New cancer therapy targeting chemokine-network in esophageal cancer
| Project/Area Number |
21591712
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KITAGAWA Yuko 慶應義塾大学, 医学部, 教授 (20204878)
IRINO Tomoyuki 慶應義塾大学, 医学部, 助教 (20445216)
NISHI Tomohiko 慶應義塾大学, 医学部, 助教 (70445386)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 食道扁平上皮癌 / ケモカインレセプター / CCR7 / CXCR4 / CCL21 / CXCL12 / CCL12 / CXCL21 / VEGF-C / ケモカイン / 食道癌 / リンパ節転移 |
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| Research Abstract |
We investigated the CCR7 expression of 105 consecutive patients with esophageal squamous cell carcinoma(ESCC) by immunohistochemistry, showing that positive CCR7 expression was significantly correlated with lymph node metastasis and poor prognosis. Cell mobility analyzer to directly assess cell migratory movements showed that CCR7-expressing ESCC cells exhibited a significant increase in velocity in response to the CC-chemokine ligand 21/secondary lymphoid-tissue chemokine(CCL21/SLC), a specific ligand for CCR7. We also investigated the CXCL12 of 81 patients with ESCC by immunohistochemistry, showing that positive CXCL12 expression was significantly correlated with poor prognosis. ESCC cell growth which over-expressed CXCL12 was significantly suppressed by AMD3100.
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Report
(4 results)
Research Products
(12 results)
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[Presentation] 食道扁平上皮癌におけるChemokine Receptor CCR7発現の基礎的検討とその臨床的意義2010
Author(s)
入野誠之, 竹内裕也, 松田祐子, 才川義朗, 和田則仁, 高橋常浩, 大山隆史, 中村理恵子, 吉川貴久, 上田政和, 北川雄光
Organizer
第110回日本外科学会定期学術集会
Place of Presentation
名古屋国際会議場(愛知県)
Year and Date
2010-04-10
Related Report
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