Prediction of recurrence in stage I gastric cancer

• Project/Area Number: 21591711
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kitasato University
• Principal Investigator: YAMASHITA Keishi 北里大学, 医学部, 助教 (70406932)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 胃癌 / 再発 / Stage I / HOPX / メチル化 / 予後因子 / 患者選択 / HOP / ホメオボックス蛋白 / 定量 / 臨床病理学的因子

Research Abstract

In stage I advanced gastric cancer, HOPX methylation and PRL-3 protein expression were investigated for prediction marker of recurrence. As a result, PRL-3 protein expression is closely correlated with recurrence of stage I advanced gastric cancer, and its validation study is the next step for this purpose.

Research Products

• [Journal Article] Therapeutic potential of PRL-3 targeting and clinical significance of PRL-3 genomic amplification in gastric cancer (2011)
  • Author(s): Ooki A, Yamashita K, Kikuchi S, Sakuramoto S, Katada N, Waraya M, Kawamata H, Nishimiya H, Nakamura K, Watanabe M.
  • Journal Title: BMC Cancer Pages: 11-122
• [Journal Article] Genomic and epigenetic profiles of gastric cancer : potential diagnostic and therapeutic applications (2011)
  • Author(s): Yamashita K, Sakuramoto S, Watanabe M
  • Journal Title: Surg Today Volume: 41(1) Pages: 24-38
  • NAID: 10027818359
• [Journal Article] Genomic and epigenetic profiles of gastric cancer : potential diagnostic and therapeutic applications. (2011)
  • Author(s): Yamashita K, et al.
  • Journal Title: Surgery Today Volume: 41(1) Pages: 24-38
  • NAID: 10027818359
  • Peer Reviewed
• [Journal Article] Phosphatase of regenerating liver-3 as a convergent therapeutic target for lymph node metastasis in esophageal squamous cell carcinoma (2010)
  • Author(s): Ooki A, Yamashita K, Kikuchi S, Sakuramoto S, Katada N, Watanabe M.
  • Journal Title: Int J Cancer Volume: 127(3) Pages: 543-54
• [Journal Article] Potential utility of HOP homeobox gene promoter methylation as a marker of tumor aggressiveness in gastric cancer (2010)
  • Author(s): Ooki A, Yamashita K, Kikuchi S, Sakuramoto S, Katada N, Kokubo K, Kobayashi H, Kim MS, Sidransky D, Watanabe M.
  • Journal Title: Oncogene Volume: 29(22) Pages: 3263-75
• [Journal Article] Potential utility of HOP homeobox gene promoter methylation as a marker of tumor aggressiveness in gastric cancer (2010)
  • Author(s): 大木、山下, ら
  • Journal Title: Oncogene Volume: 29 Pages: 3263-75
  • Peer Reviewed
• [Journal Article] Potential utility of HOP homeobox gene promoter methylation as a marker of tumor aggressiveness in gastric cancer. (2010)
  • Author(s): Ooki A, et al.
  • Journal Title: Oncogene Volume: 29(22) Pages: 3263-75
  • Peer Reviewed
• [Journal Article] Potential utility of HOP homeobox gene promoter methylation as a marker of tumor aggressiveness in gastric cancer. (2010)
  • Author(s): Ooki A, Yamshita K, et al.
  • Journal Title: Oncogene 15-Mar(E-pub ahead of print)
  • Peer Reviewed
• [Journal Article] Phosphatase of regenerating liver-3 as a prognostic biomarker in histologically node-negative gastric cancer (2009)
  • Author(s): Ooki A, Yamashita K, Kikuchi S, Sakuramoto S, Katada N, Watanabe M.
  • Journal Title: Oncol Rep Volume: 21(6) Pages: 1467-75
• [Journal Article] Phosphatase of regenerating liver-3 as a prognostic biomarker in histologically node-negative gastric cancer (2009)
  • Author(s): 大木、山下, ら
  • Journal Title: Oncol Rep Volume: 21 Pages: 1467-75
  • Peer Reviewed
• [Journal Article] Liver metastasis of colorectal cancer by protein-tyrosine phosphatase type 4A, 3(PRL-3) is mediated through lymph node metastasis and elevated serum tumor markers such as CEA and CA19-9 (2008)
  • Author(s): Hatate K, Yamashita K, Hirai K, Kumamoto H, Sato T, Ozawa H, Nakamura T, Onozato W, Kokuba Y, Ihara A, Watanabe M.
  • Journal Title: Oncol Rep Volume: 20(4) Pages: 737-43
• [Presentation] Clinical significance of PRL-3 genomic amplification/expression profiles and preclinical study of PRL-3 inhibitor in human GI cancers (2012)
  • Author(s): Yamashita K, Ooki A, Nakayama K, Hatate K, Hirai K, and Watanabe M.
  • Organizer: ASCO Annual Meeting 2012
  • Place of Presentation: Chicago, IL, USA
  • Year and Date: 2012-06-01
• [Presentation] 大腸癌における癌抑制遺伝子HOPXの同定とAP-1(c-Fos/c-Jun)経路のクロスリンクと細胞死 (2012)
  • Author(s): 山下継史, ら
  • Organizer: 第112回日本外科学会
  • Place of Presentation: 幕張
  • Year and Date: 2012-04-14
• [Presentation] Epigenetic silencing of cancer-specific methylation may converge on therapeutic targets on human cancers (2012)
  • Author(s): Yamashita K, Kim MS, Ooki A, Kato H, Waraya M, Kawamata H, Watanabe M, Sidransky D.
  • Organizer: AACR Annual Meeting(Minisymposium)
  • Place of Presentation: Chicago, IL, USA
  • Year and Date: 2012-03-31
• [Presentation] HOPX tumor suppressive pathways may be epigenetically controlled in colorectal cancer (2011)
  • Author(s): Yamashita K, Ooki A, Katoh H, Waraya M, and Watanabe M.
  • Organizer: ISOBM, Firrenze
  • Place of Presentation: Italy
  • Year and Date: 2011-10-15
• [Presentation] Tumor Suppressive Role of HOPX Gene in Pancreatic Carcinogenesis (2011)
  • Author(s): Waraya M, Yamashita K, Watanabe M
  • Organizer: ISOBM, Firrenze
  • Place of Presentation: Italy
  • Year and Date: 2011-10-15
• [Presentation] Cancer-specific epigenetic alteration of HOPX in human cancer, and its functional relevance in carcinogenesis(Workshop) (2011)
  • Author(s): Yamashita K, Ooki A, Katoh H, Waraya M, and Watanabe M.
  • Organizer: 8th ISMRC
  • Place of Presentation: Osaka
  • Year and Date: 2011-09-21
• [Presentation] 大腸癌および膵臓癌における癌抑制遺伝子(homeobox only protein) HOPXの役割 (2011)
  • Author(s): 藁谷美奈、山下継史、渡邊昌彦
  • Organizer: 第20回日本がん転移学会総会
  • Place of Presentation: 浜松
  • Year and Date: 2011-06-30
• [Presentation] Causative of tumor progression for suppressor gene HOP epigenetically regulated in gastric cancer (2010)
  • Author(s): 山下継史, ら
  • Organizer: 日本癌学会(English Workshop)
  • Place of Presentation: リーガロイヤルホテル大阪(大阪府)
  • Year and Date: 2010-09-24
• [Presentation] Causative role of tumor suppressor gene HOP epigenetically regulated in gastric cancer(International session, English Workshop) (2010)
  • Author(s): Yamashita K., Ooki A, Kato H, Waraya M, Kawamata H, Nakamura K, Nishimiya H, Okubo H, and Watanabe M.
  • Organizer: 第69回日本癌学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-22
• [Presentation] HOPX is epigenetically and cancerspecifically silenced tumor suppressor gene candidates in colorectal cancer (2010)
  • Author(s): Kato H, Yamashita K., Ooki A, Waraya M, Kawamata H, Nakamura K, Nishimiya H and Watanabe M
  • Organizer: 第69回日本癌学会総会(International session, English Workshop)
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-22
• [Presentation] 消化器癌診断・治療におけるHOP/OB1/NECC1プロモーターDNAメチレーションの臨床的有用性 (2009)
  • Author(s): 山下継史、大木暁、加藤弘、藁谷美奈、河又寛、渡邊昌彦
  • Organizer: 第29回日本分子腫瘍マーカー研究会
  • Place of Presentation: 横浜
  • Year and Date: 2009-09-30
• [Presentation] Selection of High Risk Patients in Advanced Gastric Cancer(AGC)(Paper Free) (2009)
  • Author(s): Yamashita K., Sakuramoto S, Kikuchi S, Katada N, and Watanabe M.
  • Organizer: 2009 International Surgical Week
  • Place of Presentation: Adelade, Australia