Imaging of proliferative ability and hypoxia of tumor in radioimmunotherapy
| Project/Area Number |
21591580
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kinki University |
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Principal Investigator |
HOSONO Makoto 近畿大学, 医学部附属病院, 教授 (00281303)
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| Project Period (FY) |
2009 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 放射免疫療法 / 低酸素 / 悪性リンパ腫 / 抗原抗体 / 陽電子断層撮影 / 単光子断層撮影 / FDG / 低酸素イメージング |
|---|
| Research Abstract |
In patients with CD20 positive B-cell non-Hodgkin lymphoma who underwent yttrium-90 labeled anti-CD20 ibritumomab tiuxetan therapy, glucose metabolism by FDG and hypoxia by FMISO were evaluated with PET/CT before and after therapy, and changes were analyzed over time. Antigen expression of CD20 was also evaluated by SPECT/CT using indium-111 labeled anti-CD20 antibody. Association of glucose metabolism, hypoxia, and CD20 expression with therapeutic response was analyzed.
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Report
(5 results)
Research Products
(113 results)
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[Journal Article] Adrenal masses: the value of additional fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) in differentiating between benign and malignant lesions2009
Author(s)
Okada M, Shimono T, Komeya Y, Ando R, Kagawa Y, Katsube T, Kuwabara M, Yagyu Y, Kumano S, Imaoka I, Tsuchiya N, Ashikaga R, Hosono M, Murakami T
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Journal Title
Ann Nucl Med
Volume: 23(4)
Pages: 349-354
NAID
Related Report
Peer Reviewed
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[Presentation] Prediction of tumor response by Indium-111-Zevalin SPECT/CT and FDG-PET/CT in radioimmunotherapy for B-cell non-Hodgkin lymphoma2012
Author(s)
Hosono M, Hanaoka K, Ishii K, Sakaguchi K, Im S, Tsuchiya N, Komeya Y, Yagyu Y, Tatsumi Y, Matsumura I
Organizer
Annual Congress of European Association of Nuclear Medicine
Place of Presentation
Milan, Italy
Related Report
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[Presentation] A prospective Clinical Trial on Tumor Hypoxia Imaging with 18F-misonidazole (F-MISO) positron Emission Tomography (PET)2011
Author(s)
Tachibana I, Nishimura Y, Shibata T, Kanamori S, Nakamatsu K, Tamura M, Koike R, Nishikawa T, Ishikawa K, Hosono M
Organizer
53rd annual meeting of ASTRO
Place of Presentation
Miami, Florida, USA
Related Report
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[Presentation] Indium-111-Zevalin-SPECT/CT and FDG-PET/CT as quantitative evaluation in radioimmunotherapy for B-cell non-Hodgkin's lymphoma (Abstract: P706)2011
Author(s)
Hanaoka K, Hosono M, Yamazoe Y, Tatsumi Y, Komeya Y, Tsuchiya N, Ishii K, Usami K, Murakami T, Uto T
Organizer
EANM' 11 annual congress of European Society of Nuclear Medicine
Place of Presentation
Birmingham, UK
Related Report
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[Presentation] FDG uptake in bone marrow after G-CSF administration in patients with non-Hodgkin lymphoma2010
Author(s)
Hanaoka K, Hosono M, Komeya Y, Tsuchiya N, Usami k, Yamazoe Y, Ishii K, Tatsumi Y, Murakami T
Organizer
Abstract#P502, EANM'10
Place of Presentation
Vienna, Austria
Related Report
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[Presentation] Assessment of lymph node metastasis esophageal cancer with SUV correction based on count recovery on 18F-FDG2009
Author(s)
Komeya Y, Hosono M, Tsuchiya N, Okada M, Kagawa Y, Hanaoka K, Usami K, Yamazoe Y, Murakami T, Itoh T
Organizer
56th annual meeting of Society of Nuclear Medicine
Place of Presentation
Toronto, Canada
Related Report
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[Presentation] Characteristics of FDG biodistribution in chronic hemodialysis patients2009
Author(s)
Hanaoka K, Hosono M, Komeya Y, Ohata A, Usami K, Tsuchiya N, Yamazoe Y, Sumita M, Shimono T, Itoh T
Organizer
56th annual meeting of Society of Nuclear Medicine
Place of Presentation
Toronto, Canada
Related Report
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