| Project/Area Number |
21591709
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIRATA Koichi 札幌医科大学, 医学部, 教授 (50136959)
MIZUGUCHI Toru 札幌医科大学, 医学部, 准教授 (30347174)
信岡 隆幸 札幌医科大学, 医学部, 助教 (50404603)
原田 敬介 札幌医科大学, 医学部, 助教 (00560004)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 胃十二指腸外科学 / 胃がん / 膵癌 / 同所性移植モデル / 肝転移 / リンパ節転移 / 腹膜播種 / がん / 転移 / 癌 |
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| Research Abstract |
To elucidate the mechanisms of cancer metastasis, we established highly lymphatic, liver metastatic and peritoneal disseminated models in nude mice, and then characterized several factors related to metastasis in these cells. We investigated several biological properties and mRNA levels of differentially-expressed genes involved in cancer metastasis by cDNA macroarray. We also conducted the availability of metastasis inhibition substances and the relation between metastatic potential and angiogenesis factorts. To date, Endothelin expression level in gastric cancer cell line might contribute to the liver metastasis and VEGF-C to the lymphatic metastasis. Osteopontin might also contribute to the liver metastasis in pancreatic cancer cell line.
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