 10025135707
  • Peer Reviewed
• [Journal Article] PET-CTを用いた癌の治療効果判定 (2009)
  • Author(s): 立石宇貴秀
  • Journal Title: 画像診断 29 Pages: 1458-1465
  • Peer Reviewed
• [Presentation] 核医学の進歩と展望PET導入後の新たな展開 (2011)
  • Author(s): 立石宇貴秀
  • Organizer: 日本医学放射線学会総会(招待講演)
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-04-28
• [Presentation] 核医学の進歩と展望PET導入後の新たな展開 (2011)
  • Author(s): 立石宇貴秀
  • Organizer: 日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜(招待講演)
  • Year and Date: 2011-04-08
• [Presentation] PET/CTの将来展望と課題造影PET/CT (2010)
  • Author(s): 立石宇貴秀
  • Organizer: 日本医学放射線学会総会(招待講演)
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2010-04-10
• [Presentation] PET, PET/CTの将来展望と課題 造影PET/CT (2010)
  • Author(s): 立石宇貴秀
  • Organizer: 日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜(招待講演)
  • Year and Date: 2010-04-10
• [Presentation] PET/CTと治療計画 (2009)
  • Author(s): 立石宇貴秀
  • Organizer: 日本医学放射線学会総会(招待講演)
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-04-18
• [Presentation] PET/CTと治療計画 (2009)
  • Author(s): 立石宇貴秀
  • Organizer: 日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-04-18
• [Book] 最新治療・主要検査ガイド (2011)
  • Author(s): 立石宇貴秀
  • Total Pages: 214
  • Publisher: 中山書店
• [Book] 悪性腫瘍診断のためのPET/CTパーフェクトガイド (2010)
  • Author(s): 立石宇貴秀
  • Total Pages: 150
  • Publisher: 中山書店
• [Book] エキスパートによるPET/CTがん病期診断 (2009)
  • Author(s): 立石宇貴秀、井上登美夫
  • Total Pages: 375
  • Publisher: 秀潤社
• [Book] エキスパートによるPET/CTがん病期診断 (2009)
  • Author(s): 立石宇貴秀, 井上登美夫
  • Total Pages: 375
  • Publisher: 秀潤社