| Project/Area Number |
21591634
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Nagoya University |
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Principal Investigator |
HANEDA Masataka 名古屋大学, 大学院・医学系研究科, 講座講師 (50436995)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Takaaki 名古屋大学, 医学系研究科, 講座教授 (70314010)
IWASAKI Kenta 名古屋大学, 医学系研究科, 講座助教 (10508881)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ドナー特異性 / allo reactive T細胞 / 制御性T細胞 / Anergy / clonal deletion / ELISpot assay / 移植免疫 / トレランス / anergy / Clonal deletion / TCR repertoire解析 / T cell cloning |
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| Research Abstract |
We performed analysis by using the improved ELISpot assay for monitoring the donor specific allo reactive T cells. The numbers of allo reactive T cells were not altered in one year after kidney transplantation. We also analyzed about the relationship between rejection and Treg cells number in the peripheral blood. Once the expression of Foxp3 is lowered after transplantation, one year after the transplant was recovered up to the value before transplantation. Acute rejection does not occur more than one year after, because Treg, rather than clonal deletion and anergy, may be due to immune regulation.
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