Therapeutic effect of antiangiogenic therapy and chemotherapy determined by molecular imaging
| Project/Area Number |
21591573
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YAMADA Yasuhide 国立がん研究センター中央病院, 消化器内科, 医長
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 血管新生 |
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| Research Abstract |
Integrin specific PET ligands were synthesized in order to visualize therapeutic effect of antiangiogenic agents in rat model. 68Ga-DOTA-PEG-RGDfK and 68Ga-DOTA-RGDfK, which are monomeric alpha(v) beta3 agonists were used to evaluate therapeutic effect of antiangiogenic drug in rat model. Integrin specific PET ligands were considered to be promising tool for monitering therapeutic effect of antiangiogenic agents.
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Report
(4 results)
Research Products
(26 results)
