Establishment of non-invasive diagnostic methods for allograft dysfunction and real-time monitoring of immunological status in liver transplant
| Project/Area Number |
21591637
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAGANO Hiroaki 大阪大学, 医学系研究科, 准教授 (10294050)
KOBAYASHI Shougo 大阪大学, 医学系研究科, 助教 (30452436)
TANEMURA Masahiro 大阪大学, 医学系研究科, 助教 (30379250)
TAKEDA Yu 大阪大学, 医学系研究科, 助教 (90397696)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 肝移植 / 生体材料 / 拒絶反応 / DNAマイクロアレイ / プロテオーム解析 / 整体材料 |
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| Research Abstract |
We investigated liver biopsy samples and bile samples in clinical liver transplant, applying molecular biological techniques. We found that biomarkers which were associated with acute cellular rejection after liver transplant in the two different OMICS levels ; DNA microarray and proteomic analyses. We then established the non-invasive method for diagnosing acute cellular rejection in liver transplant recipients.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Significance of alanine aminopeptidase N(APN) in bile in the diagnosis of acute cellular rejection after liver transplantation2011
Author(s)
Kim C, Aono S, Marubashi S, Wada H, Kobayashi S, Eguchi H, Takeda Y, Tanemura M, Okumura N, Takao T, Doki Y, Mori M, Nagano H.
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Journal Title
Journal of Surgical Research
Related Report
Peer Reviewed
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[Journal Article] Differential transcriptome patterns for acute cellular rejection in recipients with recurrent hepatitis C after liver transplantation2009
Author(s)
Asaoka T, Kato T, Marubashi S, Dono K, Hama N, Takahashi H, Kobayashi S, Takeda Y, Takemasa I, Nagano H, Yoshida H, Ruiz P, Tzakis AG, Matsubara K, Monden M, Doki Y, Mori M.
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Journal Title
Liver Transplantation
Volume: 15(12)
Pages: 1738-1749
Related Report
Peer Reviewed
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